CN108420938B - Traditional Chinese medicine composition capable of repairing and whitening skin and preparation method of medicine thereof - Google Patents
Traditional Chinese medicine composition capable of repairing and whitening skin and preparation method of medicine thereof Download PDFInfo
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- CN108420938B CN108420938B CN201810279350.4A CN201810279350A CN108420938B CN 108420938 B CN108420938 B CN 108420938B CN 201810279350 A CN201810279350 A CN 201810279350A CN 108420938 B CN108420938 B CN 108420938B
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Landscapes
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition capable of repairing and whitening skin and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following substances: 25.4-35.6 parts of talcum, 24.3-33.2 parts of poria cocos, 12.6-18.8 parts of rose, 5.9-14.5 parts of clove, 27.2-36.4 parts of salvia miltiorrhiza, 4.8-9.6 parts of asparagus, 2.3-7.8 parts of eucommia ulmoides, 12.6-19.5 parts of liquorice, 15.3-24.4 parts of pawpaw, 1.2-4.5 parts of ginkgo leaf, 3.7-8.6 parts of peach blossom and 4.4-9.5 parts of pine needle. The traditional Chinese medicine composition capable of repairing and whitening skin provided by the invention has the effects of clearing away heat and toxic materials, promoting diuresis, reducing phlegm, activating blood and removing stasis. The traditional Chinese medicine composition has the advantages of reasonable compatibility, precise medicine selection, capability of curing the acne symptoms, exact curative effect and small toxic and side effects, and integrates the functions of clearing away heat and toxic materials, promoting diuresis, reducing phlegm, cooling blood, eliminating carbuncle, activating blood and removing stasis into a whole for treating the acne and the remained erythema and pigmentation from the standpoint of dampness-heat stasis obstruction.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition capable of repairing and whitening skin and a preparation method of the traditional Chinese medicine composition.
Background
Acne is a common skin disease of teenagers, 85% of teenagers can be affected, the middle-aged people are often affected with the pressure and rhythm of modern life, and most of patients often face frequently. If the acne is not correctly diagnosed and treated, the acne can be repeatedly attacked frequently to generate sequela such as local permanent scar, unsmooth skin depression and the like, which can cause great psychological pressure of patients with high self-demand and bring inconvenience to interpersonal communication in life. The treatment methods of the acne vulgaris are many, the curative effects of different treatment methods are greatly different, and the clinically common treatment methods include oral drug treatment and external drug treatment, wherein the external treatment methods mainly comprise antibiotics: clindamycin, erythromycin and benzoyl peroxide are the most commonly used topical antibiotics in the treatment of acne vulgaris; the salicylic acid has the characteristics of strong lipophilicity and capability of playing a role in cutin loosening, and can enter the deep layer part of a pilosebaceous canal to play a role in sterilizing and reducing grease secretion; the isotretinoin belongs to a first generation of external preparation of the isotretinoin, and has a narrow clinical application range, mainly because the isotretinoin has common stimulation to local skin lesions. The externally applied medicine which is more commonly used clinically is adapalene and tazarotene (the third generation vitamin A acid represents the medicine). The adapalene gel has better clinical effect on treating acne vulgaris, has small irritation and is easy to tolerate, so the adapalene gel is the first choice medicine for treating mild and moderate acne drags in recent years; corticosteroid hormones, which are not normally used continuously for more than a week, should not be used for long periods of time. Sulfur has also been a common topical drug for the treatment of acne vulgaris for a long period of time in the past. General physical therapies include: photodynamic therapy, blue light therapy, red light therapy, laser therapy, photodynamic therapy, and the like.
According to a large number of documents, western medicine treatment of acne is summarized, the existing internal medicine has corresponding adverse reactions and long administration time, so that the compliance of patients is poor, the external treatment method is PDT, red and blue light therapy, laser, freezing and other treatment methods, but the range of local skin injury is large, skin pigmentation is easily caused, generally, the existing clinical treatment method has quick effect, but the side effects are obvious, the state of an illness is easy to repeat after stopping the medicine or treating, the ancient medical treatment method has the advantages of stable treatment effect, low side effect, slow effect, long treatment period and impatient psychology of the patients. The best method is to combine two treatment methods to make up for deficiencies and satisfy clinical treatment effect. Therefore, in the field of acne prevention and treatment, the characteristics and advantages of traditional Chinese medicine therapy are exerted, and the acne treatment method which is safe, effective, standard in technology, low in price and easy to popularize is feasible. The traditional Chinese medicine is prepared from natural materials, has high safety, and accords with the requirement of consumers on returning to nature for the heteropathy.
