CN116370552A - Lotion and extraction process of extract thereof - Google Patents
Lotion and extraction process of extract thereof Download PDFInfo
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- CN116370552A CN116370552A CN202310151735.3A CN202310151735A CN116370552A CN 116370552 A CN116370552 A CN 116370552A CN 202310151735 A CN202310151735 A CN 202310151735A CN 116370552 A CN116370552 A CN 116370552A
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Abstract
The invention discloses an extraction process of a lotion and an extract thereof in the technical field of lotion preparation, wherein the extraction process comprises the following steps: step one, pretreatment: weighing the medicinal materials for standby; step two, extracting and concentrating: placing the medicinal materials in a multifunctional extraction tank, soaking in water, decocting for two times, filtering the decoction with filter cloth, and mixing the filtrates to a liquid storage tank for use; pumping the filtrate into a single-effect concentration unit for concentration, and standing overnight. Step three, filtering: taking supernatant after the concentrated solution is stood, and placing the supernatant into a tube type centrifuge for centrifugation. Step four, preparing liquid: according to the batch extraction and preparation requirements, weighing sodium benzoate, dissolving with a proper amount of purified water, placing the liquid medicine after standing and centrifugation in a clean stainless steel barrel, heating and boiling for 30 minutes, stopping heating, adding sodium benzoate, stirring to uniformly mix, and preparing the liquid medicine. And fifthly, filling and labeling. And step six, packaging. The invention prepares the Hongbihao prescription from decoction into lotion, which is convenient for patients to use.
Description
Technical Field
The invention belongs to the technical field of lotion preparation, and particularly relates to a lotion and an extraction process of an extract thereof.
Background
The Hongbi Ying lotion is an ethnic medicine proved recipe of the dermatology department of the Guangxi International Zhuang medical hospital, and is prepared by processing fourteen traditional Chinese medicines such as holly bark, viola yedoensis makino, perfoliate knotweed herb, rhubarb, garden burnet root, purslane and the like, and clinical application effects of over ten years indicate that the lotion has the effects of clearing heat and detoxicating, resolving masses and detumescence, and is used for treating various types of dermatosis such as facial dermatitis, subacute eczema, folliculitis, skin furuncle swelling and the like which take erythema, pimple, nodule and cyst as clinical manifestations, and has obvious curative effects. In long-term medical practice, people in China create various methods for treating skin diseases, which are generic names of skin and skin accessory organ diseases.
The recommended use mode of the prescription is decoction. The decoction has large volume of decoction, poor taste and inconvenient administration and carrying; when in use, the wine is fresh, easy to mold and ferment after long-term storage, and difficult to store. The decoction is prepared and applied temporarily according to the prescription of doctors, which is not suitable for mass preparation and is not beneficial to timely treatment of patients. Therefore, effective dosage forms of decoction are improved in recent years, such as traditional Chinese medicine lotion, which is a new dosage form developed on the basis of decoction application, not only saves the advantages of quick decoction absorption and quick effect, but also overcomes the trouble of decoction preparation in the clinic and can lead patients to take medicines in time. The traditional Chinese medicine lotion is a concentrated preparation of common decoction, and has high concentration and small dosage due to the concentrated liquid medicine volume, is convenient to take, carry and store, and is easy to accept by patients; the finished product is added with proper preservative, has relatively stable quality, is not easy to be rotten and deteriorated, and is suitable for industrial production. The present invention contemplates preparing the formulation as a lotion.
Disclosure of Invention
In order to solve the problems, the invention aims to provide an extraction process of lotion and extract thereof, so as to prepare the Hongbihao prescription from decoction into lotion, which is convenient for patients to use.
In order to achieve the above object, the technical scheme of the present invention is as follows: a lotion comprises cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi, radix et rhizoma Rhei, radix Sangusorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici, rhizoma Polygoni Cuspidati, cortex Phellodendri, radix Sophorae Flavescentis, saviae Miltiorrhizae radix and spina Gleditsiae.
Further, the lotion is prepared from the following components in parts by weight: 3-8g of holly bark, 3-8g of herba Duchesneae Indicae, 3-8g of herba polygoni multiflori, 3-8g of rheum officinale, 3-8g of garden burnet, 3-8g of purslane, 3-8g of dandelion, 3-8g of herba violae, 3-8g of wild chrysanthemum flower, 3-8g of polygonum cuspidatum, 3-8g of cortex phellodendri, 3-8g of radix sophorae flavescentis, 3-8g of radix salviae miltiorrhizae and 3-8g of spina gleditsiae.
