CN108434217A - A kind of pharmaceutical composition and preparation method thereof for neck, shoulder, arm pain rehabilitation - Google Patents
A kind of pharmaceutical composition and preparation method thereof for neck, shoulder, arm pain rehabilitation Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of pharmaceutical compositions for neck, shoulder, arm pain rehabilitation, belong to pharmaceutical composition technical field.The pharmaceutical composition is made of the raw material of following parts by weight：8 15 parts of rheum officinale, 8 12 parts of myrrh, 8 12 parts of eclipta, 5 10 parts of radix semiaquilegiae, 38 parts of mast, 48 parts windproof, 6 10 parts of lopseed, 5 12 parts of the root of Chinese clematis, 36 parts of radix ranunculi ternati, 25 parts of Borneolum, 26 parts of Sculellaria barbata, 25 parts of Radix Glycyrrhizae, 38 parts of Bidens bipinnata, 14 parts of Inula britannica chinensis.The pharmaceutical composition of the present invention has fine curative effect for neck, shoulder, arm pain, has better effect particularly with cervical spondylosis and scapulohumeral periarthritis, has promoting blood circulation and removing blood stasis, anti-inflammation detumescence, lenitive good result, and substantially without side-effects, does not recur substantially.
Description
Technical field
The present invention relates to pharmaceutical composition technical fields, and in particular to a kind of medicine group for neck, shoulder, arm pain rehabilitation
Close object and preparation method thereof.
Background technology
People are either engaged in manual labor or mental labour, all often mainly have by the pain of neck shoulder arm
Cervical spondylosis and scapulohumeral periarthritis etc., pathogenic factor is complicated, and protracted course, recurrent exerbation causes patients ' life quality to decline.It controls at present
There are many method for treating neck shoulder arm pain, include mainly drug therapy, physiotherapy, acupuncture, massage etc..Wherein, western medicine is normal
Analgesic-antipyretic is selected, it is with obvious effects in short-term, but take for a long time, side effect is very big, is easily recurred after discontinuing medication.
Because the invention it is a kind of it is significant in efficacy, substantially without side-effects in neck, shoulder, arm pain rehabilitation pharmaceutical composition and its
Preparation method has great practical value.
Invention content
The present invention provides a kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation, can solve in the prior art
State problem.
The present invention provides a kind of pharmaceutical compositions for neck, shoulder, arm pain rehabilitation, by the raw material system of following parts by weight
At：8-15 parts of rheum officinale, 8-12 parts of myrrh, 8-12 parts of eclipta, 5-10 parts of radix semiaquilegiae, 3-8 parts of cape jasmine, 4-8 parts windproof, lopseed
6-10 parts, 5-12 parts of the root of Chinese clematis, 3-6 parts of radix ranunculi ternati, 2-5 parts of Borneolum, 2-6 parts of Sculellaria barbata, 2-5 parts of Radix Glycyrrhizae, 3-8 parts of Bidens bipinnata,
1-4 parts of Inula britannica chinensis.
Preferably, described pharmaceutical composition is made of the raw material of following parts by weight：12 parts of rheum officinale, 10 parts of myrrh, eclipta 9
Part, 6 parts of radix semiaquilegiae, 5 parts of cape jasmine, 5 parts windproof, 8 parts of lopseed, 7 parts of the root of Chinese clematis, 5 parts of radix ranunculi ternati, 3 parts of Borneolum, 4 parts of Sculellaria barbata,
4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
Preferably, described pharmaceutical composition is made of the raw material of following parts by weight：10 parts of rheum officinale, 9 parts of myrrh, eclipta 10
Part, 8 parts of radix semiaquilegiae, 6 parts of cape jasmine, 6 parts windproof, 6 parts of lopseed, 8 parts of the root of Chinese clematis, 4 parts of radix ranunculi ternati, 4 parts of Borneolum, 5 parts of Sculellaria barbata,
4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
Preferably, described pharmaceutical composition is made of the raw material of following parts by weight：10 parts of rheum officinale, 10 parts of myrrh, eclipta
11 parts, 7 parts of radix semiaquilegiae, 5 parts of cape jasmine, 8 parts windproof, 8 parts of lopseed, 8 parts of the root of Chinese clematis, 3 parts of radix ranunculi ternati, 2 parts of Borneolum, Sculellaria barbata 3
Part, 5 parts of Radix Glycyrrhizae, 8 parts of Bidens bipinnata, 4 parts of Inula britannica chinensis.