Disclosure of Invention
Technical problem to be solved
Aiming at the existing technical problems, the invention provides a traditional Chinese medicine composition capable of repairing and whitening skin and a preparation method of the traditional Chinese medicine composition.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that:
a traditional Chinese medicine composition capable of repairing and whitening skin comprises the following substances in parts by weight:
25.4-35.6 parts of talcum, 24.3-33.2 parts of poria cocos, 12.6-18.8 parts of rose, 5.9-14.5 parts of clove, 27.2-36.4 parts of salvia miltiorrhiza, 4.8-9.6 parts of asparagus, 2.3-7.8 parts of eucommia ulmoides, 12.6-19.5 parts of liquorice, 15.3-24.4 parts of pawpaw, 1.2-4.5 parts of ginkgo leaf, 3.7-8.6 parts of peach blossom and 4.4-9.5 parts of pine needle.
Preferably, the composition is prepared from the following materials in parts by weight:
26.7-33.2 parts of talcum, 25.3-30.5 parts of poria cocos, 15.9-17.8 parts of rose, 8.5-12.4 parts of clove, 29.6-34.4 parts of salvia miltiorrhiza, 5.8-7.6 parts of asparagus, 3.3-5.4 parts of eucommia ulmoides, 14.2-18.5 parts of liquorice, 16.8-22.4 parts of pawpaw, 1.5-3.4 parts of ginkgo leaf, 4.7-6.5 parts of peach blossom and 6.2-8.4 parts of pine needle.
Preferably, the composition is prepared from the following materials in parts by weight:
27.8 parts of talcum, 28.4 parts of poria cocos, 17.5 parts of rose, 10.3 parts of clove, 32.4 parts of salvia miltiorrhiza, 7.8 parts of asparagus, 3.3 parts of eucommia ulmoides, 17.2 parts of liquorice, 21.7 parts of pawpaw, 2.2 parts of ginkgo leaves, 5.6 parts of peach blossom and 7.9 parts of pine needle.
Preferably, the composition also comprises the following substances in parts by weight:
rhodiola root 4.2-7.5, Chinese angelica root 4.9-8.7, ganoderma lucidum 2.2-8.3 and prepared rhizome of rehmannia 4.6-7.7.
Preferably, the dosage form of the traditional Chinese medicine composition comprises any one of paste, spray, ointment, liniment or tincture.
The medicament prepared from the traditional Chinese medicine composition in any scheme is applied to repairing and whitening skin.
The technical scheme also provides a preparation method of the traditional Chinese medicine composition capable of repairing and whitening the skin, which comprises the following steps:
weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, tuckahoe, rose, clove, salvia miltiorrhiza, asparagus, eucommia bark, liquorice, pawpaw, ginkgo leaf, peach blossom, pine needle, rhodiola rosea, angelica, ganoderma lucidum and prepared rhizome of rehmannia, and crushing to 350-420 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in 2-3 times of distilled water for 0.3-0.8 hr to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7-10 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5-2h to obtain a first effective component extract;
placing the obtained first effective component extract into 5-7 times of distilled water for second water reflux extraction for 0.5-1.2 hr to obtain second effective component extract;
filtering the obtained second effective component extract, and standing for 20-25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20-28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
Preferably, the medicament stock solution is prepared into a clinically acceptable dosage form, including any one of paste, spray, ointment, liniment or tincture.
(III) advantageous effects
The invention has the beneficial effects that: the traditional Chinese medicine composition capable of repairing and whitening skin and the external traditional Chinese medicine preparation prepared by the preparation method of the traditional Chinese medicine composition have the effects of clearing away heat and toxic materials, promoting diuresis, reducing phlegm, activating blood and removing stasis. The traditional Chinese medicine composition has the beneficial effects of integrating heat clearing, detoxifying, dampness removing, phlegm eliminating, blood cooling, carbuncle eliminating, blood activating and blood stasis removing on the basis of treating acne and remaining erythema and pigmentation from the standpoint of dampness-heat stasis obstruction, along with reasonable compatibility, strict medicine selection, capability of curing acne symptoms, exact curative effect, small toxic and side effects and the like.
