CN102198069B - Lamiophlomis rotata toothpaste and preparation method thereof - Google Patents
Lamiophlomis rotata toothpaste and preparation method thereof Download PDFInfo
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 73
- 239000000606 toothpaste Substances 0.000 title claims abstract description 73
- 241001191006 Phlomoides rotata Species 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 53
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000011187 glycerol Nutrition 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004568 cement Substances 0.000 claims abstract description 11
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 11
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 10
- 239000000600 sorbitol Substances 0.000 claims abstract description 10
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 9
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008240 homogeneous mixture Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 9
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
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- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 abstract 2
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- 230000000694 effects Effects 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 10
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- 238000009533 lab test Methods 0.000 description 5
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- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 4
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- 229930002875 chlorophyll Natural products 0.000 description 3
- 235000019804 chlorophyll Nutrition 0.000 description 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 3
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- 206010018286 Gingival pain Diseases 0.000 description 2
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- 208000032139 Halitosis Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- 238000004140 cleaning Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
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- 230000007774 longterm Effects 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
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- 238000004064 recycling Methods 0.000 description 2
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- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
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- 239000002562 thickening agent Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 208000005080 Benign Migratory Glossitis Diseases 0.000 description 1
- 241001573881 Corolla Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 206010061274 Malocclusion Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 206010043957 Tongue geographic Diseases 0.000 description 1
- 208000014735 Tooth injury Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 208000007287 cheilitis Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- -1 filtered Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 201000003860 geographic tongue Diseases 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
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- 210000003128 head Anatomy 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
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- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 208000004480 periapical periodontitis Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- CHHHXKFHOYLYRE-STWYSWDKSA-M potassium sorbate Chemical compound [K+].C\C=C\C=C\C([O-])=O CHHHXKFHOYLYRE-STWYSWDKSA-M 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
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- 229940085605 saccharin sodium Drugs 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- 239000000230 xanthan gum Substances 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Abstract
The invention provides lamiophlomis rotata toothpaste and a preparation method thereof. The lamiophlomis rotata toothpaste comprises the following components in percentage by weight: 30-45% of sorbitol (70%), 30-45% of glycerin, 5-15% of silicon dioxide, 0.45-0.55% of carboxymethyl cellulose sodium, 0.9-1.9% of sodium lauryl sulfate, 4.5-5.5% of lamiophlomis rotata liquid medicine and 1.5-2.5% of purified water. The preparation method comprises the following steps: adding the carboxymethyl cellulose sodium to the glycerin to obtain glycerin cement for use; mixing the lamiophlomis rotata liquid medicine with the glycerin cement, and then evenly stirring to obtain a homogenized substance I; adding a homogeneous mixture of the sorbitol, the sodium lauryl sulfate and the purified water to the homogenized substance I, and then evenly stirring to obtain a homogenized substance II; and adding the silicon dioxide to the homogenized substance II, and then evenly stirring until the obtained mixture is transparent, thus obtaining the toothpaste.
Description
Technical field
The invention relates to a kind of toothpaste, specifically about a kind of preparation method that contains toothpaste and this toothpaste of Radix Lamiophlomidis Rotatae composition.
Background technology
Toothpaste is dental care products commonly used in the daily life, it is complicated mixture, usually by abrasivus (such as calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide), wetting agent is (such as glycerol, sorbitol, xylitol, Polyethylene Glycol), surfactant is (such as sodium lauryl sulfate, 2-acyl-oxygen base key sodium sulfonate), thickening agent is (such as carboxymethyl cellulose, Cornu Cervi pectin, hydroxyethyl-cellulose, xanthan gum, guar gum etc.), sweeting agent is (such as glycerol, cyclohexylamine sulfonic acid sodium, saccharin sodium etc.), antiseptic (such as sorbic acid potassium salt and sodium benzoate), active additive is (such as chlorophyll, and pigment fluoride),, essence etc. mix.
