CN103623007B - A kind of external-applied ointment and preparation and application thereof for the treatment of the ringworm of scalp - Google Patents
A kind of external-applied ointment and preparation and application thereof for the treatment of the ringworm of scalp Download PDFInfo
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- CN103623007B CN103623007B CN201310510189.4A CN201310510189A CN103623007B CN 103623007 B CN103623007 B CN 103623007B CN 201310510189 A CN201310510189 A CN 201310510189A CN 103623007 B CN103623007 B CN 103623007B
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Abstract
The present invention discloses a kind of external-applied ointment for the treatment of the ringworm of scalp, and its compositions in weight percentage is: Iodophor 8%-15%; Honey 30%-40%; Pearl powder 40%-45%; Vinegar 1.05%-1.58%; Nystatin 200U-400U/100g. Ointment preparation method: (1), that nystatin is ground to form to fine powder is for subsequent use; (2), will grind to form nystatin and honey, Nano pearl powder, iodophor solution and the vinegar mixing and stirring of fine powder, put at the temperature of 4 DEG C-10 DEG C and deposit at least three days. Ointment using method: get the present invention who deposits after three days at the temperature of 4 DEG C-10 DEG C and evenly spread upon ringworm of scalp portion, dispenser scope exceedes diseased region 1-2 centimetre; A course for the treatment of twice, seven day every day. The present invention fills a prescription simply, cheap, easy to use, is suitable for preparation and treatment operation, and no matter family, clinic or community all can make by oneself. Curative effect is reliable, has solved damage and the stimulation of other ointment to skin simultaneously, has no side effect. Can use for a long time, be suitable for hospital, community, family to promote, there is good society and economic benefit.
Description
Technical field
The present invention relates to a kind of manufacture and use of medical external-applied ointment, specifically relate to a kind of external application for the treatment of the ringworm of scalpOintment and preparation and application thereof.
Background technology
The ringworm of scalp is a kind of to be infected by fungus-caused skin and hair, and with the scalp symptom such as itch, pathogenesis isCaused by the infection of scurf brood cell bacterium, the optimal path for the treatment of is controlled conk exactly.
Current methods for the treatment of has multiple, and as medicinal bath therapy, local topical medicine, medicine for oral administration etc., oral medicine generally all can be depositedIn larger side effect, be exactly external used medicine for the best methods for the treatment of of the ringworm of scalp, but there is stronger corruption in this type of medicine at presentErosion property and excitant, have damage to skin, and medicine is all expensive simultaneously, and patient can not adhere to long-term treatment, easily causes multipleSend out.
Summary of the invention
The object of the invention is to the problem for above-mentioned prior art, propose a kind of externally applied drug for the treatment of the ringworm of scalpCream, reduces damage and the stimulation to skin when having good result for the treatment of, have no side effect, and good effect and price are lower.
For reaching above-mentioned technique effect, the invention provides a kind of external-applied ointment for the treatment of the ringworm of scalp, its component by weight hundredProportion by subtraction is:
Nystatin: present general dosage is 50U/ sheet. U represents the unit of tiring, and g is gram, metric system unit of weight; HaveMedicine can represent to tire by weight, what have can not represent by weight, just represents with U. This formulation weight percentage enters group with " U "Part, be 200U-400U/100g
Honey: proportion is 1.5g/ml, prescription consumption is 30%-40%
Nano pearl powder: 40%-45%
Iodophor: Iodophor is the preparation that meets of glycerine and the tincture of iodine, there is no certain density. If be converted into taking " g " as unit,This formula is with reference to the density=1g/ml of water, and Iodophor consumption is approximately 8%-15%
Vinegar: vinegar " drips " number and converts with reference to " number of infusion drops ", i.e. 20 of 1ml ≈, consumption is 1-2ml, its density is1.05g/ml, therefore its accounting part is 1.05%-1.58%.
Iodophor 8%-15%; Honey 30%-40%; Pearl powder 40%-45%;
Vinegar 1.05%-1.58%; Nystatin 200U-400U/100g
Preferably, pearl powder is selected Nano pearl powder.
Nystatin belongs to the polyenoid class antifungal of broad-spectrum antifungal, remarkable to Candida effect, to Aspergillus,Trichophyta, Epidermophyton, sporidiole bacteria, histoplasma capsulatum, Blastomyces dermatitidis coccidioides immitis are also effective. Partial smearing becomes with otherDistribute and increase topical remedy's valid density; Nerve endings receptor that can chafe, by nervous system, forms new anti-Penetrate, thereby destroy original pathologic reflex contact, reach the object of cure diseases.