Preferably, described pharmaceutical composition is made of the raw material of following parts by weight：8 parts of rheum officinale, 12 parts of myrrh, eclipta 10
Part, 10 parts of radix semiaquilegiae, 5 parts of cape jasmine, 6 parts windproof, 6 parts of lopseed, 10 parts of the root of Chinese clematis, 4 parts of radix ranunculi ternati, 3 parts of Borneolum, Sculellaria barbata 5
Part, 5 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 2 parts of Inula britannica chinensis.
The present invention provides the preparation methods of the pharmaceutical composition for neck, shoulder, arm pain rehabilitation, using following step
It is rapid to prepare：
Step 1：By each raw material drying, to be crushed to 80-120 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 8-10 times of total powder weight is added in mixing
Water, impregnate 2-4 hour, be heated to boiling, heat preservation 0.5-2 hours, filter to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 0.5~5 times of water of total powder weight, decocts 0.5~2h, mistake
Filter, obtains filtrate, merges filtrate twice, by the 30-80% of filtrate concentration front volume for it, waits for that filtrate is cooled to 50-65 DEG C, then
The ethyl alcohol of the filtrate volume 40~60% after accounting for concentration is added, carries out alcohol precipitation, ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.05-1.16 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, it is dry to extrude grain, obtain drug granule.
Preferably, the step 4：It is 1.10 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, is extracted
Liquid.
The pharmacology of each raw material in this pharmaceutical composition is as follows：
Rheum officinale：It is bitter in taste, it trembles with fear.Real heat constipation is cured mainly, accumulation of heat in chest ruffian, damp-heat dysentery, jaundice, gonorrhoea, oedema abdomen is full, urine
Unfavorable, hot eyes, abscess of throat, aphthae, gastropyretic vomiting spits blood, and spitting of blood, bleeding from five sense organs or subcutaneous tissue has blood in stool, hematuria, stores blood, Amenorrhea, postpartum
Stasis of blood, a lump in the abdomen causing distension and pain, traumatic injury, heat toxin large carbuncle, erysipelas, the diseases such as scald.
Myrrh：Hardship, it is pungent, it puts down.Enter spleen, kidney two warp.Cure mainly chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, Disorder lumps in the abdomen, traumatic injury, carbuncle swells sore
Ulcer, acute appendicitis, red eye, swell pain.There are promoting blood circulation and stopping pain, detumescence and promoting granulation and other effects.Drug for invigorating blood circulation and eliminating stasis.
Eclipta：Nature and flavor：It is sweet, sour, it trembles with fear.Channel tropism：Return kidney, Liver Channel.Major function：It is nourishing liver and kidney, cooling blood and hemostasis.For tooth
Loose compact, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, wound
Bleeding.
Radix semiaquilegiae：Sweet in flavor, slight bitter, micro-pungent are cold in nature, Return liver, spleen, bladder warp, have clearing heat and detoxicating；Dispersing swelling and dissipating binds；Li Shui
Treating stranguria effect.It is frightened to cure mainly children's heat；Epilepsy；Carbuncle swells；Furunculosis；Acute mastitis；Scrofula；Skin is itched sore；Red eye, swell pain；Pharyngalgia；Snakeworm
It bites；Heat gonorrhea；The cards such as sand leaching.
Cape jasmine：Smell is bitter, cold, nontoxic.Thoughts of returning home warp；Liver Channel；Lung channel；Stomach；Tri-jiao channel.It is removed for clearing heat-fire, purging intense heat
Tired, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.It cures mainly：Vexed；Irascibility hot eyes；Headache；Jaundice with damp-heat pathogen；Stranguria；Bloody flux
Hematuria；Aphthae；Sore swollen toxin；Sprain swelling and pain.
It is windproof：Acrid flavour, sweet, slightly warm in nature.Return bladder, liver, the spleen channel.It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion is jerked surely.It cures mainly outer
Feel exterior syndrome, rubella itch, arthralgia pain due to rheumatism, lockjaw.
Lopseed：Nature and flavor sweet, acrid, warm.Return lung, liver two pass through.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution poison rash.