Oral disease is one of principal disease of harm humans health, common are: (1) dental caries, be commonly called as dental caries, and be one of modal oral disease, if just treat untimely. can develop into pulpitis and periapical periodontitis; (2) periodontal also is one of modal oral disease, generally comprises gingivitis and periodontitis etc.; (3) the non-dental caries illness of tooth comprises dental fluorosis, tetracycline pigmentation teeth, odentoschim, wedge shaped defect, tooth injury etc.; (4) oral mucosa disease comprises oral ulcer, stomatitis, white macula, lichen planus, cheilitis, geographic tongue etc.; (5) malocclusion; Etc..Early stage oral disease often is accompanied by the symptoms such as gingival swelling and pain, hemorrhage, oral ulcer.In order to prevent and treat oral disease, in toothpaste, add the direction that some ingredients have become the toothpaste development.For example, add chlorophyll in the chlorophyll toothpaste, to stoping gingival hemorrhage, preventing that halitosis from having specially good effect; Toothpaste with enzyme can decompose food residual, to cleaning oral cavity, preventing from damaging by worms produces effect; The Radix Scutellariae toothpaste of selling on the market in addition, Herba Pileae Scriptae toothpaste etc., they have gingival hemorrhage, red swelling of gingiva, halitosis, dentin hypersensitiveness disease etc. obviously slows down and therapeutical effect.
Radix Lamiophlomidis Rotatae (Lamiophlomis rotata), the Labiatae Radix Lamiophlomidis Rotatae belongs to, perennial herb.Leaf is rosette-stape, acaulescence.Wheel umbrella inflorescence dense arrangement becomes head or spike; Corolla lavender, aubergine or pink brown.Radix Lamiophlomidis Rotatae is bitter, is slightly cold, and is slightly poisonous.Effect with blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.
CN101199466A discloses a kind of lamiophlomis rotata medical dental cream and preparation technology thereof, wherein be to be main pharmaceutically active raw material with Radix Lamiophlomidis Rotatae extract, be equipped with adjuvant commonly used and the common process of preparation toothpaste, be prepared from a kind of medicated toothpaste with analgesia, hemostasis, antiinflammatory, the effect such as antibacterial.In this toothpaste, the consumption of Radix Lamiophlomidis Rotatae extractum is 12%～25% of toothpaste gross weight, has strong Chinese medicine odor, and the stimulation that causes vomiting easily during use is difficult for being accepted by consumer.
Summary of the invention
One object of the present invention is to provide a kind of Lamiophlomis rotata toothpaste, when reaching good prevention, treatment oral disease effect, makes toothpaste have pure and fresh abnormal smells from the patient, and reducing the vomiting that medicated toothpaste causes stimulates, and improves the receptance of consumer.
Another object of the present invention is to provide the preparation method of described Lamiophlomis rotata toothpaste.
On the one hand, the invention provides a kind of Lamiophlomis rotata toothpaste, the prescription of this toothpaste forms and comprises (mass percent, except specifying, content described in the present invention and ratio are mass content and ratio):
According to specific embodiments of the present invention, wherein, described Radix Lamiophlomidis Rotatae medicinal liquid prepares in accordance with the following methods:
With the chopping of Radix Lamiophlomidis Rotatae medical material, add 6～10 times of water gagings and decoct 3 times, each 55～65 minutes, merge extractive liquid, filtered, and filtrate is concentrated into relative density 1.10～1.15 (60 ℃), and it is 60%～80% that adding ethanol makes concentration of alcohol, fully stirs hold over night; Alcoholic solution is filtered, and filtrate recycling ethanol is condensed into relative density and is 1.05～115 extractum (density during temperature 60 C); Radix Lamiophlomidis Rotatae extractum with 8～12 times of pure water dilutions, is made the Radix Lamiophlomidis Rotatae medicinal liquid.
In the formulation of tooth-paste of the present invention, sorbitol, glycerol are as wetting agent and index of refraction regulator each other; Silicon dioxide is as abrasivus; Sodium carboxymethyl cellulose is thickening agent, and molding effect is had certain effect; Sodium laurylsulfate is as foaming agent.
