CN104873902B - A kind of traditional Chinese medicine plaster for treating wound, osteopathy - Google Patents
A kind of traditional Chinese medicine plaster for treating wound, osteopathy Download PDFInfo
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Abstract
The present invention relates to a kind of traditional Chinese medicine plaster for treating wound, osteopathy, contained active constituent is prepared by including the following raw material medicine：The root of Chinese clematis, Radix Angelicae Sinensis, bush, safflower, Radix Notoginseng, teasel root, the rhizome of davallia, ground bettle, frankincense (system), myrrh (system), muskmelon seed, Artemisia anomala, rhizoma arisaematis, Radix Glycyrrhizae, native copper, Radix Curcumae, dragon's blood, borneol.Side effect the present invention overcomes oral medicine and the damage to hepatic and renal function directly act on diseased region, generate blocking effect, work rapid, quick.Dosage form is reasonable, easy to use, and patient can be treated with self medication and family oriented, and easy to use, success rate is up to more than 90%.
Description
Technical field
The present invention relates to a kind of Chinese medicine, more particularly to a kind of traditional Chinese medicine plaster for treating wound, osteopathy.
Background technology
Wound (soft tissue injury, fracture) is common damage.It is always reduction fracture for a long time, fix, performs the operation and control
It treats or clamping plate, gypsum is fixed etc. outside.Early clinical manifestation soft tissue swelling bubble or even there is Vascular crisis.At present, both at home and abroad
Research all designs invention in every possible means makes fracture immediate union, solves delayed union, solves the soft tissue of wound early stage appearance
Swelling and pain etc..And with the development of social modern science and technology and civilization, people's rhythm of life is constantly accelerated, and quality of life is continuously improved,
Sports are constantly universal, and energy consumption is continuously increased, the modern populars such as neck, shoulder, waist, skelagia that thing followed general joint occurs
Osteopathy annoyings people.
The present invention is according to motherland's medicine diagnosis and treatment based on an overall analysis of the illness and the patient's condition theory, it is necessary to " promoting blood circulation and removing blood stasis for first, blood is not lived as the stasis of blood, the stasis of blood is not gone
Be unable to dissipating bind ", and doctor trained in Western medicine thinks in recent years there has also been new theory, fracture and bleeding (internal haemorrhage, external hemorrhage) formed hemotoncus or
Bone damaged after pathomechanism phenomenon, prevent bleeding in early days, hemotoncus promoted to dissipate, it has also become Modern medical therapy wound
Measure and motherland's medicine theory promoting blood circulation and removing blood stasis be consistent.The present invention on this basis, develops a kind of mainly promoting blood circulationization
It becomes silted up, swelling and pain relieving, the external application Chinese medicine of reunion of bone effect.For fracturing, traumatic injury, cervical spondylosis, waist dish outstanding, canalis spinalis are narrow
Swelling caused by narrow, Osteoarthritis, rheumatic and rheumatic arthritis, ankylosing spondylitis or scapulohumeral periarthritis etc., pain, function
It is limited.
Invention content
The object of the present invention is to provide it is a kind of treat wound, osteopathy (fracture, traumatic injury, cervical spondylosis, waist dish outstanding,
Swelling caused by spinal canal stenosis, Osteoarthritis, rheumatic and rheumatic arthritis, ankylosing spondylitis or scapulohumeral periarthritis etc., pain
Bitterly, function limitation) traditional Chinese medicine plaster.Reach promoting blood circulation and removing blood stasis, swelling and pain relieving, reunion of bone effect.
The technical solution adopted by the present invention is：
A kind of traditional Chinese medicine plaster for treating wound, osteopathy, the active constituent contained by the traditional Chinese medicine plaster is by including weight as follows
The bulk pharmaceutical chemicals of amount number are prepared：600-800 parts of the root of Chinese clematis, 600-750 parts of Radix Angelicae Sinensis, 400-550 parts of bush, safflower 350-
500 parts, 200-350 parts of Radix Notoginseng, 450-500 parts of teasel root, 570-650 parts of the rhizome of davallia, 400-420 parts of ground bettle, frankincense (system)
350-500 parts, 350-500 parts of myrrh (system), 1500-1650 parts of muskmelon seed, 550-650 parts of Artemisia anomala, rhizoma arisaematis 110-130
Part, 380-400 parts of Radix Glycyrrhizae, 500-600 parts of native copper, 350-400 parts of Radix Curcumae, 20-35 parts of dragon's blood, 60-65 parts of borneol.
Preferably, the active constituent contained by the traditional Chinese medicine plaster is prepared by the bulk pharmaceutical chemicals for including following parts by weight：
600 parts of the root of Chinese clematis, 600 parts of Radix Angelicae Sinensis, 400 parts of bush, 400 parts of safflower, 200 parts of Radix Notoginseng, 480 parts of teasel root, 600 parts of the rhizome of davallia, soil
It is 400 parts of soft-shelled turtle worm, 400 parts of frankincense (system), 400 parts of myrrh (system), 1600 parts of muskmelon seed, 600 parts of Artemisia anomala, 120 parts of rhizoma arisaematis, sweet
400 parts of grass, 600 parts of native copper, 400 parts of Radix Curcumae, 20 parts of dragon's blood, 64 parts of borneol.