The root of Chinese clematis：Bitter, temperature are nontoxic.With dispelling wind and eliminating dampness, the effect of removing obstruction in channels to relieve pain.For arthralgia pain due to rheumatism, limbs fiber crops
Wood, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs the diseases such as larynx.
Radix ranunculi ternati：Sweet in flavor, pungent, slightly warm in nature, Return liver, lung channel have the effect of reducing phlegm and resolving masses, removing toxicity for detumescence, cure mainly scrofula
Subcutaneous nodule, furunculosis, worm snake bite, migraine, malaria, toothache.Pulmonary tuberculosis, scrofula, lymphnoditis, the cards such as sphagitis, cat
The ranunculus ternatus lactone contained in pawl grass can enhance the killing activity of body cell cytotoxic T cell, reach anti-drug resistance M tuberculosis
The purpose of bacillus.
Borneolum：Gas faint scent, it is acrid flavour, hardship, cool；The thoughts of returning home, spleen, lung channel；Logical all keys are cured mainly, stagnated fire is dissipated, swelling and pain relieving goes screen bright
Mesh.For apoplexy lockjaw, carbuncle phlegm confusing heart is shied.Larynx numbness dentalgia, aphtha Yong Yi, hot eyes skin screen are controlled in external application.
Sculellaria barbata：All herbal medicine has the function of clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving, anticancer etc..It is cold in nature sour, entirely
Grass is containing ingredients such as multivitamin, trace element and amino acid.There are removing pattogenic heat from the blood and toxic material from the body, removing blood stasis and analgesics, the work(of detumescence and clearing heat and promoting diuresis
Effect.
Radix Glycyrrhizae：Sweet tea sweet in flavor, it is mild-natured and, enter the heart, spleen, lung, stomach four pass through.It is raw with cooler, can purging intense heat and detonicating, relieving spasm to stop pain；Toast
With partial temperature, exterior cold, tonifying middle-Jiao and Qi can be dissipated.In addition, Radix Glycyrrhizae is also good at mediation property of medicine, the poison of hundred medicines is solved.
Bidens bipinnata：Bitter；Cold nature.Return liver, lung, large intestine channel.Function with cure mainly：Clearing heat and detoxicating, antidiarrheal of stopping blooding dissipates stagnation resolvation
It is swollen.For appendicitis, ephritis, cholecystitis, enteritis, bacillary dysentery, hepatitis, peritonitis, the infection of the upper respiratory tract, tonsillitis,
Laryngitis, amenorrhoea, scald, venomous snake bite, traumatic injury, skin infection, the diseases such as child convulsion, infantile malnutrition due to digestive disturbances or intestinalparasites.
Inula britannica chinensis：Bitter；It is pungent；It is salty；Tepor.Return lung；Stomach；Large intestine channel.Sending down abnormally ascending, dissolving phlegm, row water, preventing or arresting vomiting.For chill cough
It coughs, phlegm and retained fluid stores knot, chest diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomits gas, epigastric fullness and rigidity.
Compared with prior art, the beneficial effects of the invention are as follows：The pharmaceutical composition of the present invention is for neck, shoulder, arm pain
There is fine curative effect, have better effect particularly with cervical spondylosis and scapulohumeral periarthritis, there is promoting blood circulation and removing blood stasis, anti-inflammation detumescence, lenitive
Good result, and it is substantially without side-effects, it does not recur substantially.
Specific implementation mode
The specific implementation mode of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
It is restricted by specific implementation.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creativeness
The every other embodiment obtained under the premise of labour, shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation is made of the raw material of following parts by weight：By following heavy
The raw material of amount part is made：12 parts of rheum officinale, 10 parts of myrrh, 9 parts of eclipta, 6 parts of radix semiaquilegiae, 5 parts of cape jasmine, 5 parts windproof, lopseed 8
Part, 7 parts of the root of Chinese clematis, 5 parts of radix ranunculi ternati, 3 parts of Borneolum, 4 parts of Sculellaria barbata, 4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
Preparation method includes the following steps：
Step 1：By each raw material drying, to be crushed to 80 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 10 times of total powder weight are added in mixing
Water impregnates 3 hours, is heated to boiling, and keeps the temperature 1 hour, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 4 times of water of total powder weight, decocts 1h, and filtering obtains filtrate,
Merge filtrate twice, filtrate is concentrated the 60% of front volume for it, waits for that filtrate is cooled to 60 DEG C, adds the filtrate after accounting for concentration
The ethyl alcohol of volume 50% carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.10 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, it is dry to extrude grain, obtain drug granule.
