CN108498759A - A kind of ointment for treating rheumatism - Google Patents

A kind of ointment for treating rheumatism Download PDF

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Publication number
CN108498759A
CN108498759A CN201810477027.8A CN201810477027A CN108498759A CN 108498759 A CN108498759 A CN 108498759A CN 201810477027 A CN201810477027 A CN 201810477027A CN 108498759 A CN108498759 A CN 108498759A
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radix
chinese drug
ointment
drug gualouzi
carbon dioxide
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杨步好
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/82—Theaceae (Tea family), e.g. camellia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
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    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The invention discloses a kind of ointment for treating rheumatism, are related to technical field of traditional Chinese medicines, and a kind of ointment for treating rheumatism is made of following component：Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, fermentation Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, rosin plaster substrate；Plaster prepared by the present invention has powerful permeability, it can be by the effective component rapid osmotic of drug to subcutaneous tissue, can quickly releive patient pain and detumescence, and schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder go oil mixture that can play promoting blood circulation channels and collaterals with being used cooperatively for the Chinese Drug Gualouzi that ferments, the purpose to promote blood circulation plays good facilitation for treatment rheumatism.

Description

A kind of ointment for treating rheumatism
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of ointment for treating rheumatism.
Background technology
Rheumatic and rheumatoid diseases are a kind of chronic diseases, easily occur acute attack repeatedly.But in After acute stage, even if redness disappears It moves back, joint is indeformable, and function seems to restore normal, is still not equal to and restores completely, currently on the market existing rheumatism class wind Wet medical ointment prescription：Raw material has Radix Angelicae Sinensis, safflower, capsicum, cassia twig, schizonepeta, windproof, bark of ash, Chinese cassia tree, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, ginger The medicinal materials such as Huang, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol are made, but what this was configured to The defect of plaster, being easy to cause allergic reaction influences the performance of plaster drug effect, causes to be difficult to reach stablizing effect.How to match to existing Side and technique are improved to avoid allergic reaction, and it is current desired technical problems to be solved to improve plaster stablizing effect.
Invention content
The purpose of the present invention is for existing problem, provide a kind of ointment for treating rheumatism.
The present invention is achieved by the following technical solutions：
A kind of ointment for treating rheumatism, is made of following component by weight：It is Radix Angelicae Sinensis 5-8, cassia twig 3-5, schizonepeta 1-3, windproof 2-4, bark of ash 1-5, radix paeoniae rubra 2-6, cloves 3-5, radix aconiti lateralis preparata 8-12, brook anemone 1-4, rhizoma arisaematis 2-6, radix bupleuri 3-5, fermentation Chinese Drug Gualouzi 8-10, turmeric 5-8, Rhizoma Et Radix Notopterygii 3-6, Radix Angelicae Pubescentis 1-4, asarum 2-3, root of Dahurain angelica 4-9, dutchmanspipe root 1-4, aconiti preparata,radix 3-5, menthol 3-6, ice Piece 1-5, rosin plaster substrate 350.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 68, Caulis Spatholobi 12, mountain Tea seed 15, kuh-seng 10.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, Caulis Spatholobi, camellia seed, kuh-seng, drying to moisture content to 10%, powder are weighed by weight It is broken, 80 mesh sieve is crossed, is uniformly mixed, is obtained mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 5 times of clear water of its quality stir evenly, slurries obtained, into slurries The bacillus cereus bacterium solution for adding its quality 3.2% ferments 2 hours at 35 DEG C, then carries out steam sterilizing, fermented Liquid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.8 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the ointment preparation method of the treatment rheumatism includes the following steps：
（1）Selected raw material Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, Ferment Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, in addition to the Chinese Drug Gualouzi that ferments, It is spare that remaining raw material is crushed to 250 mesh fine powders with micronizer respectively；
（2）Schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder are put into the extraction kettle of supercritical carbon dioxide extraction apparatus, super face is carried out Boundary's carbon dioxide abstraction deoils, and obtains oil mixture；The supercritical carbon dioxide extracting, 70 DEG C of extraction temperature, when extraction Between 1.5 hours, extracting pressure 16MPa, the flow of carbon dioxide is 13kg/h；
（3）Plaster substrate is heated and is melted, Radix Angelicae Sinensis, cassia twig, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, ginger are then blended into Huang, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, the Chinese Drug Gualouzi that ferments, goes oil mixture, stirring equal at Rhizoma Et Radix Notopterygii It is even, 1 hour is kept the temperature, then takes quantitative plaster to be coated in brown paper or medicated plaster cloth with bamboo stick again and is made.
