CN108403928A - A kind of herbal cuisine element product of strengthen immunity and preparation method thereof - Google Patents
A kind of herbal cuisine element product of strengthen immunity and preparation method thereof Download PDFInfo
- Publication number
- CN108403928A CN108403928A CN201810348496.XA CN201810348496A CN108403928A CN 108403928 A CN108403928 A CN 108403928A CN 201810348496 A CN201810348496 A CN 201810348496A CN 108403928 A CN108403928 A CN 108403928A
- Authority
- CN
- China
- Prior art keywords
- herbal cuisine
- element product
- sealwort
- fruit
- mouse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036039 immunity Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title description 12
- 239000000284 extract Substances 0.000 claims abstract description 69
- 239000000047 product Substances 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 42
- 238000000605 extraction Methods 0.000 claims abstract description 37
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 33
- 244000241872 Lycium chinense Species 0.000 claims abstract description 30
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 30
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 28
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 28
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 28
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 28
- 238000010992 reflux Methods 0.000 claims abstract description 18
- 239000000706 filtrate Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 13
- 235000011194 food seasoning agent Nutrition 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000004615 ingredient Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims abstract description 4
- 238000000465 moulding Methods 0.000 claims abstract description 4
- 238000007654 immersion Methods 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 42
- 230000001954 sterilising effect Effects 0.000 claims description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 17
- 235000019640 taste Nutrition 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 14
- 238000000643 oven drying Methods 0.000 claims description 10
- 238000001704 evaporation Methods 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 238000011160 research Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 239000002304 perfume Substances 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 238000007493 shaping process Methods 0.000 claims description 4
- 235000013311 vegetables Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 235000014347 soups Nutrition 0.000 claims description 3
- 240000002234 Allium sativum Species 0.000 claims description 2
- 239000006002 Pepper Substances 0.000 claims description 2
- 235000004611 garlic Nutrition 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 235000014102 seafood Nutrition 0.000 claims description 2
- 235000013599 spices Nutrition 0.000 claims description 2
- 244000061458 Solanum melongena Species 0.000 claims 1
- 235000002597 Solanum melongena Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 38
- 230000036541 health Effects 0.000 abstract description 16
- 239000012153 distilled water Substances 0.000 abstract description 14
- 230000008569 process Effects 0.000 abstract description 8
- 230000001256 tonic effect Effects 0.000 abstract description 7
- 230000032683 aging Effects 0.000 abstract description 3
- 230000035622 drinking Effects 0.000 abstract description 3
- 235000008216 herbs Nutrition 0.000 abstract description 3
- 230000010354 integration Effects 0.000 abstract description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 89
- 210000002966 serum Anatomy 0.000 description 35
- 238000002474 experimental method Methods 0.000 description 30
- 238000012360 testing method Methods 0.000 description 27
- 210000000952 spleen Anatomy 0.000 description 21
- 239000003795 chemical substances by application Substances 0.000 description 16
- 108010006464 Hemolysin Proteins Proteins 0.000 description 15
- 239000003228 hemolysin Substances 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 13
- 210000004907 gland Anatomy 0.000 description 11
- 241001494479 Pecora Species 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 10
- 210000003743 erythrocyte Anatomy 0.000 description 10
- 238000002347 injection Methods 0.000 description 10
- 239000007924 injection Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000002504 physiological saline solution Substances 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- 238000007619 statistical method Methods 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 210000001541 thymus gland Anatomy 0.000 description 10
- -1 bulk) Substances 0.000 description 9
- 235000005911 diet Nutrition 0.000 description 9
- 230000037213 diet Effects 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 238000003304 gavage Methods 0.000 description 9
- 239000006286 aqueous extract Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 150000004676 glycans Chemical class 0.000 description 7
- 229920001282 polysaccharide Polymers 0.000 description 7
- 239000005017 polysaccharide Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000011049 filling Methods 0.000 description 6
- 238000007689 inspection Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000004806 packaging method and process Methods 0.000 description 6
- 241000700199 Cavia porcellus Species 0.000 description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
- 241000628997 Flos Species 0.000 description 5
- 210000005252 bulbus oculi Anatomy 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 210000002808 connective tissue Anatomy 0.000 description 5
- 229960004397 cyclophosphamide Drugs 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 239000013558 reference substance Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 230000002992 thymic effect Effects 0.000 description 5
- 239000003643 water by type Substances 0.000 description 5
- 230000003442 weekly effect Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004088 simulation Methods 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- 210000001835 viscera Anatomy 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000010411 cooking Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010200 validation analysis Methods 0.000 description 3
- 241000372132 Hydrometridae Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 235000004879 dioscorea Nutrition 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036449 good health Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 2
- 235000013923 monosodium glutamate Nutrition 0.000 description 2
- 239000004223 monosodium glutamate Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000132092 Aster Species 0.000 description 1
- 235000003717 Boswellia sacra Nutrition 0.000 description 1
- 240000007551 Boswellia serrata Species 0.000 description 1
- 235000012035 Boswellia serrata Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 1
- 244000226566 Psoralea corylifolia Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of herbal cuisine element product, is prepared by the component including following raw materials：Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, Chinese yam.Wherein, by weight percentage, sealwort：18%~33%, the fruit of Chinese wolfberry 12%~23%, Radix Angelicae Sinensis 12%~23%, Chinese yam 32%~52%, the sum of each ingredient is 100%.Above-mentioned herbal cuisine element product includes that following methods are prepared：Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam are mixed, with distilled water immersion, heating and refluxing extraction, filtering concentrates filtrate, obtains extract dry extract, the extract dry extract is broken into powder, and by seasoning, moulding process obtains herbal cuisine element product.The present invention, by compatibility, extraction, seasoning, molding, forms herbal cuisine element products that are a series of using tonic health as major function, and having flavouring handling characteristics based on integration of drinking and medicinal herbs medicinal material.The herbal cuisine health form of this innovation of herbal cuisine element such as can not only bring delicious food for us, and have the function of strengthen immunity, slow down aging, keep fit and healthy, raising health care at a variety of health cares.
Description
Technical field
The present invention relates to food, functional food, field of health care food, and in particular to a kind of herbal cuisine element of strengthen immunity
Product and preparation method thereof.
Background technology
Medicative diet for food therapy is the important component of traditional Chinese medicine, in disease preventing and treating, nourishing and fit keeping function, anti-aging, macrobiosis benefit
Longevity etc. has distinctive feature.In recent years, with the change that human diseases is composed, endocrine, cardiovascular and cerebrovascular etc. and life style
There is the disease incidence of direct relation in ascendant trend year by year, it is increasingly recognised that diet is promoting good health and a long life, preventing
The generation of disease, promotes the rehabilitation etc. of disease to have positive effect at the process for delaying disease, and gradually attention is turned to and is passed
System medicine, natural drug and naturopathy.
Herbal cuisine has very long history in China, is just employed in daily life since having the mankind, herbal cuisine.It is early
《The Yellow Emperor's Canon of Internal Medicine》In just about the record of herbal cuisine,《It is discussed when Plain Questions internal organs method》Middle speech：" supporting vital QI with five kinds of grains, assisting vital QI with five kinds of fruits, five
Poultry is advisable, supplementing vital QI with five kinds of veg etables, taking the mixed foods of various natures and flavors, through replenishing vital essence and invigorating vital QI ".In addition,《Sheng Nong's herbal classic》、《Prescriptions worth thousand gold》、《Dietotherapy sheet
Grass》Deng the content for having specific considerations herbal cuisine in classical medical book, the reason of " doctor's food homology " is also all illustrated.