Further, an extraction process of the lotion extract comprises the following steps:
step one, pretreatment: weighing cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi, radix et rhizoma Rhei, radix Sangusorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici, rhizoma Polygoni Cuspidati, cortex Phellodendri, radix Sophorae Flavescentis, saviae Miltiorrhizae radix and spina Gleditsiae;
step two, extracting and concentrating: placing the medicinal materials in a multifunctional extraction tank, soaking in water, decocting for two times, controlling steam pressure before boiling and steam pressure after boiling to keep boiling, filtering with filter cloth, and mixing filtrates to a liquid storage tank;
pumping the filtrate into a single-effect concentration unit for concentration, filling the concentrated solution into a clean material barrel after concentration, sealing with a cover, weighing, attaching a material clamp, placing in a cool place, and standing overnight.
Step three, filtering: taking supernatant after the concentrated solution is kept stand, putting the supernatant into a tube centrifuge for centrifugation, transferring the centrifugate into a clean material barrel after centrifugation, and adding a cover for sealing for standby.
Step four, preparing liquid: according to the batch extraction and preparation requirements, weighing sodium benzoate, dissolving with a proper amount of purified water for standby, placing the liquid medicine after standing and centrifugation in a clean stainless steel barrel, heating and boiling for 30 minutes, stopping heating, adding sodium benzoate, adding water for constant volume, stirring to uniformly mix, and preparing the liquid medicine.
Fifthly, filling and labeling: transferring the prepared liquid medicine to a liquid filling and sealing room, respectively starting an automatic bottle arranging machine, a liquid filling machine and a labeling machine linkage production line, and installing and debugging according to the batch production requirements.
Step six, packaging: and (5) taking the packaging material, wherein the label is provided with a product batch number and a production date, and packaging according to batch packaging requirements to obtain a finished product.
Further, in the second step, the water immersion time was 1 hour.
Further, in the second step, 12 times of water is added in the first decoction, and 10 times of water is added in the second decoction.
In the second step, the steam pressure before the boiling of the liquid medicine is controlled to be 0.1-0.25 MPa; the steam pressure is controlled to be 0.05-0.10 MPa after the liquid medicine is boiled.
Further, in the second step, the filter screen is a 120-mesh filter screen.
In the second step, the concentration temperature is 70-80 ℃ and the vacuum degree is-0.07 to-0.08 MPa, and the concentration is carried out until the relative density is 1.03-1.10.
Further, in the third step, the centrifugation parameter is 30-35Hz during centrifugation.
Further, in the fifth step, the debug amount was 150 ml/bottle.
The efficacy of the components used in the invention is as follows:
cortex Ilicis Rotundae: cold and bitter, has effects of clearing heat and detoxicating, clearing heat and promoting diuresis, and can be used for treating burn and scald, eczema, carbuncle, sore and furuncle by decocting with water or grinding into powder for external use;
an reddish color: bitter and cold in nature, has the effects of clearing heat and detoxicating, dispelling wind, clearing heat and promoting diuresis, and killing parasites, and can be used for treating carbuncle, furuncle and snake bite;
and (3) perfecting plate return: cold, sour and bitter, clearing heat and detoxicating, promoting diuresis and removing jaundice, treating eczema, herpes zoster, impetigo and carbuncle;
rhubarb: it can be used for treating scald and sore and carbuncle due to heat toxin after being ground into powder. The main medicine has the effects of clearing heat and detoxicating, clearing heat and promoting diuresis, dispelling pathogenic wind and killing parasites;
wild chrysanthemum flower: has effects of clearing heat, detoxicating, improving eyesight, and can be used for treating furuncle, summer furuncle and skin wet sore;
purslane: cold and sour property, detoxication, hemostasis and dysentery stopping, and is used for treating chronic carbuncle, malignant sore and turnup sore;
dandelion: cold, bitter and sweet, has the effects of clearing heat and detoxicating, clearing heat and promoting diuresis, and is used for treating infantile furuncle, insect snake bite with effects of clearing heat and toxic materials, healing sore and promoting diuresis;
viola yedoensis makino: bitter, spicy and cold in taste, and has the effects of clearing heat and detoxicating, cooling blood and detumescence, clearing heat and promoting diuresis, and can be used for treating carbuncle furuncle, snake bite and the like by external application;
