CN106889341A - A kind of feed addictive for improving pigling immunity and preparation method and application - Google Patents

A kind of feed addictive for improving pigling immunity and preparation method and application Download PDF

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Publication number
CN106889341A
CN106889341A CN201710139859.4A CN201710139859A CN106889341A CN 106889341 A CN106889341 A CN 106889341A CN 201710139859 A CN201710139859 A CN 201710139859A CN 106889341 A CN106889341 A CN 106889341A
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China
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radix
piglet
immunity
preparata
mixed
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乔家运
朱琪
李海花
陈龙宾
王文杰
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Tianjin Institute of Animal Husbandry and Veterinary Science
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Tianjin Institute of Animal Husbandry and Veterinary Science
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Abstract

The invention discloses a kind of additive for improving pigling immunity and preparation method and application.It is by the 15g of astragalus root 8, the 5g of Radix Angelicae Sinensis 3, the 5g of sealwort 3, the 5g of Radix Codonopsis 3, the 10g of Rhizoma Atractylodis Macrocephalae preparata 5, the 5g of RADIX POLYGONI MULTIFLORI PREPARATA 3, the 5g of Poria cocos 3, the 3g of dried orange peel 2, the 20g of Chinese yam rhizome 10, the 15g of Divine Comedy 8, the 10g of the fruit of glossy privet 5 composition.The present invention further discloses the additive of pigling immunity is improved in regulation piglet humoral immunity level, strengthen body specific immune function to improve the application in terms of resistance against diseases.Result shows：By adding Zeng Mian San in weaning pigs, the effect of piglet specific immunity is adjusted, the ability of piglet disease-resistant can be improved.

Description

A kind of feed addictive for improving pigling immunity and preparation method and application
Technical field
The invention belongs to farm animals nutrition technique research field, it is related to a kind of feed for improving pigling immunity to add Agent and preparation method and application.
Background technology
In pig industry intensive manufacture, the early weaning of piglet is increasingly taken seriously.Early weaning piglet is passed through Often cause stress syndrome, including feed intake reductions, growth retardation, immunity degradation, function of intestinal canal disorder.In order to reach diseases prevention With somatotrophic purpose, antibiotic is used for pig industry without restraint, and the abuse of antibiotic result in resistance of the pathogen to medicine Property enhancing, livestock products medicament residue and agroecological environment the problems such as pollute.Therefore, with natural Chinese medicinal herb by scientific composition, And be added in feed, improve weanling pig immunity purpose to reach, it has also become everybody falls over each other the focus of research.
The immunocompetence of animal body is that microorganism and harmful substance are resisted and removed to body, to keep and recover normal life Manage the ability of function.Nutrition condition is to the function important of pig immune system, and Chinese herbal medicine immunopotentiator is It is made by scientific composition compatibility with natural Chinese medicinal herb, long-term use has no toxic side effect, and does not pollute livestock products, can be with maximum limit Degree ground activation livestock and poultry immune cell.
Total serum protein, the content of albumin are relevant with the absorption of body protein and metabolism status.Many studies have shown that, Chinese herbal medicine contains polysaccharide, organic acid, alkaloids, glucoside and volatile oil etc., and these materials are in pig body by comprehensive The natural premunition and adaptive faculty for pig is had in itself are adjusted and given full play to, played a part of diseases prevention, cured the disease.White egg in blood White major function is to adjust the distribution of extracellular fluid, hormone transport and vitamin and lipid material.Participate in vivo acid generation Thank, therefore Chinese herb feed additive can improve the antibody level of animal body, strengthen its premunition, can effectively utilize vivo protein Matter, strengthens the deposition of protein.
