CN104306684B - It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart and preparation method - Google Patents

It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart and preparation method Download PDF

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CN104306684B
CN104306684B CN201410558495.XA CN201410558495A CN104306684B CN 104306684 B CN104306684 B CN 104306684B CN 201410558495 A CN201410558495 A CN 201410558495A CN 104306684 B CN104306684 B CN 104306684B
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parts
medicine
tranquilization
sleep
kidney tonifying
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CN104306684A (en
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杜明珠
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SWISHER TONGHUA PHARMACEUTICAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

It is specifically a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart and preparation method the present invention relates to a kind of topical drug or health treatment.The red sage root, the taste Chinese medicine of the bighead atractylodes rhizome 2 is taken to cut into 10-15mm sections, by spina date seed（Fry）, the fruit of Chinese magnoliavine, Poria cocos, the tuber of dwarf lilyturf, cape jasmine, prepared fleece flower root, polygala mix with above-mentioned 2 taste Chinese medicine, put in circumfluence distillation tank, plus the water of 5 times of amounts soaks 1 hour, heating and refluxing extraction 5 hours, it is concentrated into proportion 1.15-1.20,80 DEG C of drying, are ground into fine powder, particle are made, after the assay was approved, packed with composite membrane for packaging medicine, per packed 20g, 3 bags are filled per box（Or 5 bags, 6 bags, 7 bags）, load big case and produce.Healthcare function：Improve sleep.Suitable for being used because of the crowd that neurasthenia, insomnia forgetfulness, vexed anxiety and climacteric metancholia etc. cause sleep state not good.

Description

It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart and preparation method
Technical field
It is specifically that one kind can improve sleep, intelligence development peace the present invention relates to a kind of topical drug, health treatment and preparation method God, the external used medicine of kidney tonifying nourishing heart and preparation method（Trade name：The suppression of this prestige board solution, which is calmed the nerves, steeps leg particle）.
Background technology
In prior art, treatment causes sleep because of neurasthenia, insomnia forgetfulness, vexed anxiety and climacteric metancholia etc. In poor shape medicine is mostly oral formulations, excessively takes and not only has an impact to Liver and kidney function, also there is very big stimulation to stomach Property.Chinese medicine external application and plus appropriate application method, can equally reach that improve sleep has no report.
The content of the invention
The purpose of the present invention be provided for above-mentioned not enough it is a kind of can improve sleep, intelligence promoting and tranquilization, kidney tonifying nourishing heart outside With medicine and preparation method.
The present invention technical solution be：It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, by The bulk drug of following parts by weight is made：10~15 parts of Semen Ziziphi Spinosae (parched), 10~15 parts of the fruit of Chinese magnoliavine, 10~15 parts of Poria cocos, the red sage root 10 ~15 parts, 8~12 parts of the tuber of dwarf lilyturf, 8~12 parts of cape jasmine, 8~12 parts of prepared fleece flower root, 8~12 parts of the bighead atractylodes rhizome, 8~12 parts of polygala.Use Method：Polybag is put into bucket, takes one bag of 20 g of this product to pour into polybag, adding 35-45 DEG C of warm water 2-2.5Kg makes Steep leg grain dissolution, 35-45 DEG C of warm water added in bucket, both legs are put into polybag, plastic bag mouth envelope roll in knee with On, hot gas is formed gas steaming in the polybag below knee, steep 30-35 minutes leg time.
It is preferred that：It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, by the raw material of following parts by weight Particle is made in medicine：10 parts of Semen Ziziphi Spinosae (parched), 10 parts of the fruit of Chinese magnoliavine, 10 parts of Poria cocos, 10 parts of the red sage root, 12 parts of the tuber of dwarf lilyturf, 12 parts of cape jasmine, system what 12 parts of the tuber of multiflower knotweed, 12 parts of the bighead atractylodes rhizome, 12 parts of polygala.