Herbal cuisine is under traditional Chinese medicine, cookery and nutrition theoretical direction, by Chinese medicine and certain foods with medical value
Object is compatible, using the unique diet culinary art in China and modern scientific method be made have certain color,
Ticbit of shape, including dish, Tang Pin, wheaten food, rice food, congee, tea, drink, preserved fruit etc..Herbal cuisine is that the medicine of Chinese tradition is known
Know the product being combined with cooking experience.Its " residence doctor in food " not only using drug as food, but also food is assigned to medicinal, and medicine is borrowed
Power is eaten, food helps medicine prestige, the two to complement each other, brings out the best in each other；Not only there is higher nutritive value, but also preventable disease is cured the disease, health care is strong
Body is promoted longevity.Actively carry out drug food of TCM Dietotherapy health, the not good health and a long life of only Chinese people are made that significant contribution,
And the development for promoting world health physical-fitness medicine, it may have far reaching significance.
The mostly edible and medicinal product that herbal cuisine uses, are made of drug, food and condiment three parts, both maintain drug
The effect of and the characteristics such as color for having food；Even if adding part medicinal material, due to having paid attention to the selection of medicinal flavor, and
By allotment with food and the fine cooking, appetizing herbal cuisine still can be made into.
Herbal cuisine is very safe as a kind of Dietotherapy method, universal convenient for family, in the selection of Chinese medicine, answers drug of choice
Eat it is homologous, have no toxic side effect and the Chinese medicine without stringent dose requirements.Herbal cuisine focus on reconcile the five tastes, the five tastes be it is sour, bitter, sweet, pungent,
The general name of salty five kinds of tastes, after various foods of different nature enter digestion in vivo, different nature and flavor are inhaled by different internal organs
It receives, the nutrient of each organ is respectively become, to perform its own function.As《The Yellow Emperor's Canon of Internal Medicine》It is warned：It is " careful and five
Taste ... is with God's will ".Just because of the effect of the five tastes is different, so must reconcile the five tastes when selecting food, be just conducive to body
The health of body, if the five tastes will cause the generation of disease partially excessively.
Herbal cuisine requires pharmacological property gentle, will not injure internal organs, to be especially suitable for the elderly and weak crowd.By nourishing form
Following four can be divided into：(1) it puts down and mends：Refer to the sweet gentle slow physically weak prolonged illness of help decoction for the treatment, the slower person of patient's condition development, is one
The slow reinforcing method of kind.(2) clear to mend：Taking a tonic or nourishing food to build up one's health for summer is referred exclusively to, is to select to have effects that centainly to drive the diet that heat promotes the production of body fluid, to supplement human body
Consumption.(3) temperature compensation：Refer to the method with warm nature tonic treatment asthenia cold syndrome.(4) high benefit：Refer to big with strength tonic treatment qi and blood
Empty or negative and positive sudden collapse method.The high violent tonic of non-large dose is not enough to save critically ill when because of extremely feeble and critical syndrome, so life
Name.
Invention content
An object of the present invention is to provide a kind of herbal cuisine element product and preparation method thereof.
Herbal cuisine element product provided by the present invention is a kind of completely new form of herbal cuisine, is using integration of drinking and medicinal herbs medicinal material as base
Plinth, by compatibility, extraction, seasoning, molding, formation is a series of using tonic health as major function, and with monosodium glutamate (monosodium glutamate) etc.
The product of flavouring handling characteristics.
Herbal cuisine element product provided by the present invention is prepared by the component including following raw materials：Sealwort, matrimony vine
Son, Radix Angelicae Sinensis, Chinese yam.
Wherein, by weight percentage, sealwort 18%~33%, the fruit of Chinese wolfberry 12%~23%, Radix Angelicae Sinensis 12%~23%, mountain
Medicine 32%~52%, the sum of each ingredient are 100%.
Specifically, in the herbal cuisine element product,
(1) sealwort 25%, the fruit of Chinese wolfberry 17%, Radix Angelicae Sinensis 17%, Chinese yam 41%；
Or, (2) sealwort 27%, the fruit of Chinese wolfberry 14%, Radix Angelicae Sinensis 21%, Chinese yam 38%；
Or, (3) sealwort 28%, the fruit of Chinese wolfberry 18%, Radix Angelicae Sinensis 18%, Chinese yam 36%；
Or, (4) sealwort 24%, the fruit of Chinese wolfberry 21%, Radix Angelicae Sinensis 14%, Chinese yam 41%；
Or, (5) sealwort 27%, the fruit of Chinese wolfberry 18%, Radix Angelicae Sinensis 12%, Chinese yam 43%.
Above-mentioned herbal cuisine element product is prepared by the method included the following steps：
Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam are mixed, are soaked in water, heating and refluxing extraction, filtering concentrates filtrate, obtains
The extract dry extract is broken into powder by extract dry extract, needs that corresponding seasoning and food is added according to taste
Additive is seasoned, and shaping auxiliary materials are added and carry out technological forming, is packed after sterilization, is obtained herbal cuisine element product.
In the above method, the sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam are its pharmaceutical decocting piece.
Impregnating the proportioning of water and sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam mixture used can be：8-12mL：1g, concretely
12mL：1g.
The time of the immersion can be：1.5-2.5h concretely 2h.
The heating and refluxing extraction can carry out repeatedly, concretely 3 times, and the time extracted every time can be 1-2 hours, specifically
It can be 1 hour.
The operation of the heating and refluxing extraction is concretely：Heating and refluxing extraction 3 times extracts 1h every time, merges 3 water
Extract, you can.
The concentration filtrate, which obtains the operation of extract dry extract, to be：The filtrate decompression is concentrated into thick paste, is shifted
Into evaporating dish, oven drying obtains extract dry extract.
The reduced pressure can carry out under 80 DEG C, the pressure of 0.06~-0.08MPa.
The temperature of the drying can be 60 degree.
Said extracted object dry extract powder can directly be packed after sterilization without seasoning, you can；Also it can be needed according to taste
Corresponding seasoning is added and food additives are seasoned, and shaping auxiliary materials are added and carry out technological forming, packs, obtains after sterilization
To the herbal cuisine element product of various tastes.
It can be according to the market orientation and demand of product, the market distributional region feature etc. of marketing strategy and future, exploitation
Go out a series of various special favor products, including fresh perfume, spices, garlic perfume, paste flavor, sour-sweet, sour refreshing, spicy, spicy, vinegar-pepper, coffee
The tastes such as curry, seafood, tomato.
The sterilization uses irradiation sterilization method.
Specifically, dosage is used to be irradiated to packaged herbal cuisine element formulation product for the radioactive element Co60 of 3kGy
Sterilizing.
Above-mentioned herbal cuisine element product may also be fabricated which various forms, such as solid (powder, particle, bulk), liquid, lotion etc..
Above-mentioned herbal cuisine element product is preparing strengthen immunity, is slowing down aging, keeps fit and healthy, raises answering in the product of health care
With also belonging to protection scope of the present invention.
It is a further object of the present invention to provide the application methods of above-mentioned herbal cuisine element product.
The application method of herbal cuisine element product provided by the present invention, including：
Above-mentioned herbal cuisine element product is directly added into as seasoning in vegetable, soup and is eaten.
Specifically, it is put into before taking the dish out of the pot in cooking, Baoshang, boiling；Or it is direct when adjusting filling, mixing cold dish, making wheaten food
It is put into, mixes thoroughly.
Coming-of-Age Day research on maximum utilized quantity is 2 bags/time (1g/ bags), 3 times/day, is amounted to 6g/ days, wherein people is according to 60kg batheroom scales
It calculates.
