CN111298045A

CN111298045A - External medicine for treating flat wart and preparation method thereof

Info

Publication number: CN111298045A
Application number: CN201911126995.5A
Authority: CN
Inventors: 赵艳君; 王花; 王趁
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-18
Filing date: 2019-11-18
Publication date: 2020-06-19

Abstract

The invention discloses an external medicine for treating verruca plana and a preparation method thereof. The external medicine for treating verruca plana mainly comprises, by weight, 20-40 parts of coix seeds, 10-20 parts of isatis roots, 20-40 parts of safflower, 10-20 parts of sophora flavescens, 10-20 parts of dark plums and 5-15 parts of liquorice. Firstly, adding the weighed raw materials into alcohol for soaking, adding fluorouracil after soaking, shaking up, and obtaining the external medicine for treating verruca plana after shaking up. The medicament is used for treating flat wart, has no side effect in external treatment, short treatment time, low cost and obvious effect, and has the total cure rate of 92 percent and the effective rate of 98.1 percent.

Description

External medicine for treating flat wart and preparation method thereof

The technical field is as follows:

the invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to an external medicine for treating verruca plana and a preparation method thereof.

Secondly, background art:

flat warts are a common skin problem, mainly viral infections caused by low immunity, often do not easily eradicate bacteria and easily recur. The verruca plana is benign neoplasm caused by human papilloma virus infecting skin mucous membrane, is dispersed on the surface of the skin, is a viral skin disease, has certain infectivity, generally has no subjective symptom and has slight itch; the patient suffers from serious pigmentation after a long time, and the patient is seriously burdened with mind.

The flat wart is well developed in adolescents and children, most of the lesions are flat papules with needle caps large to soybean large, round or elliptical or polygonal, smooth and hard surfaces, light brown or normal skin color, and more in number, scattered or dense, can be fused with each other, appear symmetrically, and are well developed on the face, the back of the hand, the forearm and the like.

In addition, the virus causing flat wart is widely distributed in nature, including the skin surface and nails of human body, and the slight damage of epidermis may cause infection and has strong infectivity between self and human. The disease is particularly likely to occur in the exposed areas of women, such as the face and the back of the hand, and is most annoying to young women. The verruca plana has high morbidity and great treatment difficulty, and is always headache for dermatologists. The treatment methods of flat warts are many, and the traditional Chinese medicine is good at flat wart decoction, and 6 weeks is a treatment course; the western medicine mostly adopts antivirus and immunoregulation treatment. The oral administration of traditional Chinese medicine or western medicine is slow, and is combined with local medicinal treatment or physical therapy, such as freezing, laser, and topical application of vitamin A acid ointment. The discomfort of the freezing treatment is strong, and the cost of the laser treatment is expensive; the treatment course of externally applying the tretinoin is generally 4 weeks.

Thirdly, the invention content:

the technical problem to be solved by the invention is as follows: according to the problems existing in the existing traditional Chinese medicine or western medicine for treating flat wart, the invention provides an external medicine for treating flat wart, which has short treatment time, low cost and obvious effect, and a preparation method thereof.

In order to solve the problems, the invention adopts the technical scheme that:

the invention provides an external medicine for treating verruca plana, which mainly comprises, by weight, 20-40 parts of coix seed, 10-20 parts of isatis root, 20-40 parts of safflower, 10-20 parts of sophora flavescens, 10-20 parts of dark plum and 5-15 parts of liquorice.

According to the external medicine for treating the flat wart, the external medicine for treating the flat wart mainly comprises 30 parts of coix seed, 15 parts of isatis root, 30 parts of safflower, 15 parts of sophora flavescens, 15 parts of dark plum and 10 parts of liquorice in parts by weight.

In addition, the preparation method of the external medicine for treating the flat wart is provided, and the preparation method comprises the following steps:

a. firstly, weighing various raw material medicines according to the proportion of the external medicine for treating flat wart;

b. b, adding the various raw materials weighed in the step a into alcohol for soaking for 6-9 days; the adding amount of the alcohol is 3-8 times of the total weight of the raw materials;

c. and c, after the soaking in the step b is finished, adding fluorouracil, shaking up, wherein the volume ratio of the ethanol to the fluorouracil is 30-40: 1, shaking uniformly to obtain the external medicine for treating the flat wart.

According to the preparation method of the external medicine for treating flat wart, the fluorouracil in the step c is 2.25g in 1 branch and 10ml in volume.