According to specific embodiments of the present invention, in the formulation of tooth-paste of the present invention, also can further be added with the correctives compositions such as essence, glucide.Particularly, the addition of described essence is generally 0.5～1.5% of toothpaste gross mass, and the addition of glucide is generally 0.05～0.15% of toothpaste gross mass.
The present invention also provides the preparation method of described Lamiophlomis rotata toothpaste, and the method comprises:
Sodium carboxymethyl cellulose (CMC) is added in the glycerol, make glycerin cement, for subsequent use.Radix Lamiophlomidis Rotatae medicinal liquid (as containing glucide in the prescription, first glucide being added in the Radix Lamiophlomidis Rotatae medicinal liquid) is mixed with glycerin cement, and stir, get equal compound I.Then with sorbitol, liquid sodium laurylsulfate (K
12) (K
12Homogeneous mixture with pure water) adds among the equal compound I, stir, get equal compound II.Silicon dioxide is added among the equal compound II, stir to transparent, get equal compound III.As containing essence in the prescription, in equal compound III, add essence again, stir, get lotion of toothpaste.The fill Lamiophlomis rotata toothpaste that gets product.
According to the proportioning between each component in the toothpaste of the present invention, this toothpaste can be made a kind of mastic of transparence.Wherein, substantially equating with the index of refraction of the abrasivus (silicon dioxide) of adding with the toothpaste liquid phase index of refraction that water, glycerol, sorbitol were formed (can be by determining the ratio of sorbitol, glycerol, silicon dioxide during implementation with refractometer, carry out the toothpaste preparation), mastic presents good pellucidity.
Lamiophlomis rotata toothpaste of the present invention and prior art for example among the CN101199466A disclosed Lamiophlomis rotata toothpaste compare, greatly reduced the consumption of Radix Lamiophlomidis Rotatae extract, and toothpaste can have the effects such as the oral mucosa of reparation, pain easing and hemostasis, antiinflammatory equally, not only keep oral cavity cleaning, also can prevent oral disease, promote the health of tooth.The present invention is applied to toothpaste with the Radix Lamiophlomidis Rotatae medical material, has following characteristics:
1. Radix Lamiophlomidis Rotatae has the effect that promotes wound healing, and its mechanism of action and Radix Lamiophlomidis Rotatae promotion new capillary vessel generate, and promote that the expression of the correlation factors such as Endogenous EGF, VEGF in the tissue is relevant, can be used for the prevention of recurrent aphtha and promotes reparation;
2. in the Radix Lamiophlomidis Rotatae long-term clinical application, show the effect of obvious analgesia, hemostasis, antiinflammatory, and safety non-toxic, having no side effect, no dependence can be used for the prevention of periodontitis, gingivitis, gingival hemorrhage, and teeth consolidating protects gum, alleviates the suffering from oral disease misery;
3. Lamiophlomis rotata toothpaste of the present invention is only used Herba indigoferae Pseudotinctoriae, extracts purification through rational preparation technology, and cooperates other each ratio of adjuvant in the toothpaste, not only kept Effective Component of Chinese Medicine but also without the abnormal smells from the patient of Chinese medicine, can guarantee that again taste is pure and fresh, reducing vomiting stimulates, and is accepted by consumer easily.
Description of drawings
Fig. 1 is the preparation flow sketch map of Lamiophlomis rotata toothpaste of the present invention.
The specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.
Embodiment 1
The Lamiophlomis rotata toothpaste prescription:
Wherein, described Radix Lamiophlomidis Rotatae medicinal liquid prepares in accordance with the following methods:
The Radix Lamiophlomidis Rotatae medical material is selected, remove impurity after, the chopping (among the present invention to grinding particle size without specific (special) requirements, routine operation gets final product), add 8 times of water gagings and decoct each 1 hour 3 times, merge extractive liquid,, filter, filtrate is concentrated into relative density 1.10～1.15 (60 ℃), and it is 70% that adding ethanol makes concentration of alcohol, fully stir, hold over night (benefit of this Ethanol Treatment step: purer after refining, be beneficial to the making transparent toothpaste, otherwise be difficult to obtain transparent toothpaste); Alcoholic solution is filtered, and filtrate recycling ethanol is condensed into relative density and is 1.10 extractum; Radix Lamiophlomidis Rotatae extractum with 10 times of pure water dilutions, is made the Radix Lamiophlomidis Rotatae medicinal liquid.
