CN112336815A - 一种强体防癌调理三高抗衰老组合物及其应用 - Google Patents
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Abstract
本发明涉及中药组合物,具体涉及到一种强体防癌调理“三高”抗衰老组合物及其应用。其制备原料包括组分A和组分B,其中组分A和组分B的重量比例为(1:2)~(2:1);A包括菝葜和/或茯苓、人参、五味子和/或灵芝;所述组分B包括葛根、玉米须、甘草和黄精。本发明中的强体防癌调理“三高”抗衰老组合物具有优异的降血压、降血糖、降血脂的作用,有助于改善人体血液循环,具备改善身体状况,增强免疫力、抗病原微生物、抗病毒,能祛风利湿、解毒消毒的功效。此外,本发明组分均为天然中草药,长期服用不会损伤脏器,也不会产生抗药性,利用其中富含的NMN、NAD、DHA、各类氨基酸等成分达到养生防癌、抗衰老、益智等效果,安全无毒副作用。
Description
技术领域
本发明涉及药食同源中药组合物,具体涉及到一种强体防癌调理“三高”抗衰老组合物及其应用。
背景技术
人们生活质量明显改善,富裕起来的人们一方面对人体保健的要求越来越高, 另一方面伴随而来的糖尿病、心血管疾病、癌症等原发性疾病的发病率也越来越 高。据统计,我国每年因心脑血管疾病造成死亡的人数约260万,平均每小时死 亡300人,心脑血管疾病死亡者已占全部疾病死因第一位。专家指出:高血脂、 高血压、高血糖是引起脑中风、心脏病等心脑血管病的罪魁祸首,且现在高血脂、 高血压、高血糖同时患上的比例起来越高,而治疗起来却非常的麻烦。
目前,市场上的降压药有硝苯地平、尼群地平、卡托普利、氢氯噻嗪、普萘洛尔等,降脂药主要为他汀类,如:拜斯亭、立普妥等,降糖药有阿卡波糖、二甲双胍、格列齐特、格列吡嗪、伏格列波糖等。目前市场上的降血糖产品主要由口服降糖西药和胰岛素两大类。但长期服用这些药物容易产生耐药性,治疗效果会慢慢削弱,且会造成心、脑、肾等器官的损害。而胰岛素一类的药物,短期内疗效尚可,长久使用会加速胰岛功能的老化,损害胰岛组织,还有可能诱发多种并发症。
此外,随着现代生活节奏的加快,越来越多的人受到睡眠不足甚至失眠的困扰。目前,用于失眠治疗的药物主要有安眠药剂、褪黑素等。当睡眠障碍干扰人的正常活动时,间歇性使用安眠药剂可能是有用的。通常可获得的现代安眠药物都是非处方药剂并且是较常用的市售药品之一。然而,许多目前可获得的安眠药丸,特别是安眠药和镇静药不应该长期服用。连续长期使用可能导致人对所述药物建立耐受性,另外有可能恶化原来的睡眠障碍,容易成瘾,并且停止使用时引起停药症状。
而且,目前国内外已有多款用于治疗三高、改善睡眠的药物和保健品,但还没有能够从根本上改善人体免疫力,同时实现上述效果的固体饮料等产品。所以需要研发一种对人体无毒副作用且又能够起到降三高,强体养生作用的药食同源产品。
发明内容
针对上述技术问题,本发明的第一方面提供了一种强体防癌调理“三高”抗衰老组合物,其制备原料包括组分A和组分B,其中组分A和组分B的重量比例为(1:2)~(2:1);所述组分A包括菝葜和/或茯苓、人参、五味子和/ 或灵芝;所述组分B包括葛根、玉米须、甘草和黄精。
作为本发明一种优选的技术方案,所述组分A的制备原料还包括黄芪和/或半支莲。
作为本发明一种优选的技术方案,所述组分B的制备原料还包括山药。
作为本发明一种优选的技术方案,所述组分B的制备原料还包括栀子。
作为本发明一种优选的技术方案,所述栀子和山药的重量相同。
作为本发明一种优选的技术方案,所述组分A的制备原料,以重量份计,包括10~50份菝葜和/或茯苓、10~50份人参、10~50份黄芪、10~50份半支莲。
作为本发明一种优选的技术方案,所述组分B的制备原料,以重量份计,包括10~50份葛根、10~50份玉米须、10~50份甘草、10~50份黄精、10~ 50份山药、10~50份栀子。
作为本发明一种优选的技术方案,所述复合物的剂型为胶囊剂、丸剂、片剂、口服液、保健茶、固体饮料、糖果压片及药(物)品中的一种。
本发明的第二个方面提供了如上所述的强体防癌调理“三高”抗衰老组合物在制备治疗、改善或预防高血压、高血糖、高血脂的保健品或药物中的应用。
作为本发明一种优选的技术方案,所述保健品为补充膳食营养的保健食品。
有益效果:本发明中的强体防癌调理“三高”抗衰老组合物中采用药食同源的菝葜、人参、五味子、灵芝葛根、玉米须等成分,在众多组分之间的协同作用之下实现强体补气、补肺防癌、解毒防感染的功效,与此同时还能显著降糖、降压、降脂,调理三高,清肝明目、调节脾胃、利尿补肾,从而全方位改善体质。而且,本发明中公开的组合物基本上均为药食同源的组分,与常规的药物治疗相比,能够做到从根本上改善人体免疫力,利用人体免疫力来抵御各类感染和疾病。本发明中的组合物具有优异的降血压、降血糖、降血脂的作用,有助于改善人体血液循环,具备改善身体状况,增强免疫力、抗病原微生物、抗病毒,能祛风利湿、解毒消毒的功效。此外,本发明中的灵芝、人参、山药等成分中富含大量的泛酸、烟酰胺、能果酸、原儿茶酸等活性成分,有助于软化表皮过度重叠、粘连在一起的角质细胞,使其能够自然脱落,促进皮肤细胞的更新加速,使皮肤华润、细嫩和健康,从而起到抗衰老的作用。本发明组分均为天然中草药,长期服用不会损伤脏器,也不会产生抗药性,利用其中富含的NMN、NAD、DHA、各类氨基酸等成分达到养生防癌、抗衰老、益智等效果,安全无毒副作用。
具体实施方式
参选以下本发明的优选实施方法的详述以及包括的实施例可更容易地理解本发明的内容。除非另有限定,本文使用的所有技术以及科学术语具有与本发明所述领域普通技术人员通常理解的相同的含义。当存在矛盾时,以本说明书中的定义为准。
本文中所用的术语“包含”、“包括”、“具有”、“含有”或其任何其它变形,意在覆盖非排它性的包括。例如,包含所列要素的组合物、步骤、方法、制品或装置不必仅限于那些要素,而是可以包括未明确列出的其它要素或此种组合物、步骤、方法、制品或装置所固有的要素。
当量、浓度、或者其它值或参数以范围、优选范围、或一系列上限优选值和下限优选值限定的范围表示时,这应当被理解为具体公开了由任何范围上限或优选值与任何范围下限或优选值的任一配对所形成的所有范围,而不论该范围是否单独公开了。例如,当公开了范围“1至5”时,所描述的范围应被解释为包括范围“1至4”、“1至3”、“1至2”、“1至2和4至5”、“1至3和5”等。当数值范围在本文中被描述时,除非另外说明,否则该范围意图包括其端值和在该范围内的所有整数和分数。
此外,本发明要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个,并且单数形式的要素或组分也包括复数形式,除非所述数量明显旨指单数形式。
本发明中的词语“优选的”、“优选地”、“进一步地”、“更优选的”等是指,在某些情况下可提供某些有益效果的本发明实施方案。然而,在相同的情况下或其他情况下,其他实施方案也可能是优选的。此外,对一个或多个优选实施方案的表述并不暗示其他实施方案不可用,也并非旨在将其他实施方案排除在本发明的范围之外。
本发明的第一方面提供了一种强体防癌调理“三高”抗衰老组合物,其制备原料包括组分A和组分B,其中组分A和组分B的重量比例为(1:2)~(2: 1);所述组分A包括菝葜和/或茯苓、人参、五味子和/或灵芝;所述组分B包括葛根、玉米须、甘草和黄精。
本发明中的强体防癌调理“三高”抗衰老组合物的组分A中菝葜可以由茯苓替换,也可以两者同时复配使用。
本发明中的五味子可以有灵芝替换,也可以两者同时复配使用。