The plaster substrate is rosin plaster substrate.
The present invention has the following advantages compared with prior art：The ointment for the treatment of rheumatism prepared by the present invention has good steady It is qualitative, ointment pharmacological property can be kept for a long time, avoid infecting reducing effect by Escherichia coli, the present invention is prepared by special process Chinese Drug Gualouzi ferment compared to Chinese Drug Gualouzi abrasive flour, can more improve the stability of ointment, it can be seen that, by technique in the present invention Fermentation Chinese Drug Gualouzi after preparation has apparent inhibition for Escherichia coli；Medicinal ointment therapy rheumatism significant effect of the present invention, The effect for the treatment of rheumatism can be greatly improved by adding the fermentation Chinese Drug Gualouzi prepared in the present invention, and ground using Chinese Drug Gualouzi Milling end effect fruit is substantially reduced, and by carrying out oil processing to schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder, can carry to a certain extent The effect of high medicinal ointment therapy rheumatism, it can be seen that, the volatile oil that schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder contain can influence ointment and control Treat the effect of rheumatism；Plaster prepared by the present invention has powerful permeability, can be by the effective component rapid osmotic of drug extremely Subcutaneous tissue, the pain for the patient that can quickly releive and detumescence, and schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder go oil mixture with Being used cooperatively for fermentation Chinese Drug Gualouzi can play promoting blood circulation channels and collaterals, the purpose to promote blood circulation, treatment rheumatism be played good Good facilitation.
Specific implementation mode
Embodiment 1
A kind of ointment for treating rheumatism, is made of following component by weight：Radix Angelicae Sinensis 5, cassia twig 3, schizonepeta 1, windproof 2, bark of ash 1, radix paeoniae rubra 2, cloves 3, radix aconiti lateralis preparata 8, brook anemone 1, rhizoma arisaematis 2, radix bupleuri 3, fermentation Chinese Drug Gualouzi 8, turmeric 5, Rhizoma Et Radix Notopterygii 3, Radix Angelicae Pubescentis 1, thin Pungent 2, the root of Dahurain angelica 4, dutchmanspipe root 1, aconiti preparata,radix 3, menthol 3, borneol 1, rosin plaster substrate 350.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 68, Caulis Spatholobi 12, mountain Tea seed 15, kuh-seng 10.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, Caulis Spatholobi, camellia seed, kuh-seng, drying to moisture content to 10%, powder are weighed by weight It is broken, 80 mesh sieve is crossed, is uniformly mixed, is obtained mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 5 times of clear water of its quality stir evenly, slurries obtained, into slurries The bacillus cereus bacterium solution for adding its quality 3.2% ferments 2 hours at 35 DEG C, then carries out steam sterilizing, fermented Liquid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.8 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the ointment preparation method of the treatment rheumatism includes the following steps：
（1）Selected raw material Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, Ferment Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, in addition to the Chinese Drug Gualouzi that ferments, It is spare that remaining raw material is crushed to 250 mesh fine powders with micronizer respectively；
（2）Schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder are put into the extraction kettle of supercritical carbon dioxide extraction apparatus, super face is carried out Boundary's carbon dioxide abstraction deoils, and obtains oil mixture；The supercritical carbon dioxide extracting, 70 DEG C of extraction temperature, when extraction Between 1.5 hours, extracting pressure 16MPa, the flow of carbon dioxide is 13kg/h；
（3）Plaster substrate is heated and is melted, Radix Angelicae Sinensis, cassia twig, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, ginger are then blended into Huang, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, the Chinese Drug Gualouzi that ferments, goes oil mixture, stirring equal at Rhizoma Et Radix Notopterygii It is even, 1 hour is kept the temperature, then takes quantitative plaster to be coated in brown paper or medicated plaster cloth with bamboo stick again and is made.