The pharmacological actions of the various raw material medicaments adopted by the invention are as follows:

coix seed: also called coix seed, coix seed and the like, are widely planted in China, Japan and Vietnam, are traditional medical and edible cereal resources, and are known as the king of gramineous plants in the world. The seeds of the coix seed are rich in amino acids, coixol ester and triterpene compounds, and the seeds of the coix seed contain protein, fat, carbohydrate, vitamin and the like. The coix seed has rich nutritive value and pharmacological action, and has the effects of resisting oxidation, inflammation, cancer, tumor, blood sugar and pain, etc. The coix seed is rich in high-quality protein, carbohydrate, fat, mineral elements and vitamins, and also has various active ingredients such as polysaccharide, fatty acid and ester compounds thereof, flavonoid compounds, triterpenoid compounds and the like, and has the effects of reducing blood sugar, resisting tumors, eliminating free radicals and the like.

Radix isatidis: is also named as indigo root, indigo root and isatis root, and is one kind of Chinese medicinal material. Bitter taste and cold nature, entering heart and stomach meridians; has the effects of clearing away heat and toxic materials, cooling blood and relieving sore throat. It is commonly used for epidemic febrile disease, fever, pharyngalgia, epidemic macula, mumps, erysipelas, fever with swollen head, erysipelas, carbuncle, etc.

Safflower: safflower is used as a medicine. Warm in nature and pungent in flavor, enter heart and liver meridians, and have the effects of activating blood circulation, dredging channels, removing blood stasis, relieving pain and the like. It can be used for treating amenorrhea, abdominal mass, dystocia, dead fetus, puerperal lochiorrhea, blood stasis, carbuncle, swelling, traumatic injury, etc.

Flavescent sophora root: this herb is bitter in taste and cold in nature, and enters heart, liver, stomach, large intestine and bladder meridians; has the effects of clearing heat, eliminating dampness, killing parasites and promoting urination; it is commonly used for treating dysentery due to heat, hematochezia, jaundice, anuria, leucorrhea with reddish discharge, vulval swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis by external application.

Dark plum: this herb is sour, astringent and neutral in nature; it enters liver, spleen, lung and large intestine meridians. The dark plum has the effects of astringing lung, astringing intestine, promoting fluid production and calming ascaris. It is commonly indicated for chronic cough due to lung deficiency, chronic diarrhea and dysentery, diabetes due to deficiency heat, vomiting and abdominal pain due to ascariasis.

Licorice root: the product is mainly used for clearing away heat and toxic materials, eliminating phlegm, relieving cough, and relieving abdominal pain. The product can be used for treating heart-qi deficiency, palpitation, intermittent pulse, deficiency of spleen-stomach qi, listlessness, and asthenia; can be used for treating carbuncle, ulcer, sore and sore throat; for asthma and cough; can be used for treating stomach ache, abdominal pain, and acute pain of gastrocnemius muscle contracture; for harmonizing the potency of certain drugs; the liquorice has the similar adrenocortical hormone-like effect; licoflavone, glycyrrhiza extract and glycyrrhetinic acid have obvious cough relieving effect; the phlegm eliminating effect is also obvious; the Glycyrrhrizae radix has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa. The hypochlorous acid contained in Glycyrrhrizae radix can block carcinogen from inducing tumor growth.

The treatment principle of the technical scheme of the invention is as follows: the traditional Chinese medicine for eliminating dampness, resolving hard mass and relieving itching is combined with western medicine for exfoliating epidermis. The coix seed, the isatis root and the safflower in the prescription have the effects of eliminating dampness, detoxifying, resolving masses and relieving itching; the lightyellow sophora root, the dark plum fruit and the liquorice have the functions of clearing heat and eliminating dampness, and the six traditional Chinese medicines are matched to achieve the functions of clearing heat and removing toxicity, activating blood and removing stasis, and softening hardness and dissipating stagnation; fluorouracil has a keratolytic effect and can cause keratosis with thickened flat warts. The soaked traditional Chinese medicine and fluorouracil have synergistic effect, can regulate the immunity of epidermal cells, induce the normal differentiation of the epidermal cells, and inhibit the excessive proliferation of the epidermal cells, thereby achieving the purpose of removing the flat wart virus.

The invention has the following positive beneficial effects:

1. the medicament is used for treating flat wart, has no side effect in external treatment, short treatment time, low cost and obvious effect, the total cure rate reaches about 92 percent, and the effective rate reaches about 98 percent.

