ME03305B - Novi derivati fosfanina i azafosfanina, postupak njihove priprave te farmaceutski pripravci koji ih sadrže - Google Patents

Novi derivati fosfanina i azafosfanina, postupak njihove priprave te farmaceutski pripravci koji ih sadrže

Info

Publication number
ME03305B
ME03305B MEP-2019-23A MEP201923A ME03305B ME 03305 B ME03305 B ME 03305B ME P201923 A MEP201923 A ME P201923A ME 03305 B ME03305 B ME 03305B
Authority
ME
Montenegro
Prior art keywords
same
azaphosphinane
phosphinane
derivatives
novel
Prior art date
Application number
MEP-2019-23A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Philippe Gloanec
Arnaud-Pierre Schaffner
Patricia Sansilvestri-Morel
Alain Rupin
Philippe Mennecier
Marie-Odile Vallez
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55752640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME03305(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of ME03305B publication Critical patent/ME03305B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6568Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
MEP-2019-23A 2016-01-14 2017-01-13 Novi derivati fosfanina i azafosfanina, postupak njihove priprave te farmaceutski pripravci koji ih sadrže ME03305B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1670004A FR3046793B1 (fr) 2016-01-14 2016-01-14 Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP17706525.7A EP3271368B1 (fr) 2016-01-14 2017-01-13 Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2017/050075 WO2017121969A1 (fr) 2016-01-14 2017-01-13 Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ME03305B true ME03305B (me) 2019-10-20

Family

ID=55752640

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-23A ME03305B (me) 2016-01-14 2017-01-13 Novi derivati fosfanina i azafosfanina, postupak njihove priprave te farmaceutski pripravci koji ih sadrže

Country Status (47)