Preferably, the active constituent contained by the traditional Chinese medicine plaster is prepared by the bulk pharmaceutical chemicals for including following parts by weight：
700-800 parts of the root of Chinese clematis, 650-750 parts of Radix Angelicae Sinensis, 500-550 parts of bush, 450-500 parts of safflower, 300-350 parts of Radix Notoginseng, teasel root
480 parts, 600 parts of the rhizome of davallia, 400 parts of ground bettle, 450-500 parts of frankincense (system), 450-500 parts of myrrh (system), muskmelon seed 1600
Part, 600 parts of Artemisia anomala, 120 parts of rhizoma arisaematis, 400 parts of Radix Glycyrrhizae, 600 parts of native copper, 400 parts of Radix Curcumae, 30-35 parts of dragon's blood, borneol 64
Part.
Preferably, the bulk pharmaceutical chemicals further include 64 parts of menthol, and the number is parts by weight.
Preferably, the traditional Chinese medicine plaster is according to cataplasm, patch, rubber ointment or exquisite dog made of common process
Skin putty-type.
It is highly preferred that the dosage form is cataplasm or patch (Wheeling bone patch).
Preferably, the preparation method of the traditional Chinese medicine plaster, includes the following steps：
A. it by Radix Notoginseng, frankincense (system), myrrh (system), dragon's blood, borneol, crushes respectively, is ground into fine powder, cross No. 6 sieves；According to
Raw material medicines in portions by weight number weighs fine powder, remixes, and obtains fine powder mixture；It is spare；
B. by the root of Chinese clematis, Radix Angelicae Sinensis, bush, teasel root, the rhizome of davallia, ground bettle, muskmelon seed, Artemisia anomala, rhizoma arisaematis, Radix Glycyrrhizae, from
Right copper, 12 taste Chinese medicine of Radix Curcumae are weighed according to the parts by weight, and water decocts 3 times after mixing, add 10 times of quality water for the first time, are decocted
It boils 2 hours；Second plus 8 times of quality water, decoct 1 hour；Third time adds in safflower and 8 times of quality water, decocts 1 hour, merges
Filtrate three times, being condensed into cream, (65 DEG C measure relative density as 1.2-1.25, more preferably 1.25)；
C. the medicinal extract that fine powder step a obtained is obtained with step b after mixing, obtains ointment, according still further to common process
Cataplasm or patch or rubber ointment is made.
Preferably, the step c after mixing ointment and catablasm base material, to be applied on back lining materials, protect by covering separate paper
Cuticula, molding are cut up to cataplasm dosage form.It is highly preferred that the catablasm base material is 1150 parts of carbomer, glycerine 1600
Part, 2800 parts of gelatin, 33500 parts of purified water；The number is parts by weight.
Preferably, 64 parts of menthol is additionally added in the step a, the number is parts by weight.
Affected part is pasted in traditional Chinese medicine plaster external application of the present invention.Traditional Chinese medicine plaster toxic side effect of the present invention is smaller, and clinical practice is compared
Safety；It has no stimulation to normal skin and damaged skin, also without side effects such as sensitization.
Drug function in prescription of the present invention has his own strong points, and comprehensive function is played using the drug of each tool characteristic.The present invention
The root of Chinese clematis in prescription, Radix Angelicae Sinensis, bush, safflower, frankincense (system), myrrh (system), dragon's blood seven flavor medicine, relieve heat damp-clearing pain-relieving cure mainly pass
It is unfavorable to save, muscular paralysis, muscles and bones, soreness of waist and knee joint, promoting blood circulation, swelling and pain relieving.To treat the disease for storing blood and congestion blood block, with
This prescription is formed based on this seven flavor medicine.Gas row then blood, the stagnation of the circulation of vital energy then blood stasis, healthy tendency virtual loss lead to stagnation of blood stasis, " Fuzheng Huoxue,
It is the drug for playing primary treatment for main disease or main symptom.First of in its efficacy of a drug side of residence, when dosage is relatively as minister, adjutant application
Greatly, so for monarch drug in a prescription in side.It helps with teasel root, Radix Curcumae, the rhizome of davallia, ground bettle, Artemisia anomala, native copper, muskmelon seed seven flavor medicine, according to
Shen controls bone, raw marrow, muscle invest bone, filling liver kidney, hard muscles and bones, arteries and veins of invigorating blood circulation, therefore injury of tendon and muscle disease and kidney are in close relations, and muscles and bones disease also may be used
Cause kidney deficiency vital essence cannot on hold, the kidney tonifying of more than seven flavor medicine, strengthening tendons, symplectic bone, when auxiliary monarch drug in a prescription strengthen treatment it is main disease or main symptom
Drug.Second is that playing the drug of therapeutic effect for simultaneous disease or accompanying symptoms, its efficacy of a drug is less than monarch drug in a prescription, so for ministerial drug in side.Place
Radix Notoginseng, dragon's blood hemostasia and dissipation blood stasis, detumescence ding-tong in side.Rhizoma arisaematis, borneol, Radix Glycyrrhizae dredging grain, spasmolysis, analgesia.First, supplementary drug
Monarch, ministerial drug are assisted to strengthen therapeutic effect or directly treat secondary accompanying symptoms.Second is that supplementary inhibitory medicine, i.e., eliminating or slow down
Monarch, ministerial drug it is strong.The efficacy of a drug of adjutant is less than ministerial drug, so it is also contemplated that be guiding drug again, can in the side of drawing all medicines to reach disease
Drug, and be to reconcile, i.e. the drug with coordinating the drug actions of a prescription effect.The efficacy of a drug for making medicine is smaller.Above prescription composition is focused on
Local symptom, dialectical treatmert promote swelling to subside, soft tissue repair, union and functional rehabilitation.The injury of tendon and muscle is sent out simultaneously with bone fracture
It is raw, also can individually it occur, and can influence each other.So it is envisioned that treat the damage of muscle again on the composition of more than prescription
Treat the damage of bone.This be " the soft ability bone of muscle is just ", " just just muscle is soft for bone ".Iliacus wound is divided into acute and chronic damage, so side
Acute iliacus wound is considered in agent mostly with the promoting flow of qi and blood circulation, based on swelling and pain relieving, chronic iliacus hinders then suitable help righting, dispels outer
It is evil.
