CN102552734A - Gargle for treating dental ulcer - Google Patents
Gargle for treating dental ulcer Download PDFInfo
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- CN102552734A CN102552734A CN201210049607XA CN201210049607A CN102552734A CN 102552734 A CN102552734 A CN 102552734A CN 201210049607X A CN201210049607X A CN 201210049607XA CN 201210049607 A CN201210049607 A CN 201210049607A CN 102552734 A CN102552734 A CN 102552734A
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Abstract
The invention discloses a gargle for treating dental ulcer, which is prepared by mixing 45-55 parts of carrot juice, 25-35 parts of fresh bamboo leaves juice, 80-120 parts of traditional Chinese medicine concentrated solution and 100-140 parts of deionized water by volume, wherein the traditional Chinese medicine concentrated solution takes 12-18 parts of honeysuckle, 13-17 parts of radix rehmanniae, 12-18 parts of radix scrophulariae, 12-18 parts of radix ophiopogonis and 3-7 parts of asarum by weight as raw medicines. The raw medicines are decocted and made into the traditional Chinese medicine concentrated solution; and each ml of solution comprises 0.8-1 mg of crude drugs. The gargle provided in the invention is capable of cleaning mouth, adjunctively treating dental ulcer, preventing relapse and achieving a health-care effect. The gargle can cover the shortage of cleaning water or normal saline and be used together with dental ulcer anoint or corresponding drugs, so that the gargle is safely used and has no untoward effect or toxic and side effects.
Description
Technical field
The present invention relates to a kind of collutory, particularly a kind of mouthwash for oral ulcer is to be used to the ulcer of rinsing the mouth, control and auxiliary treatment oral ulcer.
Background technology
The definite cause of disease of oral ulcer so far still can not be clear and definite fully, and what it has been generally acknowledged that oral ulcer is result of various factor comprehensive action.Immunity, h and E possibly be " three factors " of oral ulcer morbidity, i.e. genetic background and appropriate environments factor (comprising spiritual neural body constitution, psychological behavior state, life and work and social environment etc.) but the immunoreation of exception throw and oral ulcer characteristic sexually transmitted disease (STD) damage occurs.Also the someone proposes " bigeminy factor " opinion, and promptly extrinsic factor (virus and antibacterial) and endogenous inducement (variation of hormone, spiritual psychological factor, malnutrition, systemic disease and immunologic function disorder) interact and cause a disease.
Existing Aphthasol thing mainly contains: local antibacterial medicine such as chlorhexidine gargarism, chlortetracycline ointment, gentamycin pad pasting etc.; Topical corticosteroid such as hydrocortisone medicine film, beclometasone gargarism or spray etc.; Local analgesia agent such as benzydamine gargarism or spray, local anesthesia gel etc.; Other local anti-inflammatory preparations such as sodium cromoglicate cough syrup, PGE2 glue etc.; Systemic administration such as prednisolone, miaow sulfur purine, levamisole, Colchicine etc.
Above medicine can produce therapeutic effect in various degree to oral ulcer; But also have in various degree untoward reaction and side effect simultaneously, like some medicine oral mucosa is had zest, it is uncomfortable that the patient feels; The side effect that also has some medicines can produce whole body such as be difficult for accepting.
In the therapeutic process of oral condition, all adopt earlier peace and quiet water or normal saline to gargle usually, the oral cavity is kept clean, and then smear medicine, disease such as oral ulcer can be cured rapidly, avoided in the oral cavity affected part unholiness and influence drug effect.But adopt peace and quiet water or normal saline to gargle the oral cavity is kept clean, function singleness still lacks the suitable collutory that can cooperate Drug therapy at present.
Summary of the invention
The purpose of this invention is to provide a kind of collutory of treating oral ulcer, this collutory can remedy the deficiency that peace and quiet water or normal saline are gargled, and cooperates oral ulcer to be coated with cream or corresponding drug use.
The collutory of treatment oral ulcer of the present invention is mixed by 45～55 parts by volume Radix Dauci Sativae juices, the bright Folium Bambusae juice of 25～35 parts by volume, 80～120 parts by volume Chinese medicine concentrated solutions and 100～140 parts by volume deionized waters and processes.Wherein, Described Chinese medicine concentrated solution is to be crude drug with 12～18 weight portion Flos Loniceraes, 13～17 weight portion Radix Rehmanniae, 12～18 weight portion Radix Scrophulariae, 12～18 weight portion Radix Ophiopogonis, 3～7 weight portion Herba Asaris, and every ml that water boiling concentration is processed contains the Chinese medicine concentrated solution of crude drug 0.8～1mg.