The present invention based on integration of drinking and medicinal herbs medicinal material, by compatibility, carries on the basis of Chinese Traditional Medicine herbal cuisine theory
It takes, season, be molded, form herbal cuisine element products a series of using tonic health as major function, and that there are flavouring handling characteristics,
Can be used as seasoning be directly added into vegetable, soup eat.The herbal cuisine health form of this innovation of herbal cuisine element, can not only be us
Bring delicious food, and the work with strengthen immunity, a variety of health cares such as slow down aging, keep fit and healthy, raising health care
With.
Description of the drawings
Fig. 1 is the flow process chart of herbal cuisine element product of the present invention.
Fig. 2 is determination of polysaccharide standard curve.
Fig. 3 is that medicinal material impregnates water suction curves.
Fig. 4 is simulation listing packaging sample.
Specific implementation mode
Below by specific embodiment, the present invention will be described, but the present invention is not limited thereto.
Experimental method used in following embodiments is conventional method unless otherwise specified；Institute in following embodiments
Reagent, material etc., are commercially available unless otherwise specified.
Embodiment 1, determination of polysaccharide
In 4 taste medicinal materials of formula, the assay in sealwort standards of pharmacopoeia is to measure Siberian solomonseal rhizome polysaccharide content；Fruit of Chinese wolfberry pharmacopeia
Assay in standard is to measure polysaccharides content；Without assay item in Chinese yam standards of pharmacopoeia, but it is documented that, mountain
Medicine polysaccharide is the active ingredient in Chinese yam；And sealwort and the fruit of Chinese wolfberry are monarch drug in a prescription altogether in being formulated, and therefore, polyoses content conduct may be selected
The assay item of formula.
1.1 experiment material
Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, yam medicinal material medicine materical crude slice are purchased from：Beijing pharmacy of Tongrentang；
D- DEXTROSE ANHYDROUSs reference substance (Zhong Jian institutes, 110833-201506)
The preparation of 1.2 standard curves
Precision weighs DEXTROSE ANHYDROUS reference substance 25mg, sets in 250mL volumetric flasks, is dissolved in water and is diluted to scale, shakes
It is even to get 0.1mg/mL reference substance mother liquors.
Precision measures reference substance mother liquor 0.2,0.4,0.6,0.8,1.0mL, sets in tool plug test tube respectively, respectively plus water mend to
2.0mL, then 5% phenol solution 1mL of each accurate addition, mixing, fast precise are added sulfuric acid 5mL, shake up, and place 10min, set 40
15min is kept the temperature in degree water-bath, takes out, is rapidly cooled to room temperature, using corresponding reagent as blank, extinction is measured at 490nm wavelength
Degree.With a concentration of ordinate, absorbance is abscissa, draws standard curve (Fig. 2).
It is y=0.0151x-0.0013 (R to obtain regression equation by Fig. 22=0.995), show in 0.0025-0.0125mg/
In mL concentration ranges, absorbance has good linear relationship with concentration of glucose.
The preparation of 1.3 test solutions
Precision weighs herbal cuisine extract dry extract 0.5g, with water dissolution and 100mL is diluted to, as test sample mother liquor.
Precision draws 1mL test sample mother liquors, dilutes 30 times, then accurate absorption 1mL dilutions, sets in tool plug test tube, sighting target directrix curve system
Method under standby item measures absorbance, is read from standard curve in accordance with the law from " 5% phenol solution 1mL of each accurate addition again "
The polyoses content in formula is calculated in the content of glucose in test solution.
1.4 methodology validation
The method for detecting polyoses content to ultraviolet-visible spectrophotometry has carried out methodology validation, the knot of methodology validation
Fruit shows that method is accurate and reliable.
(1) precision test
1 determination of polysaccharide Precision test result of table
To same test solution METHOD FOR CONTINUOUS DETERMINATION 6 times, absorbance value is recorded, as a result RSD values are 0.57%, show instrument essence
Density is good.
(2) repetitive test
2 determination of polysaccharide repetitive test result of table
6 parts of test solutions are prepared respectively, measure absorbance value respectively, and standard curve is used in combination to calculate polyoses content, and
Calculate RSD values.As a result RSD values are 0.47%, show that method repeatability is good.
The determination of embodiment 2, extraction process
According to the physicochemical properties of ingredients in formula, and consider to produce realizability and cost, determine rational
Extraction process route.Extraction process should be stablized, is easy, environmental protection, being suitable for producing greatly.
2.1 experiment material
2.1.1 drug
Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, yam medicinal material medicine materical crude slice are purchased from：Beijing pharmacy of Tongrentang；
D- DEXTROSE ANHYDROUSs reference substance (Zhong Jian institutes, 110833-201506)
2.1.2 instrument
The Shanghai FA2004 electronic balances (200g/0.1mg) Yue Ping scientific instrument Co., Ltd
The SENCC R-201 rotary evaporators Shanghai bio tech ltd Shen Shun
The III multiplex vavuum pump of circulating water type Beijing SHB- is auspicious at great achievement experimental instruments and equipment limited
The macro experimental facilities Co., Ltd of Nereid on DHG-9140A electric heating constant-temperature blowing drying boxes
Refluxing extraction device, pharmacopeia sieve, graduated cylinder, gauze etc..
The selection of 2.2 Extraction solvents
It in view of the purposes and usage of product, i.e., is added in daily gastronomical process, therefore, extraction process, which preferably uses, to be met
The extracting method of conventional use or food custom, and Extraction solvent answer it is safe and non-toxic, therefore select water as Extraction solvent.
2.3 processing of crude drugs methods are investigated
Compare the medicinal material influence of cutting or the different size that is ground into extraction respectively.In the ratio of ingredients in formula
(sealwort 25%, the fruit of Chinese wolfberry 17%, Radix Angelicae Sinensis 17%, Chinese yam 41%) weighs formula 50g, and totally 4 parts, a copy of it keeps pharmaceutical decocting piece
Specification, be in addition respectively crushed into most coarse powder, coarse powder, middle powder for 3 parts.4 parts of samples are heated at reflux extraction 3 times with distilled water respectively
(adding 10 times of volumes of water every time, extract 1h), merge 3 Aqueous extracts, filtering.Filtrate decompression is concentrated into thick paste, is transferred to evaporating dish,
Oven drying (60 DEG C) is weighed to dry extract, calculates paste-forming rate, measures polyoses content in dry extract, and be calculated in medicinal material
Polyoses content.
Experimental result is shown in Table 3.When increasing due to pulverizing medicinal materials degree, medicinal material increases with Extraction solvent contact area, can make to carry
Rate is taken to increase；On the other hand, as the increase of pulverizing medicinal materials degree, the adsorption capacity of medicinal powder enhance, loss increases, and may
Recovery rate is caused to reduce.Therefore while influence at two kinds under effect, with the increase of degree of grinding, recovery rate will appear one most
High point.
The investigation result of 3 medicinal material different size of table
Consider polyoses content in extract number, the height of yield of extract, the complexity of filtering and experiment behaviour
The simplification of work directly selects pharmaceutical decocting piece and feeds intake and tested.
The optimizing research of 2.4 extracting factors
2.4.1 soaking time and water absorption rate are investigated
It is total that four kinds of pharmaceutical decocting pieces are weighed by formula rate (sealwort 25%, the fruit of Chinese wolfberry 17%, Radix Angelicae Sinensis 17%, Chinese yam 41%)
50g adds water 500mL, impregnates.Every half an hour, whether the observation medicinal material saturating heart, and medicinal material weight in wet base is measured, do water absorption rate curve, most
Whether balance is reached by curve substantially afterwards, determines soaking time and water absorption rate.
Water absorption rate=(medicinal material weight in wet base-medicinal material dry weight)/medicinal material dry weight × 100%
Experimental result is shown in Fig. 3.The results show that water absorption rate curve can basically reach balance after 2h, medicinal material weight in wet base is protected substantially
It holds and no longer changes in 208g, therefore pharmaceutical decocting piece impregnates 2h, water absorption rate=(208-50)/50=3.16 times.