There are IgA, IgM, IgG in all of mammalian blood serum.IgG has antibacterial, antivirus action, also has antitoxin to make With it can neutralize a toxin makes it lose toxicity, and conditioning, cohesion and Precipitation Antigen are mostly important in humoral immunity.IgM is in body Interior earliest generation, but duration is short, it be body first contacts antigenic substance earliest produce antibody, also have antibacterial, Function that is antiviral and neutralizing a toxin, is combined after body is subject to pathogen infection with complement, and the effect for dissolving pathogen is very strong, " pioneer " effect is played in anti-infective；IgA is the main immunoglobulin in exocrine secretion, equally with antibacterial, antiviral, anti- Detoxifying function, it is immune to localized membranes such as body respiratory tract, alimentary canals to play considerable effect, especially for some film senses The pathogenic microorganism of dye has anti-infectious function.Therefore, the raising of piglet phase sera IgA, IgM, IgG, to a certain extent Piglet incidence can be reduced.
In the life process of pig, nutrition is to maintain function of immune system, it is ensured that improve the deciding factor of immunity, and Resources of Chinese medicinal herb in natural animal-plant and mineral matter, with aboundresources, cheap, safe ready, full-featured, noresidue And toxic and side effect it is small the advantages of, and containing the various active factor, the dual-use function with nutrition and health care, with Chinese herbal medicine as exempting from The research of epidemic disease accelerator and have a extensive future.
The content of the invention
This research adjusts piglet humoral immunity level by adding piglet Zeng Mian San in weaning pigs, strengthens body Specific immune function improves body resistance against diseases.
To achieve the above object, the invention discloses following technology contents：
A kind of feed addictive for improving pigling immunity（Zeng Mian San）, it is characterised in that it is by the raw material group of following weight Into：
Astragalus root 8-15g, Radix Angelicae Sinensis 3-5g, sealwort 3-5g, Radix Codonopsis 3-5g, Rhizoma Atractylodis Macrocephalae preparata 5-10g, RADIX POLYGONI MULTIFLORI PREPARATA 3-5g,
Poria cocos 3-5g, dried orange peel 2-3g, Chinese yam rhizome 10-20g, Divine Comedy 8-15g, fruit of glossy privet 5-10g.
The currently preferred feed addictive for improving pigling immunity（Zeng Mian San）, it is characterised in that it is by following heavy The raw material composition of amount：
Astragalus root 8g, Radix Angelicae Sinensis 3g, sealwort 3g, Radix Codonopsis 3g, Rhizoma Atractylodis Macrocephalae preparata 5g, RADIX POLYGONI MULTIFLORI PREPARATA 3g,
Poria cocos 3g, dried orange peel 2g, Chinese yam rhizome 10g, Divine Comedy 8g, fruit of glossy privet 5g.
The present invention further discloses the preparation method of the feed addictive for improving pigling immunity：
（1）Dry ice low-temperature grinding is sieved：Astragalus root adds dry ice first to crush 300 mesh sieves with General low temperature pulverizer, remaining medicine Beater grinder is fixed with small-sized low temperature to crush, cross 120 mesh sieves standby respectively.
（2）Mixed components：Based on being first well mixed in astragalus root, Poria cocos and Divine Comedy addition mixer, then will Radix Angelicae Sinensis, sealwort, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, RADIX POLYGONI MULTIFLORI PREPARATA are mixed in adding mixer, are finally gradually added to remaining traditional Chinese medicine powder by several times Mixed in mixer, until whole traditional Chinese medicine powders are mixed.All traditional Chinese medicine powders are weighed by prescribed dose electronic scale.
（3）Quality inspection is packed：Finished product should be dried, loose, well mixed, color and luster is consistent, and packaging uses built-in vinyon Bag film, external application plastic-aluminum vacuum valve bag.
The present invention further discloses the additive of pigling immunity is improved for adjusting piglet immunological level, machine is improved The application of body resistance against diseases.Result of the test shows：Piglet Zeng Mian San is added in Piglet Diets can improve piglet disease-resistant ability.
In formula of the invention astragalus root, Rhizoma Atractylodis Macrocephalae preparata, Chinese yam rhizome, the fruit of glossy privet be main ingredient, be aided with Radix Angelicae Sinensis, sealwort, RADIX POLYGONI MULTIFLORI PREPARATA, Poria cocos, dried orange peel, Divine Comedy etc., wherein astragalus root consumption are not to be exceeded 20g.