2. The external medicine for treating the verruca plana mainly utilizes the functions of promoting blood circulation and removing stasis of traditional Chinese medicines, combines the strengthening and stripping functions of western medicines, performs both tonification and purgation and hits the pathogenesis. In clinical use for many years, good economic benefit and social benefit are generated, and psychological pain and physiological pain of patients who are worried about by flat warts for a long time are solved.

3. Social benefits are as follows: the external medicine for treating flat wart is generally applied for 3-5 days, so that the skin damage area can be obviously reduced, the symptoms are completely removed in about 7 days, the treatment time of a patient is shortened, the treatment effect is improved, the normal work and life of the patient are not influenced during the treatment period, the psychological pressure of the patient is relieved, the compliance of the patient is improved, the satisfaction degree of the patient is increased, and the tombstone effect is good.

4. Economic benefits are as follows: the external medicine for treating flat wart is applied to clinic, has outstanding curative effect, simple application method, economic price and higher patient acceptance degree, highlights the characteristic of combination of Chinese and Western medicine, has more patients and considerable economic benefit.

5. Long-term benefit: the external medicine for treating flat wart has mild components, can quickly improve the symptoms of patients, has low incidence rate of untoward reactions during treatment and low recurrence rate after treatment, and can generate good economic and social benefits if popularization is increased.

6. In recent years, more than 800 patients suffering from flat warts are treated by the product (external medicine for treating flat warts) disclosed by the invention, and the treatment conditions are detailed in tables 1 and 2.

TABLE 1 therapeutic effect of the external use of the product of the present invention on 800 cases of patients with flat wart (divided by sex)

Sex of patient

Number of people

The number of cured people (rate%

The number of effective people (percentage%

The number of non-effective people (percentage%

Total effective rate

For male

432

392(90.7％)

28(6.5％)

6(1.3％)

98.6％

Woman

368

338(91.8％)

18(4.8％)

3(0.8％)

9(2.4％)

97.5％

TABLE 2 curative effect of the external use of the product of the present invention for treating flat wart patients in 800 cases (according to age group)

Age group of patients

Number of people

The number of cured people (rate%

The number of effective people (percentage%

The number of non-effective people (percentage%

Total effective rate

Young people

146

126(86.3％)

14(9.5％)

3(2％)

97.9％

Middle-aged

483

437(90.4％)

18(3.7％)

10(2％)

97.90％

Old age

171

132(77.2％)

20(11.7％)

10(5.8％)

9(5.2％)

94.70％

The evaluation standard of the treatment effect of the medicine of the invention is as follows:

1) and (3) curing: the patient had a complete resolution of the rash symptoms.

2) The effect is shown: the degree of fading of the rash area of the patient is more than or equal to 70 percent compared with the fading degree before treatment.

3) The method has the following advantages: the area of the rash after the treatment of the patient is more than or equal to 30 percent compared with the fading degree before the treatment, and the size of the rash with the fading area which is not seen in some areas is reduced.

4) And (4) invalidation: the area of the rash fading after the treatment of the patient is less than 30 percent, and even the area of the rash is increased in serious patients.

Typical cases are:

1. wangzhi, male, 36 years old, first diagnosis in 2017 in 3 months, chief complaints: the treatment of the plane, hand and forehead flat wart for 3 years in the dermatology department of local hospitals is poor in curative effect. There are many rice-grain-like large and small flat warts on the face, hand and forehead, and the skin is pale red with itching, and flat warts can be diagnosed. The external medicine is given to a patient for treatment (the medicine is prepared from the example 1), the skin rash on the face appears to be slightly flat when the patient is treated for the second time (after 3 days), the itch is relieved, the skin rash on the hand and the forehead becomes light in color, most of the skin rash on the back of the hand and the forehead subsides when the patient is treated for the third time (after 5 days), a plurality of skin rashes to be subsided exist on the face, the skin rash completely subsides when the patient is treated for the fourth time (after 7 days), the subsided skin rash does not relapse after three months of follow-up visit, the patient is satisfied, and the compliance is good.

