CN108473973A - 包含负载蛋白的外泌体的组合物以及制备和递送该组合物的方法 - Google Patents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
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KR10-2016-0126335 | 2016-09-30 | ||
KR1020160126961A KR101912315B1 (ko) | 2016-09-30 | 2016-09-30 | Bax 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물 |
KR1020160126335A KR101877010B1 (ko) | 2016-09-30 | 2016-09-30 | super-repressor-IκB 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 염증성 질환 예방 및 치료용 약학적 조성물 |
KR1020160126921A KR101912313B1 (ko) | 2016-09-30 | 2016-09-30 | Cre 재조합 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 표적 유전자의 조건적 녹아웃 대립유전자를 생성하기 위한 조성물 |
KR10-2016-0126961 | 2016-09-30 | ||
KR10-2016-0126921 | 2016-09-30 | ||
KR10-2016-0127486 | 2016-10-04 | ||
KR1020160127486A KR101912310B1 (ko) | 2016-10-04 | 2016-10-04 | 페록시레독신 i 또는 ii 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 유효성분으로 함유하는 항산화용 약학적 조성물 |
KR10-2016-0132616 | 2016-10-13 | ||
KR1020160132616A KR101900465B1 (ko) | 2016-10-13 | 2016-10-13 | CRISPR-CAS family를 이용한 게놈 에디팅 툴을 엑소솜으로 전달하는 기술 |
KR10-2017-0018637 | 2017-02-10 | ||
KR20170018637 | 2017-02-10 | ||
PCT/KR2017/011070 WO2018062973A1 (fr) | 2016-09-30 | 2017-09-29 | Compositions contenant un exosome chargé d'une protéine, et procédés de préparation et d'administration correspondants |
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EP (1) | EP3356522A4 (fr) |
JP (1) | JP2019528674A (fr) |
CN (1) | CN108473973A (fr) |
AU (1) | AU2017335084B2 (fr) |
CA (1) | CA3002520A1 (fr) |
IL (1) | IL259023B (fr) |
WO (1) | WO2018062973A1 (fr) |
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CN109097336A (zh) * | 2018-09-07 | 2018-12-28 | 深圳市新仑生物科技有限公司 | 一种干细胞外泌体、制备方法及应用 |
CN110387416A (zh) * | 2018-04-16 | 2019-10-29 | 华东理工大学 | 可控聚合调控功能的纳米金双探针体系及其应用 |
CN110669723A (zh) * | 2019-11-08 | 2020-01-10 | 赵凯 | 一种基于差速离心法的细胞外泌体提取工艺 |
CN110885789A (zh) * | 2018-09-05 | 2020-03-17 | 中国科学院生物物理研究所 | 高效可控包装內源核酸的工程化外泌体制备及其应用 |
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CN113447658A (zh) * | 2021-07-01 | 2021-09-28 | 浙江大学医学院附属儿童医院 | 一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒 |
CN114901259A (zh) * | 2019-12-30 | 2022-08-12 | 伊利亚斯生物制品公司 | 包含携带NF-kB抑制剂的外泌体的组合物及其使用方法 |
WO2022227255A1 (fr) * | 2021-04-28 | 2022-11-03 | 大连干细胞与精准医学创新研究院 | Procédé de préparation d'un vecteur d'administration de protéine cible |
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AU2016275046B2 (en) * | 2015-06-10 | 2022-07-28 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
US10709797B2 (en) | 2017-08-16 | 2020-07-14 | City University Of Hong Kong | Isolation of extracellular vesicles (EVs) from red blood cells for gene therapy |
IL277447B2 (en) * | 2018-04-10 | 2024-04-01 | Brainstorm Cell Therapeutics Ltd | Cell-adapted exosomes and their uses |
WO2020023594A1 (fr) * | 2018-07-24 | 2020-01-30 | Mayo Foundation For Medical Education And Research | Compositions et procédés impliquant la transformation de vésicules extracellulaires |
WO2020060479A1 (fr) * | 2018-09-21 | 2020-03-26 | City University Of Hong Kong | Vésicules extracellulaires avec cargaison |
US11766484B2 (en) * | 2019-01-03 | 2023-09-26 | International Business Machines Corporation | Exosome vessels for delivery of molecular cargo |
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EP4090373A4 (fr) | 2020-01-13 | 2024-01-17 | Carmine Therapeutics Pte. Ltd. | Vésicules extracellulaires de globules rouges chargées d'acide nucléique |
US20230211010A1 (en) | 2020-02-10 | 2023-07-06 | Exostemtech Co., Ltd. | Exosome comprising photocleavable protein, and use thereof |
WO2021198961A1 (fr) * | 2020-03-31 | 2021-10-07 | Ilias Biologics Inc. | Utilisation d'administration d'inhibiteurs de nf-kb à partir d'exosomes |
CN114716548A (zh) | 2021-01-05 | 2022-07-08 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
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- 2017-09-29 CN CN201780003826.5A patent/CN108473973A/zh active Pending
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CN109097336A (zh) * | 2018-09-07 | 2018-12-28 | 深圳市新仑生物科技有限公司 | 一种干细胞外泌体、制备方法及应用 |
CN110669723A (zh) * | 2019-11-08 | 2020-01-10 | 赵凯 | 一种基于差速离心法的细胞外泌体提取工艺 |
CN114901259A (zh) * | 2019-12-30 | 2022-08-12 | 伊利亚斯生物制品公司 | 包含携带NF-kB抑制剂的外泌体的组合物及其使用方法 |
CN114901259B (zh) * | 2019-12-30 | 2024-03-12 | 伊利亚斯生物制品公司 | 包含携带NF-kB抑制剂的外泌体的组合物及其使用方法 |
CN113388584A (zh) * | 2020-03-10 | 2021-09-14 | 路宝特(南京)环保科技有限公司 | 一种促进皮肤组织损伤后修复用工程化外泌体的制备方法及其应用 |
CN111905105A (zh) * | 2020-07-02 | 2020-11-10 | 华南师范大学 | 一种用于癌症靶向治疗的蛋白类纳米药物及其制备方法 |
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CN113447658A (zh) * | 2021-07-01 | 2021-09-28 | 浙江大学医学院附属儿童医院 | 一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒 |
Also Published As
Publication number | Publication date |
---|---|
AU2017335084A1 (en) | 2018-05-10 |
EP3356522A4 (fr) | 2019-03-27 |
EP3356522A1 (fr) | 2018-08-08 |
AU2017335084B2 (en) | 2023-06-29 |
JP2019528674A (ja) | 2019-10-17 |
IL259023B (en) | 2022-09-01 |
CA3002520A1 (fr) | 2018-04-05 |
WO2018062973A1 (fr) | 2018-04-05 |
IL259023A (en) | 2018-07-31 |
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