According to the various Chinese medicine physicochemical properties and active ingredient in this formula, the preparation technology to traditional Chinese powder medicine does the present invention System optimization, at utmost playing its drug action.We have mainly investigated following condition in development process：
1st, ultralow temperature superfine communication technique
Crucial medicinal material astragalus root in formula uses the broken technology of dry ice low-temperature submicron powder, and dry ice presses 2 with the Radix Astragali：1 volume ratio is mixed Close, then whole mixture is crushed on Lowtemperaturepulverizer, cross 300 mesh sieves.The pure carbon dioxide included due to dry ice gradually from Evaporated in sample, so will not leave behind any residue, maintain middle the effective elements of the medicine.
2nd, mix：Mixed using equal increments method.
3rd, divided dose：By the contrast with gravimetric method and volumetric method, we determine to use gravimetric method, and this method dosage is accurate, Error is small, easily adjustment.
4th, pack：Packaging is using built-in sealed polyethylene plastic bag, external application plastic-aluminum vacuum valve bag.Preferably prevent from inhaling Wet, caking, discoloration is decomposed, so as to guaranteed quality and take effect.
The pharmacological action of the Chinese medicine used in the present invention is as follows：
Astragalus root
Process：After taking refined honey plus certain amount of boiling water dilution, astragalus mongholicus tablet is added to mix thoroughly, it is slightly vexed, put in medicine cookeding pot, heated with slow fire, fry To buff, tack-free is degree, and taking-up is cooled.Each 100g of astragalus mongholicus tablet refined honey 25g.
Pharmacology：Tool invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, expelling pus and promoting granulation.
Radix Angelicae Sinensis
Process：Crude drug is taken, impurity is removed, cleaned, slightly moistened, shave, dried or low temperature drying, weed out chip.
Pharmacology：With replenishing and activating blood, the function of relaxing bowel.
Sealwort
Process：Crude drug is taken, impurity is removed, cleaned, slightly moistened, cut sheet, dried.
Pharmacology：Kidney-nourishing adds essence, there is the immune function of enhancing.
Radix Codonopsis
Process：Crude drug is taken, except removing LU, is cleaned, run through, cut sheet, dried.
Pharmacology：Tool tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung effect.
Rhizoma Atractylodis Macrocephalae preparata
Process：First pot is heated with moderate heat, wheat bran is sprinkled into, when smoldering, bighead atractylodes rhizome piece is put into, constantly stir-fried, fried to the bighead atractylodes rhizome in Huang Brown, takes out, and weeds out wheat bran, cools.Bighead atractylodes rhizome piece is per 100kg wheat bran 10kg.
Pharmacology：With strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect.
RADIX POLYGONI MULTIFLORI PREPARATA
Process：Radix Polygoni Multiflori piece or block are taken, is mixed thoroughly with decoction of black soybean, soaked, put non iron and steam in container, it is closed, steam or stew to juice Liquid is sucked, and when medicine is in sepia, takes out, and dries.The fleece-flower root is per 100g black soya bean 10g.
Pharmacology：With filling liver kidney, benefiting essence-blood relaxes bowel, the function of removing toxicity for eliminating carbuncles.
Poria cocos
Process：Crude drug is taken, size is separated, immersion is cleaned, and is run through, and sheet or block are cut while hot after slightly steaming.
Pharmacology：With clearing damp and promoting diuresis, invigorating the spleen calming heart effect is used for oedema, phlegm and retained fluid, heat gonorrhea, diarrhea, vomiting.
Dried orange peel
Process：Crude drug is taken, impurity is removed, clear water is sprayed, run through, chopping is dried in the shade.
Pharmacology：With regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function.
Chinese yam rhizome
Process：Crude drug is taken, impurity is removed, size is separate, cleaned, run through, cut sheet, dried, weed out chip.
Pharmacology：With engender liquid and benefic lung, tonifying spleen nourishing the stomach, the function of the puckery essence of kidney tonifying.
