CN108478700A - 一种提高亚健康人群免疫力的组合物及其制备方法与应用 - Google Patents
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Abstract
本发明公开了一种提高亚健康人群免疫力的组合物,该组合物是由以下重量份的原料制备而成:β‑酵母葡聚糖5~25份、白术5~15份、党参5~20份、茯苓5~20份、红藤5~15份、芡实5~20份、黄芩5~15份、石菖蒲5~15份、麦冬5~20份、野刺梨2~10份、松果菊1~8份、枸杞5~15份、山药5~10份,红枣1~5份。本发明还公开了该组合物在制备用于调理亚健康人群的口服药物制剂或保健食品中的应用。本发明还公开了该组合物的制备方法。本发明组合物配方合理,各组分缺一不可,产生了协同增效,具有增强免疫力和记忆力,缓解体力疲劳、解决失眠、改善便秘和减肥瘦身的功效,该组合物市场需要大、便于市场推广。
Description
技术领域
本申请属于组合物技术领域,具体地说,涉及一种提高亚健康人群免疫力的组合物及其制备方法与应用。
背景技术
随着社会的迅速发展,人们生活节奏的不断加快、生活工作压力不断加大,热天享受空调无节制,冷天饮冷食凉无早晚,故在不自觉的情况下,脾肾功能受损,人的身体抵抗力下降,亚健康问题日益突出,亚健康被视为人体除健康和疾病之外的第三状态,据估计,目前我国符合世界卫生组织健康定义的人群只占人口总数的15%,另有15%的人处于疾病状态,而70%的人属于亚健康状态。亚健康人群会出现四肢乏力无精神、易感冒、口腔溃疡、长痘痘、长斑点、黑眼圈、体重过重、便秘、失眠、记忆力下降等现象,严重影响现代人的生活质量。
市场上保健品种类繁多,营养保健功能参差不齐。开发出一种可以提高免疫力、增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身的组合物对亚健康的消费者带来切实的功效和福音,将成为解决亚健康问题的一种有效方法。针对上述问题,开发一种提高亚健康人群免疫力的组合物是业界值得研究的问题。
发明内容
有鉴于此,本申请所要解决的问题是提供一种提高亚健康人群免疫力的组合物,该组合物能提高免疫力、增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身。
为了解决上述技术问题,本发明通过以下技术方案得以实现:
本发明一方面提供了一种提高亚健康人群免疫力的组合物,该组合物是由以下重量份的原料制备而成:β-酵母葡聚糖5~25份、白术5~15份、党参5~20份、茯苓5~20份、红藤5~15份、芡实5~20份、黄芩5~15份、石菖蒲5~15份、麦冬5~20份、野刺梨2~10份、松果菊1~8份、枸杞5~15份、山药5~10份,红枣1~5份。
结合第一方面,在一种可能的实施例中,所述β-酵母葡聚糖5~20份、白术8~12份、党参10~15份、茯苓10~15份、红藤10~15份、芡实5~15份、黄芩5~10份、石菖蒲8~10份、麦冬5~15份、野刺梨5~10份、松果菊3~5份、枸杞5~10份、山药5~7份,红枣3~5份。
结合第一方面,在一种可能的实施例中,所述β-酵母葡聚糖15份、白术10份、党参12份、茯苓13份、红藤10份、芡实10份、黄芩10份、石菖蒲9份、麦冬13份、野刺梨8份、松果菊4份、枸杞10份、山药6份,红枣3份。
本发明第二方面提供了一种提高亚健康人群免疫力的组合物的制备方法,包括以下步骤:
分别称取重量份的白术、党参、茯苓、红藤、芡实、黄芩、石菖蒲、麦冬、野刺梨、松果菊、枸杞、山药,红枣,加入药材总重量10~20倍的纯化水,加热回流提取2~3次,每次提取1~3.0h,过滤,合并提取液,减压浓缩药液,经离心喷雾干燥机离心,形成干粉后加入重量份的β-酵母葡聚糖,混合均匀后制成口服药物制剂。
本发明第三方面提供了一种提高亚健康人群免疫力的组合物在制备用于调理亚健康人群的口服药物制剂或保健食品中的应用。
结合第三方面,在一种可能的实施例中,所述口服制剂为冲剂或颗粒剂。
组合物原料配方中,β-酵母葡聚糖是存在于酵母细胞壁中的一种具有增强免疫力活性的多糖。具有改善血脂、抗辐射、改善肠道功能的作用。白术为菊科多年生草本植物,味苦,甘,性温。归脾、胃经。白术的作用主要有镇静、血管扩张、抗血凝、抗胃溃疡、保肝利胆、利尿、强壮、提高免疫、抗氧化、抗菌等。党参性平,味甘,具有补中益气、健脾益肺、抗癌、降压、抗缺氧、抗衰老之功效,还可以增强人体免疫力,提高超氧化物歧化酶的活性,增强消除自由基的能力,具有调节胃肠运动、抗溃疡、抑制胃酸分泌、降低胃蛋白酶活性的作用。茯苓甘淡,平。入心、脾、肺经。含有三萜类、多聚糖类及胆碱、脂肪、卵磷脂、钾、镁等多种元素。具有利水渗湿、健脾宁心的功效。茯苓不仅可显著提高机体免疫能力,而且可使血液中氧合血红蛋白释放更多的氧,以供给组织细胞。同时,还可使细胞组织(包括皮肤、黏膜、毛发等)活性增强,活力增大,处于健康状态,从而使我们的皮肤、毛发显得更加滋润,达到美容的效果。红藤为木通科植物大血藤的藤茎。味苦,性平。归大肠、肝经。具解毒消痈,活血止痛,祛风除湿,杀虫功效。主治肠痈,痢疾,乳痛,痛经,经闭,跌打损伤,风湿痹痛,虫积腹痛。芡实味甘、涩,性平。归脾、肾经。用于遗精滑精,遗尿尿频,脾虚久泻,白浊,带下。黄芩是唇形科黄芩属多年生草本植物,性味:苦,寒。归经:入心、肺、胆、大肠经。黄芪含皂甙、蔗糖、多糖、多种氨基酸、叶酸及硒、锌、铜等多种微量元素。黄芪用于提高肺与呼吸系统免疫能力的药材。可以用于因免疫力低下导致的虚汗病症。也可用于补气和增进脾脏功能和代谢能力低下。石菖蒲能化湿开胃,开窍豁痰,醒神益智。理气,活血,散风,去湿。治癫痫,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。石菖蒲具有调节中枢神经系统、内分泌系统、心血管系统和消化系统的作用。麦冬能养阴生津,润肺清心。用于肺燥干咳,虚痨咳嗽,津伤口渴,心烦失眠,内热消渴,肠燥便秘,咽白喉。野刺梨系蔷薇科落叶灌木植物,刺梨营养价值和药用价值极高,其果肉中维生素C的含量居各类水果之冠,每100克果肉中含维生素C2054-2725毫克,比苹果、梨高500倍,柑橘高100倍,猕猴桃高9倍;维生素P的含量极高,每100克果肉中含维生P5980-12895毫克,比柑橘高120倍,蔬菜类高150倍。堪称水果之王“维C皇”。它还富含维生素B1、B2、E、K1等16种微量元素,其功能比酸枣高46倍,比银杏叶总黄酮含量高2.4倍。刺梨还被誉为“长寿防癌”的绿色珍果,含有抗癌物质及SOD抗衰老物质,同时还具有健脾消食,消食积,饱胀,滋补强肾的作用。具有调节机体免疫功能、延缓衰老、抗动脉粥样硬化和抗肿瘤等功能。松果菊性味:辛,甘,苦;归经:肺、肝经;增强免疫作用,刺激人体内白细胞等免疫细胞活力,提高肌体自身免疫力;松果菊是国际医药学界公认的具有神奇的“骨髓保存”作用的深度免疫植物,是已知药理作用最多、功效最强大的国际规范植物药之一,在欧美被誉为“全康复免疫专家”,也是最具有应用前景的“净血之王”的植物抗生素。枸杞:具有补肾养肝、润肺明目等功效;山药:补脾养胃,生津益肺,补肾涩精。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。红枣能健脾益胃、补气养血、脾胃虚弱,腹泻,倦怠无力的人,与党参,白术共用,能补中益气,健脾胃,达到增加食欲,止泻的功效。本发明提供的组合物具有合理的配方,各组分缺一不可,使本组合物具有显著的提高免疫力、增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身的作用。