本发明中的菝葜又称金刚藤、铁菱角、马加勒、筋骨柱子、红灯果,是百合科菝葜属植物菝葜Smilax china L.的根状茎。其叶也入药。全年可采,洗净,切片晒干,或用盐水浸泡数小时后蒸熟,晒干。夏季采叶,晒干。菝葜根茎含薯蓣皂甙元和多种由薯蓣皂甙元构成的皂甙,又含生物碱、酚类、氨基酸、有机酸、糖类。种子油含粗脂肪11.2%,其脂肪酸中含油酸48.4%,亚油酸39.1%。具体的,菝葜根含菝葜素(smilaxin),异内杞甙(isoengeletin),齐墩果酸(oleanolic acid),山柰素(kaempferide),二氢山柰素(dihydrokaempferide),β-谷甾醇 (β-sitosterol),β-谷甾醇葡萄糖甙(β-sitosteroylglucoside),薯蓣皂甙的原皂甙元A(prosapogenin A of dioscin),薯蓣皂甙(dioscin),纤细薯蓣皂甙(gracillin),甲基原纤细薯蓣皂甙(methylprotogracillin),甲基原薯蓣皂甙(methylprotodioscin)等。新替告皂甙元-3-O-α-L-吡喃鼠李糖-(1→6)-β-D-吡喃葡萄糖甙 (neotigogenin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside),新替告皂甙元-3-O-β-D-吡喃葡萄糖-(1→4)-O-[α-L-吡喃鼠李糖-(1→6)]-β-D-吡喃葡萄糖甙等化学成分。
本发明中的茯苓俗称云苓、松苓,为寄生在松树根上的菌类植物,形状像甘薯,外皮呈黑褐色,里边是白色或者粉红色,其原生物为多孔菌科真菌茯苓的干燥菌核,多寄生于马尾松或者是赤松的根部。茯苓性平,味甘淡,归心、肺、脾、肾经,是我国传统药材中非常重要的健脾利湿中药材,具体的功效如下:
利水消肿:茯苓味甘而淡,甘则能补,淡则能渗,药性平和,既可祛邪,又可扶正,利水而不伤正气,是中药中利水消肿的重要药材之一,可用于治疗各种寒热、虚实等原因所导致的水肿。
健脾止泻:茯苓能够健脾、渗湿而止泻,尤其擅长于治疗脾虚、湿盛所导致的泄泻症状。对于脾虚运化失常所致的泄泻、带下,应用茯苓有标本兼顾的功效,常与党参、白术、山药等配伍,又可用为补肺脾、治气虚之辅佐药。
补益心脾、宁心安神:常可用于治疗心脾两虚、气血不足等因素所引起的失眠、健忘、多梦等症状。
增强免疫功能:茯苓多糖具有增加机体免疫功能的作用,服用茯苓多糖可改善老年人的细胞免疫功能。
抗癌:其中包括抗癌的维生素和微量元素、氨基酸等,食用茯苓可以抑制癌细胞的产生,破坏癌细胞的DNA,移除体内的致癌的自由基等,不管是用来预防癌症,还是用来治疗癌症,茯苓都有着非常明显的功效。
治疗感冒、咳嗽:茯苓对于感冒有一定的治愈作用,尤其是对于湿热等原因引起的感冒,引发咳嗽、痰多,甚至伴随手脚酸软、体乏、背痛等症状,这种情况可以通过使用茯苓煮粥或者是炖汤来达到辅助治疗的目的。
茯苓功效很多,日常可以通过煮粥、炖汤等来服用,但因其具有的药用价值比较多,不宜过量服用。
本发明中的人参又名棒锤、山参、园参、参叶,为五加科植物人参Panax ginsengC.A.Mey.的干燥根。栽培者为“园参”,野生者为“山参”。多于秋季采挖,洗净;园参经晒干或烘干,称“生晒参”;山参经晒干,称“生晒山参”;经水烫,浸糖后干燥,称“白糖参”;蒸熟后晒干或烘干,称“红参”。人参皂甙0.4%,少量挥发油。油中主要成份为人参烯(panacen,C15H24)0.072%。据报导从根中分离出皂甙类:人参皂甙A、B、C、D、E和F(panaxoside A、B、C、D、E、 F)等。人参皂甙A(C42H72O14),为人参皂甙Rg1(ginsenoside Rg1)。人参皂甙B和C水解后产生人参三醇(panaxatriol)皂甙元,人参皂甙D、E和F 水解后得20-表人参二醇(20-epiproto panaxo-diol)皂甙元。又自乙醚提取物的低沸点部分分离出β-榄香烯(β-elemene,C15H24)。高沸点部分分离出人参炔醇(panaxynol,C17H26O)。此外尚含有单糖类:葡萄糖、果糖、蔗醣,三种三糖:葡萄糖-果糖-果糖、三聚葡萄糖,葡萄糖-葡萄糖-果糖,人参酸 (为软脂酸、硬脂酸及亚油酸的混和物),多钟维生素(B1、B2、菸酸、菸酰胺、泛酸),多种氨基酸、胆碱、酶(麦芽糖酶、转化酶、酯酶),精胺(spermine) 及胆胺(cholamine)。人参的地上部分含黄酮类化合物,人称人参黄甙 (panasenoside)、三叶甙(trifolin)、山柰醇、人参皂甙、β-谷甾醇及糖类。人参对中枢神经系统具有兴奋作用,而大量时反而有抑制作用。能加强动物高级神经活动的兴奋和抑制过程。并能增强机体对一切非特异性刺激的适应能力,能减少疲劳感。
五味子为木兰科植物五味子(Schisandra chinensis(Turcz.)Baill.)或华中五味子(Schisandra sphenanthera Rehd.et Wils.)的干燥成熟果实,霜降后果实完全成熟时采摘,拣去果枝及杂质,晒干使用即可。五味子果实含多种木脂素:戈米辛(gomisin)A,戈米辛B即华中五味子酯(schisantherin)B,戈米辛C即华中五味子酯(schisantherin)A,戈米辛F、G,五味子素(schisandrin)即五味子醇A(wuweizichun A,schisandrol A),戈米辛D,戈米辛H,当归酰戈米辛(angeloylgomisin)H,巴豆酰戈米辛(tigloylgomisin)H,苯甲酸戈米辛 (benzoylgomisin)H,戈米辛J,前戈米辛(pregomisin),内消旋-二氢愈创木脂酸(mexo-dihydroguaiaretic acid),表戈米辛(epigomisin)O,右旋-去氧五味子素(deoxy-schisandrin)即五味子素A,戈米辛N、O、E,二甲基戈米辛 (dimethylgomisin)J,戈米辛P,去当归酰戈米辛(deangeloylgomisin)B、F,左旋-戈米辛K1,右旋-戈米辛K2、K3,巴豆酰戈米辛P,当归酸戈米辛P,当归酰戈米辛Q,右旅-戈米辛M2,外消旋-戈米辛M1;γγ五味子素即五味子素 B,左旅-戈米辛L1、L2,当归酰戈米辛O,当归酸异戈米辛(angeloylisogomisin) O,苯甲酰异戈米辛O(benzoylisogomisin)O,戈米辛R,五味子素C,华中五味子酯D,戈米辛S、T,异五味子素(isoschisandrin)及去甲二氢愈创木脂酸(nordihydroguaiaretic acid)等;还含挥发油,其成分有α等侧柏烯(α柏烯(α挥发油,),α,及β,β蒎烯(pinene),樟烯(camphene),α,水芹烯(α-phellandrene),β,松油烯(β油烯(β烯(βββ油),4-松油烯醇(terpinen-4-ol),α,松油烯醇(α油烯醇(α烯醇(αα),α,(王古)(王巴)烯(α-copaene),β,榄香烯(β香烯(β烯()烯),菖蒲二烯(acoradiene),α,及β,β雪松烯(himachalene),橙花叔醇(nerolidol),糠醛(furaldehyde),2-十一烷酮(2-undecanone及对 -异丙基苯甲酸(p-isopropylben acid)等32种。
五味子还含有五味子醇乙(GomisinA)和五味子素(Schizandrin)等,有助于改善睡眠。而且其中的丙素、醇乙、酯甲、酯乙均能抑制一氧化碳的生成及NADPH 和氧的消耗,从而部分地阻断四氯化碳与P450的结合,使四氯化碳的代谢不能正常进行,减少毒性代谢物(自由基)的生成,因而肝细胞损伤相应减轻。此外,其中的去氧五味子素,能够调节胃酸分泌,治疗胃溃疡,调节脾胃。