2.4.2 Extraction technique is preferred
Pass through orthogonal experiment Optimized extraction techniques parameter.Solvent dosage, extraction time, extraction time are investigated, is obtained with medicinal extract
Rate, polyoses content are inspection target.
Choose Orthogonal Experiment and Design optimization method, in conjunction in produce reality operation and cost problem, work is carried using water
Skill, determines plus water is measured, decocting time, decocts 3 factors such as number again, and each factor chooses 3 levels, with L9 (34) orthogonal arrage
Design experiment, using the water extracted immersing paste yield and polyoses content as inspection target.Influence factor and level are shown in Table 4.
4 orthogonal test factor level table of table
100g pharmaceutical decocting pieces (sealwort 25g, fruit of Chinese wolfberry 17g, Radix Angelicae Sinensis 17g, Chinese yam 41g) are weighed by formula, totally 9 parts, are distinguished
It is placed in 2000mL round-bottomed flasks, according to designed experiment, the water of corresponding amount is added, impregnates 2h, is then filled with refluxing extraction
Set decoction, 3 layers of filtered through gauze, will the filtrate that obtained every time merge after filter, be concentrated under reduced pressure with Rotary Evaporators (80 DEG C ,-
0.06~-0.08MPa), it is concentrated into and pours into evaporating dish that (steaming is poured into 2-3 merging of flask wash with distilled water afterwards to a certain degree
Send out in ware), it is placed in oven and dried (60 DEG C).It is dried to obtain dry extract, is weighed, yield of extract is calculated.And it measures in medicinal extract
Polyoses content.
5 Orthogonal experiment results of table
6 intuitive analysis result of table
7 the results of analysis of variance of table
According to intuitive analysis, secondary factors are determined by the size of very poor R：C>A>B decocts number>Water is added to measure again>It decocts
Time.C factor row K3Maximum, A factor row K3Maximum, B factor row K2Maximum, but since B is secondary cause, so selection and withdrawal 1
Hour.In summary consider that excellent scheme is A3B1C3.
According to the results of analysis of variance, yield of extract index plus water measure and decoct again two factors of number and all have significantly
Property, polyoses content index plus water measure and decoct again two factors of number and all have conspicuousness, this with the primary and secondary intuitively analyzed because
Plain result is consistent.Comprehensive intuitive analysis and the results of analysis of variance finally determine that its optimum extracting method is：The distilled water of 12 times of amounts
It is heated at reflux extraction 3 times, every time 1 hour.
The determination of 2.5 extraction processes
It is by the determining optimum extraction process of Extraction technique optimization：Ingredients medicine materical crude slice is weighed by formula rate,
Add 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate decompression
(80 DEG C, -0.06~-0.08MPa) are concentrated to thick paste, being transferred to evaporating dish, (flask is merged into evaporation 2-3 times wash with distilled water
In ware), oven drying (60 degree) obtains extract dry extract.Dry extract is broken into powder, as herbal cuisine extract.
Embodiment 3, production technology amplification
The extraction production technology of herbal cuisine element is amplified and (obtains extract 1kg or more) in laboratory.To committed step
Index of correlation detection is carried out, process certification is carried out with indexs such as solid yield, polyoses contents, determines processing parameter.
Ingredients medicine materical crude slice is weighed by formula rate (sealwort 25%, the fruit of Chinese wolfberry 17%, Radix Angelicae Sinensis 17%, Chinese yam 41%), altogether
4.0kg is counted, adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filter,
Filtrate decompression concentrates (80 DEG C, -0.06~-0.08MPa) to thick paste, and oven drying (60 degree) obtains extract dry extract.It will do
Medicinal extract crushes, as herbal cuisine extract.
Embodiment 4, simulation listing packaging
Suitable packaging can play critical guarantee effect to the quality of product.According to product form, product purpose and
Eating method, collateral security product quality stability, it is easy to use angularly consider, product packaging form is set to unit dose package
Pouch is 1g per packed amount.
The selected packaging material of simulation listing packaging is the good PET/Al/PE sandwich diaphragm packing timbers of humidity resistance
Material.The material have it is good be protected from light, be moisture-proof, oxygen barrier and leakproofness, have suitable tensile strength and extensibility, can be more preferable
Guarantee product stability, so that content is had the longer shelf-life.
Herbal cuisine element formulation samples are carried out simulation listing with PET/Al/PE films to pack, bag size 25mm*70mm, three sides
Envelope, straight cut, sealing is secured, good airproof performance, and pouch-type is smooth；It is 1g per packed amount.
The determination of embodiment 5, sterilization process
The selection of 5.1 sterilizing methods
According to supplementary material composition and product property, ingredient stability, technical process microbial contamination factor and control condition
Deng selection sterilizing methods.
Common sterilizing methods have high pressure steam sterilization, ethylene oxide sterilizing, irradiation sterilization, pasteurization, micro- in food
Wave sterilizing, ultra high temperature short time sterilization (UHT) etc..Consider the advantage and disadvantage and the scope of application of various conventional food sterilizing methods,
Final choice irradiation sterilization method, because there are following advantages for irradiation sterilization：
(1) kill microorganism effect is notable, and dosage can be adjusted as needed；
(2) non-food stuff substance is not had to remain；
(3) certain dosage (<5kGy) irradiation will not make food that the significant change on sense organ occur；
(4) though using high dose (>It 10kGy) irradiates, total chemical change is also very small in food；
(5) heat generated is few, can be ignored, can keep the original characteristic of food, utmostly keep food
Original local flavor；
(6) penetration capacity of radioactive ray is strong, uniform, fleeting, and can be accurately controlled to its irradiation process；
(7) when food carries out radiation treatment, to packing without strict demand.
5.2 irradiation sterilization
It is organized to set up according to state food pharmaceuticals administration general bureau in 2015《Chinese medicine irradiation sterilization technological guidance is former
Then》In regulation about irradiation devices and irradiation dose：
" radiation source suitable for Chinese medicine irradiation has：(1) gamma-rays that the radionuclides such as Co60 generate；(2) electronics accelerates
The energy that device generates is less than the X-ray of 5MeV；(3) energy that electron accelerator generates is less than the electron beam of 10MeV.”." it is recommended that
Low dose irradiation is used to sterilize as far as possible, Chinese medicine maximum population mean irradiation dose is no more than 10kGy in principle.Aster, bright and beautiful lamp
The medicinal materials such as cage, frankincense, tabasheer, psoralea corylifolia, medicine materical crude slice, medicinal powder, and the Chinese medicine containing aforementioned more than one or plurality of raw materials half
Finished product original powder suggests that irradiation dose is no more than 3kGy.”
Since submitted sample is powdered electuary, final to determine use dosage be the radioactive element Co60 of 3kGy to packing
Good herbal cuisine element formulation product carries out irradiation sterilization.And it tests to sterilized packaging herbal cuisine element formula.
Embodiment 6, product quality inspection
Requirement with reference to country to the relevant criterion for food and the Chinese medical extract of health food, to herbal cuisine element formula
Sample is tested.Inspection content includes：Appearance and examination by sensory organs, physical and chemical index measure, sanitary index measures etc..And in inspection
Survey report is provided after the completion.
Inspection result is shown in Table 8.The result shows that the indices of herbal cuisine element formulation samples are met the requirements of the standard.
8 sample survey result of table
The preparation of embodiment 7, herbal cuisine element product
According to sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam according to mass percent 25%：17%：17%：41% mixture is
Raw material adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate
(80 DEG C, -0.06~-0.08MPa) are concentrated under reduced pressure to thick paste, oven drying (60 degree) obtains extract dry extract.By dry extract
It crushes, as herbal cuisine element product 1.