与现有技术相比,本申请可以获得包括以下技术效果:
1)本发明提供的一种提高亚健康人群免疫力的组合物中的β-酵母葡聚糖是一种具有增强免疫力活性的多糖,并具有改善血脂、抗辐射、改善肠道功能的作用。
2)本发明提供的一种提高亚健康人群免疫力的组合物能提高亚健康人群的免疫力、具有增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身的功效。确保消费者拥有健康身体,延年益寿,远离重大疾病,提高生活质量。
3)本发明提供的一种提高亚健康人群免疫力的组合物的制备方法所得的口服药物制剂稳定性好,有利于患者吸收,而且生产周期短,生产过程易于掌控,生产效率高,生产成本低,便于大规模生产。
当然,实施本申请的任一产品必不一定需要同时达到以上所述的所有技术效果。
具体实施方式
以下将通过实施例来详细说明本申请的实施方式,借此对本申请如何应用技术手段来解决技术问题并达成技术功效的实现过程能充分理解并据以实施。
本发明实施例和对比例中所用原料均来自市售产品。
本发明实施例和对比例中所用离心喷雾干燥机型号为RGSD-30。
实施例1
一种提高亚健康人群免疫力的组合物,该组合物是由以下重量份的原料制备而成:所述β-酵母葡聚糖15份、白术10份、党参12份、茯苓13份、红藤10份、芡实10份、黄芩10份、石菖蒲9份、麦冬13份、野刺梨8份、松果菊4份、枸杞10份、山药6份,红枣3份。
本实施例提供的一种提高亚健康人群免疫力的组合物的制备方法,步骤如下:
分别称取重量份的白术、党参、茯苓、红藤、芡实、黄芩、石菖蒲、麦冬、野刺梨、松果菊、枸杞、山药,红枣,加入药材总重量15倍的纯化水,加热回流提取3次,每次提取2h,过滤,合并提取液,减压浓缩药液,经离心喷雾干燥机离心,形成干粉后加入重量份的β-酵母葡聚糖,混合均匀后制成口服颗粒剂。
实施例2
本实施例的一种提高亚健康人群免疫力的组合物及其制备方法与实施例1相类似,其区别仅在于:
该组合物是由以下重量份的原料制备而成:所述β-酵母葡聚糖5份、白术15份、党参5份、茯苓20份、红藤5份、芡实20份、黄芩5份、石菖蒲15份、麦冬5份、野刺梨10份、松果菊1份、枸杞15份、山药5份,红枣5份。
本实施例提供的一种提高亚健康人群免疫力的组合物的制备方法中,加入药材总重量10倍的纯化水,加热回流提取2次,每次提取1h,混合均匀后制成口服冲剂。
实施例3
本实施例的一种提高亚健康人群免疫力的组合物及其制备方法与实施例1相类似,其区别仅在于:
该组合物是由以下重量份的原料制备而成:所述β-酵母葡聚糖25份、白术5份、党参20份、茯苓5份、红藤15份、芡实5份、黄芩15份、石菖蒲5份、麦冬20份、野刺梨2份、松果菊8份、枸杞5份、山药10份,红枣1份。
本实施例提供的一种提高亚健康人群免疫力的组合物的制备方法中,加入药材总重量20倍的纯化水,加热回流提取2次,每次提取3h,混合均匀后制成口服冲剂。
对比例1
本对比例1的一种提高亚健康人群免疫力的组合物及其制备方法与实施例1相类似,其区别仅在于:将组合物中的β-酵母葡聚糖用灵芝代替。
对比例2
本对比例2的一种提高亚健康人群免疫力的组合物及其制备方法与实施例1相类似,其区别仅在于:组合物中不含有β-酵母葡聚糖。