此外,本发明中使用的五味子对神经系统各级中枢均有兴奋作用,对大脑皮层的兴奋和抑制过程均有影响,使之趋于平衡。对呼吸系统有兴奋作用,有镇咳和祛痰的功效与作用。能降低血压。能利胆,降低血清转氨酶,对肝细胞有保护作用。与此同时,其有与人参相似的适应原样作用,能增强机体对非特异性刺激的防御能力。能增加细胞免疫功能,使脑、肝、脾脏SOD活性明显增强,故具有提高免疫,抗氧化、抗衰老之功效与作用。对金色葡萄球菌、肺炎杆菌、肠道沙门氏菌、绿脓杆菌等均有抑制作用。
本发明中所述的灵芝,别名灵芝草、菌灵芝、木灵芝,为多孔蓖科真菌灵芝Ganoderma Iucidum(Leyss.ex Fr.)Karst.的子实体。全年可采,阴干或晒干。其主含氨基酸、多肽、蛋白质、真菌溶菌酶(fungal lysozyme),以及糖类(还原糖和多糖)、麦角甾醇、三萜类、香豆精甙、挥发油、硬脂酸、苯甲酸、生物碱、维生素B2及C等;孢子还含甘露醇、海藻糖(trehalose)等。有助于滋补强壮、用于健脑、消炎、利尿、益肾。其中的氨基酸包括精氨酸(argi-nine),色氨酸 (tryptophane),天冬氨酸(aspartic acid),甘氨酸(glycine),丙氨酸(alanine),苏氨酸(threonine),丝氨酸(serine),谷氨酸(glutamic acid),脯氨酸(proline) 和微量的蛋氨酸(methio-nine),亮氨酸(leucine),酪氨酸(tyrosine),苯丙氨酸(phenylala-nine)。又含甘露醇(mannitol),α,αα海藻糖(α,ααα(α,αla-n),硬脂酸(stearic acid),棕榈酸(palmitic acid),二十四烷酸(tetracosanoic acid),十九烷酸(nonadecanoic acid),山梨酸(behenicacid),二十四烷(tetracosane),三十一烷(hentriacontane)和胆碱(choline),甜菜碱(betaine)。还含有机锗及钙、镁、钠、锰、铁、锌、铜、硫等元素,有机锗被认为是目前较理想的强有力的免疫增强剂。又含类脂,内有磷脂酰乙醇胺(phospha-tidylethanolamine),磷脂酰胆碱(phosphatidylcholine)。又含具抗肿瘤活性的水溶性多糖,具促进核酸蛋白质合成代谢作用、改善造血功能的多糖BN3C、抗肿瘤作用及阻抑由角叉菜胶所诱发的水肿的水溶性的葡聚糖(glucan)G-A、具有降血糖、降血胆甾醇和抗肿瘤作用的灵芝多糖等。
此外,灵芝中含有除了含有上述多种蛋白质、脂肪和碳水化合物外,还富含多种维生素,以及钾、锗、铜、镁、铁、锌、钴、锰、钙、磷等多种微量元素和矿物质,在补充人体所需的微量元素的同时,还能有助于使人体肌肉放松,人身体处于放松的状态,起到安眠的作用。
本发明中的灵芝可以采用灵芝子实体,也可以使用将其经过提取其中的各类氨基酸、特种多糖之后的提取物。对于其提取方式并不作特殊限定,可以采用榨取法、萃取法、蒸馏法等。
本发明中所述的葛根又名葛藤、粉葛、干葛、葛麻藤,富含大豆甙元(daidzein),大豆甙(daidzin),葛根素(puerarin),4’-甲氧基葛根素(4’-methoxypuerarin),大豆甙元-4’,7-二葡萄糖甙(daidzein-4’,7-diglucoside),大豆甙元-7-(6-O- 丙二酰基)-葡萄糖甙[daidzein-7-(6-O-malonyl)-lucoside],染料木素(genistein),刺芒柄花素(for-mononetin),大豆甙元-8-C-芹菜糖基(l→6)-葡萄糖甙 [daidzein-8-C-apiosyl(1→6)-glucoside],染料木素-8-C-芹菜糖基(1→6)-葡萄糖甙[genistein-8-C-apiosyl(1→6)-glucoside],葛根素木糖甙(puerarinxyloside, PG-2),3’-羟基葛根素(3’-hydroxypuerarin,PG-1),3,-甲氧基葛根素(3’ -methoxypuerarin,PG-3),4’-O-葡萄糖基葛根素(4’-O-glucosyl puerarin,PG-6),葛根酚(puerarol),葛根甙(pueroside)A、B,刺芒柄花素-7-葡萄糖甙 (formononetin-7-glucoside),羽扇烯酮(lupenone),β-谷甾醇(β-sitosterol),二十二烷酸(docosanoic acid),二十四烷酸(tetracosanoic acid),l-二十四烷酸甘油酯(glucerol-1-monotetracosanoate),尿囊素(allantoin),β-谷甾醇-β -D-葡萄糖甙(β-sitosteryl-β-D-glucoside),6,7-二甲氧基香豆精(6, 7-dimethoxycoumarin),5-甲基海因(5-methylhydantoin)及以槐花二醇 (sophoradiol),广东相思子三醇(cantoniensistriol),大豆皂醇(soyasapogenol) A、B,葛根皂醇(kudzusapogenol)C、A和葛根皂醇B甲酯(kudzusapogenol B methylester)为甙元的三萜皂甙。葛藤亦含有大豆甙元,大豆甙,葛根素和β- 谷甾醇。甘葛藤根含大豆甙,葛根素,4’-甲氧基葛根素,大豆甙元及痕量大豆甙元-4,7’-二葡萄糖甙等化学成分,有助于扩张血管,改善血液循环;降低心肌耗氧量,抑制癌细胞;增加冠脉流量,调整血液微循环;治疗各年龄阶段的突发性耳聋;降低心脑血管疾病危险,还有助于改善高血压病颈项强痛等症状。
本发明中所述玉米须别名玉蜀黍须、蜀黍须、包谷须,是禾本科玉蜀黍属植物玉米Zea mays L.的花柱和花头。秋季收获玉米时采收,晒干或烘干。其富含脂肪油2.5%、挥发油0.12%,树胶样物质3.8%、树脂2.7%、苦味糖甙1.15%、皂甙3.18%、生物碱0.05%。还含隐黄素(cryptoxanthin)、维生素C、泛酸(pantothenic acid),肌醇(inositol),维生素K、谷甾醇(sitosterol)、豆甾醇(stigmasterol)、苹果酸(malic acid))枸椽酸(citricacid),酒石酸(tartaric acid),草酸(oxalic acid)等。此外,还含大量硝酸钾(KNO3),a-生育醌(a-tocopheryl quinone)等化学成分,与本发明中的葛根、黄精、甘草等成分一起,有助于降低血糖。
本发明中的甘草又名甜草根、红甘草、粉甘草、粉草,为豆科甘草属植物甘草Glycyrrhiza uralensis Fisch.的根和根状茎。野生品秋季采挖,栽培品于播种3~ 4年后,在秋季采挖,除去残茎,按粗细分别晒干。甘草含有甘草甜素(glycyrrhizin,即甘草酸glycyrrhinic acid,C42H62O16)6~14%,为甘草的甜味成分,是一种三萜皂甙。甘草酸水解产生一分子甘草次酸(glycyrrhetic acid即glycyrrhetinic acid, C30H46O4)及二分子葡萄糖醛酸(glycuronic acid,C6H10O7)。并含少量甘草黄甙(即甘草甙liquiritin,C21H22O9,为一种黄烷醇flavanone的甙,其甙元名甘草素liquiritigenin,C15H12O4和甘草苦甙glycyamarin)、异甘草黄甙(iso-liquiritin, C21H24O9)、二羟基甘草次酸(dihydroxyglycyrrhetic acid即grabric acid, C30H46O5)、甘草西定(licoricidin,C25H32O5,即3’,6-二异戊烯-2’,4’, 5-三羟基异黄烷)、甘草醇(glycyrol,C21H18O6)、5-0-甲基甘草醇(5-0-methyl glycerol,C22H20O6)、异甘草醇(iso-glycyrol,C21H18O6),此外,尚含有甘露醇(mannite)、葡萄糖3.8%、蔗糖2.4~6.5%、苹果酸、桦木酸(betulicacid,C30H48O3)、天冬酰胺、菸酸、生活素(biotin,C10H16O3N2S)296微克/克、微量挥发油为甘草特有臭气的来源及淀粉等。
