ES2709376T3 - Nuevos derivados de fosfinanos y azafosfinanos, su método de preparación y las composiciones farmacéuticas que los contienen - Google Patents
Nuevos derivados de fosfinanos y azafosfinanos, su método de preparación y las composiciones farmacéuticas que los contienen Download PDFInfo
- Publication number
- ES2709376T3 ES2709376T3 ES17706525T ES17706525T ES2709376T3 ES 2709376 T3 ES2709376 T3 ES 2709376T3 ES 17706525 T ES17706525 T ES 17706525T ES 17706525 T ES17706525 T ES 17706525T ES 2709376 T3 ES2709376 T3 ES 2709376T3
- Authority
- ES
- Spain
- Prior art keywords
- mhz
- nmr
- ppm
- oxo
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **C(C(*)*C(C1(S)I=*)I)(C(*)=O)P1(*)=O Chemical compound **C(C(*)*C(C1(S)I=*)I)(C(*)=O)P1(*)=O 0.000 description 1
- OQZQDJAAGLEOMY-UHFFFAOYSA-O CCO[PH+]1CCN(Cc2ccccc2)CC1 Chemical compound CCO[PH+]1CCN(Cc2ccccc2)CC1 OQZQDJAAGLEOMY-UHFFFAOYSA-O 0.000 description 1
- JTFDZVOYSBRRBM-UHFFFAOYSA-N CCO[PH2](CCCN(Cc1ccccc1)C(OC(C)(C)C)=O)O Chemical compound CCO[PH2](CCCN(Cc1ccccc1)C(OC(C)(C)C)=O)O JTFDZVOYSBRRBM-UHFFFAOYSA-N 0.000 description 1
- WKRLPBYZGQPRIL-UHFFFAOYSA-N COc(ccc(-c1c(C=O)ccc(F)c1)c1)c1OC Chemical compound COc(ccc(-c1c(C=O)ccc(F)c1)c1)c1OC WKRLPBYZGQPRIL-UHFFFAOYSA-N 0.000 description 1
- FPVIHSALQGOUHB-UHFFFAOYSA-N COc(ccc(-c1cc(O)ccc1C=O)c1)c1OC Chemical compound COc(ccc(-c1cc(O)ccc1C=O)c1)c1OC FPVIHSALQGOUHB-UHFFFAOYSA-N 0.000 description 1
- AYOGWGPBQPKNAZ-UHFFFAOYSA-N COc1cc(-c2c(C=O)ccc(F)c2)ccn1 Chemical compound COc1cc(-c2c(C=O)ccc(F)c2)ccn1 AYOGWGPBQPKNAZ-UHFFFAOYSA-N 0.000 description 1
- BUHSFOAXGMMUSC-UHFFFAOYSA-N O=Cc([s]cc1)c1-c1ccccc1 Chemical compound O=Cc([s]cc1)c1-c1ccccc1 BUHSFOAXGMMUSC-UHFFFAOYSA-N 0.000 description 1
- DYNKRYSPMBVMPZ-UHFFFAOYSA-N O=Cc(c(-c1cc2ccccc2cc1)c1)ccc1F Chemical compound O=Cc(c(-c1cc2ccccc2cc1)c1)ccc1F DYNKRYSPMBVMPZ-UHFFFAOYSA-N 0.000 description 1
- HPIMKRCDFOQWLK-UHFFFAOYSA-N O=Cc(c(-c1ccccc1)c1)ccc1F Chemical compound O=Cc(c(-c1ccccc1)c1)ccc1F HPIMKRCDFOQWLK-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1670004A FR3046793B1 (fr) | 2016-01-14 | 2016-01-14 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2017/050075 WO2017121969A1 (fr) | 2016-01-14 | 2017-01-13 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2709376T3 true ES2709376T3 (es) | 2019-04-16 |
Family
ID=55752640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17706525T Active ES2709376T3 (es) | 2016-01-14 | 2017-01-13 | Nuevos derivados de fosfinanos y azafosfinanos, su método de preparación y las composiciones farmacéuticas que los contienen |
Country Status (47)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03001425A (es) * | 2000-08-17 | 2003-06-06 | Pfizer | Compuestos farmaceuticos. |
| SE0103272D0 (sv) * | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| AU2002249275A1 (en) * | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| US7420000B2 (en) * | 2003-09-10 | 2008-09-02 | University Of Southern California | Amino phosphonate and amino bis-phosphonate derivatives |
| US20050143349A1 (en) * | 2003-12-17 | 2005-06-30 | Quatrx Pharmaceuticals Co. | Phosphorus containing compounds useful for the regulation of LDL and Lp(a) levels |
| EP1874322A1 (en) * | 2005-04-18 | 2008-01-09 | Bayer Schering Pharma Aktiengesellschaft | Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci |
| US8367706B2 (en) * | 2007-06-20 | 2013-02-05 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2947266B1 (fr) * | 2009-06-26 | 2011-06-17 | Servier Lab | Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| BR112012005438A2 (pt) * | 2009-09-09 | 2018-03-20 | Gilead Sciences Inc | inibidores de vírus flaviviridae |