Traditional Chinese medicine plaster of the present invention promotes Transdermal absorption curative effect, passes through skin keratinocytes for improving local microcirculation
Gap, sweat gland, sebaceous glands, makes Medicated Permeation have anti-inflammatory, analgesic effect to wound, while drug penetrates skin with absorbing at follicular wall
Skin reaches corruption of dispelling, myogenic, convergence synthetism effect, so as to reach therapeutic purposes.Its mechanism of action is：
A. the expansion capilary that activates blood circulation and disperses blood clots improves local microcirculation, increases local metabolic, promotes the blood of bone fracture
Swollen dissipate absorbs.
B. various bioactivators possessed by several Chinese medicinal ingredients enhance bone fracture local immunity.Every promotion blood
Liquid cycle dissipates to be retarded by silt is known as promoting blood flow and remove blood stasis drug for the drug of major function, and the pain of limbs, and swelling is just because of stagnation of the circulation of vital energy blood
Silt causes.So using promoting blood flow and remove blood stasis drug dissipating blood stasis and reducing the stagnation, dredge tendon and vessel and the purpose of swelling and pain relieving can be played.
Advantageous effect possessed by the present invention：
Traditional Chinese medicine plaster of the present invention overcomes the side effect of oral medicine and the damage to hepatic and renal function, directly acts on lesion
Position generates blocking effect, works rapid, quick.Dosage form is reasonable, easy to use, and patient can be with self medication and family oriented
Treatment, easy to use, success rate is up to more than 90%.
Traditional Chinese medicine plaster of the present invention breaks a kind of filler of " minium " (minerals are toxic) of traditional plaster, and removal is extra
Impurity, purified plaster.Traditional Chinese medicine plaster of the present invention, which has, is kept for the lubricious time long, is easy to be absorbed by the skin, can be given full play to
Drug effect.Traditional Chinese medicine plaster of the present invention is percutaneously penetrated to have to control and not committed.It controls the inferior and does not go against one's superiors, then controlled in controlling up and down without criminal
It fits disease in its institute i.e. only, to control without leaving a legacy of trouble, for taste without wound, life is harmless.Traditional Chinese medicine plaster of the present invention is simple and practicable, very convenient,
Medicine is thrifty inexpensive, with the right method, and effect is vertical should.Satisfied treatment is reached to trauma fracture, soft tissue injury and cachectic ostealis for many years
Effect.To the swelling and pain relieving of wound site, soft tissue repair, union and functional rehabilitation, promote the improvement of microcirculation, eliminate blood
The treatment of pipe crisis is fruitful.
Experimental study
1 coating medicine-feeding 51.5g crude drugs/kg of mouse is observed 7 days, and mouse does not occur drug poisoning reaction, and 20 mouse are equal
Occur without death, growth and development is well normal, and the maximal tolerance dose to mouse is 51.5g crude drugs/kg, and liquid extract is a concentration of
2.06g crude drugs/ml.
This is tested to mouse unhairing back 1 time and applies 2.06 crude drugs/0.5m, 1/20g outside, is equivalent to 51.5g crude drugs/kg.Medicine
Mouse does not occur toxic reaction afterwards, continues observation 7 days, and 20 mouse growths are normal, and death does not occur, and work after the test is killed
Some animals, main organs also no abnormal variation.
Conclusion (of pressure testing), a coating medicine-feeding of the invention, the maximal tolerance dose to mouse are 51.5g crude drugs/kg, the results showed that
The medicine is smaller to the toxicity of mouse.Medicine clinic people dosage is 26.7g crude drugs/60kg, the quite clinical people's dosage of maximal tolerance dose
114 times, illustrate that the medicine clinical practice is safer.
2nd, animal model experiment
1. experimental animal：
The Japanese white big ear rabbit 48 of health is selected, weight is regardless of in 2500g or so, male and female, every group 8, set 2 altogether,
4th, 6 weeks 3 reduced values.(table 1-1).
Table 1-1 experimental animal grouping sheets
| Group | 2 weeks | 4 weeks | 6 weeks | It is total |
| Control group | 8 | 8 | 8 | 24 |
| Experimental group | 8 | 8 | 8 | 24 |
| It is total | 16 | 16 | 16 | 48 |
All animals take left fore defeathering, calculate dosage by 50mg/kg with amobarbital sodium, do vein and slowly inject fiber crops
Liquor-saturated, aseptically, the bone defect that left fore radius stage casing 0.65cm is caused using double leaf electric saw is (complete including periosteum and sclerotin
Portion is cut off), because suffering limb has ulna support to be not required to fix after suture, anti-infective 3 days with gentamicin.
Experimental group all animals external application Chinese medicine ointment of the present invention.Used time cuts ointment by position size, is applied with gauze, then use
Ointment is tightly fixed on limbs by adhesive plaster, only with once, is never changed again, until coming off.Control group does not have to any drug,
Normal healing.
2. research method
1) .X lines are made film：Every group of animal carries out X-ray on enlarger being zoomed at bone defect before putting to death according to plan
5x7cm photos are traced poroma shadow region in bone defect with carbon paper and are calculated on grid computation paper, poroma shade is obtained
Then the percentage of area carries out statistical procedures.
