CN108354876A - A kind of anti-inflammation and analgesic drugs toothpaste - Google Patents
A kind of anti-inflammation and analgesic drugs toothpaste Download PDFInfo
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- CN108354876A CN108354876A CN201810525867.7A CN201810525867A CN108354876A CN 108354876 A CN108354876 A CN 108354876A CN 201810525867 A CN201810525867 A CN 201810525867A CN 108354876 A CN108354876 A CN 108354876A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of medicated toothpaste, include the component of following mass percentage：0.1 10% anti-inflammatory analgesic active component；20 60% rubbing agents；1 8% foaming agent；10 40% wetting agents；0.5 3% adhesive；Surplus is water；Wherein the anti-inflammatory analgesic active component is made of the raw material of following parts by weight：Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.1 1 parts, sisal hemp（AGAVE RIGIDA）15 parts of extract.It can be stopped blooding with detumescence and promoting granulation, sore, reinforced gum intensity, removed oral peculiar smell, repair canker sore, improve swelling and aching of gum.
Description
Technical field
The present invention relates to daily necessities fields, and in particular to a kind of anti-inflammation and analgesic drugs toothpaste.
Background technology
With the development of society, requirement of the people to common oral amenities toothpaste is also higher and higher, have a single function
Toothpaste has been unable to meet the needs of people.Therefore, a variety of drugs are added, so that toothpaste is become has prevention multiple oral disease and peace
The multipurpose tooth paste of Atoxic by be toothpaste development and production developing direction.Chinese herbal medicine is with warm-natured, stimulation is small, safe and non-toxic
The features such as, using natural botanical extraction liquid production Chinese medicinal toothpaste by consumer favor.In recent years, some are not produced originally
The trans-corporation of Chinese herbal toothpaste, such as Colgate-Palmolive company, Bao Gu companies and Unilever, also set foot in Chinese herbal medicine one after another
Herbaceous toothpaste is developed and produced to field of toothpaste.It can be seen that being increasingly enhanced with people's environmental consciousness, back to nature are advocated
Green becomes a kind of inexorable trend and a kind of inevitable choice of toothpaste development and production.We should inherit and develop motherland mouthful
Invaluable experience in terms of chamber medicine utilizes modern technologies and scientific method, reinforces the research of traditional Chinese medicine ingredients and therapeutic effect mechanism,
The technology of extraction active ingredient of Chinese herbs is continuously improved, develops more efficient, safe and non-toxic Chinese medicinal toothpaste.
Periodontitis mainly since the inflammation on gum is diffused under gum, forms oral pocket, a large amount of tooth under gum
Bacterial plaque is attached to tooth surface and teeth space, and the dead angle of less cleaning in calculus dentalis and oral cavity causes the germ of mobility to invade tooth
Gum, once forming oral pocket under gum, the capillary of gum starts to expand, and the pressure of blood vessel increases, at gum long-time
In congested state, oral pocket is easy to be hit by the external world.Weather is very dry, and the salivary secretion of human body is reduced, respiratory tract
Dry, the brittleness enhancing of blood vessel is natively easy to bacterial infection.It, will if eating tonic or the food of pungent stimulation again
Accelerate the operation of blood, Chinese medicine to be referred to as " blood-heat bleeding ", take germ to whole body, cause the swelling and pain of tooth meat, nose is bleeding, dry cough,
The symptoms such as throat inflammation.
Invention content
The technical problem to be solved in the present invention is to provide a kind of medicated toothpaste of anti-inflammatory analgesic.
The specific technical solution for solving above-mentioned technical problem is as follows：
A kind of medicated toothpaste includes the component of following mass percentage：
（1）The anti-inflammatory analgesic active component of 0.1-10%；
（2）20-60% rubbing agents；
（3）1-8% foaming agents；
（4）10-40% wetting agents；
（5）0.5-3% adhesive；
（6）Surplus is water；Wherein the anti-inflammatory analgesic active component is mainly made of the raw material of following parts by weight：Rubber maple
Perfume tree（LIQUIDAMBAR STYRACIFLUA）0.1-1 parts oily, sisal hemp（AGAVE RIGIDA）1-5 parts of extract.
In wherein some embodiments, the anti-inflammatory analgesic active component further includes the raw material of following parts by weight：Ginger
（ZINGIBER OFFICINALE）1-5 parts of extract, honeysuckle（LONICERA JAPONICA）1-5 parts of flower extract.
Rubbing agent of the present invention is hydrated silica, calcium carbonate, calcium bicarbonate, calcium phosphate dihydrate, anhydrous calcium pyrophosphate, nothing
Any one of water calcium monohydrogen phosphate or several combinations.