According to sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam according to mass percent 27%：14%：21%：38% mixture is
Raw material adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate
(80 DEG C, -0.06~-0.08MPa) are concentrated under reduced pressure to thick paste, oven drying (60 degree) obtains extract dry extract.By dry extract
It crushes, as herbal cuisine element product 2.
According to sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam according to mass percent 28%：18%：18%：36% mixture is
Raw material adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate
(80 DEG C, -0.06~-0.08MPa) are concentrated under reduced pressure to thick paste, oven drying (60 degree) obtains extract dry extract.By dry extract
It crushes, as herbal cuisine element product 3.
According to sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam according to mass percent 24%：21%：14%：41% mixture is
Raw material adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate
(80 DEG C, -0.06~-0.08MPa) are concentrated under reduced pressure to thick paste, oven drying (60 degree) obtains extract dry extract.By dry extract
It crushes, as herbal cuisine element product 4.
According to sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam according to mass percent 27%：18%：12%：43% mixture is
Raw material adds 12 times of amount distilled water, impregnates 2h, be heated at reflux extraction 3 times, extract 1h every time.Merge 3 Aqueous extracts, filtering, filtrate
(80 DEG C, -0.06~-0.08MPa) are concentrated under reduced pressure to thick paste, oven drying (60 degree) obtains extract dry extract.By dry extract
It crushes, as herbal cuisine element product 5.
Embodiment 8, acute toxicity testing
In order to investigate herbal cuisine element acute toxicity size, after spy cooks herbal cuisine element formulation samples according to application method, carry out
Acute toxicity test provides foundation to evaluate its safety for clinical application research.
8.1 experiment material
8.1.1 animal
ICR mouse, SPF grades, weight 18-22g, half male and half female is provided by Si Beifu (Beijing) Bioisystech Co., Ltd,
Animal credit number：SCXK (capital) 2016-0002.
8.1.2 drug
It is given the test agent with herbal cuisine element product 1.
8.1.3 experimental situation
Life Sciences of Beijing Institute of Technology experimental animal barrier system.
8.2 experimental method
8.2.1 preliminary experiment
ICR mouse 8 are taken, are randomly divided into two groups, i.e. control group and administration group, every group 4, half male and half female.Take herbal cuisine plain
It is made into maximum concentration liquid 48.3% (mass volume ratio), gastric infusion 3 times, per minor tick 4h, each gavage volume is
0.4ml/10g, control group gavage equivalent distilled water.12h is deprived of food but not water before gavage, 7d is observed continuously in conventinal breeding after administration.
It has no dead mouse and toxic reaction, is limited in view of by tested concentration and volume, carry out the measurement of maximum dosage-feeding experiment.
8.2.2 maximum dosage-feeding measures
ICR mouse 24 are taken, are randomly divided into two groups, i.e. control group and administration group, every group 12, half male and half female, before experiment
It is deprived of food but not water 12h, interim is not for food.Every mouse of administration group is filled by maximum concentration liquid 48.3% (mass volume ratio)
Stomach gives herbal cuisine element 3 times, and per minor tick 4h, gavage volume is 0.4ml/10g, and control group gives same volume distilled water.After administration
Be observed continuously 14d, the appearance action, reflex activity of mouse, amount of drinking water, stool and urine situation after observation administration, after administration the 1st,
3, mouse appetite and weight are measured 5,7,14 days, respectively, data withIt indicates, as a result carries out statistics with SPSS17.0 softwares
Processing.Gross anatomy is carried out after observation, observes the variations such as the volume, color, quality of each organ.
8.3 experimental result
Acute toxicity testing the results are shown in Table 9, table 10, table 11, table 12.
The variation of 9 herbal cuisine element acute toxicity testing mouse weight of table (N=6)
The variation of 10 herbal cuisine element acute toxicity testing mouse food ration of table (G/10g weight, n=6)
The variation of 11 herbal cuisine element acute toxicity testing mouse amount of drinking water of table (Ml/10g weight, n=6)
12 herbal cuisine element acute toxicity testing mouse response situation of table
Note：”—”：Normally.
After experiment, 2 groups of mouse are dissected, visually observes, finds liver, kidney, spleen, intestines, stomach, the pancreas of all mouse
Gland, genitals official rank internal organs are normal, administration group no abnormality seen compared with blank.
The experimental results showed that after administration in 14 days, animal has no dead, and general status is good, and two is just normal, and appearance,
The body weight increase of fur, behavior, breathing normal, nose, eye, oral cavity secretion without exception, administration group and control group is without significance difference
It is different.Also there was no significant difference for food-intake, and each organ is normal, has no other apparent abnormal responses.Herbal cuisine element is given by intragastric administration on mice
Medicine, 1 day three times maximum dosage-feeding be 58g/kg, be equivalent to the clinical day research on maximum utilized quantity of adult (according to the daily research on maximum utilized quantity of people：
2 bags/time (1g/ bags), 3 times/day, amount to 6g/ day, people according to 70kg weight calculating) 677 times.It is therefore contemplated that herbal cuisine is plain
It is safe and non-toxic.
Embodiment 9, herbal cuisine element product inhibit the immunological regulation of mouse to test immunity
It is given the test agent with herbal cuisine element product 1,50 6-8 week old cleaning grade female BAl BIc/c mouse is taken, by mark before experiment
Quasi- diets one week.50 mouse are randomly divided into 5 groups by pre- raise after a week, and every group 10, grouping situation is shown in Table 13.Blank pair
A 0.2mL physiological saline is injected according to group mouse peritoneal, other each group mouse peritoneals injection 0.2mL cyclophosphamide (mg/kg), daily 1
Secondary, for three days on end, manufacture mouse immune inhibits model.
Since the 4th day, into the formal tested phase.It is 2 bags/time (1g/ bags) to recommend dosage according to inventive samples human body,
3 times/day, amount to 6g/ days, people calculates according to 70kg weight, converts mouse dose, the dosage of given the test agent low, middle and high dose groups
Respectively 0.78,1.56,3.12g/kg weight, the daily gavage of given the test agent is primary, gives 28 days.Blank compares certainly and model pair
0.2mL sterile salines are gavaged every time according to group mouse.
13 experiment packet of table
Mouse body index analysis
Mouse weight, record mouse weight variation are periodically weighed weekly.After filling four weeks, after cervical dislocation puts to death mouse,
It is dirty to win gland winning, weighs after surrounding connective tissue is divested totally, data are shown in Table 14.Computation immunity organ refers to as follows
Number：
Index and spleen index=spleen weight (mg)/weight (g)
Gland index=thymic weight (mg)/weight (g)
14 mouse weight of table changes and thymus index, spleen index measurement result
Through statistical analysis：Blank control group is compared with other groups, and changes of weight is without significant difference；Model control group
Thymus index, spleen index significantly reduce (P compared with blank control group<0.05), illustrate modeling success.Various dose group and model
Control group is compared to no significant difference.
Serum hemolysin content analysis
When giving the 23rd day of tested material, 2% silk floss of every mouse peritoneal injection 0.2mL sterile salines preparation
Sheep erythrocyte suspension carries out immune response.
After tested material is given in stopping (i.e. the 29th day), eyeball of mouse takes blood to be placed in 1.5mL centrifuge tubes, and serum is precipitated
And it is diluted to suitable multiple.The guinea pig serum of the sheep red blood cell (SRBC) and 1mL10% that take dilute serum 1mL and 0.5mL10% is mixed
It closes, 30min is kept the temperature in 37 DEG C of waters bath with thermostatic control, ice bath terminates reaction, and 2000r/min centrifuges 10min, takes supernatant 1mL, is added
3mL Dou Shi reagents, 10min is placed after shaking up, and absorbance is surveyed at 540nm wavelength, the results are shown in Table 15.It is replaced with physiological saline small
Mouse serum takes its supernatant to return to zero in colorimetric as blank control.