It is preferred that：It is a kind of to improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, by the raw material of following parts by weight Particle is made in medicine：How first 15 parts of Semen Ziziphi Spinosae (parched), 15 parts of the fruit of Chinese magnoliavine, 15 parts of Poria cocos, 15 parts of the red sage root, 8 parts of the tuber of dwarf lilyturf, 8 parts of cape jasmine, system be 8 parts of crow, 8 parts of the bighead atractylodes rhizome, 8 parts of polygala.
Pharmaceutical dosage form not limited to this, by the pharmaceutical carrier commonly used on above-mentioned each medicinal raw material and pharmacy, such as excipient or auxiliary Material can be mixed and made into granule, powder, liquid preparation or other conventional external preparations.
A kind of to improve sleep, intelligence promoting and tranquilization, the preparation method of the external used medicine of kidney tonifying nourishing heart, its step is as follows：
The red sage root, the taste Chinese medicine of the bighead atractylodes rhizome 2 is taken to cut into 10-15mm sections, by spina date seed（Fry）, the fruit of Chinese magnoliavine, Poria cocos, the tuber of dwarf lilyturf, Cape jasmine Son, prepared fleece flower root, polygala are mixed with above-mentioned 2 taste Chinese medicine, are put in circumfluence distillation tank, plus the water of 5 times of amounts soaks 1 hour, plus Circumfluence distillation 5 hours, is concentrated into proportion 1.15-1.20, and 80 DEG C of drying are ground into fine powder, particle is made, it is qualified to examine Afterwards, packed with composite membrane for packaging medicine, per packed 20g, 3 bags are filled per box（Or 5 bags, 6 bags, 7 bags）, load big case and produce.
Spina date seed：Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, Tianjin Wound is thirsty.Spina date seed（Fry）：Net spina date seed is taken, is put in frying container, is fried with slow fire to heaving, color is micro- to be deepened.Take out, cool. This product is warm-natured after frying, and treats the egersis as caused by asthenia cold of gallbladder；It is raw to be controlled with abnormal heat is then led and be slept disease more as caused by sthenia cholic heat, institute Semen Ziziphi Spinosae (parched) is used with we.
The fruit of Chinese magnoliavine：Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathed heavily for void of coughing long, emission, enuresis frequent micturition, chronic diarrhea Incessantly, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.
Poria cocos：Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind Uneasiness, insomnia of palpitating with fear.
The red sage root：Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain , Disorder lumps in the abdomen product It is poly-, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
The tuber of dwarf lilyturf：Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.Deficiency of Yin consumptive disease is coughed, larynx numbness pharyngalgia, injury thirst, and interior heat disappears Yearningly, vexed insomnia, dry constipation of intestines.
Cape jasmine：Purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body；Externally used detumescence is relieved pain.For Vexed, jaundice with damp-heat pathogen drenches Demonstrate,prove puckery pain, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles；Control bruise pain outside.
Prepared fleece flower root：Turbid lipid-loweringing is changed in filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.For blood deficiency chlorosis, dizziness and tinnitus, Under poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, hyperlipidemia.
The bighead atractylodes rhizome：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, Spontaneous perspiration, fetal irritability.
Polygala：Tranquilize the mind and promote the intelligence, restoring normal coordination between heart and kidney, eliminating the phlegm, detumescence.For insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear, Wandering, expectoration is not well, sore swollen toxin, mastosis.