radix Sanguisorbae: bitter, sour and astringent, slightly cold, liver-returning and large intestine channels have the effects of cooling blood and stopping bleeding, detoxifying and healing sore, and can be used for hematochezia, hemorrhoids and blood, bloody dysentery, metrorrhagia, burns and scalds, carbuncles and sores;
giant knotweed rhizome: promoting diuresis, eliminating jaundice, clearing heat, removing toxic substances, removing blood stasis, and relieving pain; cortex Phellodendri and radix Sophorae Flavescentis are used as adjuvant drugs, and radix Sophorae Flavescentis has effects of clearing heat, eliminating dampness, killing parasite and promoting urination, and can be used for treating eczema, skin pruritus, and scabies;
cortex Phellodendri: clearing heat and drying dampness, purging fire and removing steam, and detoxicating and treating sore. In the recipe, red sage root and Chinese honeylocust spine are used as guiding drugs for nourishing blood, promoting blood circulation, removing blood stasis, softening hardness and resolving hard mass;
radix Sophorae Flavescentis: has effects of clearing heat, eliminating dampness, killing parasites, and promoting urination, and can be used for treating eczema, skin pruritus, and scabies;
radix Salviae Miltiorrhizae and spina Gleditsiae: blood nourishing, blood circulation promoting, blood stasis removing, hard mass softening and resolving, and the like.
The basic scheme has the following principle and beneficial effects: in conclusion, the prescription takes cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi and radix et rhizoma Rhei as principal drugs for clearing heat and detoxicating, promoting diuresis and detumescence, and radix Sanguisorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici and rhizoma Polygoni Cuspidati as ministerial drugs for cooling blood, removing toxic substances and healing sore; the phellodendron bark and the kuh-seng are taken as adjuvant drugs to kill parasites and relieve itching; radix Salviae Miltiorrhizae and spina Gleditsiae are used as materials for promoting blood circulation, removing blood stasis, and softening and resolving hard mass. The medicines are used together, and the medicine has the effects of clearing heat and detoxicating, eliminating dampness and healing sore, promoting blood circulation by removing blood stasis, softening hardness to dissipate stagnation, killing parasites and relieving itching and pain. It is indicated for syndrome of damp-heat accumulation, qi stagnation and blood stasis. Can be used for treating dermatoses such as dermatitis, eczema, acne, tinea, carbuncle, furuncle, folliculitis, pruritus vulvae, and pityriasis scalp.
Drawings
Fig. 1 is a schematic flow chart of an extraction process of a lotion extract in an embodiment of the present invention.
Detailed Description
The following is a further detailed description of the embodiments:
example 1
A lotion comprises cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi, radix et rhizoma Rhei, radix Sangusorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici, rhizoma Polygoni Cuspidati, cortex Phellodendri, radix Sophorae Flavescentis, saviae Miltiorrhizae radix and spina Gleditsiae, and the lotion is prepared from the following components by weight: 3-8g of holly bark, 3-8g of herba Duchesneae Indicae, 3-8g of herba polygoni multiflori, 3-8g of rheum officinale, 3-8g of garden burnet, 3-8g of purslane, 3-8g of dandelion, 3-8g of herba violae, 3-8g of wild chrysanthemum flower, 3-8g of polygonum cuspidatum, 3-8g of cortex phellodendri, 3-8g of radix sophorae flavescentis, 3-8g of radix salviae miltiorrhizae and 3-8g of spina gleditsiae.
The specific implementation process is as follows: in the formula, cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi and radix et rhizoma Rhei are taken as monarch drugs for clearing heat and detoxicating, promoting diuresis and detumescence, and radix Sanguisorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici and rhizoma Polygoni Cuspidati are taken as ministerial drugs for cooling blood, removing toxic substance and healing sore; the phellodendron bark and the kuh-seng are taken as adjuvant drugs to kill parasites and relieve itching; radix Salviae Miltiorrhizae and spina Gleditsiae are used as materials for promoting blood circulation, removing blood stasis, and softening and resolving hard mass. The medicines are used together, and the medicine has the effects of clearing heat and detoxicating, eliminating dampness and healing sore, promoting blood circulation by removing blood stasis, softening hardness to dissipate stagnation, killing parasites and relieving itching and pain. It is indicated for syndrome of damp-heat accumulation, qi stagnation and blood stasis. Can be used for treating dermatoses such as dermatitis, eczema, acne, tinea, carbuncle, furuncle, folliculitis, pruritus vulvae, and pityriasis scalp.