Iodophor be iodine be combined with surfactant form indefinite form complex compound, fungicidal spectrum is wide, sterilization is rapid, necessarily denseUnder degree, can kill bacterial propagule, bacterial spore, fungi, virus. Generally, under neutrality or sour environment, bactericidal action increasesBy force.
Appropriate vinegar, brings into play to greatest extent bactericidal action for Iodophor sour environment is provided, and strengthens result for the treatment of.
Honey contains abundant vitamin, mineral matter, amino acid etc., also contains pollen, antibacterial material and biological active matterMatter, treatment skin disease and tissue injury. In the present invention, not only increase ointment viscosity, and the nutritious effect of size leatherware of playing a game,Reduce because skin damages the alopecia that causes, disconnected etc.
Pearl powder Compendium of Material Medica is recorded: " pearl, cold in nature, sweet-salty enter cardiopulmonary warp, the arresting convulsion of tool relieving palpitation, and clearing liver removes screen,Effect of myogenic removing toxic substances. " pearl powder local topical is by participating in the metabolism of cell DNA, can promote wound healing, the size skin of playing a gameThe surface of a wound has significant curative effect, more can promote its pharmaceutical characteristic after being processed as nanoscale.
The present invention adopts preparation with the following method:
(1), nystatin is ground to form to fine powder for subsequent use;
(2), by equal to the nystatin and honey, Nano pearl powder, iodophor solution and the vinegar mix and blend that grind to form fine powderEven, put at the temperature of 4 DEG C-10 DEG C and deposit at least three days.
Using method of the present invention is as follows:
Get the present invention who deposits after three days at the temperature of 4 DEG C-10 DEG C and evenly spread upon ringworm of scalp portion, dispenser scope exceedes diseaseBecome position 1-2 centimetre; A course for the treatment of twice, seven day every day.
Preferably, interval three days between the described course for the treatment of.
Beneficial effect of the present invention:
The invention provides a kind of external-applied ointment for the treatment of the ringworm of scalp, aspect treatment, there is following advantage:
The one, formula is simple, cheap, easy to use, is suitable for preparation and treatment operation, no matter family, clinic or communityAll can make by oneself.
The 2nd, curative effect is reliable, has solved damage and the stimulation of other ointment to skin simultaneously, without any side effects.
The 3rd, be applicable to any crowd of making a definite diagnosis, can use for a long time, be suitable for hospital, community, family to promote, have preferablySociety and economic benefit.
The 4th, in use procedure, do not find allergic reaction case.
Detailed description of the invention
Preparation Example 1:
Taking preparation 100g the present invention as example: get 200U nystatin and grind to form fine powder, with 30g honey, 40g nano-pearlPowder, 8g iodophor solution and 1.05g vinegar mixing and stirring, put at the temperature of 4 DEG C-10 DEG C and deposit at least three days.
Preparation Example 2:
Taking preparation 100g the present invention as example: get 400U nystatin and grind to form fine powder, with 40g honey, 45g nano-pearlPowder, 15g iodophor solution and 1.58g vinegar mixing and stirring, put at the temperature of 4 DEG C-10 DEG C and deposit at least three days.
Preparation Example 3:
Taking preparation 500g the present invention as example: get 1500U nystatin and grind to form fine powder, with 180g honey, 210g nanometer treasurePearl powder, 60g iodophor solution and 6.3g vinegar mixing and stirring, put at the temperature of 4 DEG C-10 DEG C and deposit at least three days.
Embodiment has illustrated basic preparation method of the present invention, and wherein each constituent content has been enumerated two in above-described embodimentIndividual example, should be noted that the ratio range that the invention provides an economical rationality, calculates by weight percentage each componentContent be:
Iodophor 8%-15%; Honey 30%-40%; Pearl powder 40%-45%;
Vinegar 1.05%-1.58%; Nystatin 200-400U/100g
Special instruction, pearl powder is selected Nano pearl powder, and effect is better. Vinegar is brewageed as good by hand with family.