Country Link
US (2) US10138260B2 (enExample)
EP (1) EP3271368B1 (enExample)
JP (1) JP2019504070A (enExample)
KR (1) KR20180101522A (enExample)
CN (1) CN108495857A (enExample)
AR (1) AR107433A1 (enExample)
AU (1) AU2017207003B2 (enExample)
BR (1) BR112018014020A2 (enExample)
CA (1) CA3011184C (enExample)
CL (1) CL2018001862A1 (enExample)
CO (1) CO2018007271A2 (enExample)
CU (1) CU20180072A7 (enExample)
CY (1) CY1121154T1 (enExample)
DK (1) DK3271368T3 (enExample)
DO (1) DOP2018000165A (enExample)
EA (1) EA035072B1 (enExample)
EC (1) ECSP18051972A (enExample)
ES (1) ES2709376T3 (enExample)
FR (1) FR3046793B1 (enExample)
GE (1) GEP20207092B (enExample)
HK (1) HK1244283B (enExample)
HR (1) HRP20190193T1 (enExample)
HU (1) HUE042924T2 (enExample)
IL (1) IL260425B (enExample)
JO (1) JO3660B1 (enExample)
LT (1) LT3271368T (enExample)
MA (1) MA41798B1 (enExample)
MD (1) MD3271368T2 (enExample)
ME (1) ME03305B (enExample)
MX (1) MX367319B (enExample)
NI (1) NI201800073A (enExample)
PE (1) PE20181503A1 (enExample)
PH (1) PH12018501373A1 (enExample)
PL (1) PL3271368T3 (enExample)
PT (1) PT3271368T (enExample)
RS (1) RS58338B1 (enExample)
RU (1) RU2729641C2 (enExample)
SG (1) SG11201805757WA (enExample)
SI (1) SI3271368T1 (enExample)
SV (1) SV2018005721A (enExample)
TN (1) TN2018000226A1 (enExample)
TR (1) TR201820430T4 (enExample)
TW (1) TWI625334B (enExample)
UA (1) UA121275C2 (enExample)
UY (1) UY37072A (enExample)
WO (1) WO2017121969A1 (enExample)
ZA (1) ZA201804391B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046793B1 (fr) * 2016-01-14 2018-01-05 Les Laboratoires Servier Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03001425A (es) * 2000-08-17 2003-06-06 Pfizer Compuestos farmaceuticos.
SE0103272D0 (sv) * 2001-09-28 2001-09-28 Astrazeneca Ab Chemical compounds
AU2002249275A1 (en) * 2002-03-08 2003-09-22 Warner-Lambert Company Llc Oxo azabicyclic compounds
US7420000B2 (en) * 2003-09-10 2008-09-02 University Of Southern California Amino phosphonate and amino bis-phosphonate derivatives
US20050143349A1 (en) * 2003-12-17 2005-06-30 Quatrx Pharmaceuticals Co. Phosphorus containing compounds useful for the regulation of LDL and Lp(a) levels
EP1874322A1 (en) * 2005-04-18 2008-01-09 Bayer Schering Pharma Aktiengesellschaft Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci
US8367706B2 (en) * 2007-06-20 2013-02-05 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2947266B1 (fr) * 2009-06-26 2011-06-17 Servier Lab Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR112012005438A2 (pt) * 2009-09-09 2018-03-20 Gilead Sciences Inc inibidores de vírus flaviviridae
MX2015000830A (es) * 2012-07-18 2015-10-26 Sunshine Lake Pharma Co Ltd Derivados heterociclicos nitrogenosos y su aplicacion en farmacos.
FR3046793B1 (fr) * 2016-01-14 2018-01-05 Les Laboratoires Servier Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
SV2018005721A (es) 2018-09-06
EA201891599A1 (ru) 2019-01-31
TN2018000226A1 (fr) 2019-10-04
JO3660B1 (ar) 2020-08-27
CO2018007271A2 (es) 2018-07-19
ES2709376T3 (es) 2019-04-16
US10138260B2 (en) 2018-11-27
FR3046793B1 (fr) 2018-01-05
WO2017121969A1 (fr) 2017-07-20
CA3011184A1 (fr) 2017-07-20
CL2018001862A1 (es) 2018-10-05
US10654878B2 (en) 2020-05-19
DOP2018000165A (es) 2018-09-15
FR3046793A1 (fr) 2017-07-21
CN108495857A (zh) 2018-09-04
MX2018008639A (es) 2018-11-19
AU2017207003B2 (en) 2020-10-08
PE20181503A1 (es) 2018-09-18
SG11201805757WA (en) 2018-08-30
PL3271368T3 (pl) 2019-04-30
AU2017207003A1 (en) 2018-07-26
ECSP18051972A (es) 2018-07-31
RU2729641C2 (ru) 2020-08-11
UA121275C2 (uk) 2020-04-27
UY37072A (es) 2017-07-31
MA41798B1 (fr) 2018-11-30
RU2018129027A (ru) 2020-02-14
TW201726697A (zh) 2017-08-01
RS58338B1 (sr) 2019-03-29
HK1244283B (zh) 2019-11-22
KR20180101522A (ko) 2018-09-12
AR107433A1 (es) 2018-05-02
PH12018501373B1 (en) 2019-02-27
EP3271368A1 (fr) 2018-01-24
US20180016288A1 (en) 2018-01-18
RU2018129027A3 (enExample) 2020-03-19
BR112018014020A2 (pt) 2018-12-11
PH12018501373A1 (en) 2019-02-27
MX367319B (es) 2019-08-15
MA41798A (fr) 2018-01-24
LT3271368T (lt) 2018-12-10
AU2017207003A2 (en) 2018-10-04
GEP20207092B (en) 2020-04-10
US20190031693A1 (en) 2019-01-31
IL260425B (en) 2020-05-31
HRP20190193T1 (hr) 2019-04-05
SI3271368T1 (sl) 2019-02-28
DK3271368T3 (da) 2019-02-25
NI201800073A (es) 2018-09-06
TWI625334B (zh) 2018-06-01
CA3011184C (fr) 2020-09-29
HUE042924T2 (hu) 2019-07-29
MD3271368T2 (ro) 2019-03-31
TR201820430T4 (tr) 2019-01-21
EP3271368B1 (fr) 2018-10-31
ZA201804391B (en) 2020-01-29
JP2019504070A (ja) 2019-02-14
EA035072B1 (ru) 2020-04-23
CY1121154T1 (el) 2020-05-29
CU20180072A7 (es) 2018-10-04
PT3271368T (pt) 2018-12-04

Similar Documents

Publication Publication Date Title
IL256375B (en) History of new cyclics, process for their preparation and pharmaceutical preparations containing them
ZA201708663B (en) Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same
ZA201808286B (en) New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
IL254124A0 (en) New 3-indole-transformed histories, medicinal preparations and methods of use
IL256191B (en) New amino acid compounds, a process for their preparation and pharmaceutical preparations containing them
IL256320A (en) History of new hydroxyacids, a process for their preparation and pharmaceutical preparations containing them
IL247239A0 (en) Complexes of sirolimus and its derivatives, a process for their preparation and pharmaceutical preparations containing them
IL274141A (en) New macrocyclic compounds, a process for their preparation and pharmaceutical preparations containing them
EP3284743A4 (en) Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof
IL258977B (en) Pyperidyl derivatives, their preparation and pharmaceutical compositions containing them
PL3303320T3 (pl) Nowy związek heterocykliczny, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna
ZA201804391B (en) Novel phosphinane and azaphosphinane derivatives, method for preparing same and pharmaceutical compositions containing same
HK1244283A1 (en) Novel phosphinane and azaphosphinane derivatives, method for preparing same and pharmaceutical compositions containing same
HUP1400084A2 (hu) Dabigatran és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
TH1401007659A (th) อนุพันธ์ไธอีโนไพริมิดีนแบบใหม่กระบวนการในการเตรียมอนุพันธ์ดังกล่าวและองค์ประกอบทางเภสัชกรรมที่ประกอบด้วยอนุพันธ์ดังกล่าว