CN108498873A - 用于脊柱融合手术的组合物和方法 - Google Patents

用于脊柱融合手术的组合物和方法 Download PDF

Info

Publication number
CN108498873A
CN108498873A CN201810399549.0A CN201810399549A CN108498873A CN 108498873 A CN108498873 A CN 108498873A CN 201810399549 A CN201810399549 A CN 201810399549A CN 108498873 A CN108498873 A CN 108498873A
Authority
CN
China
Prior art keywords
bone
pdgf
bone holder
holder material
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810399549.0A
Other languages
English (en)
Chinese (zh)
Inventor
S.E.林奇
L.B.斯內尔
C.K.希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomimetic Therapeutics LLC
Original Assignee
Biomimetic Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomimetic Therapeutics LLC filed Critical Biomimetic Therapeutics LLC
Publication of CN108498873A publication Critical patent/CN108498873A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Botany (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201810399549.0A 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法 Pending CN108498873A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42264910P 2010-12-13 2010-12-13
US61/422649 2010-12-13
CN201180067451.1A CN103491888A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180067451.1A Division CN103491888A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Publications (1)

Publication Number Publication Date
CN108498873A true CN108498873A (zh) 2018-09-07

Family

ID=46245079

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810399549.0A Pending CN108498873A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法
CN201180067451.1A Pending CN103491888A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180067451.1A Pending CN103491888A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Country Status (10)

Country Link
US (2) US20140308332A1 (https=)
EP (1) EP2651319A4 (https=)
JP (3) JP6116484B2 (https=)
KR (3) KR20140038348A (https=)
CN (2) CN108498873A (https=)
AU (1) AU2011343995A1 (https=)
BR (1) BR112013014686A2 (https=)
CA (1) CA2819258C (https=)
MX (1) MX362405B (https=)
WO (1) WO2012082773A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364345A (zh) * 2019-09-23 2022-04-15 库罗斯生物外科股份公司 用于脊柱融合方法的骨移植材料

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2013133813A (ru) 2010-12-21 2015-01-27 Конинклейке Филипс Электроникс Н.В. Средства для выведения биомолекул из кровотока
EP3185919A1 (en) * 2014-08-28 2017-07-05 Bioventus LLC Improved osteoinductive substrates and methods of making the same
MX2017004520A (es) * 2014-10-14 2018-03-15 Lynch Samuel Composiciones para tratar heridas.
US10130678B2 (en) 2014-12-29 2018-11-20 Bioventus, LLC. Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2017019959A1 (en) * 2015-07-30 2017-02-02 Clarion Research Group Formulations and methods for recovery from spinal surgery
CA3002565A1 (en) 2015-10-30 2017-05-04 Bioventus, Llc Matrix for enhanced delivery of osteoinductive molecules in bone repair
US12318475B2 (en) 2016-03-14 2025-06-03 The University Of Chicago Injectable pastes based on oppositely charged polymer/calcium phosphate nanoparticles
EP3468626A1 (en) 2016-06-10 2019-04-17 Bioventus LLC Protein delivery with porous metallic structure
EP3651743B1 (en) * 2017-07-14 2023-10-04 The University of Chicago Freeze-dried formulations including nanoparticles and methods of freeze-drying
WO2020186267A2 (en) * 2019-03-14 2020-09-17 Biomimetic Therapeutics, Llc Platelet-derived growth factor formulations for enhancing bone fusion
CN111481741A (zh) * 2020-04-15 2020-08-04 花沐医疗科技(上海)有限公司 复合可吸收自锁定颈椎融合器及其制备方法
KR102667977B1 (ko) 2020-05-08 2024-05-22 주식회사 에이치엘클레무브 차량용 레이더 장치 및 제어방법
WO2025042830A1 (en) 2023-08-18 2025-02-27 Biomimetic Therapeutics, Llc Platelet-derived growth factor bone graft putty formulation