本发明中的所述黄精又名老虎姜,为百合科植物滇黄精Polygonatum kingianumColl.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatum cyrtonemaHua的干燥根茎。按形状不同,习称“大黄精”、“鸡头黄精”、“姜形黄精”。春、秋二季采挖,除去须根,洗净,置沸水中略烫或蒸至透心,干燥。其富含甾体皂甙,包括呋甾烯醇型皂甙和螺甾烯醇型皂甙。具体包括26-O-β-D-吡喃葡萄糖基-22-O-甲基-(25)S-呋甾-5-烯-3β,26-二醇3-O-β-石蒜四糖甙[26-O-β-D-glucopyranosyl-22-O-methyl-25(S)-furost-5-ene-3β,26-diol3-O-β-lycotetraoside]即西伯利亚蓼甙A(sibiricoside-A)和26-O-β-D-吡喃葡萄糖基-22-O-甲基-25(S)-呋甾-5-烯-3β,14α,26-三醇3-O-β-石蒜四糖甙 [26-O-β-D-glucopyranosyl-22-O-methyl-25(S)-fruost-5-ene-3β,14α, 26-triol3-O-β-lycotetraoside]即14α-羟基西伯利亚蓼甙A(14α-hydroxysibiricoside A);属于后者的是:[(23S,25R)螺甾-5-烯-3β,14α,23-三醇3-O-β-lycotetraoside] 即西伯利亚蓼甙B(sibiricoside B)和新巴拉次薯蓣皂甙元-A3-O-β-石蒜四糖甙 (neoprazerigenin A 3-O-β-lycotetraoside)。另含黄精多糖A、B、C,三者的相对分子质量均大于20万,均由葡萄糖(glucose)、甘露糖(mannose)和半乳糖醛酸 (galacturonicacid)按照摩尔比6:26:1缩合而成;又含黄精低聚糖A、B、C,相对分子质量分别为1 630、862和472,系由果糖(fructose)与葡萄糖按摩尔比8: 1、4:1和2:1缩合而成,与本发明中的其余成分一起有助于降低人体中的血糖、血压和血脂。
在一些实施方式中,所述组分A的制备原料还包括黄芪和/或半支莲。其中,可以根据需求单独添加黄芪、单独添加半支莲,或者两者都不添加。
本发明中的黄芪又名绵芪、绵黄芪,为豆科黄芪属植物膜荚黄芪Astragalusmembranaceus(Fisch.)Bunge及内蒙古黄芪A.mongholicus Bunge的根。野生品秋季挖根;栽培品播种后4~5年春季萌芽前或秋季落叶后采挖,除去茎苗及须根,晒干。黄芪含毛蕊异黄酮(calycosin)、3羟基-9,10-二甲氧基紫檀烷,还含黄芪皂甙Ⅰ,Ⅴ,Ⅲ(astragalosideⅠ,Ⅴ,Ⅲ)等黄酮类,以及2’,4’二羟基-5,6-二甲氧基异黄酮(2’,4’-dihydroxy-5,6-dimethoxyisoflavone)、胆碱(choline)、甜菜碱(betaine)、氨基酸、蔗糖、葡萄糖醛酸及微量的叶酸,又含β-谷甾醇、亚油酸及亚麻酸等。
本发明中半支莲(Scutellaria barbata D.Don)又名赶山鞭、瘦黄芩,牙刷草,田基草,水黄芩,狭叶韩信草,是唇形科黄芩属多年生草本植物。其富含红花素(carthamidin),异红花素(iso-carthamidin),高山黄芩素(scutellarein),高山黄钤甙(scutel-larin),β-谷甾醇(β-sitosterol),硬脂酸(steraricacid),生物碱多糖等。另据报道,从地上部分分离得到汉黄芩素(wogo-nin),半枝莲素(scutervulin),半枝莲种素(rivularin),柚皮素(naringenin),芹菜素(apigenin),粗毛豚草素(hispedulin),圣草素(eriodictyol),木犀草素(suteolin),5,7,4-三羟基-8-甲氧基黄烷酮(5,7, -trihydroxy-6-methoxyflavanone)4-羟基汉黄芩素(4-hydroxywogonin),7-闳基-5, 8-二甲氧基黄酮(7-hy-droxy-5,8-dimethoxyflavane),对-闳基苯甲西藏 (p-hydroxyben-zaldehyde),对-闳基苄基丙酮(p-hydroxybenzylacetone),对-香豆酸 (p-coumaricaicd),原儿茶酸(protocatechuicacid),能果酸(ut-solicacid)植物甾醇(phytosterol),植物甾醇β-D-葡萄糖甙(phy-tosteryl-β-D-glucoside)等化学成分。具有清热解毒,活血化瘀,消肿止痛,抗癌之功效;治阑尾炎、肝炎、胃痛、早期肝癌、肺癌、子宫颈癌、乳腺炎等;外用治痛疖疗,跌打肿痛等作用。
本发明中的半支莲还可以与菝葜等或其它组分复配,制备非药食同源的药物,用来解毒,防感染,强体补气。
在一些实施方式中,所述组分B的制备原料还包括山药、山楂、鸡内金中的一种或多种。。
本发明中所述的山药又名薯蓣、土薯、山薯蓣、怀山药、淮山、白山药,为薯蓣科植物薯蓣Dioscorea opposita Thunb.的干燥根茎。冬季茎叶枯萎后采挖,切去根头,洗净,除去外皮及须根,用硫黄熏后,干燥;也有选择肥大顺直的干燥山药,置清水中,浸至无干心,闷透,用硫黄熏后,切齐两端,用木板搓成圆柱状,晒干。其富含薯蓣皂甙元(diosgenin)0.012%,多巴胺(dopamine),盐酸山药碱(batatasine hydrochloride),多酚氧化酶(polyphenoloxidase),尿囊素(allantoin) 止杈素(abscisin)Ⅱ。又含糖蛋白(glucoprotein),水解得:赖氨酸(lysine),组氨酸(histidine),精氨酸(arginine),天冬氨酸(aspartic acid),苏氨酸(threonine),丝氨酸(serine),谷氨酸(glutamic acid),脯氨酸(proline),甘氨酸(glycine),丙氨酸(alanine),缬氨酸(valine),亮氨酸(leucine),异亮氨酸(isoleucine),酷氨酸(tyrosine),苯丙氨酸(phenylalanine)和蛋氨酸(methionine)。还含包括上述氨基酸和胱氨酸(cystine),γ-氨基丁酸(γ-aminobutyricacid)在内的自由氨基酸,另含具降血糖作有用的多糖,并含由甘露糖(mannose),葡萄糖(glucose)和半乳糖(galactose)按摩尔比6.45:1:1.26构成的山药多糖,又含钡、铍、铈、钴、铬、铜、镓、镧、锂、锰、铌、镍、磷、锶、钍、钛、钒、钇、镱、锌、锆以及氧化钠、氧化钾、氧化铝、氧化铁、氧化钙、氧化镁等。根茎含多巴胺、儿茶酚胺(catecholamine),以及胆甾醇(cholesterol),麦角甾醇(ergosterol),菜油甾醇(campesterol),豆甾醇(stigmasterol),β-谷甾醇 (β-sitosterol)。