Foaming agent of the present invention is C8-16 alkyl heteroside, C14-16 alkene sulfonic acid sodiums, laruyl alcohol sodium sulfovinate, coconut palm
Any one of oleamide propyl betaine, sodium lauroyl sarcosine or several combinations.
Wetting agent of the present invention is any one of sorbierite, polyethylene glycol, glycerine, propylene glycol or several groups
It closes.
Adhesive of the present invention is sodium hydroxyethyl cellulose, xanthans, carragheen, carbomer, poloxamer188, silicon
Any one of sour magnalium or several combinations.
In wherein some embodiments, the medicated toothpaste further includes preservative, the preservative be methyl hydroxybenzoate,
The additive amount of the mixture of sodium benzoate, the methyl hydroxybenzoate is 0.1-0.3wt%, and the additive amount of the sodium benzoate is 0.1-
0.3wt%。
In wherein some embodiments, the medicated toothpaste further includes 0.05-0.5wt% sweeteners, the sweetener
For any one of saccharin sodium, xylitol, antierythrite, Sucralose, Aspartame or several combinations.
The preparation method of medicated toothpaste of the present invention is easy, can be according to following operation：First, it will soak
In agent, adhesive input agitated kettle, wetting stirring adds the raw materials such as sweetener, foaming agent, water, continues to stir, fully molten
It is swollen, uniformly translucent liquid phase is made；Then, rubbing agent, antibacterial Shu Min active components, preservative etc. are put into agitated kettle, is stirred
It mixes uniformly；It is qualified to examine, and discharge filling subpackage.
The advantageous effect that technical solution provided in an embodiment of the present invention is brought is：Anti-inflammatory analgesic toothpaste provided by the invention is rich
Containing sweet gum（LIQUIDAMBAR STYRACIFLUA）0.1-1 parts oily, honeysuckle（LONICERA JAPONICA）Flower extraction
Object isoreactivity ingredient can be stopped blooding with detumescence and promoting granulation, sore, reinforce gum intensity, remove oral peculiar smell, repair canker sore, change
Kind swelling and aching of gum.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Embodiment 1
A kind of toothpaste includes the component of following mass percentage：
（1）0.1% anti-inflammatory analgesic active component；The wherein described anti-inflammatory analgesic active component by following parts by weight raw material group
At：Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.1 part, sisal hemp（AGAVE RIGIDA）5 parts of extract；
（2）20% rubbing agent, the rubbing agent be that hydrated silica, calcium carbonate mix, the hydrated silica, calcium carbonate
Mass ratio is 1:1；
（3）8% foaming agent, the foaming agent is C8-16 alkyl heteroside, C14-16 alkene sulfonic acid sodiums mix, described
C8-16 alkyl heteroside, C14-16 alkene sulfonic acid sodiums mass ratio be 1：2；
（4）10% wetting agent, the wetting agent are made of sorbierite, polyethylene glycol, the sorbierite, polyethylene glycol matter
The ratio between amount is 3:1；
（5）3% adhesive, the adhesive are made of sodium hydroxyethyl cellulose, xanthans, carragheen,
The sodium hydroxyethyl cellulose, xanthans, carragheen mass ratio be 2:1:1；
（6）Methyl hydroxybenzoate 0.1%, sodium benzoate 0.3%, saccharin sodium 0.05%, surplus are water.
Embodiment 2
A kind of toothpaste includes the component of following mass percentage：
（1）10% anti-inflammatory analgesic active component；The wherein described anti-inflammatory analgesic active component by following parts by weight raw material group
At：Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 1 part, sisal hemp（AGAVE RIGIDA）1 part of extract；
（2）40% rubbing agent, the rubbing agent is the mixing of hydrated silica, anhydrous calcium pyrophosphate, the hydrated silica, anhydrous
The mass ratio of calcium pyrophosphate is 10:1；
（3）4.5% foaming agent, the foaming agent are the mixing of C8-16 alkyl heteroside, sodium lauroyl sarcosine, the C8-
16 alkyl heterosides, sodium lauroyl sarcosine mass ratio be 3:1；
（4）25% wetting agent, the wetting agent are sorbierite；
（5）2% adhesive, the adhesive is the mixing of sodium hydroxyethyl cellulose, carragheen, described
Sodium hydroxyethyl cellulose, the mass ratio of carragheen are 1:1；
（6）Methyl hydroxybenzoate 0.2%, sodium benzoate 0.2%, xylitol 0.2%, surplus are water.