Embodiment 2
A kind of ointment for treating rheumatism, is made of following component by weight：Radix Angelicae Sinensis 8, cassia twig 5, schizonepeta 3, windproof 4, bark of ash 5, radix paeoniae rubra 6, cloves 5, radix aconiti lateralis preparata 12, brook anemone 4, rhizoma arisaematis 6, radix bupleuri 5, fermentation Chinese Drug Gualouzi 10, turmeric 8, Rhizoma Et Radix Notopterygii 6, Radix Angelicae Pubescentis 4, Asarum 3, the root of Dahurain angelica 9, dutchmanspipe root 4, aconiti preparata,radix 5, menthol 6, borneol 5, rosin plaster substrate 350.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 68, Caulis Spatholobi 12, mountain Tea seed 15, kuh-seng 10.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, Caulis Spatholobi, camellia seed, kuh-seng, drying to moisture content to 10%, powder are weighed by weight It is broken, 80 mesh sieve is crossed, is uniformly mixed, is obtained mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 5 times of clear water of its quality stir evenly, slurries obtained, into slurries The bacillus cereus bacterium solution for adding its quality 3.2% ferments 2 hours at 35 DEG C, then carries out steam sterilizing, fermented Liquid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.8 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the ointment preparation method of the treatment rheumatism includes the following steps：
（1）Selected raw material Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, Ferment Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, in addition to the Chinese Drug Gualouzi that ferments, It is spare that remaining raw material is crushed to 250 mesh fine powders with micronizer respectively；
（2）Schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder are put into the extraction kettle of supercritical carbon dioxide extraction apparatus, super face is carried out Boundary's carbon dioxide abstraction deoils, and obtains oil mixture；The supercritical carbon dioxide extracting, 70 DEG C of extraction temperature, when extraction Between 1.5 hours, extracting pressure 16MPa, the flow of carbon dioxide is 13kg/h；
（3）Plaster substrate is heated and is melted, Radix Angelicae Sinensis, cassia twig, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, ginger are then blended into Huang, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, the Chinese Drug Gualouzi that ferments, goes oil mixture, stirring equal at Rhizoma Et Radix Notopterygii It is even, 1 hour is kept the temperature, then takes quantitative plaster to be coated in brown paper or medicated plaster cloth with bamboo stick again and is made.
Embodiment 3
A kind of ointment for treating rheumatism, is made of following component by weight：Radix Angelicae Sinensis 6, cassia twig 4, schizonepeta 2, windproof 3, bark of ash 3, radix paeoniae rubra 5, cloves 4, radix aconiti lateralis preparata 10, brook anemone 2, rhizoma arisaematis 4, radix bupleuri 4, fermentation Chinese Drug Gualouzi 9, turmeric 7, Rhizoma Et Radix Notopterygii 5, Radix Angelicae Pubescentis 2, thin Pungent 2.5, the root of Dahurain angelica 6, dutchmanspipe root 3, aconiti preparata,radix 4, menthol 5, borneol 3, rosin plaster substrate 350.
Further, the fermentation Chinese Drug Gualouzi is made of following component by weight：Chinese Drug Gualouzi 68, Caulis Spatholobi 12, mountain Tea seed 15, kuh-seng 10.
Further, the fermentation Chinese Drug Gualouzi preparation method is：
（1）Detach volatile oil：Chinese Drug Gualouzi, Caulis Spatholobi, camellia seed, kuh-seng, drying to moisture content to 10%, powder are weighed by weight It is broken, 80 mesh sieve is crossed, is uniformly mixed, is obtained mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 5 times of clear water of its quality stir evenly, slurries obtained, into slurries The bacillus cereus bacterium solution for adding its quality 3.2% ferments 2 hours at 35 DEG C, then carries out steam sterilizing, fermented Liquid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
Further, the supercritical carbon dioxide extracting, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure The flow of 18MPa, carbon dioxide are 10kg/h.
Further, bacillus cereus content is 1.8 × 10 in the bacillus cereus bacterium solution3cfu/mL。
Further, the ointment preparation method of the treatment rheumatism includes the following steps：
（1）Selected raw material Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, Ferment Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, in addition to the Chinese Drug Gualouzi that ferments, It is spare that remaining raw material is crushed to 250 mesh fine powders with micronizer respectively；
（2）Schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder are put into the extraction kettle of supercritical carbon dioxide extraction apparatus, super face is carried out Boundary's carbon dioxide abstraction deoils, and obtains oil mixture；The supercritical carbon dioxide extracting, 70 DEG C of extraction temperature, when extraction Between 1.5 hours, extracting pressure 16MPa, the flow of carbon dioxide is 13kg/h；
（3）Plaster substrate is heated and is melted, Radix Angelicae Sinensis, cassia twig, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, ginger are then blended into Huang, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, the Chinese Drug Gualouzi that ferments, goes oil mixture, stirring equal at Rhizoma Et Radix Notopterygii It is even, 1 hour is kept the temperature, then takes quantitative plaster to be coated in brown paper or medicated plaster cloth with bamboo stick again and is made.