粘液中含植酸(phytic acid),甘露多糖(mannan)Ia,Ib和Ic;有人说粘液含多糖40%,蛋白质2%,磷3%和灰分24%,多糖部分由80%的甘露糖和少量的半乳糖,木糖(xylose),果糖(fructose)及葡萄糖所组成。珠芽 (零余子)含5种分配性植物生长调节剂,命名为山药素(batatasin)Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ。还含止杈素,多巴胺和多种甾醇:胆甾烷醇(cholestanol),(24R)-α- 甲基胆甾烷醇[(24R)-α-methyl cholestanol],(24S)-β-甲基胆甾烷醇[(24S) -β-methyl cholestanol],(24R)-α-乙基胆甾烷醇[(24R)-α-ethyl cholestanol],胆甾醇,菜油甾醇,(24S)-β-甲基胆甾醇[(24S)-β-methyl cholestanol],24- 亚甲基胆甾醇(24-methylenecholesterol),β-谷甾醇,豆甾醇,异岩藻甾醇 (isfucosterol),赬桐甾醇(clerosterol),24-亚甲基-25-甲基胆甾醇 (24-emthylene-25-methyl cholesterol),7-胆甾烯醇(lathosterol),8(14)-胆甾烯醇[cholest-8(14)-enol],(24R)-α-甲基-8(14)-胆甾烯醇[(24R)-α-methyl cholest-8(14)-enol],(24S)-β-甲基-8(14)-胆甾烯醇[(24S)-β-methyl cholest-8 (14)-enol],(24R)-α-乙基-8(14)-胆甾烯醇[(24R)-α-ethyl cholest-8(14) -enol]。同属植物日本薯蓣块茎含三萜皂甙,尿囊素,胆碱(choline),17种氨基酸(比山药块茎所含的自由氨基酸缺γ-氨基丁酸)及无机化合物(比山药块茎所含的无机化合物缺镧)。又含修养降血糖活性的日本薯蓣多糖(dioscoran)A、 B、C、D、E、F等化学成分,有助于降低人体血糖、血脂和血压的作用。
本发明中所述的山楂为蔷薇科植物山里红Crataegus pinnatifidaBge.var.major N.E.Br.或山楂Crataegus pinnatifida Bge.的干燥成熟果实。秋季果实成熟时采收,切片,干燥。山楂含表儿茶精[(-)-epicatechin]、槲皮素(quercetin)、金丝桃甙(hyperin)、绿原酸(chlorogenic acid)、山楂酸(crataegolic acid)、柠檬酸(citricacid)、苦杏仁甙(amygdalin)等。此外,此外,山楂里面含有三萜类和黄酮类成分,能降低血清胆固醇,山楂的维生素C,具有减肥降脂的作用。所以山楂是高脂血症患者食用的佳品。对抑制血清胆固醇和甘油三酯增高都有好的疗效。
本发明中所述鸡内金为雉科动物家鸡Gallus gallus domesticus Brisson的干燥沙囊内壁。杀鸡后,取出鸡肫,趁热立即剥下内壁(不要先用水洗,否则难剥离且易破碎),洗净,干燥。其富含胃激素(胃激素ventriculin),角蛋白(keratin),微量胃蛋白酶(pepsin),淀粉酶(diastase),多种维生素。出生4-8星期的小鸡砂囊内膜还含有胆汁三烯(bilatriene)和胆绿素的黄色衍生物,并含赖氨酸 (lysaine),组氨酸(histidine),精氨酸(arginine),谷氨酸(glutamic acid) 天冬氨酸(aspartic acid),亮氨酸(leucine),苏氨酸(threonine),丝氨酸(serine),甘氨酸(glycine),丙氨酸(methionine),异亮氨酸(isoleucine),酪氨酸(tyrosine),苯丙氨酸(phenylalanine),脯氨酸(proline),色氨酸(tryptophane)等18种氨基酸,及铝、钙、铬、钴、铜、铁、镁、锰、钼、铅、锌等微量元素。
在一些实施方式中,所述组分B的制备原料还包括栀子。
本发明中所述的栀子又名黄栀子、黄果树、山栀子、红枝子,为茜草科植物栀子Gardenia jasminoides Ellis的干燥成熟果实,其根也可入药。9~11月果实成熟呈红黄色时采收,除去果梗及杂质,蒸至上汽或置沸水中略烫,取出,干燥。根夏秋采挖,洗净晒干。富含黄酮类栀子素、果胶、鞣质、藏红花素、藏红花酸、 D-甘露醇、廿九烷、β露谷甾醇。另含多种具环臭蚁醛结构的甙:栀子甙、去羟栀子甙泊素-1-葡萄糖甙,格尼泊素-1-甙,格尼龙胆二糖甙及小量的山栀甙等化学成分具有镇静、降血压等作用。
在一些实施方式中,所述组分A的制备原料,以重量份计,包括10~50份菝葜和/或茯苓、10~50份人参、10~50份黄芪、10~50份半支莲。
进一步地,所述黄芪的用量为菝葜和半支莲用量之和的45~60wt%。
进一步地,所述组分A的原料,以重量份计,包括40~50份菝葜和/或茯苓、 30~40份人参、20~30份半支莲、30~48份黄芪。
进一步地,所述组分A的原料,以重量份计,包括45份菝葜、35份人参、 20份半支莲、38份黄芪。
或者,所述组分A的原料,以重量份计,包括45份茯苓、35份人参、20 份半支莲、38份黄芪。
申请人在完成本发明的过程中发现,长期使用菝葜水煮提取物后,虽然能够有助于疏通狭窄食管,以及利尿消肿、增强体力、提高红细胞及血红蛋白,和一定的止痛安眠作用,然而长期使用后容易引起肠胃不适,刺激肠胃,出现胀气等现象,当在和半支莲一起服用后,这种不舒服显现更加明显,尤其是脾胃虚寒体质的人长期服用之后苦寒伤胃的现象更加严重,甚至出现腹胀泄泻、血便、呕吐等情况。而当菝葜与半支莲、黄芪、人参等成分按照特定的比例复配使用后,在有助于强体补气、补肺防癌的同时,还能解毒防感染,而且有效降低复合物对肠胃的刺激,减少呕吐、胀气等不舒服的现象。尤其是在复合物中黄芪的用量达到一定的含量,例如超过半支莲和菝葜重量总和的45wt%时,解毒防感染以及改善肠胃副作用的效果最佳。申请人推测可能是由于菝葜和半支莲等成分中含有的皂素及鞣酸等杂质对胃肠道粘膜有一定的刺激性,刺激肠胃分泌大量的者粘液涎沫,使使用者肠胃内出现大量的胀气。与此同时,对一些脾胃虚寒的使用者肠胃可能产生较严重的刺激,导致其肠胃发炎、充血,从而引起肠胃的不舒服。而在和一定含量的黄芪和人参复配使用之后,黄芪等结构中的胆碱、黄酮成分有助于中和或稳定复合物中的一些鞣酸、皂素等成分,同时在肠胃内壁形成保护膜,减少上述鞣酸等成分对肠胃的刺激,改善使用者肠胃对的刺激性成分的过度反应,从而减少复合物使用中可能产生的副作用。
此外,本发明中的灵芝、人参、山药等成分中富含大量的泛酸、烟酰胺(NMN、 NAD烟酰胺能使NMN从而快速提升NAD水平,增加胰岛素的分泌,改善腺粒体功能,增加脂肪分解、调节血脂、血糖)、能果酸、原儿茶酸等活性成分,有助于软化表皮过度重叠、粘连在一起的角质细胞,使其能够自然脱落,促进皮肤细胞的更新加速,使皮肤华润、细嫩和健康,从而起到抗衰老的作用。
在一些优选的实施方式中,所述栀子和山药的重量相同。
在一些实施方式中,所述组分B的制备原料,以重量份计,包括10~50份葛根、10~50份玉米须、10~50份甘草、10~50份黄精、10~50份山药、10~ 50份栀子。
进一步优选的,所述组分B的制备原料,以重量份计,包括40份葛根、28 份玉米须、25份甘草、30份黄精、28份山药、28份栀子。