2. First officer, female, age 52, first diagnosis in month 10 of 2017, chief complaint: flat warts appear on the face, back of hand and forearm for half a year. The medical history: several rice-grain-like flat warts appeared in the front of 2 years, which were not treated, and developed into mung bean-like warts in nearly half a year, and gradually reached the back of the hand and the forearm. The slight red swelling of the rash can be diagnosed in the last few days, and the flat wart can be confirmed. The product is administered to patients for treatment by external use (the medicine is prepared from the example 1), the rash is red and swollen and fades when the patients visit for the second time (after 3 days), the rash on the face is slightly itchy, the color of the rash on the back and the front of the hands becomes light, most of the rash fades when the patients visit for the third time (after 5 days), the rash completely fades when the patients visit for the fourth time (after 7 days), the rash fades for three months, the rash does not recur, and the satisfaction degree of the patients is higher.

3. Chen and Yi, women, 26 years old, first diagnosis in 2018 in 11 months, chief complaints: flat wart appeared on face for 1 year. The medical history: the face had flat papules 1 year ago, no sensation symptoms, no treatment and confirmed diagnosis of flat warts. The product is administered to a patient for treatment by an external medicine (the medicine is prepared from the example 1), the change of the skin rash is not obvious when the patient is treated for the second time (after 3 days), a small part of the skin rash regresses when the patient is treated for the third time (after 5 days), the large skin rash completely regresses when the patient is treated for the fourth time (after 7 days), the skin rash completely regresses when the patient is treated for the fifth time (after 10 days), a little light brown color is settled at the position where the skin lesion regresses after 1 month, the color is settled and faded after 2 months, the skin is slowly faded, the skin returns to be normal when the color is settled after three months, the patient is more satisfied, and the compliance is good.

Fourthly, the specific implementation mode:

the invention is further illustrated by the following examples, which do not limit the scope of the invention.

Example 1:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 30g of coix seed, 15g of isatis root, 30g of safflower, 15g of sophora flavescens, 15g of dark plum fruit and 10g of liquorice.

Example 2:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 26g of coix seed, 18g of isatis root, 26g of safflower, 13g of sophora flavescens, 13g of dark plum fruit and 12g of liquorice.

Example 3:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 28g of coix seeds, 13g of isatis roots, 25g of safflower, 17g of sophora flavescens, 18g of dark plums and 9g of liquorice.

Example 4:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 31g of coix seed, 16g of isatis root, 32g of safflower, 15g of sophora flavescens, 16g of dark plum fruit and 7g of liquorice.

Example 5:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 32g of coix seed, 17g of isatis root, 27g of safflower, 18g of sophora flavescens, 12g of dark plum fruit and 10g of liquorice.

Example 6:

the invention relates to an external medicine for treating flat wart, which comprises the following raw materials in parts by weight: 29g of coix seeds, 14g of isatis roots, 32g of safflower, 18g of sophora flavescens, 15g of dark plums and 12g of liquorice.

Examples 1-6 methods for preparing topical medicaments for treating flat wart are as follows:

a. firstly, weighing various raw material medicines according to the proportion of the external medicine for treating flat wart in any embodiment 1-6;

b. b, adding the various raw materials weighed in the step a into alcohol for soaking for 8 days; the adding amount of the alcohol is 6 times of the total weight of the raw materials;

c. b, after soaking, adding fluorouracil, shaking up, wherein the volume ratio of the ethanol to the fluorouracil is 36: 1, shaking uniformly to obtain the external medicine for treating the flat wart.

The specification of fluorouracil adopted by the invention is that the content of 1 branch is 2.25g, and the volume is 10 ml.

Claims

1. An external medicine for treating flat wart is characterized in that: the external medicine for treating verruca plana mainly comprises, by weight, 20-40 parts of coix seeds, 10-20 parts of isatis roots, 20-40 parts of safflower, 10-20 parts of sophora flavescens, 10-20 parts of dark plums and 5-15 parts of liquorice.

2. The external medicine for treating flat wart as claimed in claim 1, wherein: the external medicine for treating verruca plana mainly comprises 30 parts of coix seed, 15 parts of isatis root, 30 parts of safflower, 15 parts of sophora flavescens, 15 parts of dark plum fruit and 10 parts of liquorice in parts by weight.

3. A preparation method of an external medicine for treating flat wart is characterized by comprising the following steps:

a. firstly, weighing various raw material medicines according to the proportion of the external medicine for treating flat wart in claim 1;

4. The method for preparing the external medicine for treating flat wart as claimed in claim 3, wherein the external medicine comprises the following components: the specification of the fluorouracil in the step c is that the content of 1 branch is 2.25g, and the volume is 10 ml.