Nystatin belongs to the polyenoid class antifungal of broad-spectrum antifungal, remarkable to Candida effect, to Aspergillus,Trichophyta, Epidermophyton, sporidiole bacteria, histoplasma capsulatum, Blastomyces dermatitidis coccidioides immitis are also effective. Partial smearing becomes with otherDistribute and increase topical remedy's valid density; Nerve endings receptor that can chafe, by nervous system, forms new anti-Penetrate, thereby destroy original pathologic reflex contact, reach the object of cure diseases.
Iodophor be iodine be combined with surfactant form indefinite form complex compound, fungicidal spectrum is wide, sterilization is rapid, necessarily denseUnder degree, can kill bacterial propagule, bacterial spore, fungi, virus. Generally, under neutrality or sour environment, bactericidal action increasesBy force.
Appropriate vinegar, brings into play to greatest extent bactericidal action for Iodophor sour environment is provided, and strengthens result for the treatment of.
Honey contains abundant vitamin, mineral matter, amino acid etc., also contains pollen, antibacterial material and biological active matterMatter, treatment skin disease and tissue injury. In the present invention, not only increase ointment viscosity, and the nutritious effect of size leatherware of playing a game,Reduce because skin damages the alopecia that causes, disconnected etc.
Pearl powder Compendium of Material Medica is recorded: " pearl, cold in nature, sweet-salty enter cardiopulmonary warp, the arresting convulsion of tool relieving palpitation, and clearing liver removes screen,Effect of myogenic removing toxic substances. " pearl powder local topical is by participating in the metabolism of cell DNA, can promote wound healing, the size skin of playing a gameThe surface of a wound has significant curative effect, more can promote its pharmaceutical characteristic after being processed as nanoscale.
Nystatin use amount of the present invention control must be strict, has uncomfortable reaction after exceeding; Making of vinegar and IodophorConsumption also needs strict control, otherwise has compared with strong and stimulating or the phenomenon appearance not good with other components matching results for the treatment of, thisBright should strict control storage temperature and storage time, otherwise have drug effect deficiency, the possibility that result for the treatment of is not good.
Embodiment 1 cures the disease:
Zhou Xiaohui, women, 43 years old, discontinuity outbreak scalp many places are local occurred that white is as the scales of skin that peel off as dandruff, withGargalesthesia, often scratches, and has epilation, disconnected sends out etc. more than 4 years while increasing the weight of. Oral drug therapy is outbreak effectively but repeatedly. Use thisThe treatment of invention partial smearing, dispenser scope exceedes diseased region 1-2 centimetre, and every day 2 times, after 4 days, the scales of skin that peel off reduces, and gargalesthesia disappears,Adhere to treating 2 courses for the treatment of and cure, four days, interval between the course for the treatment of. Follow up a case by regular visits to and have no recurrence half a year.
Embodiment 2 cures the disease:
Jia Yuechao, the male sex, 27 years old, scalp left side temporo top diameter 4-5cm scope had a large amount of white scales of skin that peel offs, with gargalesthesia,Epilation, disconnected send out etc. more than 1 year. Invalid and the scope of multi-treatment expands gradually, and diameter 1-appears in scalp right side temporo top thereuponThe pathology that 1.5cm scope is same. Use partial smearing treatment of the present invention, dispenser scope exceedes diseased region 1-2 centimetre, every day 2Inferior, after 7 days, the scales of skin that peel off reduces, and gargalesthesia disappears, and adheres to treating 3 courses for the treatment of and cures, three days, interval between the course for the treatment of. Follow up a case by regular visits to and within 1 year, have no recurrence.
Embodiment 3 cures the disease:
Carelessness, the male sex, 15 years old, crown portion and rear pillow part had respectively diameter 4-5cm, a large amount of white scales of skin that peel offs of 2-3cm scope, companionThere are titillation, epilation, disconnectedly send out etc. 10 months. Multi-treatment is invalid, the thick scab of knot of scratching, decrustation repeatedly, incrustation, and model repeatedlyEnclose gradually and expand. Use partial smearing treatment of the present invention, dispenser scope exceedes diseased region 1-2 centimetre, every day 2 times, squama after 7 daysBits reduce, and gargalesthesia alleviates; Carried out for second course for the treatment of after 3 days at interval, smears with method, and after 11 days, the scales of skin that peel off no longer occurs, crust is de-graduallyFall, the scalp colour of skin is recovered gradually, hair restoration. Adhere to treating 3 courses for the treatment of and cure, four days, interval between the course for the treatment of. Follow up a case by regular visits to and within 1 year, have no multipleSend out.