Embodiment 3
A kind of toothpaste includes the component of following mass percentage：
（1）5% anti-inflammatory analgesic active component；Wherein the anti-inflammatory analgesic active component is made of the raw material of following parts by weight：
Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.5 part, honeysuckle（LONICERA JAPONICA）Flower extract 5
Part, ginger（ZINGIBER OFFICINALE）1 part of extract, sisal hemp（AGAVE RIGIDA）2.5 parts of extract；
（2）40% rubbing agent, the rubbing agent is the mixing of hydrated silica, anhydrous calcium pyrophosphate, the hydrated silica, anhydrous
The mass ratio of calcium pyrophosphate is 10:1；
（3）4.5% foaming agent, the foaming agent are the mixing of C8-16 alkyl heteroside, sodium lauroyl sarcosine, the C8-
16 alkyl heterosides, sodium lauroyl sarcosine mass ratio be 3:1；
（4）25% wetting agent, the wetting agent are sorbierite；
（5）2% adhesive, the adhesive is the mixing of sodium hydroxyethyl cellulose, carragheen, described
Sodium hydroxyethyl cellulose, the mass ratio of carragheen are 1:1；
（6）Methyl hydroxybenzoate 0.2%, sodium benzoate 0.2%, xylitol 0.2%, surplus are water.
Embodiment 4
A kind of toothpaste includes the component of following mass percentage：
（1）5% anti-inflammatory analgesic active component；Wherein the anti-inflammatory analgesic active component is made of the raw material of following parts by weight：
Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.5 part, honeysuckle（LONICERA JAPONICA）Flower extract 1
Part, ginger（ZINGIBER OFFICINALE）5 parts of extract, sisal hemp（AGAVE RIGIDA）2.5 parts of extract；
（2）40% rubbing agent, the rubbing agent is the mixing of hydrated silica, anhydrous calcium pyrophosphate, the hydrated silica, anhydrous
The mass ratio of calcium pyrophosphate is 10:1；
（3）4.5% foaming agent, the foaming agent are the mixing of C8-16 alkyl heteroside, sodium lauroyl sarcosine, the C8-
16 alkyl heterosides, sodium lauroyl sarcosine mass ratio be 3:1；
（4）25% wetting agent, the wetting agent are sorbierite；
（5）2% adhesive, the adhesive is the mixing of sodium hydroxyethyl cellulose, carragheen, described
Sodium hydroxyethyl cellulose, the mass ratio of carragheen are 1:1；
（6）Methyl hydroxybenzoate 0.2%, sodium benzoate 0.2%, xylitol 0.2%, surplus are water.
Embodiment 5
Toothpaste obtained by embodiment 1-4 is tested, with a commercially available toothpaste taste pair for laying claim to anti-inflammatory analgesic effect
According to group 1, in addition control group 2-5 is set；
Wherein control group 2 the difference from example 2 is that, anti-inflammatory analgesic active component is by sweet gum（LIQUIDAMBAR
STYRACIFLUA）Oil composition；
Wherein control group 3 the difference from example 2 is that, anti-inflammatory analgesic active component is by sisal hemp（AGAVE RIGIDA）Extract
Composition；
Wherein difference lies in, the anti-inflammatory analgesic active components by the raw material group of following parts by weight for control group 4 and embodiment 4
At：Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.5 part, honeysuckle（LONICERA JAPONICA）Flower extract
1 part, sisal hemp（AGAVE RIGIDA）2.5 parts of extract；
Wherein difference lies in, the anti-inflammatory analgesic active components by the raw material group of following parts by weight for control group 5 and embodiment 4
At：Sweet gum（LIQUIDAMBAR STYRACIFLUA）Oily 0.5 part, ginger（ZINGIBER OFFICINALE）Extract 5
Part, sisal hemp（AGAVE RIGIDA）2.5 parts of extract.
Test 1 volunteer test on probation
The specific test method is as follows：Each experimental group chooses 15 volunteers, there is periodontal disease；Volunteer uses 2 weeks
Afterwards, according to personal use situation（Whether whether mild, periodontitis, which obtains improving, is even fully recovered）It point gives a mark from 0 to 10, most
Each group overall average scoring event is counted afterwards, is denoted as consumer's scoring.Specific test result is see table 1.