Comparative example 1：It is differed only in embodiment 1 and does not add fermentation Chinese Drug Gualouzi.
Comparative example 2：It is differed only in embodiment 1 and fermentation Chinese Drug Gualouzi is replaced with into Chinese Drug Gualouzi abrasive flour.
Comparative example 3：It is differed only in embodiment 1 in the ointment preparation method for the treatment of rheumatism without step（2）Processing.
The stability test of the Chinese medicine preparation of obtained treatment rheumatism and rheumatoid：The treatment rheumatism that will be obtained in embodiment And the Chinese medicine preparation of rheumatoid, it is placed in the environment that temperature is 25 DEG C, relative humidity is 85% and places 10 months, carry out large intestine bar Bacterium (ATYCC25922) total plate count is tested, and GB/T4789.2-2008 is controlled in reference《Food microbiological examination total plate count is surveyed It is fixed》
Experiment
Commercial polypropylene itrile group fiber precursor performance, such as table 1；
Table 1
As can be seen from Table 1, the ointment for the treatment rheumatism that prepared by the present invention is with good stability, can keep medicine for a long time Plaster avoids infecting reducing effect by Escherichia coli, and the present invention prepares fermentation Chinese Drug Gualouzi compared to Snakegourd Fruit by special process Sub- abrasive flour can more improve the stability of ointment, it can be seen that, the fermentation Chinese Drug Gualouzi pair after prepared by technique in the present invention There is apparent inhibition in Escherichia coli.
The medicinal ointment therapy effect that embodiment and comparative example obtains is tested.
Patient is grouped：700 patients are all from the rheumatism of hospital outpatient, rheumatoid patient, age 20-65 Sui, course of disease 1-3 Year, it is divided into 7 groups, every group of 100 people, there was no significant difference for each group age, gender, state of an illness etc., is comparable.
Therapy：Using embodiment and comparative example ointment as medicine, equivalent is attached to affected part, 2 times a day, applies every time It is 4 hours to paste the time, and 15d is 1 course for the treatment of, after treating 2 courses for the treatment of, comparison；
Judge curative effect；Patient avoids eating scorching food during treatment；
Curative effect determinate standard：
It cures：Clinical symptoms all disappear, and indices check that normally, observation has no repeatedly for 3 months；
Effectively：Clinical symptom relief, the state of an illness are controlled, and indices inspection makes moderate progress；
In vain：No significant improvement or aggravated in clinical symptoms；
2 clinical efficacy test result of table
Control group uses application number：201310725480.3 ointment for treating rheumatism；
Existing rheumatic and rheumatoid medical ointment prescription：Radix Angelicae Sinensis 5, safflower 3, capsicum 2, cassia twig 3, schizonepeta 1, windproof 2, bark of ash 1, Chinese cassia tree 5, Radix paeoniae rubra 2, cloves 3, radix aconiti lateralis preparata 8, turmeric 5, Rhizoma Et Radix Notopterygii 3, Radix Angelicae Pubescentis 1, asarum 2, the root of Dahurain angelica 4, dutchmanspipe root 1, aconiti preparata,radix 3, menthol 3, ice Piece 1, rosin plaster substrate 350；
As can be seen from Table 2, medicinal ointment therapy rheumatism significant effect of the present invention, by adding the fermentation Chinese Drug Gualouzi prepared in the present invention The effect for the treatment of rheumatism can be greatly improved, and use the reduction with obvious effects of Chinese Drug Gualouzi abrasive flour, by schizonepeta, anti- Wind, bark of ash, radix paeoniae rubra fine powder carry out oil processing, can improve the effect of medicinal ointment therapy rheumatism to a certain extent, it can be seen that, chaste tree The volatile oil that mustard, windproof, bark of ash, radix paeoniae rubra fine powder contain can influence the effect of medicinal ointment therapy rheumatism.