2) histological examinations：Animal is put to death on time after, the gross specimen at bone defect both ends is cut, is routinely located after decalcification
Manage sample, row paraffin section, slice thickness 7cm is dyed with tri- kinds of methods of HE, Masson, PTAH, observe hemotoncus at bone defect,
The situation of cell, glue thickness and area of new bone.
3) histochemistries check：Fresh gross specimen is fixed with ice acetone, undecalcified slice cuts the group at bone defect
It knits, alkaline phosphatase is checked with ComoriShi methods.Glycogen is checked with PAS methods.
4) tetracycline fluorescent labeled microscopics are observed：7 days before every group of animal execution, calculate dosage vein by 50mg/kg and slowly inject
Tetracycline.Animal is cooked the 2nd tetracycline injection for 24 hours before putting to death.Animal cuts sample after putting to death, by FrostShi legal systems Cheng Xin
Fresh, undecalcified and thin bone grinding, observes on fluorescence microscope and light microscopic, does the calculating of following index：
A. the calculating of the fluorescence ring of light.
B. the calculating of fluorescence ring of light area (%)：Every animal selects the knot of cortex bone, area of new bone and cortex bone and area of new bone
Microphotograph is done in conjunction portion, and photo, which is put, to be twice, and the ring of light is traced with carbon paper on grid computation paper, calculate the ring of light shared by lattice number with
Gross area lattice number is compared, and obtains the numerical value of ring of light area (%), then carries out statistical procedures.
C. the calculating of fluorescence ring of light weight (mg)：With the above-mentioned material for tracing the ring of light, the ring of light is cut off, in the day of a ten thousandth
Flat upper weighing, obtains ring of light weight, then carries out statistical procedures.
D. the measurement of fluorescence ring of light diameter and the calculating of mineralization appositional rate (MR)：With CMSD series micro eyepieces digital display/
Printing instrument, arbitrarily measures the data of ten fluorescence ring diameters in every grinding under mirror, and equal print record then calculates
Value represents the ring of light average diameter of every grinding.Calculate the average diameter of every group of all grindings, then empirically group and control group
It is separately summed, calculates two groups of overall average ring of light diameters, removed within (7 days) with the interval number of days of double injection tetracycline,
Mineralising deposition (MAR) is obtained um/ days.
3rd, result
1), table 1-2 experimental groups and the statistics x-ray film making observation of control group poroma shaded area (%) and poroma shaded area
Calculating：By each animal x-ray film making observation of each week, most of experimental group X-ray photograph growth of spur is better than control group, shows
Experimental group poroma shade occurs early, and growth of spur speed is fast, and poroma hatching density is high, and the bone defect having to 4th week is cured substantially
It closes, has more healings within the 6th week.And growth of spur is slow in control group bone defect, until the 6th week, still none can reach more
It closes.Two groups of poroma shaded area is calculated using grid calculating method and the results are shown in Table 1-2.
The statistics of table 1-2 experimental groups and control group poroma shaded area (%)
The result shows that experimental group averagely increases 30.57% (P than control group poroma shaded area<0.01) present invention, is proved
Play the role of promoting growth of spur.
2), histological examination：Two groups of histotomy is observed, the growth for finding the new bone in bone defect is all to pass through cartilage
What interior skeletonization developed, but morning time of new bone is grown in two epiphysis of experimental group, range is big, during entochondrostosis, and
There is evening time of new bone in two epiphysis of control group, and cartilage area range is big, and entochondrostosis process is long, thus growth of spur is slow,
Until the 6th week both ends poroma cannot connect, intermediate there are still large stretch of fibr tissue areas, illustrate that control group new bone growth delays
Slowly.
3), histochemistry checks：Liang Zu histochemistries alkaline phosphatase and glycogen dyeing, ossific process is equally in cartilage
Based on skeletonization, the new bone that is formed at the edge of experimental group entochondrostosis and cartilage has abundant alkaline phosphatase model
Enclose that big content is more, and alkaline phosphatase enriches, to new bone growth is accelerated undoubtedly to play good effect.And control group alkaline phosphatase
The small content of range is few.Glycogen coloration result also demonstrates that the red dye range of experimental group area of new bone area periphery is small, illustrates that glycogen utilizes
Soon.And the red dye range of control group area of new bone area periphery is big, and it is slow to illustrate that glycogen utilizes.
4), tetracycline fluorescent labeled microscopic：In terms of counting first from experimental group with the control group fluorescence ring of light, experimental group overall mean
34, control group 27, experimental group is each ground average more 7 rings of light with control group, illustrates that experimental group bone new life range is big.
In the comparison of experimental group and two groups of fluorescence ring of light areas (%) of control group and fluorescence ring of light weight (mg), it can also be seen that experimental group
It is significantly more than control group (table 1-3,1-4)
Table 1-3 experimental groups and the statistics of one ring of light area (%) of control group
The statistics of table 1-4 experimental groups and control group fluorescence ring of light weight (mg)
Meter is measured to experimental group and control group fluorescence ring of light diameter with CMSD series micro eyepiece quantity/printing instrument
It calculates, acquired results experimental group overall average fluorescence ring of light diameter 13.89um, control group 7.4um, the ratio control group fluorescence light of experiment
Ring diameter is averaged more 6.48um, illustrates that the new bone apposition of experimental group is more, with the fluorescence ring of light diameter data measured, further calculates two
The mineralising deposition (MAR) of group, is shown in Table 1-5.
Table 1-5 experimental groups and control group mineralization appositional rate (MAR) contrast table
The MAR that can be seen that control group from table 1-5 meets normal value, and experimental group 0.84um more than control group, through statistics
Handle, p<0.01, illustrate that experimental group area of new bone mineralising deposition is fast and more.