Embodiment 2：
A kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation is made of the raw material of following parts by weight：10 parts of rheum officinale,
9 parts of myrrh, 10 parts of eclipta, 8 parts of radix semiaquilegiae, 6 parts of cape jasmine, 6 parts windproof, 6 parts of lopseed, 8 parts of the root of Chinese clematis, 4 parts of radix ranunculi ternati, plum
4 parts of piece, 5 parts of Sculellaria barbata, 4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
Preparation method includes the following steps：
Step 1：By each raw material drying, to be crushed to 100 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 9 times of total powder weight are added in mixing
Water impregnates 3.5 hours, is heated to boiling, and keeps the temperature 1 hour, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 3 times of water of total powder weight, decocts 1.5h, and filtering is filtered
Liquid merges filtrate twice, and filtrate is concentrated the 70% of front volume for it, waits for that filtrate is cooled to 65 DEG C, is added after accounting for concentration
The ethyl alcohol of filtrate volume 55% carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.13 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, it is dry to extrude grain, obtain drug granule.
Embodiment 3：
A kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation is made of the raw material of following parts by weight：10 parts of rheum officinale,
10 parts of myrrh, 11 parts of eclipta, 7 parts of radix semiaquilegiae, 5 parts of cape jasmine, 8 parts windproof, 8 parts of lopseed, 8 parts of the root of Chinese clematis, 3 parts of radix ranunculi ternati,
2 parts of Borneolum, 3 parts of Sculellaria barbata, 5 parts of Radix Glycyrrhizae, 8 parts of Bidens bipinnata, 4 parts of Inula britannica chinensis.
Preparation method includes the following steps：
Step 1：By each raw material drying, to be crushed to 110 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 8 times of total powder weight are added in mixing
Water impregnates 3 hours, is heated to boiling, and keeps the temperature 1.5 hours, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 3 times of water of total powder weight, decocts 0.5h, and filtering is filtered
Liquid merges filtrate twice, and filtrate is concentrated the 70% of front volume for it, waits for that filtrate is cooled to 65 DEG C, is added after accounting for concentration
The ethyl alcohol of filtrate volume 45% carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.08 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, auxiliary material is added, it is dry to extrude grain, obtain drug
Grain.
Embodiment 4：
A kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation is made of the raw material of following parts by weight：8 parts of rheum officinale,
12 parts of myrrh, 10 parts of eclipta, 10 parts of radix semiaquilegiae, 5 parts of cape jasmine, 6 parts windproof, 6 parts of lopseed, 10 parts of the root of Chinese clematis, radix ranunculi ternati 4
Part, 3 parts of Borneolum, 5 parts of Sculellaria barbata, 5 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 2 parts of Inula britannica chinensis.
Preparation method includes the following steps：
Step 1：By each raw material drying, to be crushed to 100 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 8 times of total powder weight are added in mixing
Water impregnates 3 hours, is heated to boiling, and keeps the temperature 1.5 hours, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 3 times of water of total powder weight, decocts 0.5h, and filtering is filtered
Liquid merges filtrate twice, and filtrate is concentrated the 70% of front volume for it, waits for that filtrate is cooled to 65 DEG C, is added after accounting for concentration
The ethyl alcohol of filtrate volume 45% carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.12 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, auxiliary material is added, it is dry to extrude grain, obtain drug
Grain.
Clinical application
In order to verify therapeutic effect of the pharmaceutical composition to neck, shoulder, arm pain of the present invention, we have done following clinical examination
It tests.
One, it is directed to cervical spondylosis
1, test method
We choose treatment patient with cervical Spondylopathy 120, wherein man 60, female 60, average age 46 years old, medical history are most short by 3
A month, longest 15 years was divided into four test groups and a control group, and four test groups take embodiment prepared by the present invention respectively
The pharmaceutical composition of 1-4, control group use certain commercially available Chinese medicine, and Gender, age, course of disease of five groups etc. are through statistical analysis
It is comparable.