Example 2
The difference from the above embodiment is that a process for extracting a lotion extract is provided, substantially as shown in fig. 1, comprising the steps of:
step one, pretreatment: weighing 6g of cortex holly bark, 6g of herba Duchesneae Indicae, 6g of herba Polygoni Cymosi, 6g of radix et rhizoma Rhei, 6g of radix Sangusorbae, 6g of herba Portulacae, 6g of herba Taraxaci, 6g of herba Violae, 6g of flos Chrysanthemi Indici, 6g of rhizoma Polygoni Cuspidati, 6g of cortex Phellodendri, 6g of radix Sophorae Flavescentis, 6g of Saviae Miltiorrhizae radix and 6g of spina Gleditsiae for use;
step two, extracting and concentrating: placing the medicinal materials in a multifunctional extraction tank, soaking in water for 1 hr, decocting twice, adding 12 times of water in the first decoction and 10 times of water in the second decoction, controlling the steam pressure before boiling and the steam pressure after boiling to keep boiling, filtering the decoction with 120 mesh filter cloth, and mixing the filtrates to a liquid storage tank; wherein the steam pressure is controlled to be 0.1-0.25 MPa before the liquid medicine boils; the steam pressure is controlled to be 0.05-0.10 MPa after the liquid medicine is boiled;
pumping the filtrate into a single-effect concentration unit for concentration, wherein the concentration temperature is 70-80 ℃, the vacuum degree is-0.07 to-0.08 MPa, the concentration is carried out until the relative density is 1.03-1.10, the concentrated solution is filled into a clean material barrel after the concentration, the material barrel is covered and sealed, the weighing is carried out, the material card is attached, and the material barrel is placed at a shady place and stands overnight.
Step three, filtering: taking supernatant after the concentrated solution is kept stand, putting the supernatant into a tube centrifuge for centrifugation, centrifuging the supernatant with the centrifugation parameter of 30-35Hz, transferring the centrifugate into a clean material barrel after centrifuging, and adding a cover for sealing for standby.
Step four, preparing liquid: according to the batch extraction and preparation requirements, weighing sodium benzoate, dissolving with a proper amount of purified water for standby, placing the liquid medicine after standing and centrifugation in a clean stainless steel barrel, heating and boiling for 30 minutes, stopping heating, adding sodium benzoate, adding water for constant volume, stirring to uniformly mix, and preparing the liquid medicine.
Fifthly, filling and labeling: transferring the prepared liquid medicine to a liquid filling and sealing room, respectively starting an automatic bottle arranging machine, a liquid filling machine and a labeling machine linkage production line, and installing and debugging according to the batch production requirement, wherein the debugging and filling amount is 150 ml/bottle.
Step six, packaging: and (5) taking the packaging material, wherein the label is provided with a product batch number and a production date, and packaging according to batch packaging requirements to obtain a finished product.
The equipment used in this example is shown in table 1:
table 1 list of equipment and instruments
| Sequence number | Main production equipment | Specification and model | Main inspection instrument | Specification and model |
| 1 | Multifunctional extracting pot | TQNS-1500 | Electronic balance | ME155DU |
| 2 | Single-effect concentration unit | TQNS-1500 | PH meter | MP511 |
| 3 | Stainless steel barrel | 20L | Density tester | AR-300Y |
| 4 | Stainless steel barrel | 50L | Electrothermal constant temperature blast drying box | PHG-9206A |
The method has the following specific beneficial effects: compared with the prior art that the medicament is used in the form of decoction, the medicament is not convenient enough and is not suitable for the masses, and the technical scheme prepares the medicament into the lotion, so that the medicament is convenient for patients to use, carry and store medicaments and better plays the curative effect of the medicaments.
The experiment is as follows:
the test selects the dry paste rate as an extraction process evaluation index and determines extraction process parameters.