In addition, the medicament prepared from the traditional Chinese medicine composition can be added with conventional auxiliary materials according to a conventional process to prepare clinically acceptable emplastrum, spray, ointment, liniment or tincture for repairing and whitening skin, and has the advantages of quick response, short treatment course, no relapse, no side effect and the like.
Detailed Description
For a better understanding of the present invention, its detailed description will be given by way of the following detailed description.
The invention develops the treatment advantages of the traditional Chinese medicine and combines the advanced means of the modern medicine, the medicinal materials of the invention are formed by combining the medical materials of Jade muscle powder in < surgery authentic and freckle >, < Qianjin important prescription, seven orifices disease and face medicine >, < Wuxiang powder in < Qianjin essential prescription > face medicine >, < Qianjin > clinical experience, and the invention is used for treating acne and the erythema and pigmentation left by the acne, and obtains more satisfactory curative effect through clinical examination. Aims to expand the application range of the ancient prescription, change the dosage form to improve the clinical curative effect, exert the dominant treatment technology of the traditional Chinese medicine external treatment, achieve the aims of simplicity, convenience, cheapness and effectiveness, and benefit the majority of patients.
Example 1
Preparing the following medicinal materials by weight
25.4 parts of talcum, 24.3 parts of poria cocos, 12.6 parts of rose, 5.9 parts of clove, 27.2 parts of salvia miltiorrhiza, 4.8 parts of asparagus, 2.3 parts of eucommia ulmoides, 12.6 parts of liquorice, 15.3 parts of pawpaw, 1.2 parts of ginkgo leaves, 3.7 parts of peach blossom and 4.4 parts of pine leaves.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles, and crushing to 350 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2 times of the mixed medicinal powder for 0.3h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water of which the weight is 5 times of that of the mixed medicinal slurry for second-time water reflux extraction for 0.5h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 20 hr to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 2
Preparing the following medicinal materials by weight
35.6 parts of talcum, 33.2 parts of poria cocos, 18.8 parts of rose, 14.5 parts of clove, 36.4 parts of salvia miltiorrhiza, 9.6 parts of asparagus, 7.8 parts of eucommia ulmoides, 19.5 parts of liquorice, 24.4 parts of pawpaw, 4.5 parts of ginkgo leaves, 8.6 parts of peach blossom and 9.5 parts of pine needle.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles, and crushing to 420 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water of 3 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water with the weight part being 10 times that of the mixed medicinal slurry for carrying out first water reflux extraction for 2 hours to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 1.2h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 3
Preparing the following medicinal materials by weight
26.7 parts of talcum, 25.3 parts of poria cocos, 15.9 parts of rose, 8.5 parts of clove, 29.6 parts of salvia miltiorrhiza, 5.8 parts of asparagus, 3.3 parts of eucommia ulmoides, 14.2 parts of liquorice, 16.8 parts of pawpaw, 1.5 parts of ginkgo leaves, 4.7 parts of peach blossom and 6.2 parts of pine leaves.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles, and crushing to 350 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 0.5h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 4
Preparing the following medicinal materials by weight
33.2 parts of talcum, 30.5 parts of poria cocos, 17.8 parts of rose, 12.4 parts of clove, 34.4 parts of salvia miltiorrhiza, 7.6 parts of asparagus, 5.4 parts of eucommia ulmoides, 18.5 parts of liquorice, 22.4 parts of pawpaw, 3.4 parts of ginkgo leaves, 6.5 parts of peach blossom and 8.4 parts of pine leaves.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles, and crushing to 360 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2.5 times the weight of the mixed medicinal powder for 0.5h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water with the weight of 8 times of that of the mixed medicinal slurry for carrying out first water reflux extraction for 1.8h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water with the weight part 6 times of that of the mixed medicinal slurry for carrying out second water reflux extraction for 1h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 22h to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 24h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The medicament stock solution in the embodiment is prepared into clinically acceptable formulations, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 5