2, therapy
Four test groups are each taking drug 5.0g, twice daily, 7 days as one therapeutic course.5 groups take two courses for the treatment of.
3, curative effect determinate standard
It is effective：Pain numbness sense completely disappears, and dermal sensation numbness area disappears, and neck activity is normal.
Effectively：Pain numbness sense is substantially reduced, and dermal sensation numbness area is reduced, and neck activity is normal.
In vain：The above symptom is without being clearly better, some even aggravations.
4, test result
Test result is shown in Table 1.
1 test group of table and control group efficacy result
Interpretation of result：As it can be seen from table 1 the effect of pharmaceutical composition of each embodiment of the present invention, is superior to compare
Group, it is significant in efficacy.Follow-up 1 year, no recurrence.
Two, it is directed to scapulohumeral periarthritis
1, test method
We choose cure scapulohumeral periarthritis patient 120, wherein man 60, female 60, average age 43 years old, medical history are most short by 2
A month, longest 10 years was divided into two test groups and a control group, and two test groups take embodiment prepared by the present invention respectively
The pharmaceutical composition of 1-2, control group use certain commercially available Chinese medicine, and Gender, age, course of disease of three groups etc. are through statistical analysis
It is comparable.
2, therapy
Three test groups are each taking drug 5.0g, twice daily, 7 days as one therapeutic course.3 groups take two courses for the treatment of.
3, curative effect determinate standard
It is effective：Pain numbness sense completely disappears, and dermal sensation numbness area disappears, and neck activity is normal.
Effectively：Pain numbness sense is substantially reduced, and dermal sensation numbness area is reduced, and neck activity is normal.
In vain：The above symptom is without being clearly better, some even aggravations.
4, test result
Test result is shown in Table 2.
2 test group of table and control group efficacy result
Follow-up 1 year, no recurrence.
Three, zoopery
1 experiment purpose
To the Traditional Chinese medicine composition formula of embodiment 1, rheum officinale, myrrh, eclipta, radix semiaquilegiae, cape jasmine, windproof, deep is weighed
Grass, the root of Chinese clematis, radix ranunculi ternati, Borneolum, Sculellaria barbata, Radix Glycyrrhizae, Bidens bipinnata, Inula britannica chinensis, crush respectively, are uniformly mixed, then according to normal
Powder is made in rule method, and makes evaluation to its acute toxicity, and experimental basis is provided for data for clinical drug use.
2 experiment materials
2.1 test medicine：The Traditional Chinese medicine composition formula of embodiment 1 weighs rheum officinale, myrrh, eclipta, radix semiaquilegiae, Cape jasmine
Sub, windproof, lopseed, the root of Chinese clematis, radix ranunculi ternati, Borneolum, Sculellaria barbata, Radix Glycyrrhizae, Bidens bipinnata, Inula britannica chinensis crush respectively, are uniformly mixed
Medicinal mixture is obtained, powder is then conventionally made.
2.2 experimental animal：Kun Ming mice, weight 20g-25g, half male and half female, by Heilongjiang University of Chinese Medicine animal
Experimental center provides.
It is prepared by 2.3 laboratory samples：A certain amount of powder is weighed, is put into mortar and is ground into fine powder, water is added to mix well, is made
At certain density drug suspension.Fine drug powder weight of the dosage by animal per kg body weight calculates.
2.4 method
2.4.1 trial test：20 mouse are randomly divided into 2 groups, every group 10, half male and half female, ig is administered after fasting 16h.
Administration group mouse with biggest quality concentration (0.6g/mL), ig administration can bear maximum volume (40mL/kg), 2 minor tick 6h to
Give drug suspension.Blank group ig equivalent distilled water.As a result successive administration 14 days shows whole mouse survivals, fails to measure this
Tested material LD50 values prompt the tested material toxicity very low, foundation《Chinese medicine, natural drug studies on acute toxicity technological guidance's principle》
Use maximum dosage-feeding administration instead.