1. Dry paste rate determination
And measuring the volume of the extracted liquid medicine, precisely sucking 25ml, placing the liquid medicine in an evaporation dish dried to constant weight, evaporating in a water bath, placing the liquid medicine in an electrothermal constant temperature drying oven at 105 ℃ for drying for 5 hours, placing the liquid medicine in a dryer, cooling the liquid medicine for 30 minutes, precisely weighing the liquid medicine, drying the liquid medicine at the temperature for 1 hour, cooling the liquid medicine, and weighing the liquid medicine until the difference between two continuous weighing is not more than 5 mg. Dry paste yields were calculated according to the following formula.
Dry extract yield = (dry extract mass/sampling volume) × (total liquid medicine volume/total medicinal material mass) ×100%
2. Establishment of dry paste rate determination method
Precisely sucking 25ml of the extracted liquid medicine, placing into an evaporation dish dried to constant weight, evaporating in water bath, placing into a forced air drying oven, drying to constant weight, cooling, precisely weighing, and calculating dry paste yield according to the following formula.
Dry extract rate = (dry extract mass/25) ×150/total medicinal material mass×100%
Dry extract rate (%) = (dry extract mass×total liquid medicine volume)/(total medicinal material mass×sampling volume) ×100%
3. Water absorption test of medicinal materials
The dry Chinese medicinal materials can absorb a certain amount of water, and in order to accurately add the water, the water absorption rate is measured firstly, so that the water equivalent to the water absorption rate is added when water is added for the first time, and the error caused by water absorption of the medicinal materials is reduced.
Precisely weighing a single-day prescription amount of medicinal material, soaking in 10 times of water, observing the soaking condition every 1h until the medicinal material is soaked to the heart, filtering until no water drops drop from the medicinal material, filtering out unabsorbed water solution, weighing the wet medicinal material, and calculating the water absorption rate according to the following formula, wherein the result is shown in Table 2.
Water absorption (%) = (wet medicinal material mass-dry medicinal material mass)/dry medicinal material mass×100%
Table 2 results of water absorption test of medicinal materials
As shown by the result, the water absorption rate after the medicinal materials are soaked is 188.49 percent, which is about 2 times of the mass of the medicinal materials, so that the water is needed to be added for the first time, and the water is needed to be added for the second time.
4. Single factor investigation
(1) Investigation of soaking time
Taking 7 parts of medicinal materials with a single-day prescription dosage, respectively adding 10 times of water, soaking for 0, 0.5, 1.0, 1.5, 2.0 and 2.5 hours, heating and extracting for 1.0 hour, filtering, measuring the volume of filtrate, and calculating the dry paste rate under each condition according to the method under the item "3.2.1", wherein the result is shown in Table 3.
Table 3 soaking time investigation results (x+s, n=3)
As shown by analysis of experimental results, the soaking time of the medicinal materials has no influence on the dry paste rate of the medicinal materials basically, so the soaking time is not taken as a research factor for optimizing the extraction process. However, in actual production, the amount of the medicinal materials is large, and in order to make the medicinal materials as thoroughly wet as possible, the soaking time before extraction is determined to be 1h.
(2) Water adding multiple quantity investigation
Taking 6 parts of medicinal materials with a single-day prescription dosage, respectively adding 6, 8, 10, 12, 14 and 16 times of water, soaking for 1.0h, heating and extracting for 1.0h, filtering, measuring the volume of filtrate, and calculating the dry paste rate under each condition according to the method under the item of 3.2.1, wherein the result is shown in Table 4.
Table 4 water addition investigation results (x+s, n=3)
The analysis of experimental results shows that the change of the water addition has a great influence on the dry paste rate, the increase of the dry paste rate is gradually flattened after the water addition reaches 10 times, and the water addition is selected as a research factor for optimizing the extraction process and is horizontally selected to be 8, 10 and 12 times in combination with actual mass production.
(3) Investigation of extraction time
Taking 5 parts of medicinal materials with a single-day prescription dosage, respectively adding 10 times of water, soaking for 1.0h, heating and extracting for 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0h, filtering, measuring the volume of filtrate, and calculating the dry paste rate under each condition according to the method under the item "4.2.1", wherein the result is shown in Table 5.
