CN108495857A - 新的磷杂环己烷类化合物和氮杂磷杂环己烷类化合物，它们的制备方法和包含它们的药用组合物 - Google Patents
新的磷杂环己烷类化合物和氮杂磷杂环己烷类化合物，它们的制备方法和包含它们的药用组合物 Download PDFInfo
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- CN108495857A CN108495857A CN201780008078.XA CN201780008078A CN108495857A CN 108495857 A CN108495857 A CN 108495857A CN 201780008078 A CN201780008078 A CN 201780008078A CN 108495857 A CN108495857 A CN 108495857A
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- 0 CC(C)(C)*C(N(CCCCBr)C(OC(C)(C)C)=O)=O Chemical compound CC(C)(C)*C(N(CCCCBr)C(OC(C)(C)C)=O)=O 0.000 description 2
- YRXVQCRYUULKMO-OYKVQYDMSA-N CC(C)N(C(C)C)P1(CC(CN(Cc2ccccc2)C2)[C@@H]2C1)O Chemical compound CC(C)N(C(C)C)P1(CC(CN(Cc2ccccc2)C2)[C@@H]2C1)O YRXVQCRYUULKMO-OYKVQYDMSA-N 0.000 description 1
- AKJWGGCZMPRWHF-UHFFFAOYSA-N COCOc1cc(-c2cc(F)ccc2C=O)ccc1 Chemical compound COCOc1cc(-c2cc(F)ccc2C=O)ccc1 AKJWGGCZMPRWHF-UHFFFAOYSA-N 0.000 description 1
- INNRHKRQSAXWST-UHFFFAOYSA-N COc(cc1)ccc1C1=CC(F)=CCC=C1C=O Chemical compound COc(cc1)ccc1C1=CC(F)=CCC=C1C=O INNRHKRQSAXWST-UHFFFAOYSA-N 0.000 description 1
- XSIDFSPSFHXBKI-UHFFFAOYSA-N O=CC(C=CCC1)=C1c1c[o]cc1 Chemical compound O=CC(C=CCC1)=C1c1c[o]cc1 XSIDFSPSFHXBKI-UHFFFAOYSA-N 0.000 description 1
- SDWRUJHCAOSKPC-UHFFFAOYSA-N O=Cc(c(-c(cc1)ccc1Cl)c1)ccc1F Chemical compound O=Cc(c(-c(cc1)ccc1Cl)c1)ccc1F SDWRUJHCAOSKPC-UHFFFAOYSA-N 0.000 description 1
- URCOOTXEANETFV-UHFFFAOYSA-N O=Cc(c(-c(cc1)ccc1F)c1)ccc1F Chemical compound O=Cc(c(-c(cc1)ccc1F)c1)ccc1F URCOOTXEANETFV-UHFFFAOYSA-N 0.000 description 1
- RKYQJFQQALYBEM-UHFFFAOYSA-N O=Cc(ccc(F)c1)c1-c1cc(cccc2)c2[s]1 Chemical compound O=Cc(ccc(F)c1)c1-c1cc(cccc2)c2[s]1 RKYQJFQQALYBEM-UHFFFAOYSA-N 0.000 description 1
- PJNJVFWVQRIGKX-UHFFFAOYSA-N O=Cc1c(-c(cc2)ccc2Cl)nccc1 Chemical compound O=Cc1c(-c(cc2)ccc2Cl)nccc1 PJNJVFWVQRIGKX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR16/70004 | 2016-01-14 | ||
| FR1670004A FR3046793B1 (fr) | 2016-01-14 | 2016-01-14 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2017/050075 WO2017121969A1 (fr) | 2016-01-14 | 2017-01-13 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108495857A true CN108495857A (zh) | 2018-09-04 |
Family
ID=55752640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780008078.XA Pending CN108495857A (zh) | 2016-01-14 | 2017-01-13 | 新的磷杂环己烷类化合物和氮杂磷杂环己烷类化合物，它们的制备方法和包含它们的药用组合物 |
Country Status (47)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050234021A1 (en) * | 2003-09-10 | 2005-10-20 | Petasis Nicos A | Amino phosphonate and amino bis-phosphonate derivatives |
| CN1738806A (zh) * | 2002-03-08 | 2006-02-22 | 沃纳-兰伯特公司 | 氧代－氮杂双环化合物 |
| CN101386594A (zh) * | 2007-09-11 | 2009-03-18 | 瑟维尔实验室 | 1,2,4,5-四氢-3h-苯并氮杂䓬化合物、其制备方法与包含它们的药物组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2334101T3 (es) * | 2000-08-17 | 2010-03-05 | Pfizer Limited | Imidazoles sustituidos como inhibidores de tafia. |
| SE0103272D0 (sv) * | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| WO2005058330A1 (en) * | 2003-12-17 | 2005-06-30 | Quatrx Pharmaceuticals Co. | Phosphorus containing compounds useful for the regulation of ldl and lp(a) levels |
| CA2604912A1 (en) * | 2005-04-18 | 2006-10-26 | Bayer Schering Pharma Aktiengesellschaft | Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci |
| AU2008266883B2 (en) * | 2007-06-20 | 2014-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| FR2947266B1 (fr) * | 2009-06-26 | 2011-06-17 | Servier Lab | Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR20120081123A (ko) * | 2009-09-09 | 2012-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리대 바이러스의 억제제 |
| US9434695B2 (en) * | 2012-07-18 | 2016-09-06 | Sunshine Lake Pharma Co., Ltd | Nitrogenous heterocyclic derivatives and their application in drugs |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2016