Preparing the following medicinal materials by weight
27.8 parts of talcum, 28.4 parts of poria cocos, 17.5 parts of rose, 10.3 parts of clove, 32.4 parts of salvia miltiorrhiza, 7.8 parts of asparagus, 3.3 parts of eucommia ulmoides, 17.2 parts of liquorice, 21.7 parts of pawpaw, 2.2 parts of ginkgo leaves, 5.6 parts of peach blossom and 7.9 parts of pine needle.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles, and crushing to 400 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water of 3 times of the mixed medicinal powder for 0.3h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water of which the weight is 10 times that of the mixed medicinal slurry, and performing first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 1.2h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 20 hr to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 6
Preparing the following medicinal materials by weight
25.4 parts of talcum, 24.3 parts of poria cocos, 12.6 parts of rose, 5.9 parts of clove, 27.2 parts of salvia miltiorrhiza, 4.8 parts of asparagus, 2.3 parts of eucommia ulmoides, 12.6 parts of liquorice, 15.3 parts of pawpaw, 1.2 parts of ginkgo leaf, 3.7 parts of peach blossom, 4.4 parts of pine needle, 4.2 parts of rhodiola rosea, 4.9 parts of angelica sinensis, 2.2 parts of ganoderma lucidum and 4.6 parts of prepared rehmannia root.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom, pine needles, rhodiola rosea, angelica sinensis, ganoderma lucidum and prepared rehmannia root, and crushing to 380 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 0.5h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 20 hr to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 7
Preparing the following medicinal materials by weight
35.6 parts of talcum, 33.2 parts of poria cocos, 18.8 parts of rose, 14.5 parts of clove, 36.4 parts of salvia miltiorrhiza, 9.6 parts of asparagus, 7.8 parts of eucommia ulmoides, 19.5 parts of liquorice, 24.4 parts of pawpaw, 4.5 parts of ginkgo leaf, 8.6 parts of peach blossom, 9.5 parts of pine needle, 7.5 parts of rhodiola rosea, 8.7 parts of angelica sinensis, 8.3 parts of ganoderma lucidum and 7.7 parts of prepared rehmannia root.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom, pine needles, rhodiola rosea, angelica sinensis, ganoderma lucidum and prepared rehmannia root, and crushing to 420 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water of 3 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water with the weight part being 10 times that of the mixed medicinal slurry for carrying out first water reflux extraction for 2 hours to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 1.2h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 8
Preparing the following medicinal materials by weight
26.7 parts of talcum, 25.3 parts of poria cocos, 15.9 parts of rose, 8.5 parts of clove, 29.6 parts of salvia miltiorrhiza, 5.8 parts of asparagus, 3.3 parts of eucommia ulmoides, 14.2 parts of liquorice, 16.8 parts of pawpaw, 1.5 parts of ginkgo leaf, 4.7 parts of peach blossom, 6.2 parts of pine needle, 4.2 parts of rhodiola rosea, 4.9 parts of angelica sinensis, 2.2 parts of ganoderma lucidum and 4.6 parts of prepared rehmannia root.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom, pine needles, rhodiola rosea, angelica sinensis, ganoderma lucidum and prepared rehmannia root, and crushing to 400 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 0.5h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 20 hr to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
The raw liquid of the medicament in the embodiment is prepared into clinically acceptable dosage forms, including any one of paste, gel, spray, ointment, liniment or tincture.
Example 9
Preparing the following medicinal materials by weight
33.2 parts of talcum, 30.5 parts of poria cocos, 17.8 parts of rose, 12.4 parts of clove, 34.4 parts of salvia miltiorrhiza, 7.6 parts of asparagus, 5.4 parts of eucommia ulmoides, 18.5 parts of liquorice, 22.4 parts of pawpaw, 3.4 parts of ginkgo leaf, 6.5 parts of peach blossom, 8.4 parts of pine needle, 7.5 parts of rhodiola rosea, 8.7 parts of angelica sinensis, 8.3 parts of ganoderma lucidum and 7.7 parts of prepared rehmannia root.
Weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom, pine needles, rhodiola rosea, angelica sinensis, ganoderma lucidum and prepared rehmannia root, and crushing into 360 meshes to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in distilled water 2 times of the mixed medicinal powder for 0.8h to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water of which the weight is 10 times that of the mixed medicinal slurry, and performing first water reflux extraction for 1.5h to obtain a first effective component extract;
putting the obtained first effective component extract into distilled water 7 times of the weight of the mixed medicinal slurry, and performing second water reflux extraction for 0.5h to obtain a second effective component extract;
filtering the obtained second effective component extract, and standing for 20 hr to obtain a third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
In this embodiment, the stock solution of the medicament is prepared into any clinically acceptable dosage form, including any one of paste, gel, spray, ointment, liniment or tincture.
Scope of application
(1) Direction of application
The composition and the medicament thereof are added with conventional auxiliary materials according to the conventional process to prepare clinically acceptable emplastrum, spray, ointment, liniment or tincture.
(2) The main acne population, symptoms and grades are as follows:
(1) is better for adolescent male and female; skin lesions are well developed on cheeks, forehead, chest, back and shoulders; lesions manifested as acne, inflammatory papules, pustules, cysts, nodules; skin lesions generally have no subjective symptoms, and inflammation is obviously accompanied by pain.
(2) Grading the clinical severity:
mild (grade I): acne is the main, small amount of papules and pustules, and the total number of lesions is less than 30.
Medium (grade ii): with comedones, moderate numbers of papules and pustules, and a total lesion count of between 31-50.
Medium (grade iii): a large number of papules and pustules, occasionally large inflammatory lesions, are widely distributed, the total number of lesions is 51-100, and the number of nodules is less than 3.
Severe (vi grade): nodular, cystic or aggregate acne with pain and cyst formation, with a lesion count of greater than 100 and nodules or cysts of greater than 3.
Patients who meet the following criteria:
(1) common acne patients of 14-35 years old have unlimited character.
(2) The medicine accords with the diagnosis standard of western medicine acne, the clinical classification is mainly II and III, and the patient with erythema and pigmentation after acne exists in the initial diagnosis. Has the advantages of obvious curative effect, quick response, short treatment course, no relapse, no side effect and the like.
Matters of attention
(1) It is contraindicated for allergy to this product.
(2) The product can be used for patients with anaphylaxis, pustule ulceration, and infection.
Clinical trial cases
Case 1
Zhi Chi, woman, age 21, student. Initial diagnosis in 2016, 12 months and 13 days.
The main complaints are: the face repeatedly becomes red, papule, cyst and nodule for more than 2 years.
The current medical history: at present, acne marks are obvious, are scattered on papules and cysts, produce much oil, have serious cheeks on two sides, are occasionally itchy and painful, and are irrelative to menstruation. The tongue is pale red, with teeth marks on the edge, white coating and slippery pulse.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (wind-heat in lung channel)
The ointment prepared from the traditional Chinese medicine composition developed by the applicant in the embodiment 1 is tried.
After two diagnoses in 1 month and 14 days, the skin rash on the face basically subsides, part of acne marks remain, the menstruation is delayed for 2 weeks, the tongue is pale red, the fur is thin and white, and the pulse is wiry and smooth.
Three diagnoses are carried out in 3 months and 14 days, the acne marks basically disappear, and the skin is tender and white. A pale-red tongue with thin and white coating and a slippery pulse.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 2
Pangzhi, female 21 years old. Initial diagnosis 2016, 2 months and 11 days.
The main complaints are: the papules and cysts appear on both cheeks for more than 3 years.
The current medical history: the cheeks on both sides have papules and cysts, mainly cysts, accompanied by pain and itching, smooth menstruation, smooth sleep, convenient adjustment, pale red tongue, thin yellow and greasy coating, and smooth and rapid pulse.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (spleen deficiency phlegm dampness)
External treatment: the acne squeezer is aseptically disposed.
The gel prepared from the traditional Chinese medicine composition developed in the example 2 by the applicant is tried.
And (3) twice diagnosis in 3 months and 4 days: the cyst subsided and the double-cheek pox marks were evident. Regulating sleep, regulating the sleep, a pale-red tongue with thin, yellow and greasy coating and a slippery and rapid pulse.
Three diagnoses in 3 months and 18 days: the pox mark becomes lighter than before, and no new pimple appears. Regulating sleep, regulating the sleep, a pale-red tongue with thin, yellow and greasy coating and a slippery and rapid pulse.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Example 3
Bai Zhi, female, 23 years old. First diagnosis in 2017, 1 month and 7 days.