申请人发现菝葜、半支莲、黄芪等组分A中的成分有助于强体补气,增强人体的免疫力,提高体内细胞及蛋白的活性,有助于人体对各种病毒和细菌的抵抗力。而B组分中的葛根、玉米须等之间的相互作用下有助于扩张末梢血管,改善人体的血液循环,有助与降低体内的血压、血糖和血脂。在A组分和B组分之间的协同作用之下,能够进一步加强对人体的调理,直接将下人体血压、血糖和血脂的同时,还能从根本上的增强人体的免疫力,对人体进行调理,达到改善身体状况,增强免疫力、抗病原微生物、抗病毒,能祛风利湿、解毒消痈的作用,而且本发明的A组分和B组分均为天然中草药,其间的相互作用之下长期服用不会损伤脏器,也不会产生抗药性,具有养生防癌的效果,安全无毒副作用。申请人发现B组分中含有主要组分葛根和玉米须的同时,加入一定量的甘草和黄精时有助于提高对人体的调理效果。当B组分中含有上述组分的前提下,加入山药和栀子时复合物对人体的调理效果达到最佳,可能是由于山药和栀子的加入,能够在一定程度上加强A组分和B组分之间的互补性,进一步改善其间的协同作用,从而达到最佳的调理效果。此外,当B组分中的山药和栀子用量相同的时候,可以在一定程度上减少葛根的用量,并且达到一样的效果,而且还能进一步改善复合物对炭疽杆菌等细菌的抑制效果。可能是由于山药和栀子在A 组分和B组分中的植物成分的作用下,发挥特定功能上的关联作用或互补作用,增效复合物功效的发挥。
在一些优选的实施方式中,所述葛根采用葛根提取物。
在一些实施方式中,所述葛根提取物为葛根采用去离子水提取得到的成分。本发明中对所述葛根提取物的提取方式并不做特殊限定,也可以根据本领域技术人员所熟知的方法进行提取制备,例如:称取一定量的葛根,粉碎,然后加入料液比为1g:45ml的去离子水,加热回流提取1~3小时,然后过滤,将滤渣取出后再次采用相同的料液比提取一次,将过滤得到的液体弄过烘干得到所述葛根提取物。本发明中的葛根提取物也可以从市面上购买得到,例如购自宣城百草药业有限公司等。
在一些优选的实施方式中,所述葛根提取物中的黄酮含量不低于40wt%。
进一步优选的,所述葛根提取物中的黄酮含量不低于50wt%。
进一步优选的,所述葛根提取物中的总黄酮含量为50~65wt%。本发明中满足上总黄酮含量的提取物可以通过将不同总黄酮含量的提取物之间相混合,复配的方式进行调节得到。
本发明的葛根中总黄酮的含量是按照本领域技术人员所熟知的发方法进行测试得到的,具体可以采用分光光度法进行测试,例如量取0.2g/L的芦丁标准溶液0.1ml,0.2ml,0.3ml,0.4ml,0.5ml,置于25ml容量瓶中,加入70wt%甲醇溶液至10ml,加入50g/L亚硝酸钠溶液1ml,放置6min,再加100g/L的硝酸铝溶液1ml,放置6min,再加40g/L的氢氧化钠溶液8ml,用70wt%甲醇溶液稀释至刻度,摇匀,放置30min,以空白溶液为参照比,在波长510nm处测量吸光度,以测出的吸光度绘制标准曲线,并根据标准曲线计算葛根中总黄酮的含量。
申请人发现,葛根用葛根提取物来代替,能够进一步改善高血糖和高血脂,尤其是在葛根提取物中总黄酮含量较高(不低于40wt%)时,并且复合物中加入相同重量的山药和栀子时,复合物对人体高血糖,高血脂的降低作用更加明显,可能是由于葛根提取物中的总黄酮与山药、栀子以及B组分、A组分中的植物成分的作用下,有助于人体增强肾上腺素和ACTH所诱导的脂肪分解作用,抑制胰岛素诱导的由葡萄糖转化为脂肪的作用,而发挥间接促进脂肪分解和抑制脂肪合成的作用。也可以在一定程度上可以促进体内胰岛素的分泌作用,抵抗高血糖和高血脂。而当山药和栀子用量相同的时候,葛根提取物中的总黄酮,以及复合物中的甘草、菝葜等成分之间的相互达到好的平衡,在改善三高问题的同时,对金黄色葡萄杆菌、炭疽杆菌等有较好的抑制作用,避免由这些细菌引起的各种感染。
本发明中组合物原料可以采用组分直接入药,制备药食同源的组合物使用,也可以通过对上述成分进行提取,将其中的特定氨基酸、微量元素、多糖等有效成分提取出来,使用其中的提取物。本发明中对其具体提取方法并不作特殊限定,可以采用溶剂提取法、超声波提取法、微波提取法、酶提取法、超临界流体萃取法、微波辅助提取法等方式。
其中,溶剂提取法是用溶剂从固体原料中提取有效成分,所用的溶剂必须具备与所提取的溶质互溶的特性。将植物材料粉碎后,放入适合的容器内,加入数倍量溶剂,可采用浸渍、渗漉、煎煮、回流和连续提取法进行提取。在溶剂提取法的提取工艺过程中,溶剂的浓度、料液比、提取温度、提取的时间会直接影响有效成分的提取率。
超声波提取是利用超声波产生的强烈振动和空化效应加速植物细胞内物质的释放、扩散并溶解进入溶剂中,同时可以保持被提取物质的结构和生物活性不发生变化。超声波提取原理主要为物理过程,是近年来逐渐受到重视的一个较新的提取方法。对多数成分来说,超声波提取方法较常规的溶剂提取能大幅地缩短提取时问,消耗溶剂少,浸出率高,因此具有较高的提取效率。在超声波法提取工艺过程中,溶剂的选择和浓度、料液比、提取温度、提取的时间会直接影响提取率。
超临界流体提取(supercriticalfluid extraction,SFE)是一种较新型的提取分离技术,一般采用CO2作为提取剂。超临界流体萃取法的原理是利用超临界流体的独特溶解能力和物质在超临界流体中的溶解度对压力温度的变化非常敏感的特性,通过升温降压手段(或两者兼用)将超临界流体中所溶解的物质分离出来,达到分离提纯的目的,它兼有精馏和提取两种作用,具有活性成分不易失活、产品质量高、提取分离过程同步完成等优点,被认为是绿色环保的高新分离技术,特别适合于不稳定天然产物和生理活性物质的分离与精制。
微波辅助提取技术(microwave.assistedextraction,MAE)是利用微波能提高提取效率的一种新技术。微波辅助提取就是利用微波加热的特性对物料中目标成分进行选择性提取的方法,通过调节微波的参数,可有效加热目标成分,以利于目标成分的提取与分离。微波辅助提取法提取植物的原理是植物样品在微波场中吸收大量的能量,而周围的溶剂则吸收较少,从而在细胞内部产生热应力,植物细胞因内部产生的热应力而破裂,使细胞内部的物质直接与相对冷的提取溶剂接触,进而加速了目标产物由细胞内部转移到提取溶剂中,从而强化了提取过程。微波辅助提取法技术原理上与浸泡和过滤一样也使用热能,但是提取植物提取物的速度却要比传统的方法快得多,在减少提取时间的同时避免有价值的植物提取物被破坏和降解。
微波是一种非电离的电磁辐射,被辐射物质的极性分子在微波电磁场中快速转向及定向排列,从而产生撕裂和相互摩擦引起发热,这可以保证能量的快速传递和充分利用,具有高效节能无工业污染等优点,但微波的穿透深度有限(与其波长在同一数量级),且它在强化提取过程中传质功能并不显著。超声波是一种高频机械波,具有湍动效应微扰效应界面效应和聚能效应等,但超声波所产生的热效应不显著,且局限在空化泡周围的极小范围。将它们两者结合起来,协同作用有利于破壁组分释放等,即通过微波-超声波协同强化提取技术可获取一种高效价廉无污染的生物活性物质的提取方法。
天然植物的细胞壁由纤维素构成,其中植物的有效成分往往被包裹在细胞壁内。酶提取法就是利用纤维素酶果胶酶蛋白酶等(主要是纤维素酶),破坏植物的细胞壁,以促使植物有效成分最大限度溶解分离出的一种方法。在酶提取法的提取工艺中,酶的选择、酶浓度、pH值、酶解温度、酶解时间都会影响植物提取物的提取率。
在一些实施方式中,本发明的强体防癌调理“三高”抗衰老组合物中还可以加入适量的纳豆激酶。纳豆激酶是纳豆发酵过程中由纳豆枯草杆菌产生的一种丝氨酸蛋白酶。具有溶解血栓、降低血粘度、改善血液循环,软化血管和增加血管弹性等作用。因为纳豆激酶可以溶解血栓,并且安全、无毒副作用,因此可以说目前来说是抗击血栓的强大战力。
本发明的抑菌复合物并没有特别限定其剂型,可以根据本领域技术人员所熟知的方式制备成常规剂型进行使用。
在一些实施方式中,所述复合物的剂型为胶囊剂、丸剂、片剂、口服液、保健茶、固体饮料、糖果压片及药(物)品中的一种。