- 2016-01-14 FR FR1670004A patent/FR3046793B1/fr not_active Expired - Fee Related
- 2016-12-27 JO JOP/2016/0275A patent/JO3660B1/ar active
-
2017
- 2017-01-11 UY UY0001037072A patent/UY37072A/es unknown
- 2017-01-12 TW TW106100930A patent/TWI625334B/zh not_active IP Right Cessation
- 2017-01-12 AR ARP170100074A patent/AR107433A1/es unknown
- 2017-01-13 PT PT17706525T patent/PT3271368T/pt unknown
- 2017-01-13 HK HK18103808.6A patent/HK1244283B/zh not_active IP Right Cessation
- 2017-01-13 CN CN201780008078.XA patent/CN108495857A/zh active Pending
- 2017-01-13 MX MX2018008639A patent/MX367319B/es active IP Right Grant
- 2017-01-13 CU CUP2018000072A patent/CU20180072A7/es unknown
- 2017-01-13 SG SG11201805757WA patent/SG11201805757WA/en unknown
- 2017-01-13 WO PCT/FR2017/050075 patent/WO2017121969A1/fr not_active Ceased
- 2017-01-13 RS RS20190105A patent/RS58338B1/sr unknown
- 2017-01-13 MD MDE20180097T patent/MD3271368T2/ro not_active IP Right Cessation
- 2017-01-13 US US15/548,533 patent/US10138260B2/en not_active Expired - Fee Related
- 2017-01-13 ME MEP-2019-23A patent/ME03305B/me unknown
- 2017-01-13 SI SI201730013T patent/SI3271368T1/sl unknown
- 2017-01-13 HR HRP20190193TT patent/HRP20190193T1/hr unknown
- 2017-01-13 EA EA201891599A patent/EA035072B1/ru not_active IP Right Cessation
- 2017-01-13 BR BR112018014020-1A patent/BR112018014020A2/pt not_active IP Right Cessation
- 2017-01-13 GE GEAP201714853A patent/GEP20207092B/en unknown
- 2017-01-13 HU HUE17706525A patent/HUE042924T2/hu unknown
- 2017-01-13 ES ES17706525T patent/ES2709376T3/es active Active
- 2017-01-13 RU RU2018129027A patent/RU2729641C2/ru not_active IP Right Cessation
- 2017-01-13 EP EP17706525.7A patent/EP3271368B1/fr active Active
- 2017-01-13 TR TR2018/20430T patent/TR201820430T4/tr unknown
- 2017-01-13 AU AU2017207003A patent/AU2017207003B2/en not_active Expired - Fee Related
- 2017-01-13 KR KR1020187023228A patent/KR20180101522A/ko not_active Abandoned
- 2017-01-13 CA CA3011184A patent/CA3011184C/fr not_active Expired - Fee Related
- 2017-01-13 UA UAA201808634A patent/UA121275C2/uk unknown
- 2017-01-13 PE PE2018001210A patent/PE20181503A1/es unknown
- 2017-01-13 JP JP2018536455A patent/JP2019504070A/ja active Pending
- 2017-01-13 MA MA41798A patent/MA41798B1/fr unknown
- 2017-01-13 TN TNP/2018/000226A patent/TN2018000226A1/fr unknown
- 2017-01-13 LT LTEP17706525.7T patent/LT3271368T/lt unknown
- 2017-01-13 PL PL17706525T patent/PL3271368T3/pl unknown
- 2017-01-13 DK DK17706525.7T patent/DK3271368T3/da active
-
2018
- 2018-06-26 PH PH12018501373A patent/PH12018501373A1/en unknown
- 2018-06-29 ZA ZA2018/04391A patent/ZA201804391B/en unknown
- 2018-07-04 IL IL260425A patent/IL260425B/en active IP Right Grant
- 2018-07-05 SV SV2018005721A patent/SV2018005721A/es unknown
- 2018-07-06 NI NI201800073A patent/NI201800073A/es unknown
- 2018-07-09 DO DO2018000165A patent/DOP2018000165A/es unknown
- 2018-07-09 CL CL2018001862A patent/CL2018001862A1/es unknown
- 2018-07-11 EC ECSENADI201851972A patent/ECSP18051972A/es unknown
- 2018-07-12 CO CONC2018/0007271A patent/CO2018007271A2/es unknown
- 2018-10-04 US US16/151,597 patent/US10654878B2/en not_active Expired - Fee Related
- 2018-12-10 CY CY20181101320T patent/CY1121154T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1738806A (zh) * | 2002-03-08 | 2006-02-22 | 沃纳-兰伯特公司 | 氧代－氮杂双环化合物 |
| US20050234021A1 (en) * | 2003-09-10 | 2005-10-20 | Petasis Nicos A | Amino phosphonate and amino bis-phosphonate derivatives |
| CN101386594A (zh) * | 2007-09-11 | 2009-03-18 | 瑟维尔实验室 | 1,2,4,5-四氢-3h-苯并氮杂䓬化合物、其制备方法与包含它们的药物组合物 |
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