Divine Comedy
Process：Take raw six songs to put in medicine cookeding pot, heated with slow fire, constantly stir-fry, it is internal slightly yellow to surface coke yellow, there is perfume (or spice) When gas is escaped, take out, cool.
Pharmacology：Function with food digesting stomach fortifying.
The fruit of glossy privet
Process：Crude drug is taken, impurity and stalk leaf, cleaning, drying is removed.Used time smashs to pieces.
Pharmacology：With nourshing kidney benefit liver, the function of crow palpus improving eyesight.
More detailed description of the present invention is as follows：
1 materials and methods
1.1 feed addictive prescriptions
Prescription title：Piglet Zeng Mian San
Formula：Astragalus root 8g, Radix Angelicae Sinensis 3g, sealwort 3g, Radix Codonopsis 3g, Rhizoma Atractylodis Macrocephalae preparata 5g, RADIX POLYGONI MULTIFLORI PREPARATA 3g, Poria cocos 3g, dried orange peel 2g, Chinese yam rhizome 10g, Divine Comedy 8g, fruit of glossy privet 5g.
Indication：Benefiting qi and nourishing blood, dehumidify invigorating the spleen, liver protection.We are remarkable to improving piglet specific immune function effect.
Usage and dosage：It is for oral administration, piglet consumption 0.5-1g/Kg body weight.When spice is used, above-mentioned feed addictive is pressed into 1-2% Addition and pig starter feed mix after use.
Experiment uses corn-soybean meal diet, with reference to NRC（1998）Swine rearing standard preparation pig starter feed.Experiment daily ration Composition it is as follows：
Corn 60.35, dregs of beans 25, whey powder 5, fish meal 4, soya-bean oil 2.0, calcium monohydrogen phosphate 1.2, stone flour 0.8, salt 0.3, lysine 0.35th, premix 1.
Premix provides VA 12000 IU, VD3 3000 IU, VE 60 IU, VK3 3 ㎎, VB1 3 for every kilogram of diet ㎎, VB2 7.5 ㎎, VB6 4.8 ㎎, VB12 40 ug, the ㎎ of D-VB5 30, the ㎎ of folic acid 1.2, the ㎎ of nicotinic acid 45, biotin 0.22 ㎎, the ㎎ of copper 15, the ㎎ of manganese 50, the ㎎ of zinc 120, the ㎎ of iron 120, the ㎎ of selenium 0.6, the ㎎ of iodine 0.3.
1.2 experimental designs
Experiment 28 ages in days of selection（Du × long × big）Weanling pig 72, average weight is 7.21 ± 0.36 kg, by completely random Divide into two treatment, blank control group, diet is without feed addictive；Test group, diet is by 2% addition feed addition Agent.Each 3 repetition for the treatment of, each repeats 12 piglets, tests in after the wean of the age in days of piglet 28, and 56 ages in days terminate, examination The phase is tested for 28 d.
1.3 feedings and managements
Pig enclosed grazing during experiment, test pig uses identical feeding and management and environmental condition, and dry mash feeding is freely adopted Food and drinking-water, are immunized during experiment by pig farm normal procedure, are carried out disinfection and sanitation and hygiene by pig farm feeding and management code Deng work.
During off-test, each repeat randomly select 5 piglet jugular vein blood collections, for determine Swine serum IgG, IgA, IgM levels, and antibody against swine fever virus and pig blue-ear disease antibody level.
During off-test, each repeats to randomly select 2 piglets, is put to death using the method for jugular vein bloodletting, butchers immediately, Spleen, thymus gland and the liver of piglet are gathered, Immune Organs Index is determined.
1.4 Testing index and method
1.4.1 sero-immunity index
Immunoglobulin G（IgG）, immunoglobulin M（IgM）, immunoglobulin A（IgA）, kit is purchased from Nanjing and builds up life Thing Graduate School of Engineering, assay method is carried out according to kit explanation.
Antibody against swine fever virus detection kit and pig blue-ear disease antibody assay kit, purchased from IDEXX companies, according to reagent Box specification is measured.