Table 5 extraction time investigation results (x+s, n=3)
According to analysis of experimental results, the increase of the extraction time has a great influence on the dry paste rate, the increase of the dry paste rate tends to be gentle after the extraction time reaches 1.5 hours, and the actual mass production is combined, so that the extraction time is selected as a research factor for optimizing the extraction process, and the horizontal factors are selected to be 0.5, 1.0 and 1.5 hours.
5. Factor level design
According to the single factor test result and the actual production condition, from the consideration of the property of the extract, the extraction process factors are influenced: adding water, extracting time, extracting times, soaking time, etc. Combining production practice, selecting water adding amount (A), extraction time (B) and extraction times (C) as investigation factors of orthogonal test, taking comprehensive score of dry paste rate as evaluation index, and adopting L 9 (3 4 ) The orthogonal design optimizes the extraction process of the Hongbihuang lotion, and the factor level is shown in 6.
TABLE 6 factor level Table
6. Orthogonal design
The experiment uses the dry paste rate as an evaluation index to determine the optimal extraction process. The orthogonal test arrangement and results are shown in Table 7.
TABLE 7 orthogonal test arrangement and results
The dry extract rate extraction analysis of variance data is shown in table 8:
TABLE 8 extraction analysis of variance table for dry extract rate
The analysis of variance data extracted from the dry extract rate shows that the water adding amount (A) and the extraction time (B) are due toThe element has no obvious influence on the extraction process>0.05 The factor of the extraction times (C) has significant influence on the extraction process. Primary and secondary influencing factors: c (C)>A>B, i.e. number of extractions>Adding water in multiple amount>The extraction time, namely the number of times of extraction, has the greatest influence, the next is the water adding amount, and the least influence is the extraction time. Among the A factors, A 2 >A 3 >A 1 ，A 2 The level is optimal; among B factors, B 3 >B 2 >B 1 ，B 3 The level is optimal; among the factors C, C 3 >C 2 >C 1 ，C 3 The level is optimal, and the combination condition of the optimal extraction process is selected by combining visual analysis results: a is that 2 B 3 C 3 。
In combination with practical mass production and economic cost factors, and in order to adapt to industrialized mass production, and in combination with traditional decoction method, the extraction process of the product is determined as A 2 B 2 C 2 The preparation method comprises weighing the above materials according to the prescription, soaking in water for 1 hr, extracting twice, adding 10 times of water for 1 hr, adding 8 times of water for 1 hr, and extracting.
7. Verification of extraction process
And performing process verification according to the extraction process optimization result. Weighing the medicinal materials according to the prescription, soaking in water for 1h, adding 10 times of water for the first time, adding 8 times of water for the second time, extracting twice for 1h each time, and mixing decoctions. The test was repeated 3 times successively, and the dry paste rate of the product was measured, and the results are shown in Table 9.
TABLE 9 results of the wash extraction process validation test
The verification test result shows that the lotion prepared according to the optimized process has the average dry paste rate of 26.07 percent and better result, and the process is reasonable and feasible.
8. Summary
In summary, the preparation process of the determined Hongbi lotion comprises the following steps: soaking medicinal materials with standard prescription amount in water for 1 hour, decocting twice, adding 12 times of water for the first time and 10 times of water for the second time, decocting for 1 hour each time, filtering, combining filtrates, concentrating to a relative density of 1.03-1.10 (60 ℃), standing, filtering, boiling the filtrate for 30 minutes, adding 3g of sodium benzoate, adding pure water to 1000ml, stirring uniformly, and filling to obtain the traditional Chinese medicine. The research data show that the lotion prepared according to the preparation process of the product has stable quality.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The specific implementation process is as follows:
the foregoing is merely an embodiment of the present invention, and a specific structure and characteristics of common knowledge in the art, which are well known in the scheme, are not described herein, so that a person of ordinary skill in the art knows all the prior art in the application day or before the priority date of the present invention, and can know all the prior art in the field, and have the capability of applying the conventional experimental means before the date, so that a person of ordinary skill in the art can complete and implement the present embodiment in combination with his own capability in the light of the present application, and some typical known structures or known methods should not be an obstacle for a person of ordinary skill in the art to implement the present application. It should be noted that modifications and improvements can be made by those skilled in the art without departing from the structure of the present invention, and these should also be considered as the scope of the present invention, which does not affect the effect of the implementation of the present invention and the utility of the patent. The protection scope of the present application shall be subject to the content of the claims, and the description of the specific embodiments and the like in the specification can be used for explaining the content of the claims.