此外,本发明中可以将组合物制成饮料(含固体饮料)、糖果压片等预包装食品、保健食品、膳食类食品、医用营养食品等做为临床辅助治疗。
在一些实施方式中,所述抗衰老组合物中还包含地龙。可以根据实际需要进行添加,也可以不添加。
本发明中所述地龙别名蚓、蛐蟮、曲虫、土蟺、赤虫,巨蚓科动物参环毛蚓Pheretima aspergillum(E.Perrier)、通俗环毛蚓Pheretima vulgaris Chen、威廉环毛蚓Pheretima guillelmi(Michaelsen)或栉盲环毛蚓Pheretima pectinifera Michaelsen的干燥体。其富含众多化学成分,例如参环毛蚓和背暗异唇蚓含溶血成分:蚯蚓素(lumbritin),解热成分:蚯蚓解热碱(lumbrofebin),有毒成分:蚯蚓毒素(terrestro-lumbrilysin)等。还含6-羟基嘌呤(hypoxanthine),黄嘌呤(xanthine),腺嘌呤(adenine),鸟嘌呤(guanine),胍(guanidine),胆碱(choline),以及丙氨酸(alanine),缬氨酸(valine),亮氨酸(leucine),苯丙氨酸(phenylalanine),酪氨酸(tyrosine),赖氨酸(lysine)等氨基酸。我国市面出售的赤子爱胜蚓和美国红蚓即红色爱胜蚓的杂交种,称为“大平二号蚓”,其中含有天冬氨酸(aspartic acid),苏氨酸(threonine),丝氨酸(serine),谷氨酸(glutamic acid),甘氨酸(glycine),丙氨酸,缬氨酸,蛋氨酸(methionine),异亮氨酸(isoleucine),亮氨酸,酪氨酸,苯丙氨酸,赖氨酸,组氨酸(histidine),精氨酸(arginine),脯氨酸(proline)和锌、铜、铁、铬、硒、钼、佤、镁等元素。近年从赤子爱性蚓体内找出血小板活化因子(platelet activating factor),其前体物质1-O-烷基-2-酰基-sn-甘油-3-磷酸胆碱 (1-O-alkyl-2-acyl-sn-glycerophosphocholine)占磷脂酰胆碱(phosphatidylcholine) 的比例高达61.4%等。
地龙具有清热定惊、通络平喘、利尿等功效。地龙具有清热定惊,通络平喘,利尿的功效。经常临床用于治疗身体出现的高热神昏,惊痫抽搐,关节疼痛,肺热咳嗽,尿少水肿,高血压等疾病的治疗。另外,含有丰富的氨基酸,对于身体的补充和调理都有良好的益处。对于身体出现的高热惊痫、癫狂,具有解痉;对于小孩出现的惊风、高热抽搐,有良好的治疗。另外,对于身体出现的闭证和半身不遂,因为地龙具有通络作用,可以通过疏通血脉、肢体关节不利的作用,解除疼痛以及痹症的表现症状。另外,可以清肺平喘,对于身体出现的肺热、肺失宣降的喘息、喉中痰鸣,都有良好的调理治疗作用。还具有利尿清热的功效,对于身体出现的热证、小便不通、尿闭等都有良好的调理和治疗。
本发明的第二个方面提供了如上所述的强体防癌调理“三高”抗衰老组合物在制备治疗、改善或预防高血压、高血糖、高血脂的保健品或药物中的应用。
在一些实施方式中,所述保健品为补充膳食营养的保健食品,其包括预包装食品、保健食品、膳食类食品、医用营养食品及药(物)品。
此外,本申请的强体防癌调理“三高”抗衰老组合物还可以额外加入复合矿物质、复合维生素、核桃粉、芝麻粉等成分,用以对人体微量元素和维生素的补充。此外,核桃粉、芝麻粉等成分中富含DHA等改善大脑活性成分,能够有助于使青少年注意力集中,改善精气神,提高智力,起到显著的益智效果。
本发明中的组合物在制备过程中,可以将组分A和B组分中的众多成分单独提取,然后相混合制备得到,也可以将众多成分事先混合,然后一起提取制备。A组分和B组分中的单独组分,可以自行提取,也可以从市面上购买使用。
下面通过实施例对本发明进行具体描述。有必要在此指出的是,以下实施例只用于对本发明作进一步说明,不能理解为对本发明保护范围的限制,该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整,仍属于本发明的保护范围。
实施例
实施例1:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1:1;
所述A组分的制备原料,以重量份计,包括:
菝葜 45份;
人参 35份;
黄芪 38份;
所述B组分的制备原料,以重量份计,包括:
实施例2:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.5:1;
所述A组分的制备原料,以重量份计,包括:
茯苓 50份;
人参 25份;
黄芪 45份;
所述B组分的制备原料,以重量份计,包括:
实施例3:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
实施例4:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
实施例5:本实施例提供了一种养生防癌菝葜抑菌复合物,其包括A组分和 B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为22wt%,购自宣城百草药业有限公司。
实施例6:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
实施例7:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
菝葜 45份;
人参 35份;
半支莲 20份;
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
实施例8:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
实施例9:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
实施例10:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
菝葜 45份;
人参 35份;
黄芪 38份;
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司。
申请人将上述实施例中的种强体防癌调理“三高”抗衰老组合物按照常规的重要制作流程研磨过筛,混合制成丸剂,并将其按照随机数字表法分组,分为 1-8组。
实验组1:采用实施例3中的丸剂;
实验组2:采用实施例4中的丸剂;
实验组3:采用实施例5中的丸剂;
实验组4:采用实施例6中的丸剂;
实验组5:采用实施例7中的丸剂;
实验组6:采用实施例8中的丸剂;
实验组7:采用实施例9中的丸剂;
实验组8:采用实施例10中的丸剂。
使用方法:每日三次,饭前咀嚼,温水服用,周期为4周,实验期间保持均衡饮食,保证正常的生活起居。
疗效评定标准:
(1)治愈:高血压、高血脂、高血糖各项指标恢复在正常范围值内;
(2)有效:高血压、高血脂、高血糖原有指标明显改善,大多指标趋于正常范围值内;
(3)无效:高血压、高血脂、高血糖原有指标没有得到改善,或者改善不明显,大多指标仍在超出正常范围值。
表1疗效结果
人数 | 治愈 | 有效 | 无效 | 有效率 | |
实验组1 | 58 | 44 | 14 | 0 | 100% |
实验组2 | 55 | 28 | 16 | 11 | 80% |
实验组3 | 57 | 37 | 13 | 7 | 88% |
实验组4 | 55 | 31 | 18 | 6 | 89% |
实验组5 | 58 | 32 | 16 | 10 | 82% |