The preparation method of the Lamiophlomis rotata toothpaste of present embodiment is please in conjunction with referring to flow process shown in Figure 1, and the method comprises:
CMC is added in the glycerol, make glycerin cement, for subsequent use.Glucide is added in the Radix Lamiophlomidis Rotatae medicinal liquid, then mix with glycerin cement, and stir (mixing of physics, without chemical reaction, mechanical type stirs, and alr mode is many, as long as effect reaches, temperature is at 20 ± 5 ℃), equal compound I got.Then with sorbitol, liquid sodium laurylsulfate (sodium laurylsulfate (K
12) with the homogeneous mixture of pure water) add among the equal compound I, stir, get equal compound II.Silicon dioxide is added among the equal compound II, stir to transparent, get equal compound III.In equal compound III, add essence again, stir, join cream processed in the vacuum Manufacturing medicine extract machine, get lotion of toothpaste.Go out cream, chemical examination, result of laboratory test sees table.Sterile filling enters in flexible pipe or the box to seal, and Lamiophlomis rotata toothpaste gets product.
Result of laboratory test:
Lamiophlomis rotata toothpaste to present embodiment carries out following clinical observation experiment, one month experimental period, the experimental session use (sooner or later each once, the each long mastic of about 1.5cm) of normally brushing teeth every day, each subject oral cavity disease condition before and after the observation experiment, the result adds up in following table.The toothpaste of susceptible of proof present embodiment has significant treatment, preventive effect to gingival swelling and pain, oral ulcer, gingivitis, gingival hemorrhage, periodontitis, dental caries etc.
Embodiment 2
The Lamiophlomis rotata toothpaste prescription:
Preparation technology's (preparation method that comprises the Radix Lamiophlomidis Rotatae medicinal liquid) is with embodiment 1.
Result of laboratory test:
Lamiophlomis rotata toothpaste to present embodiment carries out clinical observation experiment, one month experimental period, and uses of sooner or later normally brushing teeth experimental session every day, each subject oral cavity disease condition of observation experiment front and back, the result adds up in following table.
Embodiment 3
The Lamiophlomis rotata toothpaste prescription:
Preparation technology's (preparation method that comprises the Radix Lamiophlomidis Rotatae medicinal liquid) is with embodiment 1.
Result of laboratory test:
Lamiophlomis rotata toothpaste to present embodiment carries out clinical observation experiment, one month experimental period, and uses of sooner or later normally brushing teeth experimental session every day, each subject oral cavity disease condition of observation experiment front and back, the result adds up in following table.
Embodiment 4
The Lamiophlomis rotata toothpaste prescription:
Preparation technology's (preparation method that comprises the Radix Lamiophlomidis Rotatae medicinal liquid) is with embodiment 1.
Result of laboratory test:
Lamiophlomis rotata toothpaste to present embodiment carries out clinical observation experiment, one month experimental period, and uses of sooner or later normally brushing teeth experimental session every day, each subject oral cavity disease condition of observation experiment front and back, the result adds up in following table.
Can find out that from above embodiment and the experiment of corresponding result of use Lamiophlomis rotata toothpaste of the present invention can be used for the prevention of recurrent aphtha and promotes to repair; In the long-term clinical application, show the effect of obvious analgesia, hemostasis, antiinflammatory, no dependence can be used for the prevention of periodontitis, gingivitis, gingival hemorrhage, and teeth consolidating protects gum, alleviates the suffering from oral disease misery.And the Lamiophlomis rotata toothpaste of the various embodiments described above is in clinical observation experiment, and the experimenter represents toothpaste again without the penetrating odor of Chinese medicine, and not occurring vomiting in the use procedure stimulates phenomenon, sensation taste breath freshening, and reducing vomiting stimulates, and is accepted by consumer easily.