Claims (6)

1. a kind of ointment for treating rheumatism, which is characterized in that be made by weight of following component：Radix Angelicae Sinensis 5-8, cassia twig 3-5, Schizonepeta 1-3, windproof 2-4, bark of ash 1-5, radix paeoniae rubra 2-6, cloves 3-5, radix aconiti lateralis preparata 8-12, brook anemone 1-4, rhizoma arisaematis 2-6, radix bupleuri 3- 5, fermentation Chinese Drug Gualouzi 8-10, turmeric 5-8, Rhizoma Et Radix Notopterygii 3-6, Radix Angelicae Pubescentis 1-4, asarum 2-3, root of Dahurain angelica 4-9, dutchmanspipe root 1-4, aconiti preparata,radix 3-5, Menthol 3-6, borneol 1-5, rosin plaster substrate 350.
2. a kind of ointment for treating rheumatism according to claim 1, which is characterized in that the fermentation Chinese Drug Gualouzi is by weight Meter is made of following component：Chinese Drug Gualouzi 68, Caulis Spatholobi 12, camellia seed 15, kuh-seng 10.
3. a kind of ointment for treating rheumatism according to claim 2, which is characterized in that the fermentation Chinese Drug Gualouzi preparation method For：
（1）Detach volatile oil：Chinese Drug Gualouzi, Caulis Spatholobi, camellia seed, kuh-seng, drying to moisture content to 10%, powder are weighed by weight It is broken, 80 mesh sieve is crossed, is uniformly mixed, is obtained mixed powder, mixed powder is put into the extraction of supercritical carbon dioxide extraction apparatus In kettle, supercritical carbon dioxide extracting is carried out, volatile oil and solid extract are obtained；
（2）Fermentation：It will be added in solids obtained above after 5 times of clear water of its quality stir evenly, slurries obtained, into slurries The bacillus cereus bacterium solution for adding its quality 3.2% ferments 2 hours at 35 DEG C, then carries out steam sterilizing, fermented Liquid concentrates zymotic fluid, and drying to moisture content to 10% is to get fermentation Chinese Drug Gualouzi.
4. a kind of ointment for treating rheumatism according to claim 3, which is characterized in that the supercritical carbon dioxide extraction It takes, 55 DEG C of extraction temperature, extraction time 3 hours, extracting pressure 18MPa, the flow of carbon dioxide is 10kg/h.
5. a kind of ointment for treating rheumatism according to claim 3, which is characterized in that in the bacillus cereus bacterium solution Bacillus cereus content is 1.8 × 103cfu/mL。
6. a kind of ointment for treating rheumatism according to claim 1, which is characterized in that prepared by the ointment of the treatment rheumatism Method includes the following steps：
（1）Selected raw material Radix Angelicae Sinensis, cassia twig, schizonepeta, windproof, bark of ash, radix paeoniae rubra, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, Ferment Chinese Drug Gualouzi, turmeric, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, in addition to the Chinese Drug Gualouzi that ferments, It is spare that remaining raw material is crushed to 250 mesh fine powders with micronizer respectively；
（2）Schizonepeta, windproof, bark of ash, radix paeoniae rubra fine powder are put into the extraction kettle of supercritical carbon dioxide extraction apparatus, super face is carried out Boundary's carbon dioxide abstraction deoils, and obtains oil mixture；The supercritical carbon dioxide extracting, 70 DEG C of extraction temperature, when extraction Between 1.5 hours, extracting pressure 16MPa, the flow of carbon dioxide is 13kg/h；
（3）Plaster substrate is heated and is melted, Radix Angelicae Sinensis, cassia twig, cloves, radix aconiti lateralis preparata, brook anemone, rhizoma arisaematis, radix bupleuri, ginger are then blended into Huang, Radix Angelicae Pubescentis, asarum, the root of Dahurain angelica, dutchmanspipe root, aconiti preparata,radix, menthol, borneol, the Chinese Drug Gualouzi that ferments, goes oil mixture, stirring equal at Rhizoma Et Radix Notopterygii It is even, 1 hour is kept the temperature, then takes quantitative plaster to be coated in brown paper or medicated plaster cloth with bamboo stick again and is made.
CN201810477027.8A 2018-05-18 2018-05-18 A kind of ointment for treating rheumatism Pending CN108498759A (en)

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Application publication date: 20180907