The prescription is Chinese medicine preparation, using the mutual compatibility of the medicines such as spina date seed, the fruit of Chinese magnoliavine, Poria cocos, the red sage root, the tuber of dwarf lilyturf, so that Reach the health care for improving sleep or control treatment functions.Spina date seed nourishing heart tonifying liver in side, antitoxic heart-soothing and sedative, arrest sweating, promote the production of body fluid, fruit of Chinese magnoliavine convergence Astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming, Poria cocos clearing damp and promoting diuresis, invigorating the spleen, calming heart, red sage root promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, Cool blood to disappear carbuncle, tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire, cape jasmine purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, externally used detumescence stop in addition Bitterly, prepared fleece flower root filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, the turbid lipid-loweringing of change, bighead atractylodes rhizome strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, peace Tire, polygala tranquilize the mind and promote the intelligence, restoring normal coordination between heart and kidney, eliminating the phlegm, detumescence；Traditional Chinese medical theory is used for reference, using circumfluence distillation technology, medicine is extracted Active ingredient in thing, is made particle, by leg foot bath therapy, with hot-water soak both legs and both feet, makes rapid drug absorption, promotees Enter body tissue's metabolism, improve blood circulation, activate each organ of whole body, reaching improves the healthcare function of sleep.
Healthcare function：Improve sleep, intelligence promoting and tranquilization, kidney tonifying nourishing heart.
Suitable population：This product is applied to sleep because neurasthenia, insomnia forgetfulness, vexed anxiety and climacteric metancholia etc. cause The in poor shape crowd that sleeps uses.
Application method：Polybag is put into bucket, takes one bag of this product to pour into polybag, 40 DEG C or so of warm water is added 2-2.5Kg makes to add 40 DEG C or so of warm water in bubble leg grain dissolution, bucket, and both legs are put into polybag, plastic bag mouth envelope folding Steamed in above knee, making hot gas form gas in the polybag below knee, may advantageously facilitate kneed blood circulation and skin Skin absorbs, and the 30-35 minutes leg time of bubble is advisable, and continuous using effect is more preferable.
Advantages of the present invention：1st, reasonable recipe, definite effect.2nd, the medicinal material active ingredient of product of the present invention is made using heat Refluxing extraction technology, extracts the effective ingredient in medicine, high with cream rate is received, and energy consumption reduction, extract quality is significantly improved Advantage.3rd, using unique external application application method, external preparation for skin is directly used in, the security of clinical application is improved.Such as warm water Steep pin, polybag gas to steam, may advantageously facilitate kneed blood circulation and skin absorbs, the effect for improving sleep is more preferable.4th, originally The health treatment of invention is through Jilin Province's sanitary monitoring and testing work Spot detection, to rat skin acute toxicity test LD50It is more than 5000mg/kg, its toxicity grading belongs to actual nontoxic level；It is nonirritant to the multiple irritation test of family's rabbit skin；To cavy Skin allergy test is weak sensitization；According to《Health treatment function assessment assessment process and the method for inspection》In criterion Judge：This product, which has, improves sleep function.5th, this prestige board solution presses down obvious effective rate 14% of the bubble leg particle in 50 users of calming the nerves, Total effective rate is 92%, is as a result shown, the suppression of this prestige board solution calms the nerves the health care of bubble leg particle, therapeutic efficiency definitely, and the thing that has no adverse reaction Part.
Embodiment
Embodiment 1
It is a kind of can improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, its feature by following parts by weight raw material Particle is made in medicine：Spina date seed（Fry）10 parts, 10 parts of the fruit of Chinese magnoliavine, 10 parts of Poria cocos, 10 parts of the red sage root, 12 parts of the tuber of dwarf lilyturf, 12 parts of cape jasmine, system what 12 parts of the tuber of multiflower knotweed, 12 parts of the bighead atractylodes rhizome, 12 parts of polygala.
Preparation method：The red sage root, the taste Chinese medicine of the bighead atractylodes rhizome 2 is taken to cut into 10-15mm sections, by spina date seed（Fry）, the fruit of Chinese magnoliavine, Fu Siberian cocklebur, the tuber of dwarf lilyturf, cape jasmine, prepared fleece flower root, polygala are mixed with above-mentioned two tastes Chinese medicine, are put in circumfluence distillation tank, plus 5 times of water loggings measured Bubble 1 hour, heating and refluxing extraction 5 hours is concentrated into proportion 1.15-1.20, and 80 DEG C of drying are ground into fine powder, particle is made, After the assay was approved, packed with composite membrane for packaging medicine, per packed 20g, 3 bags are filled per box（Or 5 bags, 6 bags, 7 bags）, load big Case is produced.