Claims (6)
1. Lamiophlomis rotata toothpaste, the prescription of this toothpaste forms and comprises:
Wherein, described Radix Lamiophlomidis Rotatae medicinal liquid prepares in accordance with the following methods:
With the chopping of Radix Lamiophlomidis Rotatae medical material, add 6～10 times of water gagings and decoct 3 times, each 55～65 minutes, merge extractive liquid, filtered, and relative density 1.10～1.15 when filtrate was concentrated into 60 ℃, and it is 60%～80% that adding ethanol makes concentration of alcohol, fully stirs hold over night; Alcoholic solution is filtered, and filtrate is with receiving ethanol, and relative density is 1.05～1.15 extractum when being condensed into 60 ℃; Radix Lamiophlomidis Rotatae extractum with 8～12 times of pure water dilutions, is made the Radix Lamiophlomidis Rotatae medicinal liquid;
And this Lamiophlomis rotata toothpaste prepares in accordance with the following methods, and the method comprises:
Sodium carboxymethyl cellulose is added in the glycerol, make glycerin cement, for subsequent use;
The Radix Lamiophlomidis Rotatae medicinal liquid is mixed with glycerin cement, and stir, get equal compound I;
The homogeneous mixture of sorbitol, sodium laurylsulfate and pure water is added among the above-mentioned equal compound I, stir, get equal compound II;
Silicon dioxide is added among the equal compound II, stir to transparent, get lotion of toothpaste.
2. Lamiophlomis rotata toothpaste according to claim 1, wherein, the prescription of this toothpaste forms and also comprises essence 0.5～1.5%.
3. Lamiophlomis rotata toothpaste according to claim 1, wherein, the prescription of this toothpaste forms and also comprises glucide 0.05～0.15%.
4. the preparation method of each described Lamiophlomis rotata toothpaste of claim 1～3, the method comprises:
Sodium carboxymethyl cellulose is added in the glycerol, make glycerin cement, for subsequent use;
The Radix Lamiophlomidis Rotatae medicinal liquid is mixed with glycerin cement, and stir, get equal compound I;
The homogeneous mixture of sorbitol, sodium laurylsulfate and pure water is added among the above-mentioned equal compound I, stir, get equal compound II;
Silicon dioxide is added among the equal compound II, stir to transparent, get lotion of toothpaste.
5. preparation method according to claim 4 wherein, also comprises glucide in the prescription of the described Lamiophlomis rotata toothpaste composition, is glucide to be added in the Radix Lamiophlomidis Rotatae medicinal liquid first in this preparation method, then mixes with glycerin cement.
6. preparation method according to claim 4, wherein, the prescription of described Lamiophlomis rotata toothpaste also comprises essence in forming, and in this preparation method is to join essence in the equal compound that has added silicon dioxide and stir, and gets lotion of toothpaste.
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| CN106138196B (en) * | 2016-08-24 | 2021-03-05 | 成都中医药大学附属医院 | Toothpaste containing pseudo-ginseng extract and lamiophlomis rotata extract and preparation method thereof |
| CN107496257A (en) * | 2017-09-26 | 2017-12-22 | 中国药科大学 | A kind of formula of mouthwash containing genuine Tibetan herbal medicine lamiophlomis rotata and preparation |
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| CN101199466A (en) * | 2007-11-24 | 2008-06-18 | 甘肃奇正藏药有限公司 | Lamiophlomis rotata medical dental cream and process for preparing same |
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| CN101199466A (en) * | 2007-11-24 | 2008-06-18 | 甘肃奇正藏药有限公司 | Lamiophlomis rotata medical dental cream and process for preparing same |
Non-Patent Citations (3)
| Title |
|---|
| 何沁桂.中草药在牙膏中的应用现状.《牙膏工业》.2006,(第4期),第42-45页. * |
| 潘超.藏药独一味在口腔护理用品中的应用.《口腔护理用品工业》.2010,(第06期), * |
| 王延军.中药与牙膏配伍性研究.《牙膏工业》.1995,(第02期), * |
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