Embodiment 4 cures the disease:
Li Yuying, women, 32 years old, a large amount of white scales of skin that peel offs of diameter 7-10cm scope were arranged at temporo top, left side, with the pain of very itchingSense, epilation, disconnected send out etc., interruption increases the weight of, and is interrupted and takes a turn for the better more than 5 years. Multi-treatment is invalid, hardening after disease damage position scalp increases,Incrustation repeatedly, and scope expands gradually. Use partial smearing treatment of the present invention, dispenser scope exceedes diseased region 1-2 centimetre, everyDay 2 times, after 7 days, the scales of skin that peel off reduces, and sufferings sense alleviates, and crust starts to come off; ; Carried out for second course for the treatment of after 3 days at interval, smear with method,After 13 days, the scales of skin that peel off no longer occurs, crust comes off gradually, and the scalp colour of skin is recovered gradually, and hair is regenerated gradually. Adhere to treating 3 courses for the treatment ofCure three days, interval between the course for the treatment of. Further consultation after one month, pathology scalp is normal, and hair is pitch-black glossy. Follow up a case by regular visits to and within 1 year, have no recurrence.
Embodiment 5 cures the disease:
Xue Chenggong, the male sex, 51 years old, top occipitalia had a large amount of white scales of skin that peel offs of diameter 4-5cm scope, took off with titillation, hairFall, disconnected send out etc., when fashion, send out more than 2 years. Multi-treatment is invalid, and scope expands gradually. Use partial smearing treatment of the present invention, executeMedicine scope exceedes diseased region 1-2 centimetre, and every day 2 times, after 7 days, the scales of skin that peel off reduces, and gargalesthesia alleviates, and crust starts to come off; 3 days, intervalAfter carried out for second course for the treatment of, smear with method, after 9 days, the scales of skin that peel off disappears, crust comes off gradually, the scalp colour of skin is recovered gradually, hair startsDemutation. Adhere to treating 3 courses for the treatment of and cure, three days, interval between the course for the treatment of. Follow up a case by regular visits to and year have no recurrence in 1 year.
Above-described is only preferred embodiment of the present invention. Should be understood that for the person of ordinary skill of the art,Under technology enlightenment provided by the present invention, as the common practise of this area, can also make other equivalent modifications and improvement,Also should be considered as protection scope of the present invention.
Claims (5)
1. an external-applied ointment for the treatment of the ringworm of scalp, is characterized in that: described ointment by compositions in weight percentage is:
Iodophor 8%-15%; Honey 30%-40%; Pearl powder 40%-45%;
Vinegar 1.05%-1.58%; Nystatin 200-400U/100g.
2. a kind of external-applied ointment for the treatment of the ringworm of scalp according to claim 1, is characterized in that: pearl powder is selected nano-pearlPowder.
3. for the preparation of an a kind of method of external-applied ointment for the treatment of the ringworm of scalp as claimed in claim 1 or 2, its feature existsIn: described preparation method comprises the following steps:
(1), nystatin is ground to form to fine powder for subsequent use;
(2), by grinding to form nystatin and honey, Nano pearl powder, iodophor solution and the vinegar mixing and stirring of fine powder, putAt the temperature of 4 DEG C-10 DEG C, deposit at least three days.
4. treat as claimed in claim 1 or 2 the external-applied ointment of the ringworm of scalp in the application of preparing in the medicine for the treatment of the ringworm of scalp, itsBe characterised in that: described application is as follows:
Get the external-applied ointment of depositing after three days at the temperature of 4 DEG C-10 DEG C and evenly spread upon ringworm of scalp portion, dispenser scope exceedes pathologyPosition 1-2 centimetre; A course for the treatment of twice, seven day every day.
5. treat as claimed in claim 4 the external-applied ointment of the ringworm of scalp the application of preparing in the medicine for the treatment of the ringworm of scalp, its spyLevy and be: three or four days, interval between the described course for the treatment of.
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| CN201310510189.4A CN103623007B (en) | 2013-10-25 | 2013-10-25 | A kind of external-applied ointment and preparation and application thereof for the treatment of the ringworm of scalp |
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| CN201310510189.4A CN103623007B (en) | 2013-10-25 | 2013-10-25 | A kind of external-applied ointment and preparation and application thereof for the treatment of the ringworm of scalp |
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| CN103623007B true CN103623007B (en) | 2016-05-18 |
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