Embodiment 2
It is a kind of can improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, its feature by following parts by weight raw material Particle is made in medicine：Spina date seed（Fry）15 parts, 15 parts of the fruit of Chinese magnoliavine, 15 parts of Poria cocos, 15 parts of the red sage root, 8 parts of the tuber of dwarf lilyturf, 8 parts of cape jasmine, what is first for system 8 parts of crow, 8 parts of the bighead atractylodes rhizome, 8 parts of polygala.
Preparation method：The red sage root, the taste Chinese medicine of the bighead atractylodes rhizome 2 is taken to cut into 10-15mm sections, by spina date seed（Fry）, the fruit of Chinese magnoliavine, Fu Siberian cocklebur, the tuber of dwarf lilyturf, cape jasmine, prepared fleece flower root, polygala are mixed with above-mentioned 2 taste Chinese medicine, are put in circumfluence distillation tank, plus 5 times of water loggings measured Bubble 1 hour, heating and refluxing extraction 5 hours is concentrated into proportion 1.15-1.20, and 80 DEG C of drying are ground into fine powder, particle is made, After the assay was approved, packed with composite membrane for packaging medicine, per packed 20g, 3 bags are filled per box（Or 5 bags, 6 bags, 7 bags）, load big Case is produced.
Experimental example 1
Process choice Orthogonal experiment results are：
Factor level table
Orthogonal test designs table and result
It is by above-mentioned result of the test selection optimum experimental condition：5 hours extraction times of medicinal material, the consumption of solvent is medicinal material 5 times.
Experimental example 2
Experiment crowd：Informed subject of the age between 32 years old to 64 years old 50.
Healthcare function：Improve sleep.
Suitable population：This product is applied to sleep because neurasthenia, insomnia forgetfulness, vexed anxiety and climacteric metancholia etc. cause The in poor shape crowd that sleeps uses.
Operational version：Polybag is put into bucket, takes one bag of 20g of this product to pour into polybag（Embodiment 1）, add 40 DEG C 2-2.5Kg of warm water of left and right makes to add 40 DEG C or so of warm water in bubble leg grain dissolution, bucket, and both legs are put into polybag, modeling Pocket mouthful envelope is rolled in above knee, making hot gas form gas steaming in the polybag below knee, may advantageously facilitate kneed blood Liquid is circulated and skin absorbs, and the 30-35 minutes leg time of bubble is advisable, use daily.
Observing time：14 days
Observation index：Improve the degree of sleep.
Divide following several types：
Difficulty falling asleep.
Sleep shallow, Yi Xing.
Mixed type is had a sleepless night.
Analysis and summary：
This prestige board solution suppression calm the nerves bubble leg particle be Tonghua Siwei Pharmaceutical Co., Ltd. develop Traditional Chinese medicine health-care article it One, with the healthcare function of sleep is improved, to evaluate its security and validity, sampled and adjusted using crowd We conducted 50 Look into.
Result of the test is shown：
50 are had because of neurasthenia, insomnia forgetfulness, vexed anxiety and more using population ages between 32 years old to 64 years old, all Term syndrome etc. causes various different degrees of poor sleeps, by soaking 30-35 points of both legs, both feet per the daily product Clock, continuous to use two weeks, its sleep all has different degrees of improvement.
0 taken a turn for the better completely after treatment.
Compare 7 be clearly better before treating after treatment.
39 turned after treatment than slightly being got better before treating.
Than 4 before treatment without improvement after treatment.
Knowable to data above, the suppression of this prestige board solution, which is calmed the nerves, steeps health-care efficacy always the having in 50 sample investigations of leg particle Efficiency is 92%, obvious effective rate 14%, different the reason for because causing poor sleep, is applicable the constitution difference of crowd, and the suppression of this prestige board solution is pacified Effect that god's bubble leg particle improves sleep embodies different.