实验组6 | 60 | 33 | 18 | 9 | 85% |
实验组7 | 59 | 32 | 18 | 9 | 85% |
实验组8 | 58 | 37 | 15 | 6 | 89% |
其次,根据上述实验组中参与实验人员在使用丸剂过程中出现的不适,对上述丸剂的副作用进行分1~4级,其中1级为没有出现明显的不适,或者出现轻微的胀气;2级为出现明显的胀气以及轻微的头晕、恶心等情况;3级为出现较严重的恶心、呕吐等情况;4级为出现至少一次便血的情况。
表2疗效副作用
此外,申请人对上述实施例中的抑菌复合物进行了抑菌测试:取1g上述实施例中的复合物,加入20ml的50wt%乙醇溶液后搅拌溶解后得到植物源抑菌剂溶液,保存以备用,然后分别将大肠杆菌和炭疽杆菌接种于试管培养基中,在恒温箱中37℃下培养48小时后加入无菌处理的蒸馏水,震荡得到实验菌悬浊液。取15ml融化的SOB培养基,并置于灭菌平皿内,然后分别滴加1ml实验菌种,并使其铺平平皿底部。待培养基凝固后,在每个平板上立放4个牛津杯,然后分别加入0.1ml植物源抑菌剂溶液,在37℃培养24小时后分别量取抑菌圈直径的大小(单位:mm),对抑菌结果进行分级,抑菌圈直径小于9mm则评为1级;抑菌圈直径在9mm≤d≤12mm为2级;抑菌圈直径在12mm<d≤14mm为3级;抑菌圈直径大于14mm为4级。
表3抑菌试验结果
大肠杆菌 | 炭疽杆菌 | |
实验组1 | 4级 | 4级 |
实验组2 | 3级 | 3级 |
实验组3 | 4级 | 3级 |
实验组4 | 4级 | 3级 |
实验组6 | 3级 | 3级 |
实验组7 | 3级 | 3级 |
实验组8 | 3级 | 2级 |
从上述实验结果中可以看出,本发明中的强体防癌调理“三高”抗衰老组合物具有优异的降血压、降血糖、降血脂的作用,有助于改善人体血液循环,具备改善身体状况,增强免疫力、抗病原微生物、抗病毒,能祛风利湿、解毒消毒的功效。此外,本发明组分均为天然中草药,长期服用不会损伤脏器,也不会产生抗药性,具有养生防癌的效果,安全无毒副作用。
实施例11:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司;所述矿物质中含有锂、钙和镁,其总含量站矿物质重量的60wt%。
实施例12:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司;所述矿物质中含有锂、钙和镁,其总含量站矿物质重量的60wt%;所述复合维生素由VA、VD、VB1和辅料组成,其中,每100g 复合维生素中包括700μ0维生的VA、20μ0的VD和500D维的VB1,余量为辅料,辅料为麦芽糊精。
实施例13:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1.2:1;
所述A组分的制备原料,以重量份计,包括:
所述B组分的制备原料,以重量份计,包括:
所述葛根为葛根的去离子水提取物,所述葛根提取物中总黄酮含量为58wt%,购自宣城百草药业有限公司;所述矿物质中含有锂、钙和镁,其总含量站矿物质重量的60wt%;所述复合维生素由VA、VD、VB1和辅料组成,其中,每100g 复合维生素中包括700μgRE的VA、20μg的VD和500μg的VB1,余量为辅料,辅料为麦芽糊精。
实施例14:本实施例提供了一种强体防癌调理“三高”抗衰老组合物,其包括A组分和B组分,其中A组分与B组分之间的重量比例为1:1;
所述A组分的制备原料,以重量份计,包括:
菝葜 45份;
人参 35份;
黄芪 38份;
所述B组分的制备原料,以重量份计,包括:
申请人在原实施例3的基础上额外添加复合矿物质、复合维生素、地龙等成分,得到了强体防癌和调理三高效果更好的抗衰老组合物。此外,申请人将上述实施例11、实施例12、实施例13中的组合物中的原料经搅拌混合之后烘干,采用研磨设备研磨粉碎,利用分筛设备进行分筛,质检得到固体饮料粉,并制备得到固体饮料。将上述实施例11和12中的固体饮料粉食用之后收到很好的反馈,饮用2~3周左右之后明显能够改善体验者睡眠,改善身体状况。此外,上述实施例13中组合物制备得到的固体饮料中富含大量的DHA等成分,有显著改善儿童的精神状态,长期食用之后有效改善儿童注意力,达到一定程度的益智效果,收到家长们的正面反馈。
综上,本发明中的强体防癌调理“三高”抗衰老组合物具有优异的降血压、降血糖、降血脂的作用,其中富含的泛酸、烟酰胺(NMN、NAD烟酰胺能使 NMN从而快速提升NAD水平,增加胰岛素的分泌,改善腺粒体功能,增加脂肪分解、调节血脂、血糖,有助于改善人体血液循环,具备改善身体状况,增强免疫力、抗病原微生物、抗病毒,能祛风利湿、解毒消毒的功效。此外,本发明组分均为天然中草药,长期服用不会损伤脏器,也不会产生抗药性,利用其中富含的NMN、NAD、DHA、各类氨基酸等成分达到养生防癌、抗衰老、益智的效果,安全无毒副作用。
前述的实例仅是说明性的,用于解释本发明所述方法的一些特征。所附的权利要求旨在要求可以设想的尽可能广的范围,且本文所呈现的实施例仅是根据所有可能的实施例的组合的选择的实施方式的说明。因此,申请人的用意是所附的权利要求不被说明本发明的特征的示例的选择限制。在权利要求中所用的一些数值范围也包括了在其之内的子范围,这些范围中的变化也应在可能的情况下解释为被所附的权利要求覆盖。
Claims (10)
1.一种强体防癌调理“三高”抗衰老组合物,其特征在于,其制备原料包括组分A和组分B,其中组分A和组分B的重量比例为(1:2)~(2:1);所述组分A包括菝葜和/或茯苓、人参、五味子和/或灵芝;所述组分B包括葛根、玉米须、甘草和黄精。
2.根据权利要求1所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述组分A的制备原料还包括黄芪和/或半支莲。
3.根据权利要求1所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述组分B的制备原料还包括山药、山楂、鸡内金中的一种或多种。
4.根据权利要求3所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述组分B的制备原料还包括栀子。
5.根据权利要求4所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述栀子和山药的重量相同。
6.根据权利要求2所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述组分A的制备原料,以重量份计,包括10~50份菝葜或茯苓、10~50份人参、10~50份黄芪、10~50份半支莲。
7.根据权利要求4所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述组分B的制备原料,以重量份计,包括10~50份葛根、10~50份玉米须、10~50份甘草、10~50份黄精、10~50份山药、10~50份栀子。
8.根据权利要求1~7任意一项所述的强体防癌调理“三高”抗衰老组合物,其特征在于,所述复合物的剂型为胶囊剂、丸剂、片剂、口服液、保健茶、固体饮料、糖果压片及药品中的一种。
9.根据权利要求1~8任意一项所述的强体防癌调理“三高”抗衰老组合物在制备治疗、改善或预防高血压、高血糖、高血脂的保健品或药物中的应用。
10.根据权利要求9所述的应用,其特征在于,所述保健品为补充膳食营养的保健食品,其包括预包装食品、保健食品、膳食类食品、医用营养食品及药(物)品。
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