The collutory of treatment oral ulcer provided by the invention has cleaning oral cavity, the auxiliary treatment oral ulcer, and prevention is had a relapse and function of health care.Collutory of the present invention can remedy the deficiency that peace and quiet water or normal saline are gargled, and clean and disinfectant effect are played in the ulcer of before making medicament, rinsing the mouth affected part, simultaneously, can also cooperate oral ulcer to be coated with cream or relative medicine, make medicine bring into play drug effect better.Collutory of the present invention is safe in utilization effectively, and any untoward reaction or toxic and side effects do not take place.
Clinical trial:
Oral ulcer patient's 60 examples, average course of disease two days, clinical manifestation is main with the local redness of oral mucosa and center ulcer, erosion, pain; Recurrent oral ulceration 47 examples wherein; Traumatic ulcer 8 examples, other 5 examples, all patients do not have other oral mucosa pathological changes except that oral ulcer; No medication history does not have serious systemic disease.60 routine patients are divided into mouthwash for oral ulcer treatment group and watermelon crystal treatment group at random, every group of each 30 example, treatment group male 13 examples, women's 17 examples, 17～56 years old age; Matched group male 14 examples, women's 16 examples, 21～60 years old age.The equal not statistically significant of clinical manifestation difference (P＞0.05) before two groups sex, age, the course of disease, the treatment has comparability.
Advise the patient to gargle before the treatment, keep oral hygiene.Mouthwash for oral ulcer treatment group adopts mouthwash for oral ulcer to be sprayed on the affected part, every day 3～4 times; Watermelon crystal treatment group adopts watermelon crystal spray (Sanjin Pharmaceutical Co., Ltd., Guilin) to be sprayed on the affected part, and every day 3～4 times, two groups of equal routines are taken vitamin C, vitamin B
2Deng medicine, observation is also compared two groups of treatment back affected part contrafluxions, edema, pain and ulcer healing situation.
Therapeutic evaluation standard: produce effects: medication after 3 days the office redness go down no pain symptom, ulcer healing.Effectively: ulcer heals no pain symptom basically after 1 week of medication.Invalid: above 1 week still having pain, ulcer does not have improvement.Total effective rate=(produce effects+effectively)/total routine number * 100%.Statistical procedures: two groups of efficient X 2 test, inspection level α=0.05 of relatively adopting.
Mouthwash for oral ulcer treatment group produce effects 22 examples, effective 8 examples, total effective rate is 100%; Watermelon crystal treatment group produce effects 17 examples, effective 7 examples, invalid 6 examples, total effective rate is 80%.Mouthwash for oral ulcer treatment group total effective rate is apparently higher than watermelon crystal treatment group (P＜0.01).
The specific embodiment
Embodiment 1
Extracting honeysuckle 12 grams, the Radix Rehmanniae 17 grams, Radix Scrophulariae 18 restrains, and restrain Radix Ophiopogonis 12, and Herba Asari 7 grams add in 1.5 liters of deionized waters, decoct 15 minutes at 180 ℃ earlier, and in 120 ℃ of decoctions 30 minutes, filtration obtained filtrating about 500 milliliters again.Add 1.5 liters of deionized waters in the medicinal residues again, 180 ℃ decocted 15 minutes, and 120 ℃ decocted 30 minutes, filtered and obtained filtrating about 300 milliliters.Merge filtrating twice, 120 ℃ are concentrated into 120 milliliters, process the Chinese medicine concentrated solution, and every ml contains crude drug 0.8～1mg.
Get 600 KEHU Radix Raphani, cook after the cleaning, squeeze out about 45 milliliters of Radix Dauci Sativae juices, wherein content beta-carotene is 0.14～0.24mg/ml.
Get 45 milliliters of Radix Dauci Sativae juices, 80 milliliters of Chinese medicine concentrated solutions, bright Folium Bambusae juice 35 milliliters of (Folium Bambosae flavone content is 0.25～0.35 mg/ml) and 110 ml deionized water, mixing is mixed with mouthwash for oral ulcer.