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034116A2 (en) * 2000-10-24 2002-05-02 Sdgi Holdings, Inc. Spinal fusion methods and devices
CN1640368A (zh) * 2004-01-06 2005-07-20 宋跃明 椎间融合装置
CN1774220A (zh) * 2003-02-14 2006-05-17 德普伊斯派尔公司 原位成型的椎间融合器械和方法
US20060292200A1 (en) * 2005-06-22 2006-12-28 David Delaney Porous beta-tricalcium phosphate and methods for producing the same
US20080124397A1 (en) * 1999-12-29 2008-05-29 Regeneration Technologies, Inc. System For Reconstituting Pastes And Methods Of Using Same
WO2008073628A2 (en) * 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
CN101330934A (zh) * 2005-12-14 2008-12-24 Scil技术有限公司 一种用于骨再生的可模压的生物材料
US20100183515A1 (en) * 2006-06-30 2010-07-22 Hart Charles E Compositions and methods for treating the vertebral column
CN101820895A (zh) * 2007-06-04 2010-09-01 生物模拟治疗公司 用于治疗脊柱的组合物和方法
CN101835434A (zh) * 2007-08-29 2010-09-15 埃泰克斯公司 骨水泥混合和递送系统及其应用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193270A1 (en) * 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
US8114841B2 (en) * 2004-10-14 2012-02-14 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
US8241357B2 (en) * 2007-04-25 2012-08-14 Jmea Corporation Prosthesis with a selectively applied bone growth promoting agent
US20090048675A1 (en) * 2007-04-25 2009-02-19 Bhatnagar Mohit K Spinal Fusion Implants with Selectively Applied Bone Growth Promoting Agent
CN101121753B (zh) * 2007-06-06 2011-11-16 天津林达生物科技有限公司 对多种皮肤细胞修复具持续作用的人血清白蛋白重组融合蛋白
EP2259807B1 (en) * 2008-02-07 2013-04-24 Biomimetic Therapeutics, Inc. Compositions for distraction osteogenesis
WO2010102266A1 (en) * 2009-03-05 2010-09-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080124397A1 (en) * 1999-12-29 2008-05-29 Regeneration Technologies, Inc. System For Reconstituting Pastes And Methods Of Using Same
WO2002034116A2 (en) * 2000-10-24 2002-05-02 Sdgi Holdings, Inc. Spinal fusion methods and devices
CN1774220A (zh) * 2003-02-14 2006-05-17 德普伊斯派尔公司 原位成型的椎间融合器械和方法
CN1640368A (zh) * 2004-01-06 2005-07-20 宋跃明 椎间融合装置
US20060292200A1 (en) * 2005-06-22 2006-12-28 David Delaney Porous beta-tricalcium phosphate and methods for producing the same
CN101330934A (zh) * 2005-12-14 2008-12-24 Scil技术有限公司 一种用于骨再生的可模压的生物材料
US20100183515A1 (en) * 2006-06-30 2010-07-22 Hart Charles E Compositions and methods for treating the vertebral column
WO2008073628A2 (en) * 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
CN101820895A (zh) * 2007-06-04 2010-09-01 生物模拟治疗公司 用于治疗脊柱的组合物和方法
CN101835434A (zh) * 2007-08-29 2010-09-15 埃泰克斯公司 骨水泥混合和递送系统及其应用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.S. YOUNG等: "Release, biological potency, and biochemical integrity of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) combined with AugmentTM Bone Graft or GEM 21S beta-tricalcium phosphate (β-TCP)", 《JOURNAL OF CONTROLLED RELEASE》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364345A (zh) * 2019-09-23 2022-04-15 库罗斯生物外科股份公司 用于脊柱融合方法的骨移植材料

Also Published As

Publication number Publication date
MX2013006697A (es) 2013-10-30
JP2013545584A (ja) 2013-12-26
BR112013014686A2 (pt) 2016-10-04
KR20180121674A (ko) 2018-11-07
MX362405B (es) 2019-01-15
KR20140038348A (ko) 2014-03-28
US20140308332A1 (en) 2014-10-16
EP2651319A4 (en) 2016-08-17
JP2017018710A (ja) 2017-01-26
CA2819258A1 (en) 2012-06-21
JP6116484B2 (ja) 2017-04-19
EP2651319A1 (en) 2013-10-23
CN103491888A (zh) 2014-01-01
JP2018161541A (ja) 2018-10-18
WO2012082773A1 (en) 2012-06-21
US20190365946A1 (en) 2019-12-05
KR20200055149A (ko) 2020-05-20
CA2819258C (en) 2020-03-10
AU2011343995A1 (en) 2013-06-20

Similar Documents

Publication Publication Date Title
JP6116484B2 (ja) 脊椎固定術用の組成物および方法
TWI394597B (zh) 骨科用生物可分解性補綴物
EP3181157B1 (en) Compositions and methods for arthrodetic procedures
US11786634B2 (en) Demineralized bone matrix having improved handling characteristics
JP5368102B2 (ja) ｒｈＰＤＧＦ−ＢＢ及び生体適合性マトリックスを用いた顎顔面骨強化
CN102014977B (zh) 用于牵引成骨术的组合物和方法
Damron Use of 3D β-tricalcium phosphate (Vitoss®) scaffolds in repairing bone defects
US20240390558A1 (en) Plate-derived growth factor formulation for enhancing bone fusion
CN106110299A (zh) 用于治疗脊柱的组合物和方法
WO2024197316A1 (en) Bone growth composition
AU2017213462A1 (en) Compositions and methods for spine fusion procedures
HK1230962A1 (en) Compositions and methods for treating the vertebral column
MX2008006373A (en) Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180907