Clinical data
120 bone-fracture patients, random number are divided into experimental group and control group, and experimental group (uses Chinese herbs paste of the present invention, i.e.,
Wheeling bone pastes), control group not medication.Man 84, female 36,12~75 years old age, classification of fracture：Fresh fracture 112, wherein
Fracture of tibia and fibula 64 (random experiments group and each 32 of control group), patellar fracture 20 (random experiments group and control group each 10
Example), ankle fracture 16 (random experiments group and each 8 of control group), pelvic fracture 6 (random experiments group and control group each 3
Example), forearm fracture 6 (random experiments group and each 3 of control group).Old fracture disunion 8 is (lower 1/ wherein in tibiofibula
3 fracture fixation operations nonunions 2, the postoperative nonunion of forearm fracture Plate internal fixiation 4 of forearm opening, lock
Bone nonunion 2.) (random experiments group and each 4 of control group).
It is after experimental group injury or postoperative using Chinese herbs paste of the present invention, according to swelling range, once a day, each basis
The patch of position 1~3 is (per note specification:7x10cm), 4~6 weeks it is as a treatment course.Old fracture patient medication 8~10 weeks, control group does not make
With this medicine, two groups of other treatment all sames.
Test inspection item, criterion
1) subjective symptoms：Whether burning heat sensation, distending pain sense, pain need to use anodyne.
2) parts sign：Soft tissue tension, the dermal ecchymosis, soft tissue swelling degree.Soft tissue swelling degree：At soft group
It knits at swelling with tape measuring Zhou Jing, and compared with strong side.The two difference is swelling coefficient.Coefficient>More than 4cm persons are
Severe swelling, 2~4cm are moderate swelling, and below 2cm is mild swelling.
3) .X mating plates show the time that poroma occurs.
4) the clinicals union of bone time.
Clinical observation and result
1. experimental group patient is using after Chinese herbs paste of the present invention, suffering limb distending pain and heats and feel substantially reduced, control group is then suffered from
Limb distending pain heats sense significantly, is required to be relieved pain with anodyne after control group patient wound.
2. soft tissue swelling regression time experimental group is 4 days average, control group is 7 days average, general 3~5 days internal injuries of experimental group
Place's skin is shown in fold, swelling recession ecchymosis range shorter, and ecchymosis shoals, seldom blebbing, and control group soft tissue swelling is subsided
Delay and bubble easily occur.
3.X light first shows that poroma goes out current time：Experimental group average out to 20 days, control group are 30 days average.Wherein experimental group
There is male's both arms fracture patient, after internal fixation, using this medicine, postoperative 3 weeks i.e. visible growth of spur, uses
See that fracture line obscures within 2 months after this medicine, there are a large amount of growth of spur.
4. the clinical union of bone time：Experimental group is 40 days average, and control group is 60 days average, and experimental group is significantly faster than that control
Group.
Table 2-1 observation item results
| Project | Experimental group | Control group |
| Heat sense | It is substantially reduced | Significantly |
| Swelling and pain sense | It is substantially reduced | Significantly |
Table 2-2 observation item results
| Project | Experimental group | Control group | V values | P values | Conclusion |
| Swelling is subsided | 4 days (average) | 7 days (average) | ﹥ 2.58 | P ﹤ 0.01 | Significant difference |
| Poroma occurs | 20 days (average) | 30 days (average) | ﹥ 2.58 | P ﹤ 0.01 | Significant difference |
| Clinical healing | 40 days (average) | 60 days (average) | ﹥ 2.58 | P ﹤ 0.01 | Significant difference |
Pass through the observation to 120 patients, it can be seen that Chinese herbs paste of the present invention has analgesic, invigorates blood circulation, and detumescence promotes fracture
Healing.
1) subsides a swelling：Soft tissue injury rupture haemorrhage after limbs are hit by violence, fracture end bleeding, injury region blood vessel ooze
Permeability enhances, and exudation increases, and synovium of joint is formed because hyperemia exudation when reasons cause injured limb or intra-articular Liquid deposition
Swelling, pressure increases in tissue, and blood circulation is poor, and anoxic makes vascular permeability increase exudation to increase, and swelling is apparent, gradually forms evil
Property cycle, then act on tissue for exopathogen by theory of traditional Chinese medical science, damage muscles and bones, channels and collaterals are obstructed, and qi and blood stagnation forms swelling, the present invention
Chinese herbs paste its main ingredient is Radix Notoginseng, dragon's blood, and hemostasia and dissipation blood stasis is subsided a swelling, analgesic.Safflower, the bush promoting flow of qi and blood circulation reduce bleeding exudation,
So as to play detumescence effect.Achieve the purpose that swell except stagnation resolvation by traditional Chinese medical science viewpoint, i.e., because solution degasification is sluggish, dredging the channel.
2) is relieved pain：Local swelling makes the pressure raising of tissue bone, the metabolite that tissue damage and anoxic are released after wound
(K+, H+, histamine, five tryptamines) form physics and chemical factor stimulation nerve endings, generate pain, Chinese herbs paste of the present invention
Have promoting blood circulation and removing blood stasis, eliminate the effect of swelling, pressure in tissue can be mitigated, improve anoxic conditions, because and also have analgesic effect, in pressing
Medical knowledge opinion is " not general rule pain, no pain by smooth breath ".