The main complaints are: the papules on the face and the lower jaw are more than 2 years,
the current medical history: pimple on face, no pain, no itching, some acne marks, regular menstruation, easy sleep, convenient regulation, pale red tongue with thin white coating and rapid pulse.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (wind-heat in lung channel)
The liniment prepared from the traditional Chinese medicine composition developed by the applicant in the embodiment 3 is tried.
Twice diagnosis in 1 month and 14 days: acne marks are obvious, the tongue is red and white, and the pulse is wiry and smooth.
Three diagnoses are performed 1 month and 21 days: the whelk is pale in color, a new papule on the forehead, red in color, red tongue with white coating, and wiry and smooth pulse.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 4
Zhenzao, male, 25 years old. The initial diagnosis time is 2016, 12 and 20 days.
The main complaints are: the face and the chest have cyst and nodules for 3 years, and the weight is increased for 2 months.
The current medical history: the face and the chest part have cyst and nodules for 3 years, the face is aggravated for 2 months, occasionally has pain and itch, the face is oily, the face can be taken for a long time and sleeps, the stool is carried out for 2 to 3 days, the tongue is red, the coating is yellow and greasy, and the pulse is smooth and rapid.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (Heat and phlegm)
External treatment: aseptic disposal by adopting a acne squeezer.
The ointment prepared from the traditional Chinese medicine composition in the embodiment 4 developed by the applicant is tried.
And (2) taking two diagnoses in 12 months and 27 days: the most lateral cheek swelling becomes soft, the oil production is reduced, the patient can take and sleep, the patient can defecate one day, the tongue is red, and the tongue coating is thin and white.
Three diagnoses in 1 month and 3 days in 2017: the skin rash is obviously reduced, no new rash appears, some acne marks remain, the tongue is red, the fur is thin and yellow, and the pulse is wiry and smooth.
Four diagnoses in 2 months and 11 days: the rash was reduced earlier, the whelk was pale in color, the tongue was red, the coating was thin and yellow, and the pulse was wiry and smooth.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 5
Wangzhi, female, 25 years old. The initial diagnosis time is 2016, 12 and 10 days.
The main complaints are: the forehead starts more than half a year in size and looks like a papule.
The current medical history: the forehead has the symptoms of red papules with different sizes, obvious acne marks, no pain and no itching, and regular menstruation, the menstruation is delayed for 1 week recently, the patients can take and sleep conveniently, the tongue is pale red, the edges of the tongue have tooth marks, and the fur is thin and white.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (spleen deficiency phlegm dampness)
The spray prepared from the traditional Chinese medicine composition in the embodiment 5 developed by the applicant is tried.
And 2, twice diagnosis in 2 months and 27 days: the forehead rash decreased, some whelk marks remained, the tongue coating was thin and white, and the pulse was wiry and smooth.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 6
Huang-Yi, female, 17 years old. First diagnosis in 2017, 1 month and 7 days.
The main complaints are: the face repeatedly develops dense papules for 3 years.
The current medical history: at present, acne marks are obvious, oil is produced, menstruation is regular, people can take and sleep conveniently, the tongue is red, the coating is thin and yellow, and the pulse is wiry and rapid.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (Heat and phlegm)
The ointment prepared from the traditional Chinese medicine composition developed by the applicant in the embodiment 6 is tried.
And 2, twice diagnosis in 11 days in month: the acne marks on the cheek and the face are obvious, and the menstrual flow is small.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 7
Zhangqi, female, age 22. The initial diagnosis time is 2016, 12 and 27 days.
The main complaints are: the left cheek started on the red pimple of unequal size for 4 months.
The current medical history: the left cheek has a red pimple, occasionally accompanied by pain, no itching, good appetite, poor sleep, delayed menstruation, red tongue with little coating and wiry and rapid pulse.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (wind-heat in lung channel)
The ointment prepared from the traditional Chinese medicine composition developed by the applicant in the embodiment 7 is tried.
And (3) twice diagnosis in 1 month and 7 days: the rash was reduced and some whelk marks remained. Sleep is improved. A red tongue with a thin and white coating and a wiry and rapid pulse. It is applied externally.
Three diagnoses in 1 month and 14 days: no new pimple and no pale acne marks. A red tongue with a thin and white coating and a wiry and rapid pulse.
