JO3660B1 - مشتقات فوسفينان وآز افوسفينان جديدة، وطريقة لتحضيرها وتركيبات صيدلانية تحتوي عليها - Google Patents
مشتقات فوسفينان وآز افوسفينان جديدة، وطريقة لتحضيرها وتركيبات صيدلانية تحتوي عليهاInfo
- Publication number
- JO3660B1 JO3660B1 JOP/2016/0275A JOP20160275A JO3660B1 JO 3660 B1 JO3660 B1 JO 3660B1 JO P20160275 A JOP20160275 A JO P20160275A JO 3660 B1 JO3660 B1 JO 3660B1
- Authority
- JO
- Jordan
- Prior art keywords
- same
- azaphosphinane
- phosphinane
- derivatives
- novel
- Prior art date
Links
- 150000008285 azaphosphinanes Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VXTFGYMINLXJPW-UHFFFAOYSA-N phosphinane Chemical compound C1CCPCC1 VXTFGYMINLXJPW-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
مركبات الصيغة (I) : و فيه : Ak1 هو سلسلة الكيل ، X تمثل - (CH2) m- ، -CH (R) - ، -N (R) - ، -CH2-N (R) - ، -N (R) -CH2- أو -CH2-N (R) -CH2 - ، m و R كما هى معرفة فى الوصف ، R1 و R2 كل منها يمثل ذرة هيدروجين عندما X تمثل - (CH2) m- ، -CH (R) - ، -N (R) - ، -CH2-N (R) - أو -N (R) -CH2- ، أو تكون مع بعضها رابطة عندما X تكون -CH2-N (R) -CH2- ، R3 تمثل NH2 ، NH2-Cy ، Cy-AK3-NH2 أو بيبريدين ـــ 4 ـــ يل ، Cy و AK3تكون كما هى معرفة فى الوصف ، ، R4و R5 تكون متطابقة أو مختلفة ، كل منها يمثل H أو F ، ايزومراته البصرية و أملاحه الاضافية مع حمض مقبول صيدليا . دواء .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1670004A FR3046793B1 (fr) | 2016-01-14 | 2016-01-14 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3660B1 true JO3660B1 (ar) | 2020-08-27 |
Family
ID=55752640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2016/0275A JO3660B1 (ar) | 2016-01-14 | 2016-12-27 | مشتقات فوسفينان وآز افوسفينان جديدة، وطريقة لتحضيرها وتركيبات صيدلانية تحتوي عليها |
Country Status (47)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1311488E (pt) * | 2000-08-17 | 2009-12-30 | Pfizer Ltd | Imidazóis substituídos utilizados como inibidores de tafia |
| SE0103272D0 (sv) * | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| AU2002249275A1 (en) * | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| US7420000B2 (en) * | 2003-09-10 | 2008-09-02 | University Of Southern California | Amino phosphonate and amino bis-phosphonate derivatives |
| US20050143349A1 (en) * | 2003-12-17 | 2005-06-30 | Quatrx Pharmaceuticals Co. | Phosphorus containing compounds useful for the regulation of LDL and Lp(a) levels |
| US20060234986A1 (en) * | 2005-04-18 | 2006-10-19 | Schering Aktiengesellschaft | Use of TAFI inhibitors for enhanced myocardial reperfusion and facilitated PCI |
| CA2690141A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2947266B1 (fr) * | 2009-06-26 | 2011-06-17 | Servier Lab | Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2010292411B2 (en) * | 2009-09-09 | 2015-04-09 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| EP2875001B1 (en) * | 2012-07-18 | 2019-01-09 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2016
- 2016-01-14 FR FR1670004A patent/FR3046793B1/fr not_active Expired - Fee Related
- 2016-12-27 JO JOP/2016/0275A patent/JO3660B1/ar active
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2017
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- 2017-01-12 TW TW106100930A patent/TWI625334B/zh not_active IP Right Cessation
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- 2017-01-13 US US15/548,533 patent/US10138260B2/en not_active Expired - Fee Related
- 2017-01-13 DK DK17706525.7T patent/DK3271368T3/da active
- 2017-01-13 HU HUE17706525A patent/HUE042924T2/hu unknown
- 2017-01-13 KR KR1020187023228A patent/KR20180101522A/ko active IP Right Grant
- 2017-01-13 EP EP17706525.7A patent/EP3271368B1/fr active Active
- 2017-01-13 CU CUP2018000072A patent/CU20180072A7/es unknown
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- 2017-01-13 UA UAA201808634A patent/UA121275C2/uk unknown
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- 2017-01-13 ES ES17706525T patent/ES2709376T3/es active Active
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- 2017-01-13 TN TNP/2018/000226A patent/TN2018000226A1/fr unknown
- 2017-01-13 LT LTEP17706525.7T patent/LT3271368T/lt unknown
- 2017-01-13 SI SI201730013T patent/SI3271368T1/sl unknown
- 2017-01-13 EA EA201891599A patent/EA035072B1/ru not_active IP Right Cessation
- 2017-01-13 JP JP2018536455A patent/JP2019504070A/ja active Pending
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- 2017-01-13 CN CN201780008078.XA patent/CN108495857A/zh active Pending
- 2017-01-13 BR BR112018014020-1A patent/BR112018014020A2/pt not_active IP Right Cessation
- 2017-01-13 MA MA41798A patent/MA41798B1/fr unknown
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- 2017-01-13 RS RS20190105A patent/RS58338B1/sr unknown
- 2017-01-13 WO PCT/FR2017/050075 patent/WO2017121969A1/fr active Application Filing
- 2017-01-13 PE PE2018001210A patent/PE20181503A1/es unknown
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2018
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- 2018-06-26 PH PH12018501373A patent/PH12018501373A1/en unknown
- 2018-06-29 ZA ZA2018/04391A patent/ZA201804391B/en unknown
- 2018-07-04 IL IL260425A patent/IL260425B/en active IP Right Grant
- 2018-07-05 SV SV2018005721A patent/SV2018005721A/es unknown
- 2018-07-06 NI NI201800073A patent/NI201800073A/es unknown
- 2018-07-09 CL CL2018001862A patent/CL2018001862A1/es unknown
- 2018-07-09 DO DO2018000165A patent/DOP2018000165A/es unknown
- 2018-07-11 EC ECSENADI201851972A patent/ECSP18051972A/es unknown
- 2018-07-12 CO CONC2018/0007271A patent/CO2018007271A2/es unknown
- 2018-10-04 US US16/151,597 patent/US10654878B2/en not_active Expired - Fee Related
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2019
- 2019-01-30 HR HRP20190193TT patent/HRP20190193T1/hr unknown
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