1 test recording table of table
From upper table 1 as it can be seen that the toothpaste obtained by embodiment 1-2 has shared sweet gum（LIQUIDAMBAR
STYRACIFLUA）Oil, honeysuckle（LONICERA JAPONICA）It is commercially available to improve situation ratio for mildness and periodontitis after flower extract
Product will be got well.Embodiment 2 and comparative example 2-3 comparisons are as it can be seen that sweet gum（LIQUIDAMBAR STYRACIFLUA）Oil,
Sisal hemp（AGAVE RIGIDA）Extract shares better；Embodiment 4 and comparative example 4-5 comparisons are as it can be seen that honeysuckle（LONICERA
JAPONICA）1 part of flower extract, ginger（ZINGIBER OFFICINALE）Extract can be obviously improved the present invention when sharing made
The mildness and periodontitis improvement of the toothpaste obtained.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (9)
1. a kind of medicated toothpaste, which is characterized in that include the component of following mass percentage：
（1）The anti-inflammatory analgesic active component of 0.1-10%；
（2）20-60% rubbing agents；
（3）1-8% foaming agents；
（4）10-40% wetting agents；
（5）0.5-3% adhesive；
（6）Surplus is water；Wherein the anti-inflammatory analgesic active component is mainly made of the raw material of following parts by weight：Rubber maple
Perfume tree（LIQUIDAMBAR STYRACIFLUA）0.1-1 parts oily, sisal hemp（AGAVE RIGIDA）1-5 parts of extract.
2. drug ointment according to claim 1, which is characterized in that the anti-inflammatory analgesic active component further includes following
The raw material of parts by weight：Ginger（ZINGIBER OFFICINALE）1-5 parts of extract, honeysuckle（LONICERA JAPONICA）Flower extraction
1-5 parts of object.
3. drug ointment according to claim 1 or 2, which is characterized in that the rubbing agent be hydrated silica, calcium carbonate,
Any one of calcium bicarbonate, calcium phosphate dihydrate, anhydrous calcium pyrophosphate, calcium phosphate dibasic anhydrous or several combinations.
4. drug ointment according to claim 1 or 2, which is characterized in that the foaming agent be C8-16 alkyl heteroside,
Any one of C14-16 alkene sulfonic acid sodiums, laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, sodium lauroyl sarcosine or
Several combination of person.
5. drug ointment according to claim 1 or 2, which is characterized in that the wetting agent be sorbierite, polyethylene glycol,
Any one of glycerine, propylene glycol or several combinations.
6. drug ointment according to claim 1 or 2, which is characterized in that the adhesive is sodium hydroxyethyl cellulose, Huang
Any one of virgin rubber, carragheen, carbomer, poloxamer188, aluminum magnesium silicate or several combinations.
7. drug ointment according to claim 1 or 2, which is characterized in that the medicated toothpaste further includes preservative, institute
The preservative stated is the mixture of methyl hydroxybenzoate, sodium benzoate, and the additive amount of the methyl hydroxybenzoate is 0.1-0.3wt%, the benzene
The additive amount of sodium formate is 0.1-0.3wt%.
8. drug ointment according to claim 1 or 2, which is characterized in that the medicated toothpaste further includes 0.05-
0.5wt% sweeteners, the sweetener are any one of saccharin sodium, xylitol, antierythrite, Sucralose, Aspartame
Or several combination.
9. drug ointment according to claim 1 or 2, which is characterized in that the preparation method of the medicated toothpaste according to
Following operation：First, by wetting agent, adhesive input agitated kettle, wetting stirring adds sweetener, foaming agent, water
Equal raw materials, continue to stir, and are fully swollen, and uniformly translucent liquid phase is made；Then, by rubbing agent, antibacterial Shu Min active components, anti-
Rotten agent etc. is put into agitated kettle, is stirred evenly；It is qualified to examine, and discharge filling subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810525867.7A CN108354876A (en) | 2018-05-28 | 2018-05-28 | A kind of anti-inflammation and analgesic drugs toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810525867.7A CN108354876A (en) | 2018-05-28 | 2018-05-28 | A kind of anti-inflammation and analgesic drugs toothpaste |
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| Publication Number | Publication Date |
|---|---|
| CN108354876A true CN108354876A (en) | 2018-08-03 |
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ID=63012551
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810525867.7A Withdrawn CN108354876A (en) | 2018-05-28 | 2018-05-28 | A kind of anti-inflammation and analgesic drugs toothpaste |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110731935A (en) * | 2019-12-13 | 2020-01-31 | 汉源县昊业花椒产业研究院 | toothpaste for diminishing inflammation and relieving pain |
-
2018
- 2018-05-28 CN CN201810525867.7A patent/CN108354876A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110731935A (en) * | 2019-12-13 | 2020-01-31 | 汉源县昊业花椒产业研究院 | toothpaste for diminishing inflammation and relieving pain |
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