2.4.2 the measurement of maximum dosage-feeding：It presses mass of object and divides 2 groups (administration group and control groups) at random, every group 30
Only, half male and half female.After fasting 16h, mouse ig gives tested material biggest quality concentration 0.6g/mL and maximum ig administration volumes
40mL/kg, daily ig are administered 2 times, are spaced 6h.Blank group ig equivalent distilled water.It is observed continuously in 4h after administration, daily morning and afternoon
Each observation 1 time, is observed continuously 14 days.Observe animal body quality, the state of mind, hair color, autonomic activities, breathing, diet, two just,
The general states such as mouth and nose secretion, and the appearance of record symptom, recovery and death time in detail.Weight measures：Buy day, animal
It measures 1 time when grouping, after administration every 2 days, measures 1 time when animal dissect.Entire off-test next day animal dislocation is put to death,
It is dissected.Animal appearance, each internal organs of whole body are visually observed when dissect, make histopathology inspection if noting abnormalities
It looks into.
2.4.3 all data of data processing withIt indicates, comparison among groups are examined using t, are carried out using SPSS17.0
Data analysis.
3 experimental results
The influence of 3.1 pairs of mouse weights
For each group animal to difference trend when off-test, is not showed before experiment, each animal subject weight is in one
The growth for determining degree illustrates the growth for not influencing animal subject after tested material ig is administered, the results are shown in Table 3, table 4.
3.2 toxic reaction
From the administration same day up to off-test, mouse is in good condition, and activity and diet are acted normally, and hair frontlighting is bright,
Formed stools do not occur animal dead situation, also do not observe apparent abnormal response situation.
It is 16g/kg to calculate and always give within 24 hours dose, and the clinical day dosage of adult's (pressing 70kg batheroom scales) is 10g/
70kg (i.e. 0.43g/kg) extrapolates being equivalent to the multiple (multiple=48/0.43=111 times) of clinical day dosage and be more than
100 times, show that the Chinese medicine composition toxicity is relatively low, safe range is big.
The influence of 3.3 pairs of mouse Histopathology
Off-test next day, all animals have carried out gross anatomy observation, and naked eyes do not find that volume, face occurs in organ
The changes such as color, quality.Especially observe the important organs such as brain, the heart, liver, spleen, lung, kidney, have no bleeding, hyperemia, exudation, ulcer,
Perforation, inflammation, thoracic cavity, abdominal cavity and cavum pericardiale show that the Chinese medicine composition toxicity is relatively low, safe range is big without hydrops.
Influence of the table 3 to male mice weight
Influence of the table 4 to female mice weight
The pharmaceutical composition of the present invention has fine curative effect for neck, shoulder, arm pain, particularly with cervical spondylosis and scapulohumeral periarthritis
It has better effect, there is promoting blood circulation and removing blood stasis, anti-inflammation detumescence, lenitive good result, and substantially without side-effects, it is substantially not multiple
Hair.
Although preferred embodiments of the present invention have been described, it is created once a person skilled in the art knows basic
Property concept, then additional changes and modifications may be made to these embodiments.So it includes excellent that the following claims are intended to be interpreted as
It selects embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (7)
1. a kind of pharmaceutical composition for neck, shoulder, arm pain rehabilitation, which is characterized in that be made of the raw material of following parts by weight：
8-15 parts of rheum officinale, 8-12 parts of myrrh, 8-12 parts of eclipta, 5-10 parts of radix semiaquilegiae, 3-8 parts of cape jasmine, 4-8 parts windproof, lopseed 6-
10 parts, 5-12 parts of the root of Chinese clematis, 3-6 parts of radix ranunculi ternati, 2-5 parts of Borneolum, 2-6 parts of Sculellaria barbata, 2-5 parts of Radix Glycyrrhizae, 3-8 parts of Bidens bipinnata, rotation
It covers 1-4 parts colored.
2. the pharmaceutical composition for neck, shoulder, arm pain rehabilitation as described in claim 1, which is characterized in that by following weight
The raw material of part is made：12 parts of rheum officinale, 10 parts of myrrh, 9 parts of eclipta, 6 parts of radix semiaquilegiae, 5 parts of cape jasmine, 5 parts windproof, 8 parts of lopseed,
7 parts of the root of Chinese clematis, 5 parts of radix ranunculi ternati, 3 parts of Borneolum, 4 parts of Sculellaria barbata, 4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
3. the pharmaceutical composition for neck, shoulder, arm pain rehabilitation as described in claim 1, which is characterized in that by following weight
The raw material of part is made：10 parts of rheum officinale, 9 parts of myrrh, 10 parts of eclipta, 8 parts of radix semiaquilegiae, 6 parts of cape jasmine, 6 parts windproof, 6 parts of lopseed,
8 parts of the root of Chinese clematis, 4 parts of radix ranunculi ternati, 4 parts of Borneolum, 5 parts of Sculellaria barbata, 4 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 3 parts of Inula britannica chinensis.