Claims (10)
1. A lotion characterized in that: the lotion comprises cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi, radix et rhizoma Rhei, radix Sangusorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici, rhizoma Polygoni Cuspidati, cortex Phellodendri, radix Sophorae Flavescentis, saviae Miltiorrhizae radix and spina Gleditsiae.
2. The lotion of claim 1 wherein: the lotion is prepared from the following components in parts by weight: 3-8g of holly bark, 3-8g of herba Duchesneae Indicae, 3-8g of herba polygoni multiflori, 3-8g of rheum officinale, 3-8g of garden burnet, 3-8g of purslane, 3-8g of dandelion, 3-8g of herba violae, 3-8g of wild chrysanthemum flower, 3-8g of polygonum cuspidatum, 3-8g of cortex phellodendri, 3-8g of radix sophorae flavescentis, 3-8g of radix salviae miltiorrhizae and 3-8g of spina gleditsiae.
3. An extraction process of a lotion extract is characterized in that: the method comprises the following steps:
step one, pretreatment: weighing cortex Ilicis Rotundae, herba Duchesneae Indicae, herba Polygoni Cymosi, radix et rhizoma Rhei, radix Sangusorbae, herba Portulacae, herba Taraxaci, herba Violae, flos Chrysanthemi Indici, rhizoma Polygoni Cuspidati, cortex Phellodendri, radix Sophorae Flavescentis, saviae Miltiorrhizae radix and spina Gleditsiae;
step two, extracting and concentrating: placing the medicinal materials in a multifunctional extraction tank, soaking in water, decocting for two times, controlling steam pressure before boiling and steam pressure after boiling to keep boiling, filtering with filter cloth, and mixing filtrates to a liquid storage tank;
pumping the filtrate into a single-effect concentration unit for concentration, filling the concentrated solution into a clean material barrel after concentration, sealing with a cover, weighing, attaching a material clamp, placing in a cool place, and standing overnight;
step three, filtering: taking supernatant after the concentrated solution is kept stand, putting the supernatant into a tube centrifuge for centrifugation, transferring the centrifugate into a clean material barrel after centrifugation, and adding a cover for sealing for later use;
step four, preparing liquid: according to the batch extraction preparation requirement, weighing sodium benzoate, dissolving with a proper amount of purified water for standby, placing the liquid medicine after standing and centrifugation in a clean stainless steel barrel, heating and boiling for 30 minutes, stopping heating, adding sodium benzoate, adding water for constant volume, stirring to uniformly mix, and preparing the liquid medicine;
fifthly, filling and labeling: transferring the prepared liquid medicine to a liquid filling and sealing room, respectively starting an automatic bottle arranging machine, a liquid filling machine and a labeling machine linkage production line, and installing and debugging according to the batch production requirements;
step six, packaging: and (5) taking the packaging material, wherein the label is provided with a product batch number and a production date, and packaging according to batch packaging requirements to obtain a finished product.
4. A process for extracting a lotion extract as claimed in claim 3, characterized in that: in the second step, the water soaking time is 1 hour.
5. The extraction process of the lotion extract of claim 4, wherein the process comprises the steps of: in the second step, 12 times of water is added in the first decoction, and 10 times of water is added in the second decoction.
6. The extraction process of the lotion extract of claim 5, wherein the process comprises the steps of: in the second step, the steam pressure before the boiling of the liquid medicine is controlled to be 0.1-0.25 MPa; the steam pressure is controlled to be 0.05-0.10 MPa after the liquid medicine is boiled.
7. The extraction process of the lotion extract of claim 6, wherein the process comprises: in the second step, the filter screen is a 120-mesh filter screen.
8. The extraction process of the lotion extract of claim 7, wherein: in the second step, the concentration temperature is 70-80 ℃ and the vacuum degree is-0.07 to-0.08 MPa, and the concentration is carried out until the relative density is 1.03-1.10.
9. The extraction process of the lotion extract of claim 8, wherein: in the third step, the centrifugation parameter is 30-35Hz during centrifugation.
10. The extraction process of the lotion extract of claim 9, wherein: in the fifth step, the debugging filling amount is 150 ml/bottle.
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| 孙建飞, 马宽玉, 李展绒: "综合疗法治疗感染创面骨外露28例", 实用中医药杂志, no. 06 * |
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