3) improving micro_circulation effects：The energy such as the drug of Chinese herbs paste of the present invention such as Radix Angelicae Sinensis, Radix Notoginseng, safflower, frankincense, myrrh
Increase coronary blood flow, reduce myocardial oxygen consumption, and the excited breath cycle maincenter of energy, hence it is evident that improve recurrent state, accelerate
The absorption of wound general character medium is so as to achieve the purpose that improve microcirculation.
4) promotes union：Clinical and zoopery proves many trace elements, and positive tune is played to osteoblast
Section effect can be such that poroma occurs in advance, shorten clinical healing time, the healing of fracture dependent on hemotoncus between two fracture ends and
The removing of slough and the hyperplasia of periosteum are denaturalized and ossify, and accomplish this point, it is necessary to and fracture reduction is good, is in close contact,
Strong fixation and part has good blood supply, and experimental group patient is through gimmick or operative reduction, contraposition satisfaction, fix tightly
It leans on, adds and use Chinese herbs paste of the present invention, so as to accelerate the repair of fracture end, by theory of traditional Chinese medical science i.e. by promoting blood circulation and removing blood stasis, rush
Into the operation of qi and blood, play the role of supporting to muscles and bones, the helps liver such as teasel root, the root of Chinese clematis, native copper in Chinese herbs paste of the present invention
Kidney, the application of strong muscles and bones drug, thus promote the healing of fracture.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but does not limit protection scope of the present invention.
Embodiment 1
A kind of Chinese medicine patcher for treating wound, osteopathy, the bulk pharmaceutical chemicals and its dosage for playing main active are：The root of Chinese clematis
600g, Radix Angelicae Sinensis 600g, bush 400g, safflower 400g, Radix Notoginseng 200g, teasel root 480g, rhizome of davallia 600g, ground bettle 400g, frankincense
(system) 400g, myrrh (system) 400g, muskmelon seed 1600g, Artemisia anomala 600g, rhizoma arisaematis 120g, Radix Glycyrrhizae 400g, native copper 600g,
Radix Curcumae 400g, dragon's blood 20g, borneol 64g, menthol 64g.(menthol can not also add)
Preparation process is：
A. it by Radix Notoginseng, frankincense (system), myrrh (system), dragon's blood, borneol, menthol, crushes respectively, is ground into fine powder, cross No. 6
Sieve；Fine powder is weighed according to raw material survival dose, remixes, obtains fine powder mixture；It is spare；
B. by the root of Chinese clematis, Radix Angelicae Sinensis, bush, teasel root, the rhizome of davallia, ground bettle, muskmelon seed, Artemisia anomala, rhizoma arisaematis, Radix Glycyrrhizae, from
Right copper, 12 taste Chinese medicine of Radix Curcumae are weighed according to dosage, and water decocts 3 times after mixing, add 10 times of quality water for the first time, are decocted 2 hours；
Second plus 8 times of quality water, decoct 1 hour；Third time adds in safflower and 8 times of quality water, decocts 1 hour, merges filtrate three times,
Being condensed into cream, (65 DEG C measure relative density as 1.2-1.25, more preferably 1.25)；
C. the medicinal extract that fine powder step a obtained is obtained with step b after mixing, obtains ointment, by ointment and cataplasm
It after matrix is mixed, is applied on back lining materials, covers separate paper protective film, molding is cut up to cataplasm dosage form；The cataplasm
Matrix is carbomer 1150g, glycerine 1600g, gelatin 2800g, purified water 33.5kg.
Embodiment 2
A kind of Chinese herbs paste (Wheeling bone patch) for treating osteopathy, the bulk pharmaceutical chemicals and its dosage for playing main active are：Prestige
Medicine xiaolingxian 600g, Radix Angelicae Sinensis 600g, bush 400g, safflower 400g, Radix Notoginseng 200g, teasel root 480g, rhizome of davallia 600g, ground bettle 400g,
Frankincense (system) 400g, myrrh (system) 400g, muskmelon seed 1600g, Artemisia anomala 600g, rhizoma arisaematis 120g, Radix Glycyrrhizae 400g, native copper
600g, Radix Curcumae 400g, dragon's blood 20g, borneol 64g, menthol 64g.(menthol can not also add)
Preparation process is：
A. it by Radix Notoginseng, frankincense (system), myrrh (system), dragon's blood, borneol, menthol, crushes respectively, is ground into fine powder, cross No. 6
Sieve；Fine powder is weighed according to raw material survival dose, remixes, obtains fine powder mixture；It is spare；
B. by the root of Chinese clematis, Radix Angelicae Sinensis, bush, teasel root, the rhizome of davallia, ground bettle, muskmelon seed, Artemisia anomala, rhizoma arisaematis, Radix Glycyrrhizae, from
Right copper, 12 taste Chinese medicine of Radix Curcumae are weighed according to dosage, and water decocts 3 times after mixing, add 10 times of quality water for the first time, are decocted 2 hours；
Second plus 8 times of quality water, decoct 1 hour；Third time adds in safflower and 8 times of quality water, decocts 1 hour, merges filtrate three times,
Being condensed into cream, (65 DEG C measure relative density as 1.2-1.25, more preferably 1.25)；
C. the medicinal extract that fine powder step a obtained is obtained with step b after mixing, obtains ointment, according still further to common process
Patch is made.
Embodiment 3
A kind of traditional Chinese medicine plaster for treating osteopathy, the bulk pharmaceutical chemicals and its dosage for playing main active are：Root of Chinese clematis 700g,
Radix Angelicae Sinensis 700g, bush 550g, safflower 450g, Radix Notoginseng 320g, teasel root 480g, rhizome of davallia 600g, ground bettle 400g, frankincense (system)
480g, myrrh (system) 480g, muskmelon seed 1600g, Artemisia anomala 600g, rhizoma arisaematis 120g, Radix Glycyrrhizae 400g, native copper 600g, Radix Curcumae
400g, dragon's blood 30g, borneol 64g, menthol 64g.(menthol can not also add)
When patch is made, preparation process is the same as the preparation process of embodiment 2.