1.4.2 Immune Organs Index
During off-test, spleen, thymus gland and the liver of piglet are gathered, weigh weight in wet base, Computation immunity shoot formation.
Immune Organs Index (g/kg)=Organ Wet Weight (g)/carcass weight (kg)
1.5 statistical analyses
The indexs such as the serum immune globulin of statistical analysis each group, antibody level and Immune Organs Index, using one-way ANOVA （IBM SPSS Statistics 20.0）Variance test is analyzed.Data are represented with " means standard deviation " in text, probabilityP < Significant difference, probability are thought when 0.05P <Think that difference is extremely notable when 0.01.
2 results and analysis
2.1 sero-immunity indexs
As shown in Table 1, during off-test, the IgG of test group piglet improves 10.06%, significant difference than control group（P<0.05）, IgM, IgA of test group piglet have different degrees of raising, but difference is not notable；The hog cholera antibody blocking rate of test group piglet And blue otopathy antibody level is respectively increased 5.88%, 18.60% than control group, but difference is not notable（P ＞ 0.05）.From result above Understand, diet addition Zeng Mian San can significantly improve piglet immunological protein content, hog cholera antibody blocking rate and blue ear can be improved Sick antibody level.
The sero-immunity index of table 1
Note：Colleague's shoulder notes different lowercase letter control groups and test group significant difference（p<0.05）.
2.2 Immune Organs Indexes
As shown in Table 2, during off-test, piglet thymus index test group improves 8.29%, significant difference than control group（P< 0.05）.Piglet index and spleen index and liver index test group have been respectively increased 5.26%, 4.06% than control group, but difference is not notable. Knowable to result above, diet addition Zeng Mian San can improve piglet immunological shoot formation.
The piglet immunological shoot formation of table 2
Note：Colleague's shoulder notes different lowercase letter control groups and test group significant difference（p<0.05）.
The present invention adds 2% feed addictive in pig starter feed（Zeng Mian San）, to feed addictive（Zeng Mian San）Carry out Safety experiment, its method is as follows：
1 step：
（1）Material and method：Du × length × big the piglet 10 of 28 ages in days is selected, clinical health, development are normal, experimental period 28 My god, poisoning manifestations and death condition are observed in experimental period at any time.
（2）The pig starter feed raw material composition of feeding：
Corn 60.35, dregs of beans 25, whey powder 5, fish meal 4, soya-bean oil 2.0, calcium monohydrogen phosphate 1.2, stone flour 0.8, salt 0.3, lysine 0.35th, premix 1.
Premix provides VA 12000 IU, VD3 3000 IU, VE 60 IU, VK3 3 ㎎, VB1 3 for every kilogram of diet ㎎, VB2 7.5 ㎎, VB6 4.8 ㎎, VB12 40 ug, the ㎎ of D-VB5 30, the ㎎ of folic acid 1.2, the ㎎ of nicotinic acid 45, biotin 0.22 ㎎, the ㎎ of copper 15, the ㎎ of manganese 50, the ㎎ of zinc 120, the ㎎ of iron 120, the ㎎ of selenium 0.6, the ㎎ of iodine 0.3.
Be added to Zeng Mian San in pig starter feed by the ratio in 2%, is made experiment and is tested with daily ration.
2 results：Zeng Mian San is added to pig starter feed, continuous feeding 28 days has no obvious intoxicating phenomenon, nothing in the observation period Death, each main organs of cut open inspection show no obvious abnormalities.
3 conclusions：The Zeng Mian San feeding piglet of addition 2% in pig starter feed, feeding effect safety.
The good effect that the feed addictive for improving pigling immunity disclosed by the invention has compared with prior art It is：
（1）The Radix Astragali, Radix Angelicae Sinensis in the present invention are main ingredient, with qi-blood tonifying effect, can effectively improve piglet humoral immunity water Gentle Immune Organs Index.
（2）In the present invention ten simply medicine compatibility must make mutual aid, can be as the immunologic adjuvant of piglet, to improving specificity Immune level has good effect.