Four diagnoses in 2 months and 11 days: the acne marks became markedly pale.
After half a month of use, the acne marks are obviously faded, and no obvious new eruption exists.
Case 8
Zhangqi, female, 24 years old, first visit 2017, 9 months and 29 days.
The main complaints are: the double cheeks developed dense red papules for 3 years.
The current medical history: the red pimple appears on the cheek, which is partly itchy and painful, and can accommodate and sleep, regulate the stomach and spleen and delay menstruation. The tongue is pale red with thin and white coating.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (wind-heat in lung channel)
The liniment prepared by the traditional Chinese medicine composition developed by the applicant in the embodiment 8 is tried.
And (3) taking two diagnoses in 10 months and 10 days: the rash is reduced, the acne mark is obvious, and the acne mark is not painful and itchy. Regulating sleep, regulating the sleep, a pale-red tongue with thin and white coating.
Three diagnoses in 11 months and 11 days: the pox mark becomes lighter than before. Regulating sleep, regulating the sleep, a pale-red tongue with thin and white coating.
After half a month, the acne marks are faded, and no obvious new eruption exists.
Case 9
Payment for a woman, 27 years old. The initial diagnosis time is 2017, 1 month and 17 days.
The main complaints are: the face develops dark red papules with different sizes, the lower jaw develops cysts and nodules for 6 years, and the weight is increased for one week.
The current medical history: the patients have no obvious inducement to repeatedly develop dark red papules with different sizes on the face and the lower jaw, and have obvious cyst, nodule and acne mark before 6 years, and the disease condition is aggravated in nearly one week with pain and itch. The face has more oil, regular menstruation, less amount, and convenient eating and drinking.
And (3) Western diagnosis: acne
Traditional Chinese medicine diagnosis: acne (Heat and phlegm)
The gel prepared from the traditional Chinese medicine composition developed by the applicant in the example 9 is tried.
Twice diagnosis in 1 month and 24 days: some pox marks are left for the new pimple. Regulating sleep, regulating the condition, and a slippery pulse with yellow and greasy coating. Applied externally.
Three diagnoses in 2 months and 11 days: the rash is reduced and the pox mark becomes lighter than before. A red tongue with yellow and greasy coating and a slippery and rapid pulse. The above is taken sequentially.
After 1 week of use, the acne marks are obviously faded.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the structure of the present invention in any way, and all simple modifications, equivalent variations and modifications made to the above embodiments according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (8)
1. A traditional Chinese medicine composition capable of repairing and whitening skin is characterized by being prepared from the following substances in parts by weight:
25.4-35.6 parts of talcum, 24.3-33.2 parts of poria cocos, 12.6-18.8 parts of rose, 5.9-14.5 parts of clove, 27.2-36.4 parts of salvia miltiorrhiza, 4.8-9.6 parts of asparagus, 2.3-7.8 parts of eucommia ulmoides, 12.6-19.5 parts of liquorice, 15.3-24.4 parts of pawpaw, 1.2-4.5 parts of ginkgo leaf, 3.7-8.6 parts of peach blossom and 4.4-9.5 parts of pine needle.
2. The traditional Chinese medicine composition of claim 1, which is prepared from the following substances in parts by weight:
26.7-33.2 parts of talcum, 25.3-30.5 parts of poria cocos, 15.9-17.8 parts of rose, 8.5-12.4 parts of clove, 29.6-34.4 parts of salvia miltiorrhiza, 5.8-7.6 parts of asparagus, 3.3-5.4 parts of eucommia ulmoides, 14.2-18.5 parts of liquorice, 16.8-22.4 parts of pawpaw, 1.5-3.4 parts of ginkgo leaf, 4.7-6.5 parts of peach blossom and 6.2-8.4 parts of pine needle.
3. The traditional Chinese medicine composition as claimed in claim 2, which is prepared from the following materials in parts by weight:
27.8 parts of talcum, 28.4 parts of poria cocos, 17.5 parts of rose, 10.3 parts of clove, 32.4 parts of salvia miltiorrhiza, 7.8 parts of asparagus, 3.3 parts of eucommia ulmoides, 17.2 parts of liquorice, 21.7 parts of pawpaw, 2.2 parts of ginkgo leaves, 5.6 parts of peach blossom and 7.9 parts of pine needle.