对比例3
本对比例3的一种提高亚健康人群免疫力的组合物及其制备方法与实施例1相类似,其区别仅在于:该组合物是由以下重量份的原料制备而成:β-酵母葡聚糖3份、白术4份、党参4份、茯苓25份、红藤20份、芡实3份、黄芩20份、石菖蒲5份、麦冬20份、野刺梨1份、松果菊1份、枸杞15份、山药20份,红枣5份。
本发明对改善亚健康人群免疫力的临床疗效
1、患者:240例中老年亚健康人群,随机分为6组,其中男性患者160例,女性患者80例,年龄段30-60岁,平均年龄为38岁,所有患者在性别和年龄组成及病程上均无统计学差异(P﹥0.05)。
2、服药方法及疗程:口服本发明实施例1至3和对比例1至3提供的组合物口服制剂;
成人,每次45g,每日3次,一个月为一个疗程,治疗1个疗程。
3、临床评价项目:进行血、尿、大便常规化验和心、肺、肝、胆、脾、肾功能检查,并观察改善情况:四肢乏力无精神、易感冒、口腔溃疡、长痘痘、长斑点、黑眼圈、体重过重、便秘、失眠、记忆力下降等改善情况,分别进行疗效评价。
4、疗效评定标准:
明显改善:进行血、尿、大便常规化验和心、肺、肝、胆、脾、肾功能检查均正常;所述四肢乏力无精神、易感冒、口腔溃疡、长痘痘、长斑点、黑眼圈、体重过重、便秘、失眠、记忆力下降的项目均改善良好。
改善:进行血、尿、大便常规化验和心、肺、肝、胆、脾、肾功能检查中有1-2项不正常;所述四肢乏力无精神、易感冒、口腔溃疡、长痘痘、长斑点、黑眼圈、体重过重、便秘、失眠、记忆力下降的项目中有1-3项改善不明显,其他项目改善良好。
无效:进行血、尿、大便常规化验和心、肺、肝、胆、脾、肾功能检查,有3项或3项以上不正常;所述四肢乏力无精神、易感冒、口腔溃疡、长痘痘、长斑点、黑眼圈、体重过重、便秘、失眠、记忆力下降的项目中有4项或4项以上改善不明显,其他项目有所改善。
总改善率=(明显改善+改善)/总例数×100%;
表1:本发明实施例1至3、对比例1至3改善人体免疫功能的临床疗效
组合物 | 总例数 | 明显改善 | 改善 | 无效 | 总改善率% |
实施例1 | 40 | 28 | 9 | 3 | 92.5 |
实施例2 | 40 | 23 | 12 | 5 | 87.5 |
实施例3 | 40 | 26 | 10 | 4 | 90.0 |
对比例1 | 40 | 16 | 12 | 12 | 70.0 |
对比例2 | 40 | 10 | 13 | 17 | 57.5 |
对比例3 | 40 | 8 | 17 | 15 | 62.5 |
从上表1知,本发明实施例1至3提供的组合物的总改善率明显高于对比例1至3,因此,本发明实施例1至3提供的一种提高亚健康人群免疫力的组合物能提高亚健康人群的免疫力,具有增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身的功效。
发明人通过对比例1发现,本发明的组合物中β-酵母葡聚糖对提高亚健康人群免疫力的效果优于价格昂贵的灵芝。通过对比例2发现,β-酵母葡聚糖对增强亚健康人群免疫力、改善肠道功能效果良好。通过对比例3发现,本发明的组合物各组份在优选数值范围内能够协同增效,本发明提供的组合物具有合理的配方,且各组分缺一不可,各组份具有协同增效的作用,本发明中的“协同增效”的定义理解为几种药材组合后,其药效相对于单独使用时的提高,药效更为持久,组合物在新的防治或保健领域产生意想不到的效果。
与现有技术相比,本发明实施例可以获得包括以下技术效果:
1)本发明实施例提供的一种提高亚健康人群免疫力的组合物中的β-酵母葡聚糖是一种具有增强免疫力活性的多糖,并具有改善血脂、抗辐射、改善肠道功能的作用。