（3）The natural Chinese medicinal herb that the present invention is selected contains the various active factor, with aboundresources, cheap, safe The advantages of convenient, full-featured, noresidue and small toxic and side effect, the dual-use function with nutrition and health care can long-term taking, effect Fruit safety.
Specific embodiment
The present invention is described below by specific embodiment.Unless stated otherwise, technological means used in the present invention It is method known in those skilled in the art.In addition, embodiment is interpreted as illustrative, it is not intended to limit the present invention Scope, the spirit and scope of the invention are limited only by the claims that follow.To those skilled in the art, without departing substantially from this On the premise of invention spirit and scope, the various changes that are carried out to the material component and consumption in these embodiments or change Belong to protection scope of the present invention.Chinese herbal medicine used of the invention and reagent are commercially available.
Embodiment 1
Zeng Mian San is made up of the raw material of following weight：
Astragalus root 10g, Radix Angelicae Sinensis 3g, sealwort 5g, Radix Codonopsis 3g, Rhizoma Atractylodis Macrocephalae preparata 5g, RADIX POLYGONI MULTIFLORI PREPARATA 3g,
Poria cocos 5g, dried orange peel 3g, Chinese yam rhizome 15g, Divine Comedy 10g, fruit of glossy privet 5g.
Embodiment 2
Zeng Mian San is made up of the raw material of following weight：
Astragalus root 8g, Radix Angelicae Sinensis 3g, sealwort 3g, Radix Codonopsis 3g, Rhizoma Atractylodis Macrocephalae preparata 5g, RADIX POLYGONI MULTIFLORI PREPARATA 3g,
Poria cocos 3g, dried orange peel 2g, Chinese yam rhizome 10g, Divine Comedy 8g, fruit of glossy privet 5g.
Embodiment 3（Embodiment 1-2）
Improve the preparation method of the feed addictive of pigling immunity：
（1）Dry ice low-temperature grinding is sieved：Astragalus root adds dry ice first to crush 300 mesh sieves with General low temperature pulverizer, remaining medicine Beater grinder is fixed with small-sized low temperature to crush, cross 120 mesh sieves standby respectively.
（2）Mixed components：Based on being first well mixed in astragalus root, Poria cocos and Divine Comedy addition mixer, then will Radix Angelicae Sinensis, sealwort, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, RADIX POLYGONI MULTIFLORI PREPARATA are mixed in adding mixer, are finally gradually added to remaining traditional Chinese medicine powder by several times Mixed in mixer, until whole traditional Chinese medicine powders are mixed.All traditional Chinese medicine powders are weighed by prescribed dose electronic scale.
（3）Quality inspection is packed：Finished product should be dried, loose, well mixed, color and luster is consistent, and packaging uses built-in vinyon Bag film, external application plastic-aluminum vacuum valve bag.

Claims (4)

1. it is a kind of improve pigling immunity feed addictive, it is characterised in that it is made up of the raw material of following weight：
Astragalus root 8-15g, Radix Angelicae Sinensis 3-5g, sealwort 3-5g, Radix Codonopsis 3-5g, Rhizoma Atractylodis Macrocephalae preparata 5-10g,
RADIX POLYGONI MULTIFLORI PREPARATA 3-5g, Poria cocos 3-5g, dried orange peel 2-3g, Chinese yam rhizome 10-20g, Divine Comedy 8-15g, fruit of glossy privet 5-10g.
2. the additive described in claim 1, it is characterised in that it is made up of the raw material of following weight：
Astragalus root 8g, Radix Angelicae Sinensis 3g, sealwort 3g, Radix Codonopsis 3g, Rhizoma Atractylodis Macrocephalae preparata 5g, RADIX POLYGONI MULTIFLORI PREPARATA 3g,
Poria cocos 3g, dried orange peel 2g, Chinese yam rhizome 10g, Divine Comedy 8g, fruit of glossy privet 5g.