When cataplasm is made, preparation process is the same as the preparation process of embodiment 1.
Embodiment 4
A kind of traditional Chinese medicine plaster for treating osteopathy, the bulk pharmaceutical chemicals and its dosage for playing main active are：Root of Chinese clematis 750g,
Radix Angelicae Sinensis 680g, bush 500g, safflower 400g, Radix Notoginseng 290g, teasel root 460g, rhizome of davallia 620g, ground bettle 410g, frankincense (system)
400g, myrrh (system) 400g, muskmelon seed 1580g, Artemisia anomala 620g, rhizoma arisaematis 124g, Radix Glycyrrhizae 390g, native copper 550g, Radix Curcumae
380g, dragon's blood 32g, borneol 64g, menthol 64g.(menthol can not also add)
When patch is made, preparation process is the same as the preparation process of embodiment 2.
When cataplasm is made, preparation process is the same as the preparation process of embodiment 1.
Typical case history
1) king XX, man, 51 years old, left tibia and fibula old fracture (used 2 patch of embodiment)
| Project | 0 week | 2 weeks | 4 weeks | 6 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Swelling sense | Moderate | Slightly | Slightly | Nothing |
| Heat sense | Significantly | It is substantially reduced | Nothing | Nothing |
| X-ray | Without apparent poroma | Without apparent poroma | Slight poroma | Apparent poroma |
2) grandson XX, female, 28 years old, left forearm forearm fracture (used 2 cataplasm of embodiment)
| Project | 0 week | 2 weeks | 4 weeks | 6 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Swelling sense | Moderate | Slightly | Without apparent | Nothing |
| Heat sense | Significantly | Slightly | Nothing | Nothing |
| X-ray | Cortex of bone is discontinuous | Without apparent poroma | Slight poroma | Apparent poroma |
3) Lee XX, man, 30 years old, stiff neck (used 3 patch of embodiment)
| Project | 0 week | 1 day | 2 days | 3 days |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Mobility | It can not activity | It is clearly better | Without significant discomfort | Activity is freely |
4) Lee XX, female, 42 years old, scapulohumeral periarthritis (used 3 patch of embodiment)
| Project | 0 week | 1 week | 2 weeks | 3 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Swelling sense | Slightly | Without apparent | Nothing | Nothing |
| Mobility (anteflexion) | 90° | 110° | 130° | 170° |
| After stretch | 10° | 20° | 45° | 60° |
| Abduction | 60° | 90° | 120° | 170° |
| Interior receipts | 70° | 90° | 110° | 130° |
| Abduction inward turning | 45° | 50° | 60° | 70° |
| Abduction rotation is outer | 45° | 60° | 75° | 90° |
5) Korea Spro XX, female, 23 years old, right injury of knee joint (using 4 patch of embodiment)
| Project | 0 week | 4 days | 7 days | 10 days |
| Feeling of pain | Significantly | It is substantially reduced | Without apparent | Nothing |
| Swelling sense | Moderate | It is substantially reduced | Without apparent | Nothing |
| Heat sense | Significantly | Slightly | Nothing | Nothing |
| Mobility is bent and stretched | 60° | 100° | 130° | 130° |
| Inward turning | 0° | 15° | 30° | 30° |
| Outward turning | 0° | 20° | 40° | 40° |
6) Shen XX, female, 26 years old, sprained ankle (used 4 patch of embodiment)
| Project | 0 week | 4 days | 7 days | 10 days |
| Feeling of pain | Significantly | It is substantially reduced | Without apparent deep by pain | Nothing |
| Swelling sense | Moderate | It is substantially reduced | Without apparent | Nothing |
| Heat sense | Significantly | Slightly | Nothing | Nothing |
| Mobility | It can not activity | It is slight limited | Without apparent limited | Nothing |
7) Zhao XX, man, 55 years old, cervical spondylosis (used 3 cataplasm of embodiment)
| Project | 0 week | 1 week | 3 weeks | 5 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Feeling of numbness | Significantly | It is substantially reduced | Slightly | Slightly |
| Mobility is anteflexion | 15° | 25° | 30° | 40° |
| After stretch | 15° | 30° | 40° | 40° |
| Rotation | 45° | 500° | 60° | 60° |
8) king XX, man, 52 years old, lumbar muscle strain (used 2 patch of embodiment)
| Project | 0 week | 1 week | 2 weeks | 3 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Swelling sense | Slightly | It is substantially reduced | Without apparent | Nothing |
| Heat sense | Slightly | Slightly | Nothing | Nothing |
| Mobility is anteflexion | 45° | 60° | 80° | 80° |
| Lateroflexion | 10° | 30° | 40° | 40° |
| Rotation | 15° | 30° | 45° | 45° |
9) Liu XX, man, 42 years old, protrusion of lumber intervertebral disc (used 2 cataplasm of embodiment)
| Project | 0 week | 1 week | 2 weeks | 4 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Numb and radiation sense | Significantly | It is substantially reduced | Slightly | Slightly |
| Slope row | Slightly | It is substantially reduced | Without apparent | Nothing |
| Mobility is anteflexion | 30° | 45° | 60° | 70° |
| Lateroflexion | 10° | 20° | 30° | 40° |
| Rotation | 15° | 20° | 30° | 40° |
10) fourth XX, man, 71 years old, hip joint synovitis (used 2 patch of embodiment)
| Project | 0 week | 1 week | 2 weeks | 4 weeks |
| Feeling of pain | Significantly | It is substantially reduced | Slightly | Nothing |
| Swelling sense | Slightly | It is substantially reduced | Without apparent | Nothing |
| Mobility is anteflexion | 70° | 90° | 100° | 120° |
| After stretch | 0° | 0° | 10° | 10° |
| Interior receipts | 5° | 10° | 15° | 20° |
| Abduction | 20° | 30° | 45° | 45° |
| Inward turning | 5° | 10° | 20° | 30° |
| Outward turning | 5° | 15° | 30° | 40° |
Claims (7)
1. a kind of traditional Chinese medicine plaster for treating wound, osteopathy, it is characterised in that：The traditional Chinese medicine plaster by following parts by weight original
Material medicine is prepared：600 parts of the root of Chinese clematis, 400 parts of bush, 400 parts of safflower, 200 parts of Radix Notoginseng, continues at 600 parts of Radix Angelicae Sinensis
480 parts disconnected, 600 parts of the rhizome of davallia, 400 parts of ground bettle, 400 parts of frankincense, 400 parts of myrrh, 1600 parts of muskmelon seed, Liu
Post 600 parts of slave, 120 parts of rhizoma arisaematis, 400 parts of Radix Glycyrrhizae, 600 parts of native copper, 400 parts of Radix Curcumae, 20 parts of dragon's blood, borneol
64 parts.