4. A traditional Chinese medicine composition capable of repairing and whitening skin is characterized by being prepared from the following substances in parts by weight:
25.4 to 35.6 parts of talcum, 24.3 to 33.2 parts of tuckahoe, 12.6 to 18.8 parts of rose, 5.9 to 14.5 parts of clove, 27.2 to 36.4 parts of salvia miltiorrhiza, 4.8 to 9.6 parts of asparagus, 2.3 to 7.8 parts of eucommia bark, 12.6 to 19.5 parts of liquorice, 15.3 to 24.4 parts of pawpaw, 1.2 to 4.5 parts of ginkgo leaf, 3.7 to 8.6 parts of peach blossom, 4.4 to 9.5 parts of pine needle, 4.2 to 7.5 parts of rhodiola rosea, 4.9 to 8.7 parts of angelica, 2.2 to 8.3 parts of lucid ganoderma and 4.6 to 7.7 parts of prepared rehmannia root;
or,
26.7 to 33.2 of talcum, 25.3 to 30.5 of tuckahoe, 15.9 to 17.8 of rose, 8.5 to 12.4 of clove, 29.6 to 34.4 of salvia miltiorrhiza, 5.8 to 7.6 of asparagus, 3.3 to 5.4 of eucommia bark, 14.2 to 18.5 of liquorice, 16.8 to 22.4 of pawpaw, 1.5 to 3.4 of ginkgo leaf, 4.7 to 6.5 of peach blossom, 6.2 to 8.4 of pine needle, 4.2 to 7.5 of rhodiola rosea, 4.9 to 8.7 of angelica, 2.2 to 8.3 of lucid ganoderma and 4.6 to 7.7 of prepared rehmannia root.
5. The traditional Chinese medicine composition of any one of claims 1 to 4, wherein the dosage form of the traditional Chinese medicine composition comprises any one of paste, spray and tincture.
6. The preparation method of the traditional Chinese medicine composition capable of repairing and whitening the skin according to any one of claims 1 to 3, which comprises the following steps:
weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing and crushing weighed talc, poria cocos, rose, clove, salvia miltiorrhiza, asparagus, eucommia ulmoides, liquorice, pawpaw, ginkgo leaves, peach blossom and pine needles to 350-mesh and 420-mesh powder to obtain mixed medicinal powder;
soaking the obtained mixed medicinal powder in 2-3 times of distilled water for 0.3-0.8 hr to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7-10 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5-2h to obtain a first effective component extract;
placing the obtained first effective component extract into 5-7 times of distilled water for second water reflux extraction for 0.5-1.2 hr to obtain second effective component extract;
filtering the obtained second effective component extract, and standing for 20-25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20-28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
7. The preparation method of the traditional Chinese medicine composition capable of repairing and whitening skin according to claim 4, characterized by comprising the following steps:
weighing the following medicinal materials in proportion: respectively cleaning the weighed medicinal materials, removing impurities and draining for later use;
mixing weighed talc, tuckahoe, rose, clove, salvia miltiorrhiza, asparagus, eucommia, liquorice, pawpaw, ginkgo leaf, peach blossom, pine needle, rhodiola rosea, angelica, ganoderma lucidum and prepared rhizome of rehmannia, and crushing to form mixed medicinal powder of 360 meshes and 420 meshes;
soaking the obtained mixed medicinal powder in 2-3 times of distilled water for 0.3-0.8 hr to obtain mixed medicinal slurry;
putting the obtained mixed medicinal slurry into distilled water 7-10 times of the mixed medicinal slurry by weight for first water reflux extraction for 1.5-2h to obtain a first effective component extract;
placing the obtained first effective component extract into 5-7 times of distilled water for second water reflux extraction for 0.5-1.2 hr to obtain second effective component extract;
filtering the obtained second effective component extract, and standing for 20-25 hr to obtain third effective component extract;
placing the obtained third effective component extract into active carbon with volume of 5% of the liquid medicine for decolorizing for 20-28h to obtain the original medicine of the Chinese medicinal composition for repairing and whitening skin.
8. The method of claim 6 or 7, wherein the pharmaceutical stock solution is prepared into a clinically acceptable dosage form comprising any one of a paste, a spray, or a tincture.
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