15 serum hemolysin experimental result of table
Note：“a”：There is significant difference compared with A blank control groups, " b " there were significant differences compared with B model control groups, P
<0.05。
Through statistical analysis：The significant work of B group models control group antibody product compared with A blank control groups declines；Low dose of C groups
Amount group is with model control group without significant difference；Middle dosage (1.56g/kgD) group and high dose (3.12g/kgD) group and model
Control group is compared and is dramatically increased.
It is drawn a conclusion by zoopery, middle dose group and the experiment of high dose group serum hemolysin are positive, medicine of the invention
Meals element has the function of strengthen immunity.
It is given the test agent with herbal cuisine element product 2,50 6-8 week old cleaning grade female BAl BIc/c mouse is taken, by mark before experiment
Quasi- diets one week.50 mouse are randomly divided into 5 groups by pre- raise after a week, and every group 10, grouping situation is shown in Table 16.Blank pair
A 0.2mL physiological saline is injected according to group mouse peritoneal, other each group mouse peritoneals injection 0.2mL cyclophosphamide (mg/kg), daily 1
Secondary, for three days on end, manufacture mouse immune inhibits model.
Since the 4th day, into the formal tested phase.It is 2 bags/time (1g/ bags) to recommend dosage according to inventive samples human body,
3 times/day, amount to 6g/ days, people calculates according to 70kg weight, converts mouse dose, the dosage of given the test agent low, middle and high dose groups
Respectively 0.78,1.56,3.12g/kg weight, the daily gavage of given the test agent is primary, gives 28 days.Blank compares certainly and model pair
0.2mL sterile salines are gavaged every time according to group mouse.
16 experiment packet of table
Mouse body index analysis
Mouse weight, record mouse weight variation are periodically weighed weekly.After filling four weeks, after cervical dislocation puts to death mouse,
It is dirty to win gland winning, weighs after surrounding connective tissue is divested totally, data are shown in Table 17.Computation immunity organ refers to as follows
Number：
Index and spleen index=spleen weight (mg)/weight (g)
Gland index=thymic weight (mg)/weight (g)
17 mouse weight of table changes and thymus index, spleen index measurement result
Through statistical analysis：Blank control group is compared with other groups, and changes of weight is without significant difference；Model control group
Thymus index, spleen index significantly reduce (P compared with blank control group<0.05), illustrate modeling success.Various dose group and model
Control group is compared to no significant difference.
Serum hemolysin content analysis
When giving the 23rd day of tested material, 2% silk floss of every mouse peritoneal injection 0.2mL sterile salines preparation
Sheep erythrocyte suspension carries out immune response.
After tested material is given in stopping (i.e. the 29th day), eyeball of mouse takes blood to be placed in 1.5mL centrifuge tubes, and serum is precipitated
And it is diluted to suitable multiple.The guinea pig serum of the sheep red blood cell (SRBC) and 1mL10% that take dilute serum 1mL and 0.5mL10% is mixed
It closes, 30min is kept the temperature in 37 DEG C of waters bath with thermostatic control, ice bath terminates reaction, and 2000r/min centrifuges 10min, takes supernatant 1mL, is added
3mL Dou Shi reagents, 10min is placed after shaking up, and absorbance is surveyed at 540nm wavelength, the results are shown in Table 18.It is replaced with physiological saline small
Mouse serum takes its supernatant to return to zero in colorimetric as blank control.
18 serum hemolysin experimental result of table
Note：“a”：There is significant difference compared with A blank control groups, " b " there were significant differences compared with B model control groups, P
<0.05。
Through statistical analysis：The significant work of B group models control group antibody product compared with A blank control groups declines；Low dose of C groups
Amount group is with model control group without significant difference；Middle dosage (1.56g/kgD) group and high dose (3.12g/kgD) group and model
Control group is compared and is dramatically increased.
It is drawn a conclusion by zoopery, middle dose group and the experiment of high dose group serum hemolysin are positive, medicine of the invention
Meals element has the function of strengthen immunity.
It is given the test agent with herbal cuisine element product 3,50 6-8 week old cleaning grade female BAl BIc/c mouse is taken, by mark before experiment
Quasi- diets one week.50 mouse are randomly divided into 5 groups by pre- raise after a week, and every group 10, grouping situation is shown in Table 19.Blank pair
A 0.2mL physiological saline is injected according to group mouse peritoneal, other each group mouse peritoneals injection 0.2mL cyclophosphamide (mg/kg), daily 1
Secondary, for three days on end, manufacture mouse immune inhibits model.
Since the 4th day, into the formal tested phase.It is 2 bags/time (1g/ bags) to recommend dosage according to inventive samples human body,
3 times/day, amount to 6g/ days, people calculates according to 70kg weight, converts mouse dose, the dosage of given the test agent low, middle and high dose groups
Respectively 0.78,1.56,3.12g/kg weight, the daily gavage of given the test agent is primary, gives 28 days.Blank compares certainly and model pair
0.2mL sterile salines are gavaged every time according to group mouse.
19 experiment packet of table
Mouse body index analysis
Mouse weight, record mouse weight variation are periodically weighed weekly.After filling four weeks, after cervical dislocation puts to death mouse,
It is dirty to win gland winning, weighs after surrounding connective tissue is divested totally, data are shown in Table 20.Computation immunity organ refers to as follows
Number：
Index and spleen index=spleen weight (mg)/weight (g)
Gland index=thymic weight (mg)/weight (g)
20 mouse weight of table changes and thymus index, spleen index measurement result
Through statistical analysis：Blank control group is compared with other groups, and changes of weight is without significant difference；Model control group
Thymus index, spleen index significantly reduce (P compared with blank control group<0.05), illustrate modeling success.Various dose group and model
Control group is compared to no significant difference.
Serum hemolysin content analysis
When giving the 23rd day of tested material, 2% silk floss of every mouse peritoneal injection 0.2mL sterile salines preparation
Sheep erythrocyte suspension carries out immune response.
After tested material is given in stopping (i.e. the 29th day), eyeball of mouse takes blood to be placed in 1.5mL centrifuge tubes, and serum is precipitated
And it is diluted to suitable multiple.The guinea pig serum of the sheep red blood cell (SRBC) and 1mL10% that take dilute serum 1mL and 0.5mL10% is mixed
It closes, 30min is kept the temperature in 37 DEG C of waters bath with thermostatic control, ice bath terminates reaction, and 2000r/min centrifuges 10min, takes supernatant 1mL, is added
3mL Dou Shi reagents, 10min is placed after shaking up, and absorbance is surveyed at 540nm wavelength, the results are shown in Table 21.It is replaced with physiological saline small
Mouse serum takes its supernatant to return to zero in colorimetric as blank control.
21 serum hemolysin experimental result of table
Note：“a”：There is significant difference compared with A blank control groups, " b " there were significant differences compared with B model control groups, P
<0.05。
Through statistical analysis：The significant work of B group models control group antibody product compared with A blank control groups declines；Low dose of C groups
Amount group is with model control group without significant difference；Middle dosage (1.56g/kgD) group and high dose (3.12g/kgD) group and model
Control group is compared and is dramatically increased.
It is drawn a conclusion by zoopery, middle dose group and the experiment of high dose group serum hemolysin are positive, medicine of the invention
Meals element has the function of strengthen immunity.