4. the pharmaceutical composition for neck, shoulder, arm pain rehabilitation as described in claim 1, which is characterized in that by following weight
The raw material of part is made：10 parts of rheum officinale, 10 parts of myrrh, 11 parts of eclipta, 7 parts of radix semiaquilegiae, 5 parts of cape jasmine, 8 parts windproof, lopseed 8
Part, 8 parts of the root of Chinese clematis, 3 parts of radix ranunculi ternati, 2 parts of Borneolum, 3 parts of Sculellaria barbata, 5 parts of Radix Glycyrrhizae, 8 parts of Bidens bipinnata, 4 parts of Inula britannica chinensis.
5. the pharmaceutical composition for neck, shoulder, arm pain rehabilitation as described in claim 1, which is characterized in that by following weight
The raw material of part is made：8 parts of rheum officinale, 12 parts of myrrh, 10 parts of eclipta, 10 parts of radix semiaquilegiae, 5 parts of cape jasmine, 6 parts windproof, lopseed 6
Part, 10 parts of the root of Chinese clematis, 4 parts of radix ranunculi ternati, 3 parts of Borneolum, 5 parts of Sculellaria barbata, 5 parts of Radix Glycyrrhizae, 6 parts of Bidens bipinnata, 2 parts of Inula britannica chinensis.
6. the preparation method of the pharmaceutical composition according to any one of claims 1 to 5 for neck, shoulder, arm pain rehabilitation, special
Sign is, is prepared using following steps：
Step 1：By each raw material drying, to be crushed to 80-120 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, then 8-10 times of water of total powder weight is added in mixing,
It impregnates 2-4 hours, is heated to boiling, keep the temperature 0.5-2 hours, filter to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 0.5~5 times of water of total powder weight, decocts 0.5~2h, and filtering obtains
To filtrate, merge filtrate twice, filtrate is concentrated to the 30-80% of front volume for it, waits for that filtrate is cooled to 50-65 DEG C, adds
The ethyl alcohol of the filtrate volume 40~60% after concentration is accounted for, alcohol precipitation is carried out, ethyl alcohol is recovered under reduced pressure after standing 48h；
Step 4：It is 1.05-1.16 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution；
Step 5：By the extracting solution it is spray-dried after dry extract, it is dry to extrude grain, obtain drug granule.
7. being used for the preparation method of the pharmaceutical composition of neck, shoulder, arm pain rehabilitation as claimed in claim 6, which is characterized in that
The step 4：It is 1.10 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains extracting solution.
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| CN110585354A (en) * | 2019-08-07 | 2019-12-20 | 宁夏医科大学 | Formula and preparation method of substitutional tea for preventing and treating oral ulcer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933991A (en) * | 2009-07-03 | 2011-01-05 | 吉林一正药业集团有限公司 | Analgesic and anti-inflammatory medicament and preparation method thereof |
| CN107126482A (en) * | 2017-04-14 | 2017-09-05 | 新疆农业职业技术学院 | A kind of veterinary drug and preparation method for fowl cough |
| CN107320539A (en) * | 2017-07-31 | 2017-11-07 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treating disc herniation |
-
2018
- 2018-05-26 CN CN201810571546.0A patent/CN108434217A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933991A (en) * | 2009-07-03 | 2011-01-05 | 吉林一正药业集团有限公司 | Analgesic and anti-inflammatory medicament and preparation method thereof |
| CN107126482A (en) * | 2017-04-14 | 2017-09-05 | 新疆农业职业技术学院 | A kind of veterinary drug and preparation method for fowl cough |
| CN107320539A (en) * | 2017-07-31 | 2017-11-07 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treating disc herniation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110585354A (en) * | 2019-08-07 | 2019-12-20 | 宁夏医科大学 | Formula and preparation method of substitutional tea for preventing and treating oral ulcer |
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