This collutory is a brown liquid, and is lightly seasoned sweet.Be preferably at ordinary times sooner or later and use between two meal, suck 20～30 milliliters of collutory, in the oral cavity, kept 5～10 minutes, promptly spue after gargling.Avoid the use of for the infant or the person that can gargle voluntarily as far as possible.
Embodiment 2
Extracting honeysuckle 15 grams, the Radix Rehmanniae 15 grams, Radix Scrophulariae 15 restrains, and restrain Radix Ophiopogonis 15, and Herba Asari 5 grams add in 1.5 liters of deionized waters, decoct 15 minutes at 180 ℃ earlier, and in 120 ℃ of decoctions 30 minutes, filtration obtained filtrating about 500 milliliters again.Add 1.5 liters of deionized waters in the medicinal residues again, 180 ℃ decocted 15 minutes, and 120 ℃ decocted 30 minutes, filtered and obtained filtrating about 300 milliliters.Merge filtrating twice, 120 ℃ are concentrated into 120 milliliters, process the Chinese medicine concentrated solution, and every ml contains crude drug 0.8～1mg.
Get 600 KEHU Radix Raphani, cook after the cleaning, squeeze out about 50 milliliters of Radix Dauci Sativae juices, add 100 milliliters of Chinese medicine concentrated solutions, 30 milliliters in bright Folium Bambusae juice and 120 ml deionized water again, mixing is mixed with mouthwash for oral ulcer.
Claims (1)
1. a collutory of treating oral ulcer is to be mixed by 45～55 parts by volume Radix Dauci Sativae juices, the bright Folium Bambusae juice of 25～35 parts by volume, 80～120 parts by volume Chinese medicine concentrated solutions and 100～140 parts by volume deionized waters to process; Wherein, Described Chinese medicine concentrated solution is to be crude drug with 12～18 weight portion Flos Loniceraes, 13～17 weight portion Radix Rehmanniae, 12～18 weight portion Radix Scrophulariae, 12～18 weight portion Radix Ophiopogonis, 3～7 weight portion Herba Asaris, and every ml that water boiling concentration is processed contains the Chinese medicine concentrated solution of crude drug 0.8～1mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210049607XA CN102552734B (en) | 2012-02-29 | 2012-02-29 | Gargle for treating dental ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210049607XA CN102552734B (en) | 2012-02-29 | 2012-02-29 | Gargle for treating dental ulcer |
Publications (2)
| Publication Number | Publication Date |
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| CN102552734A true CN102552734A (en) | 2012-07-11 |
| CN102552734B CN102552734B (en) | 2013-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210049607XA Expired - Fee Related CN102552734B (en) | 2012-02-29 | 2012-02-29 | Gargle for treating dental ulcer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748516A (en) * | 2016-03-30 | 2016-07-13 | 黄宇松 | Pharmaceutical composition for treating repeated oral ulcers |
| CN106620612A (en) * | 2016-12-24 | 2017-05-10 | 李大兴 | Traditional Chinese medicine gargle |
| CN108498721A (en) * | 2017-02-28 | 2018-09-07 | 北京智诚拓展广告传媒有限公司 | A kind of fresh leaf of bamboo nanometer juice and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554361A (en) * | 2008-04-11 | 2009-10-14 | 崔守尧 | Mouthwash for oral ulcer |
-
2012
- 2012-02-29 CN CN201210049607XA patent/CN102552734B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554361A (en) * | 2008-04-11 | 2009-10-14 | 崔守尧 | Mouthwash for oral ulcer |
Non-Patent Citations (1)
| Title |
|---|
| 张海红: "增液释邪法治疗复发性口腔溃疡53例", 《实用中医内科杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748516A (en) * | 2016-03-30 | 2016-07-13 | 黄宇松 | Pharmaceutical composition for treating repeated oral ulcers |
| CN106620612A (en) * | 2016-12-24 | 2017-05-10 | 李大兴 | Traditional Chinese medicine gargle |
| CN108498721A (en) * | 2017-02-28 | 2018-09-07 | 北京智诚拓展广告传媒有限公司 | A kind of fresh leaf of bamboo nanometer juice and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102552734B (en) | 2013-12-11 |
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Granted publication date: 20131211 Termination date: 20210228 |