2)本发明实施例提供的一种提高亚健康人群免疫力的组合物能提高亚健康人群的免疫力、具有增强记忆力、舒缓压力、缓解体力疲劳、祛除色斑、调整情绪、解决失眠、促进消化、改善便秘、减肥瘦身的功效。确保消费者拥有健康身体,延年益寿,远离重大疾病,提高生活质量。
3)本发明实施例提供的一种提高亚健康人群免疫力的组合物的制备方法所得的口服药物制剂稳定性好,有利于患者吸收,而且生产周期短,生产过程易于掌控,生产效率高,生产成本低,便于大规模生产。
本发明说明书中未作详细描述的内容属于本领域技术人员的公知常识。
如在通篇说明书及权利要求当中所提及的“包含”为一开放式用语,故应解释成“包含但不限定于”。“大致”是指在可接收的误差范围内,本领域技术人员能够在一定误差范围内解决所述技术问题,基本达到所述技术效果。
还需要说明的是,术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含,从而使得包括一系列要素的商品或者系统不仅包括那些要素,而且还包括没有明确列出的其他要素,或者是还包括为这种商品或者系统所固有的要素。在没有更多限制的情况下,由语句“包括一个……”限定的要素,并不排除在包括所述要素的商品或者系统中还存在另外的相同要素。
上述说明示出并描述了本发明的若干优选实施例,但如前所述,应当理解本发明并非局限于本文所披露的形式,不应看作是对其他实施例的排除,而可用于各种其他组合、修改和环境,并能够在本文所述发明构想范围内,通过上述教导或相关领域的技术或知识进行改动。而本领域人员所进行的改动和变化不脱离本发明的精神和范围,则都应在本发明所附权利要求的保护范围内。
Claims (6)
1.一种提高亚健康人群免疫力的组合物,其特征在于,该组合物是由以下重量份的原料制备而成:β-酵母葡聚糖5~25份、白术5~15份、党参5~20份、茯苓5~20份、红藤5~15份、芡实5~20份、黄芩5~15份、石菖蒲5~15份、麦冬5~20份、野刺梨2~10份、松果菊1~8份、枸杞5~15份、山药5~10份,红枣1~5份。
2.如权利要求1所述的一种提高亚健康人群免疫力的组合物,其特征在于,所述β-酵母葡聚糖5~20份、白术8~12份、党参10~15份、茯苓10~15份、红藤10~15份、芡实5~15份、黄芩5~10份、石菖蒲8~10份、麦冬5~15份、野刺梨5~10份、松果菊3~5份、枸杞5~10份、山药5~7份,红枣3~5份。
3.如权利要求2所述的一种提高亚健康人群免疫力的组合物,其特征在于,所述β-酵母葡聚糖15份、白术10份、党参12份、茯苓13份、红藤10份、芡实10份、黄芩10份、石菖蒲9份、麦冬13份、野刺梨8份、松果菊4份、枸杞10份、山药6份,红枣3份。
4.如权利要求1至3任一项所述的一种提高亚健康人群免疫力的组合物的制备方法,其特征在于,包括以下步骤:
分别称取重量份的白术、党参、茯苓、红藤、芡实、黄芩、石菖蒲、麦冬、野刺梨、松果菊、枸杞、山药,红枣,加入药材总重量10~20倍的纯化水,加热回流提取2~3次,每次提取1~3.0h,过滤,合并提取液,减压浓缩药液,经离心喷雾干燥机离心,形成干粉后加入重量份的β-酵母葡聚糖,混合均匀后制成口服药物制剂。
5.如权利要求1至3任一项所述的一种提高亚健康人群免疫力的组合物在制备用于调理亚健康人群的口服药物制剂或保健食品中的应用。
6.如权利要求5所述的应用,其特征在于,所述口服制剂为冲剂或颗粒剂。
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