CN108431042A - 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途 - Google Patents

抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途 Download PDF

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Publication number
CN108431042A
CN108431042A CN201680077315.3A CN201680077315A CN108431042A CN 108431042 A CN108431042 A CN 108431042A CN 201680077315 A CN201680077315 A CN 201680077315A CN 108431042 A CN108431042 A CN 108431042A
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China
Prior art keywords
seq
il1rap
acid sequence
amino acid
antibody
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Pending
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CN201680077315.3A
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Chinese (zh)
Inventor
B.J.黑里奇
J.F.内梅思
W.K.小尼施奥卡
T.丁
R.M.F.卡多索
D.皮祖蒂
B.斯特拉克
J.费希尔
R.M.阿塔
F.戈代
M.E.萨尔瓦蒂
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN108431042A publication Critical patent/CN108431042A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201680077315.3A 2015-11-02 2016-11-01 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途 Pending CN108431042A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562249466P 2015-11-02 2015-11-02
US62/249466 2015-11-02
PCT/US2016/059842 WO2017079121A2 (en) 2015-11-02 2016-11-01 Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof

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CN108431042A true CN108431042A (zh) 2018-08-21

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US (2) US20170121420A1 (https=)
EP (1) EP3371220A2 (https=)
JP (1) JP2018534933A (https=)
KR (1) KR20180072820A (https=)
CN (1) CN108431042A (https=)
AR (1) AR106555A1 (https=)
AU (1) AU2016350705A1 (https=)
BR (1) BR112018008908A2 (https=)
CA (1) CA3003899A1 (https=)
CL (1) CL2018001175A1 (https=)
CO (1) CO2018005695A2 (https=)
CR (1) CR20180250A (https=)
EA (1) EA201891084A1 (https=)
EC (1) ECSP18040535A (https=)
IL (1) IL259082A (https=)
JO (1) JO3800B1 (https=)
MA (1) MA43164A (https=)
MX (1) MX2018005545A (https=)
NI (1) NI201800057A (https=)
PE (1) PE20181310A1 (https=)
PH (1) PH12018500938A1 (https=)
SG (1) SG11201803675RA (https=)
TW (1) TW201734045A (https=)
UY (1) UY36974A (https=)
WO (1) WO2017079121A2 (https=)

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CN113454113A (zh) * 2018-12-21 2021-09-28 23与我公司 抗il-36的抗体及其使用方法
WO2024160076A1 (zh) * 2023-01-30 2024-08-08 北京智仁美博生物科技有限公司 针对人il-36r和/或人il-1r3的多种抗体及其用途
WO2025201513A1 (zh) * 2024-03-29 2025-10-02 珠海丹序生物制药有限公司 抗il1rap抗体及其用途
WO2025209480A1 (zh) * 2024-04-02 2025-10-09 福佑泰生物制药公司 抗il1rap抗体以及其用途

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US9403906B2 (en) 2011-01-19 2016-08-02 Cantargia Ab Method of treatment of a solid tumor with interleukin-1 accessory protein antibody
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
SI3371171T1 (sl) 2015-11-02 2024-03-29 Blueprint Medicines Corporation Inhibitorji ret
MX2018005232A (es) * 2015-11-03 2018-08-15 Ambrx Inc Anticuerpos anti-cd3 novedosos y sus usos.
EA201891753A1 (ru) 2016-02-03 2019-01-31 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкции антител к psma и cd3, вовлекающие т-клетки
TWI781108B (zh) 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
JOP20190095A1 (ar) 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
EP3548055A4 (en) 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
CA3066918A1 (en) * 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
AU2018312563A1 (en) * 2017-08-01 2020-03-12 City Of Hope Anti-IL1RAP antibodies
EP3489259A1 (en) * 2017-11-23 2019-05-29 Etablissement Français du Sang Anti-il-1rap-car-t cells and their use
PE20210096A1 (es) 2018-04-03 2021-01-12 Blueprint Medicines Corp Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret
CA3101271A1 (en) 2018-05-24 2019-11-28 Janssen Biotech, Inc. Anti-cd3 antibodies and uses thereof
WO2020035577A1 (en) * 2018-08-16 2020-02-20 Cantargia Ab Anti-il1rap antibody compositions
TW202021618A (zh) 2018-08-17 2020-06-16 美商２３與我有限公司 抗ｉｌ１ｒａｐ抗體及其使用方法
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