It is given the test agent with herbal cuisine element product 4,50 6-8 week old cleaning grade female BAl BIc/c mouse is taken, by mark before experiment
Quasi- diets one week.50 mouse are randomly divided into 5 groups by pre- raise after a week, and every group 10, grouping situation is shown in Table 22.Blank pair
A 0.2mL physiological saline is injected according to group mouse peritoneal, other each group mouse peritoneals injection 0.2mL cyclophosphamide (mg/kg), daily 1
Secondary, for three days on end, manufacture mouse immune inhibits model.
Since the 4th day, into the formal tested phase.It is 2 bags/time (1g/ bags) to recommend dosage according to inventive samples human body,
3 times/day, amount to 6g/ days, people calculates according to 70kg weight, converts mouse dose, the dosage of given the test agent low, middle and high dose groups
Respectively 0.78,1.56,3.12g/kg weight, the daily gavage of given the test agent is primary, gives 28 days.Blank compares certainly and model pair
0.2mL sterile salines are gavaged every time according to group mouse.
22 experiment packet of table
Mouse body index analysis
Mouse weight, record mouse weight variation are periodically weighed weekly.After filling four weeks, after cervical dislocation puts to death mouse,
It is dirty to win gland winning, weighs after surrounding connective tissue is divested totally, data are shown in Table 23.Computation immunity organ refers to as follows
Number：
Index and spleen index=spleen weight (mg)/weight (g)
Gland index=thymic weight (mg)/weight (g)
23 mouse weight of table changes and thymus index, spleen index measurement result
Through statistical analysis：Blank control group is compared with other groups, and changes of weight is without significant difference；Model control group
Thymus index, spleen index significantly reduce (P compared with blank control group<0.05), illustrate modeling success.Various dose group and model
Control group is compared to no significant difference.
Serum hemolysin content analysis
When giving the 23rd day of tested material, 2% silk floss of every mouse peritoneal injection 0.2mL sterile salines preparation
Sheep erythrocyte suspension carries out immune response.
After tested material is given in stopping (i.e. the 29th day), eyeball of mouse takes blood to be placed in 1.5mL centrifuge tubes, and serum is precipitated
And it is diluted to suitable multiple.The guinea pig serum of the sheep red blood cell (SRBC) and 1mL10% that take dilute serum 1mL and 0.5mL10% is mixed
It closes, 30min is kept the temperature in 37 DEG C of waters bath with thermostatic control, ice bath terminates reaction, and 2000r/min centrifuges 10min, takes supernatant 1mL, is added
3mL Dou Shi reagents, 10min is placed after shaking up, and absorbance is surveyed at 540nm wavelength, the results are shown in Table 24.It is replaced with physiological saline small
Mouse serum takes its supernatant to return to zero in colorimetric as blank control.
24 serum hemolysin experimental result of table
Note：“a”：There is significant difference compared with A blank control groups, " b " there were significant differences compared with B model control groups, P
<0.05。
Through statistical analysis：The significant work of B group models control group antibody product compared with A blank control groups declines；Low dose of C groups
Amount group is with model control group without significant difference；Middle dosage (1.56g/kgD) group and high dose (3.12g/kgD) group and model
Control group is compared and is dramatically increased.
It is drawn a conclusion by zoopery, middle dose group and the experiment of high dose group serum hemolysin are positive, medicine of the invention
Meals element has the function of strengthen immunity.
It is given the test agent with herbal cuisine element product 5,50 6-8 week old cleaning grade female BAl BIc/c mouse is taken, by mark before experiment
Quasi- diets one week.50 mouse are randomly divided into 5 groups by pre- raise after a week, and every group 10, grouping situation is shown in Table 25.Blank pair
A 0.2mL physiological saline is injected according to group mouse peritoneal, other each group mouse peritoneals injection 0.2mL cyclophosphamide (mg/kg), daily 1
Secondary, for three days on end, manufacture mouse immune inhibits model.
Since the 4th day, into the formal tested phase.It is 2 bags/time (1g/ bags) to recommend dosage according to inventive samples human body,
3 times/day, amount to 6g/ days, people calculates according to 70kg weight, converts mouse dose, the dosage of given the test agent low, middle and high dose groups
Respectively 0.78,1.56,3.12g/kg weight, the daily gavage of given the test agent is primary, gives 28 days.Blank compares certainly and model pair
0.2mL sterile salines are gavaged every time according to group mouse.
25 experiment packet of table
Mouse body index analysis
Mouse weight, record mouse weight variation are periodically weighed weekly.After filling four weeks, after cervical dislocation puts to death mouse,
It is dirty to win gland winning, weighs after surrounding connective tissue is divested totally, data are shown in Table 26.Computation immunity organ refers to as follows
Number：
Index and spleen index=spleen weight (mg)/weight (g)
Gland index=thymic weight (mg)/weight (g)
26 mouse weight of table changes and thymus index, spleen index measurement result
Through statistical analysis：Blank control group is compared with other groups, and changes of weight is without significant difference；Model control group
Thymus index, spleen index significantly reduce (P compared with blank control group<0.05), illustrate modeling success.Various dose group and model
Control group is compared to no significant difference.
Serum hemolysin content analysis
When giving the 23rd day of tested material, 2% silk floss of every mouse peritoneal injection 0.2mL sterile salines preparation
Sheep erythrocyte suspension carries out immune response.
After tested material is given in stopping (i.e. the 29th day), eyeball of mouse takes blood to be placed in 1.5mL centrifuge tubes, and serum is precipitated
And it is diluted to suitable multiple.The guinea pig serum of the sheep red blood cell (SRBC) and 1mL10% that take dilute serum 1mL and 0.5mL10% is mixed
It closes, 30min is kept the temperature in 37 DEG C of waters bath with thermostatic control, ice bath terminates reaction, and 2000r/min centrifuges 10min, takes supernatant 1mL, is added
3mL Dou Shi reagents, 10min is placed after shaking up, and absorbance is surveyed at 540nm wavelength, the results are shown in Table 27.It is replaced with physiological saline small
Mouse serum takes its supernatant to return to zero in colorimetric as blank control.
27 serum hemolysin experimental result of table
Note：“a”：There is significant difference compared with A blank control groups, " b " there were significant differences compared with B model control groups, P
<0.05。
Through statistical analysis：The significant work of B group models control group antibody product compared with A blank control groups declines；Low dose of C groups
Amount group is with model control group without significant difference；Middle dosage (1.56g/kgD) group and high dose (3.12g/kgD) group and model
Control group is compared and is dramatically increased.
It is drawn a conclusion by zoopery, middle dose group and the experiment of high dose group serum hemolysin are positive, medicine of the invention
Meals element has the function of strengthen immunity.
Claims (10)
1. a kind of herbal cuisine element product is prepared by the component including following raw materials：Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis, Chinese yam；
Wherein, by weight percentage, sealwort：18%~33%, the fruit of Chinese wolfberry 12%~23%, Radix Angelicae Sinensis 12%~23%, Chinese yam
32%~52%, the sum of each ingredient is 100%.
2. the method for preparing herbal cuisine element product described in claim 1, including：Sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam are mixed,
It is soaked in water, heating and refluxing extraction, filtering concentrates filtrate, obtains extract dry extract, the extract dry extract is broken into
Powder according to taste needs that corresponding seasoning is added and food additives is seasoned, and shaping auxiliary materials are added and carry out technique
Molding, packs after sterilization, obtains herbal cuisine element product.
3. according to the method described in claim 1, it is characterized in that：The sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam are its medicinal material
Medicine materical crude slice；
The proportioning for impregnating used water and sealwort, the fruit of Chinese wolfberry, Radix Angelicae Sinensis and Chinese yam mixture is：8-12mL：1g；
The time of the immersion is：1.5-2.5h；
The heating and refluxing extraction carries out repeatedly, concretely 3 times, and the time extracted every time is 1-2 hours.