Sample survey results show that the suppression of this prestige board solution, which is calmed the nerves, steeps leg granule therapy, health-care efficacy definitely, and has no adverse reaction Event.
Experimental example 3
Through Jilin Province's sanitary monitoring and testing work Spot detection, the suppression of this prestige board solution, which is calmed the nerves, steeps leg granules in rats skin sensibiligen Test LD50More than 5000mg/kg, its toxicity grading belongs to actual nontoxic level；It is stingless to the multiple irritation test of family's rabbit skin Swash property；It is weak sensitization to the experiment of guinea pig skin allergy.
Experimental example 4
Through Jilin Province sanitary monitoring and testing work center according to《Health treatment function assessment assessment process and the method for inspection》In sentence Determine standard determination ［ Ji defends searching BJ201204032 ］：The suppression of this prestige board solution calms the nerves bubble leg particle with improvement sleep function（Implement Example 1）.

Claims (4)

1. a kind of can improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart, it is characterised in that by the original of following parts by weight Granule is made in material medicine：10~15 parts of Semen Ziziphi Spinosae (parched), 10~15 parts of the fruit of Chinese magnoliavine, 10~15 parts of Poria cocos, 10~15 parts of the red sage root, wheat 8~12 parts of winter, 8~12 parts of cape jasmine, 8~12 parts of prepared fleece flower root, 8~12 parts of the bighead atractylodes rhizome, 8~12 parts of polygala；Application method：Will modeling Pocket is put into bucket, takes one bag of 20 g of this product to pour into polybag, is added 35-45 DEG C of warm water 2-2.5Kg and is made bubble leg particle Dissolve, 35-45 DEG C of warm water is added in bucket, both legs are put into polybag, plastic bag mouth envelope is rolled in above knee, makes hot gas Gas is formed in the polybag below knee to steam, and steeps 30-35 minutes leg time.
2. improving the external used medicine of sleep, intelligence promoting and tranquilization, kidney tonifying nourishing heart according to a kind of energy described in claim 1, its feature exists Particle is made in the bulk drug by following parts by weight：10 parts of Semen Ziziphi Spinosae (parched), 10 parts of the fruit of Chinese magnoliavine, 10 parts of Poria cocos, 10 parts of the red sage root, 12 parts of the tuber of dwarf lilyturf, 12 parts of cape jasmine, 12 parts of prepared fleece flower root, 12 parts of the bighead atractylodes rhizome, 12 parts of polygala.
3. improving the external used medicine of sleep, intelligence promoting and tranquilization, kidney tonifying nourishing heart according to a kind of energy described in claim 1, its feature exists Particle is made in the bulk drug by following parts by weight：15 parts of Semen Ziziphi Spinosae (parched), 15 parts of the fruit of Chinese magnoliavine, 15 parts of Poria cocos, 15 parts of the red sage root, 8 parts of the tuber of dwarf lilyturf, 8 parts of cape jasmine, 8 parts of prepared fleece flower root, 8 parts of the bighead atractylodes rhizome, 8 parts of polygala.
4. described a kind of it can improve sleep, intelligence promoting and tranquilization, the external used medicine of kidney tonifying nourishing heart according to claim 1-3 is any Preparation method, it is characterised in that step is as follows：
The red sage root, the taste Chinese medicine of the bighead atractylodes rhizome two is taken to cut into 10-15mm sections, by Semen Ziziphi Spinosae (parched), the fruit of Chinese magnoliavine, Poria cocos, the tuber of dwarf lilyturf, cape jasmine, system The fleece-flower root, polygala are mixed with above-mentioned two tastes Chinese medicine, are put in circumfluence distillation tank, plus the water of 5 times of amounts soaks 1 hour, heats back Stream is extracted 5 hours, is concentrated into proportion 1.15-1.20, and 80 DEG C of drying are ground into fine powder, particle is made, after the assay was approved, use Composite membrane for packaging medicine is packed.
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