2. a kind of traditional Chinese medicine plaster for treating wound, osteopathy according to claim 1, it is characterised in that：The bulk pharmaceutical chemicals
64 parts of menthol is further included, the number is parts by weight.
3. a kind of traditional Chinese medicine plaster for treating wound, osteopathy according to claim 1 or claim 2, it is characterised in that：The Traditional Chinese medicine plaster
Paste is according to cataplasm, patch or rubber ointment made of common process.
4. a kind of traditional Chinese medicine plaster for treating wound, osteopathy according to claim 3, it is characterised in that：The dosage form is bar
Cloth agent or patch.
5. described in claim 1 it is a kind of treat wound, osteopathy traditional Chinese medicine plaster preparation method, it is characterised in that：Including such as
Lower step：
A. it by Radix Notoginseng, frankincense, myrrh, dragon's blood, borneol, crushes respectively, is ground into fine powder, cross No. 6 sieves；According to bulk pharmaceutical chemicals weight
Amount number weighs fine powder, remixes, obtains fine powder mixture, spare；
B. by the root of Chinese clematis, Radix Angelicae Sinensis, bush, teasel root, the rhizome of davallia, ground bettle, muskmelon seed, Artemisia anomala, rhizoma arisaematis, Radix Glycyrrhizae, native copper,
12 taste Chinese medicine of Radix Curcumae is weighed according to the parts by weight, and water decocts 3 times after mixing, adds 10 times of quality water for the first time, decocts 2
Hour；Second plus 8 times of quality water, decoct 1 hour；Third time adds in safflower and 8 times of quality water, decocts 1 hour, merges three times
Filtrate is condensed into medicinal extract；
C. the medicinal extract that fine powder step a obtained is obtained with step b after mixing, obtains ointment, is made according still further to common process
Cataplasm or patch or rubber ointment.
6. the preparation method of traditional Chinese medicine plaster according to claim 5, it is characterised in that：The concentration step causes what is obtained
65 DEG C of medicinal extract measures relative density as 1.2-1.25.
7. according to the preparation method of the traditional Chinese medicine plaster of claim 5 or 6, it is characterised in that：The step c be by ointment and
It after catablasm base material mixes, is applied on back lining materials, covers separate paper protective film, molding is cut up to cataplasm dosage form；Described
Catablasm base material is 1150 parts of carbomer, 1600 parts of glycerine, 2800 parts of gelatin, 33500 parts of purified water；The number is parts by weight
Number.
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| CN201510304377.0A CN104873902B (en) | 2015-06-05 | 2015-06-05 | A kind of traditional Chinese medicine plaster for treating wound, osteopathy |
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| CN104873902B true CN104873902B (en) | 2018-06-12 |
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| CN106389787A (en) * | 2016-11-04 | 2017-02-15 | 么世成 | External-application plaster and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084761A (en) * | 1993-07-29 | 1994-04-06 | 夏树安 | Bone wound medicine (gushangling) |
| CN1436558A (en) * | 2002-02-07 | 2003-08-20 | 贵州仙灵药业股份有限公司 | Plaster for treating pain and swelling |
| CN101474331A (en) * | 2009-01-20 | 2009-07-08 | 董国强 | Chinese medicine plaster for dispersing swelling |
| CN104491762A (en) * | 2015-01-19 | 2015-04-08 | 李宏良 | Medicine composition for treating traumatic injury and preparation method |
-
2015
- 2015-06-05 CN CN201510304377.0A patent/CN104873902B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084761A (en) * | 1993-07-29 | 1994-04-06 | 夏树安 | Bone wound medicine (gushangling) |
| CN1436558A (en) * | 2002-02-07 | 2003-08-20 | 贵州仙灵药业股份有限公司 | Plaster for treating pain and swelling |
| CN101474331A (en) * | 2009-01-20 | 2009-07-08 | 董国强 | Chinese medicine plaster for dispersing swelling |
| CN104491762A (en) * | 2015-01-19 | 2015-04-08 | 李宏良 | Medicine composition for treating traumatic injury and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 跌打损伤后如何选用中成药;姚小青;《江西中医药》;20070615(第06期);第62页 * |
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