3. the preparation method of additive described in any one of claim 1-2, it is characterised in that carried out by the steps：
（1）Dry ice low-temperature grinding is sieved：Astragalus root adds dry ice first to crush 300 mesh sieves with General low temperature pulverizer, remaining medicine Beater grinder is fixed with small-sized low temperature to crush, cross 120 mesh sieves standby respectively；
（2）Mixed components：First will astragalus root, Poria cocos and Divine Comedy add mixer in be well mixed based on, then by Radix Angelicae Sinensis, Sealwort, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae preparata, RADIX POLYGONI MULTIFLORI PREPARATA are mixed in adding mixer, and remaining traditional Chinese medicine powder is gradually finally added into mixing by several times Mixed in machine, until whole traditional Chinese medicine powders are mixed, all traditional Chinese medicine powders are weighed by prescribed dose electronic scale；
（3）Quality inspection is packed：Finished product should be dried, loose, well mixed, color and luster is consistent, and packaging uses built-in sealed polyethylene plastic Bag, external application plastic-aluminum vacuum valve bag.
4. the feed addictive that pigling immunity is improved described in claim 1 is improving piglet humoral immunity level, strengthens body Application in terms of specific immune function.
CN201710139859.4A 2017-03-10 2017-03-10 A kind of feed addictive for improving pigling immunity and preparation method and application Pending CN106889341A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107712373A (en) * 2017-12-05 2018-02-23 安徽皇佳生物工程技术有限公司 A kind of pig starter feed for improving immunity and preparation method thereof
CN108685990A (en) * 2018-08-27 2018-10-23 山东汇融畜牧养殖有限公司 Enhance the nonreactive Chinese prescription and preparation method thereof of hog cholera vaccine immunization
CN110051770A (en) * 2019-05-28 2019-07-26 皖西学院 Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet
CN113304220A (en) * 2021-03-30 2021-08-27 上海市第七人民医院(上海中医药大学附属第七人民医院) Traditional Chinese medicine composition and traditional Chinese medicine mixture for treating deficiency syndrome in traditional Chinese medicine

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CN102688417A (en) * 2012-06-19 2012-09-26 山西双鹰动物药业有限公司 Chinese medicinal composition for treating porcine reproductive and respiratory syndrome
CN102772703A (en) * 2012-08-02 2012-11-14 山西双鹰动物药业有限公司 Drug for treating porcine reproductive and respiratory syndrome
CN103613674A (en) * 2013-09-09 2014-03-05 华南农业大学 Extraction method for astragalus polysacharin
CN105053703A (en) * 2015-08-28 2015-11-18 王莉 Immunity improving pig feed

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Publication number Priority date Publication date Assignee Title
CN102688417A (en) * 2012-06-19 2012-09-26 山西双鹰动物药业有限公司 Chinese medicinal composition for treating porcine reproductive and respiratory syndrome
CN102772703A (en) * 2012-08-02 2012-11-14 山西双鹰动物药业有限公司 Drug for treating porcine reproductive and respiratory syndrome
CN103613674A (en) * 2013-09-09 2014-03-05 华南农业大学 Extraction method for astragalus polysacharin
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107712373A (en) * 2017-12-05 2018-02-23 安徽皇佳生物工程技术有限公司 A kind of pig starter feed for improving immunity and preparation method thereof
CN108685990A (en) * 2018-08-27 2018-10-23 山东汇融畜牧养殖有限公司 Enhance the nonreactive Chinese prescription and preparation method thereof of hog cholera vaccine immunization
CN110051770A (en) * 2019-05-28 2019-07-26 皖西学院 Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet
CN110051770B (en) * 2019-05-28 2021-09-10 皖西学院 Compound Chinese herbal medicine immunopotentiator for treating weak piglets and preparation method thereof
CN113304220A (en) * 2021-03-30 2021-08-27 上海市第七人民医院(上海中医药大学附属第七人民医院) Traditional Chinese medicine composition and traditional Chinese medicine mixture for treating deficiency syndrome in traditional Chinese medicine

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Application publication date: 20170627