4. according to the method in claim 2 or 3, it is characterised in that：The concentration filtrate obtains the behaviour of extract dry extract
As：The filtrate decompression is concentrated into thick paste, is transferred in evaporating dish, oven drying, extract dry extract is obtained.
5. according to the method described in claim 4, it is characterized in that：It is described to be concentrated under reduced pressure at 80 DEG C, -0.06~-0.08MPa's
It is carried out under pressure；
The temperature of the drying is 60 degree.
6. according to the method described in any one of claim 2-4, it is characterised in that：The extract dry extract powder without
Seasoning directly packs after sterilization, obtains final herbal cuisine element product；
Also it can need that corresponding seasoning is added according to taste and food additives are seasoned, and shaping auxiliary materials are added and carry out work
Skill is molded, and is packed after sterilization, is obtained the herbal cuisine element product of various tastes；
The wherein described taste include fresh perfume, spices, garlic perfume, paste flavor, sour-sweet, sour refreshing, spicy, spicy, vinegar-pepper, curried, seafood, kind
Eggplant and other tastes；
The herbal cuisine element product may also be fabricated which various forms, solid, liquid or lotion.
7. according to the method described in claim 6, it is characterized in that：The sterilization uses irradiation sterilization method；Use dosage for
The radioactive element Co60 of 3kGy carries out irradiation sterilization to packaged herbal cuisine element formulation product.
8. application of the herbal cuisine element product described in claim 1 in strengthen immunity.
9. application of the herbal cuisine element product described in claim 1 in the product for preparing strengthen immunity.
10. the application method of herbal cuisine element product described in claim 1, including：The herbal cuisine element product is straight as seasoning
It connects to be added in vegetable, soup and eat；
Coming-of-Age Day research on maximum utilized quantity is 2 bags/time (1g/ bags), 3 times/day, is amounted to 6g/ days, wherein people calculates according to 70kg weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810348496.XA CN108403928A (en) | 2018-04-18 | 2018-04-18 | A kind of herbal cuisine element product of strengthen immunity and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810348496.XA CN108403928A (en) | 2018-04-18 | 2018-04-18 | A kind of herbal cuisine element product of strengthen immunity and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108403928A true CN108403928A (en) | 2018-08-17 |
Family
ID=63134270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810348496.XA Pending CN108403928A (en) | 2018-04-18 | 2018-04-18 | A kind of herbal cuisine element product of strengthen immunity and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108403928A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601978A (en) * | 2018-12-04 | 2019-04-12 | 北京理工亘舒科技有限公司 | A kind of ginseng of strengthen immunity, Radix Angelicae Sinensis, Radix Glycyrrhizae, herbal cuisine element product of Poria cocos and preparation method thereof |
| CN111329061A (en) * | 2020-03-30 | 2020-06-26 | 广东跨元航天医学工程技术有限公司 | A medicated diet product for enhancing immunity, and its preparation method |
| CN111728216A (en) * | 2020-07-06 | 2020-10-02 | 北京理工亘舒科技有限公司 | Medicated diet vegetarian product and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039839A (en) * | 2012-12-31 | 2013-04-17 | 陈慧珊 | Health-care cake capable of relieving deficiency of qi and blood and preparation method of health-care cake |
| CN104288495A (en) * | 2014-09-23 | 2015-01-21 | 孟州世博生物科技有限公司 | Chinese yam-rhizoma polygonati capsule and preparation method thereof |
| RU2015123114A (en) * | 2015-06-16 | 2017-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации | A method for the treatment of chronic generalized catarrhal gingivitis |
-
2018
- 2018-04-18 CN CN201810348496.XA patent/CN108403928A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039839A (en) * | 2012-12-31 | 2013-04-17 | 陈慧珊 | Health-care cake capable of relieving deficiency of qi and blood and preparation method of health-care cake |
| CN104288495A (en) * | 2014-09-23 | 2015-01-21 | 孟州世博生物科技有限公司 | Chinese yam-rhizoma polygonati capsule and preparation method thereof |
| RU2015123114A (en) * | 2015-06-16 | 2017-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации | A method for the treatment of chronic generalized catarrhal gingivitis |
Non-Patent Citations (1)
| Title |
|---|
| 高学敏: "《中药学》", 31 March 2017, 中国中医药出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601978A (en) * | 2018-12-04 | 2019-04-12 | 北京理工亘舒科技有限公司 | A kind of ginseng of strengthen immunity, Radix Angelicae Sinensis, Radix Glycyrrhizae, herbal cuisine element product of Poria cocos and preparation method thereof |
| CN111329061A (en) * | 2020-03-30 | 2020-06-26 | 广东跨元航天医学工程技术有限公司 | A medicated diet product for enhancing immunity, and its preparation method |
| CN111728216A (en) * | 2020-07-06 | 2020-10-02 | 北京理工亘舒科技有限公司 | Medicated diet vegetarian product and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102204678B (en) | Instant cubilose powder with efficacy of immunity enhancement and preparation method thereof | |
| CN108403928A (en) | A kind of herbal cuisine element product of strengthen immunity and preparation method thereof | |
| CN104920704B (en) | A kind of dry measure used in former times mandarin orange tea and preparation method thereof | |
| CN108094810A (en) | For nursing one's health the solid beverage of blood stasis constitution and its processing method | |
| CN109601978A (en) | A kind of ginseng of strengthen immunity, Radix Angelicae Sinensis, Radix Glycyrrhizae, herbal cuisine element product of Poria cocos and preparation method thereof | |
| CN104222412A (en) | Health herbal tea capable of improving immunity and preparation method thereof | |
| CN104585776A (en) | Blood replenishing and Qi cultivating porridge and preparation method thereof | |
| CN106889341A (en) | A kind of feed addictive for improving pigling immunity and preparation method and application | |
| CN108991529A (en) | The food compositions and preparation method thereof of member are supported in a kind of invigorating the spleen | |
| CN104957709A (en) | Glossy ganoderma coarse cereal fruit vegetable beverage capable of invigorating spleen-stomach and replenishing qi and preparation method of glossy ganoderma coarse cereal fruit vegetable beverage | |
| CN107149116A (en) | A kind of Chinese angelica mutton spice bag and the spice packet preparation method | |
| CN103735855A (en) | Traditional Chinese medicine composition containing dendrobium officinale leaves and flowers and application thereof | |
| CN104306684B (en) | It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart and preparation method | |
| CN109847047A (en) | One formula and preparation method thereof grown tea | |
| CN109362921A (en) | A kind of travel suit herbal tea and its preparation and concocting method | |
| CN109528971A (en) | A kind of infant spleen-tonifying stomach oral solution and preparation method thereof containing donkey-hide gelatin | |
| CN104524292A (en) | Application of traditional Chinese medicine preparation in preparation of medicament for treating obesity | |
| CN105126007B (en) | A kind of patch for treating baby diarrhea | |
| CN105011228A (en) | Goby health-care egg | |
| CN110403166A (en) | A kind of energy food and preparation method thereof | |
| CN106562196A (en) | Health-care food for patients suffering from chronic indigestion to eat, and preparation method of health-care food | |
| CN106260348A (en) | A kind of SANYE Jingya Daipao Teas and preparation method thereof | |
| CN108968066A (en) | A kind of ginseng of strengthen immunity, Rhizoma Atractylodis Macrocephalae, Poria cocos, herbal cuisine element product of fructus lycii and preparation method thereof | |
| CN104585580A (en) | Blood replenishing and Qi cultivating rice cake and preparation method thereof | |
| CN110279804A (en) | A kind of antifatigue rhizoma polygonati Chinese medicine composition and its health liquor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180817 |