| MX2015000830A (es) * | 2012-07-18 | 2015-10-26 | Sunshine Lake Pharma Co Ltd | Derivados heterociclicos nitrogenosos y su aplicacion en farmacos. |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2016
- 2016-01-14 FR FR1670004A patent/FR3046793B1/fr not_active Expired - Fee Related
- 2016-12-27 JO JOP/2016/0275A patent/JO3660B1/ar active
-
2017
- 2017-01-11 UY UY0001037072A patent/UY37072A/es unknown
- 2017-01-12 TW TW106100930A patent/TWI625334B/zh not_active IP Right Cessation
- 2017-01-12 AR ARP170100074A patent/AR107433A1/es unknown
- 2017-01-13 PT PT17706525T patent/PT3271368T/pt unknown
- 2017-01-13 UA UAA201808634A patent/UA121275C2/uk unknown
- 2017-01-13 JP JP2018536455A patent/JP2019504070A/ja active Pending
- 2017-01-13 MD MDE20180097T patent/MD3271368T2/ro not_active IP Right Cessation
- 2017-01-13 CU CUP2018000072A patent/CU20180072A7/es unknown
- 2017-01-13 EA EA201891599A patent/EA035072B1/ru not_active IP Right Cessation
- 2017-01-13 RU RU2018129027A patent/RU2729641C2/ru not_active IP Right Cessation
- 2017-01-13 MX MX2018008639A patent/MX367319B/es active IP Right Grant
- 2017-01-13 GE GEAP201714853A patent/GEP20207092B/en unknown
- 2017-01-13 CN CN201780008078.XA patent/CN108495857A/zh active Pending
- 2017-01-13 CA CA3011184A patent/CA3011184C/fr not_active Expired - Fee Related
- 2017-01-13 HK HK18103808.6A patent/HK1244283B/zh not_active IP Right Cessation
- 2017-01-13 PL PL17706525T patent/PL3271368T3/pl unknown
- 2017-01-13 ME MEP-2019-23A patent/ME03305B/me unknown
- 2017-01-13 HR HRP20190193TT patent/HRP20190193T1/hr unknown
- 2017-01-13 DK DK17706525.7T patent/DK3271368T3/da active
- 2017-01-13 BR BR112018014020-1A patent/BR112018014020A2/pt not_active IP Right Cessation
- 2017-01-13 SG SG11201805757WA patent/SG11201805757WA/en unknown
- 2017-01-13 HU HUE17706525A patent/HUE042924T2/hu unknown
- 2017-01-13 US US15/548,533 patent/US10138260B2/en not_active Expired - Fee Related
- 2017-01-13 SI SI201730013T patent/SI3271368T1/sl unknown
- 2017-01-13 TR TR2018/20430T patent/TR201820430T4/tr unknown
- 2017-01-13 WO PCT/FR2017/050075 patent/WO2017121969A1/fr not_active Ceased
- 2017-01-13 EP EP17706525.7A patent/EP3271368B1/fr active Active
- 2017-01-13 LT LTEP17706525.7T patent/LT3271368T/lt unknown
- 2017-01-13 KR KR1020187023228A patent/KR20180101522A/ko not_active Abandoned
- 2017-01-13 AU AU2017207003A patent/AU2017207003B2/en not_active Expired - Fee Related
- 2017-01-13 RS RS20190105A patent/RS58338B1/sr unknown
- 2017-01-13 MA MA41798A patent/MA41798B1/fr unknown
- 2017-01-13 PE PE2018001210A patent/PE20181503A1/es unknown
- 2017-01-13 ES ES17706525T patent/ES2709376T3/es active Active
- 2017-01-13 TN TNP/2018/000226A patent/TN2018000226A1/fr unknown
-
2018
- 2018-06-26 PH PH12018501373A patent/PH12018501373A1/en unknown
- 2018-06-29 ZA ZA2018/04391A patent/ZA201804391B/en unknown
- 2018-07-04 IL IL260425A patent/IL260425B/en active IP Right Grant
- 2018-07-05 SV SV2018005721A patent/SV2018005721A/es unknown
- 2018-07-06 NI NI201800073A patent/NI201800073A/es unknown
- 2018-07-09 DO DO2018000165A patent/DOP2018000165A/es unknown
- 2018-07-09 CL CL2018001862A patent/CL2018001862A1/es unknown
- 2018-07-11 EC ECSENADI201851972A patent/ECSP18051972A/es unknown
- 2018-07-12 CO CONC2018/0007271A patent/CO2018007271A2/es unknown
- 2018-10-04 US US16/151,597 patent/US10654878B2/en not_active Expired - Fee Related
- 2018-12-10 CY CY20181101320T patent/CY1121154T1/el unknown
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