CN113795502A - Cd80变体蛋白及其应用 - Google Patents
Cd80变体蛋白及其应用 Download PDFInfo
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Abstract
Description
CTLA4-CD80 | TopOD | EC50(ug/m |
CD80-WT | 1.50 | 0.0110 |
S156I/A165S | 1.41 | 0.0120 |
S156I/S131A | 1.59 | 0.0100 |
A165S/S131A | 1.47 | 0.0120 |
S156I/A165S/S131A | 1.50 | 0.0130 |
S156F | 1.58 | 0.0090 |
S156R | 1.57 | 0.0140 |
S156E | 1.34 | 0.0110 |
S156D | 1.55 | 0.0150 |
S156Q | 1.68 | 0.0120 |
S131V | 1.48 | 0.0200 |
S1311 | 1.60 | 0.0150 |
S131F | 1.68 | 0.0141 |
S131R | 1.60 | 0.0058 |
S131E | 1.50 | 0.0130 |
S131D | 1.30 | 0.0260 |
S131Q | 1.46 | 0.0130 |
A165V | 1.44 | 0.0370 |
A165I | 1.32 | 0.0890 |
A165F | 0.90 | 0.0310 |
A165R | 1.01 | 0.0210 |
A165E | 1.04 | 0.0090 |
A165D | 0.87 | 0.0180 |
A165Q | 0.82 | 0.0120 |
Top | EC50 | |
CD80-WT | 1.11 | 0.04846 |
T130A | 1.198 | 0.01983 |
S131V | 1.053 | 0.0321 |
L139V | 1.314 | 0.0268 |
V155A | 1.095 | 0.02888 |
V155I | 0.9623 | 0.08108 |
V155T | 0.8803 | 0.06053 |
S156A | 1.159 | 0.04707 |
V166A | 0.9512 | 0.06625 |
V166L | 1.162 | 0.02897 |
V166T | 0.9639 | 0.01365 |
v155A/S156A | 1.151 | 0.02742 |
V155I/S156A | 1.095 | 0.1835 |
V155T/S156A | 0.8386 | 0.05937 |
CD28-CD80 | Top OD | EC50(ug/ml) |
CD80-WT | 2.51 | 2.42 |
S156I/A165S | 2.22 | 2.42 |
S156I/S131A | 2.20 | 4.36 |
A165S/S131A | 2.33 | 5.02 |
S156I/A165S/S131A | 2.26 | 4.85 |
S156F | 2.19 | 2.20 |
S156R | 1.83 | 7.66 |
S156E | 2.12 | 4.18 |
S156D | 2.12 | 4.29 |
S156Q | 2.14 | 4.05 |
S131V | 1.27 | 32.46 |
S131I | 1.76 | 10.75 |
S131F | 1.22 | .... |
S131R | 1.75 | 23.26 |
S131E | 1.72 | .... |
S131D | 1.31 | .... |
S131Q | 1.63 | 13.60 |
A165V | 1.02 | 135.30 |
A165I | 0.67 | 2.10 |
A165F | 0.74 | 14.86 |
A165R | 1.10 | .... |
A165E | 1.78 | 34.07 |
A165D | 1.36 | .... |
A165Q | 1.76 | 157.10 |
PD-L1-CD80 | Top OD | EC50(ug/ml |
CD80-WT | 1.07 | 0.98 |
S1561/A165S | 0.70 | 1.17 |
S156I/S131A | 0.74 | 0.52 |
A165S/S131A | 0.83 | 1.23 |
S156I/A165S/S131A | 0.71 | 1.96 |
S156F | 0.94 | 0.37 |
S156R | 0.91 | 0.49 |
S156E | 0.72 | 0.67 |
S156D | 0.83 | 0.57 |
S156Q | 0.92 | 0.55 |
S131V | 0.94 | 0.40 |
S1311 | 0.87 | 0.24 |
S131F | 0.96 | 0.21 |
S131R | 0.79 | 0.58 |
S131E | 0.83 | 0.51 |
S131D | 0.89 | 0.28 |
S131Q | 0.76 | 0.48 |
A165V | 0.81 | 0.14 |
A165I | 0.81 | 0.19 |
A165F | 0.94 | 0.38 |
A165R | 0.97 | 0.26 |
A165E | 0.80 | 0.32 |
A165D | 0.82 | 0.30 |
A165Q | 0.92 | 0.29 |
EC<sub>50</sub> | |
A.mCD80(WT) | 3.606 |
mCD80(T165E) | 10.59 |
mCD80(T165Q) | 3.462 |
mCD80(T165R) | 6.914 |
mCD80(T165A) | 5.705 |
mCD80(T165S) | 1.603 |
B.mCD80(WT) | 3.499 |
mCD80(T165V) | 17.56 |
mCD80(T165I) | 17.69 |
mCD80(T165F) | 18.27 |
mCD80(T165D | 10.37 |
mCD80(S131V) | 11.19 |
C.mCD80(WT) | 5.467 |
mCD80(S131I) | 19.25 |
mCD80(S131F) | 3.485 |
mCD80(S131R) | 5.127 |
mCD80(S131E) | 3.755 |
mCD80(S131Q) | 2.879 |
D.mCD80(WT) | 4.343 |
mCD80(S131A) | 3.709 |
mCD80(S131P) | 15.3 |
EC<sub>50</sub> | |
A.mCD80(WT) | 8.987 |
mCD80(T165E) | 3.865 |
mCD80(T165Q) | 4.261 |
mCD80(T165R) | 4.97 |
mCD80(T165A) | 4.795 |
mCD80(T165S) | 6.856 |
B.mCD80(WT) | 9.688 |
mCD80(T165V) | 5.873 |
mCD80(T165I) | 7.567 |
mCD80(T165F) | 17.13 |
mCD80(T165D | 5.879 |
mCD80(S131V) | 6.079 |
C.mCD80(WT) | 9.914 |
mCD80(S131I) | 8.58 |
mCD80(S131F) | 7.044 |
mCD80(S131R) | 4.661 |
mCD80(S131E) | 9.23 |
mCD80(S131Q) | 8.217 |
D.mCD80(WT) | 8.698 |
mCD80(S131A) | 8.801 |
mCD80(S131P) | 6.098 |
Claims (63)
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US62/839,542 | 2019-04-26 | ||
PCT/US2020/029834 WO2020219896A1 (en) | 2019-04-26 | 2020-04-24 | Cd80 variant proteins and uses thereof |
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CN (1) | CN113795502B (zh) |
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WO2024007872A1 (zh) * | 2022-07-05 | 2024-01-11 | 杭州阿诺生物医药科技有限公司 | 一种cd80突变体多肽及其用途 |
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AU2021285068A1 (en) * | 2020-06-03 | 2023-01-19 | Boehringer Ingelheim International Gmbh | Recombinant rhabdovirus encoding for a CD80 extracellular domain Fc-fusion protein |
TW202405012A (zh) * | 2022-04-02 | 2024-02-01 | 大陸商杭州尚健生物技術有限公司 | Cd80蛋白變體及cd80融合蛋白 |
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TW202106703A (zh) | 2021-02-16 |
US20220227833A1 (en) | 2022-07-21 |
CN113795502B (zh) | 2024-06-11 |
KR20220002526A (ko) | 2022-01-06 |
AU2020262424B2 (en) | 2023-09-28 |
JP2022530628A (ja) | 2022-06-30 |
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EP3959225A1 (en) | 2022-03-02 |
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