CN108350504B - 膀胱癌的诊断方法 - Google Patents
膀胱癌的诊断方法 Download PDFInfo
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- CN108350504B CN108350504B CN201680048957.0A CN201680048957A CN108350504B CN 108350504 B CN108350504 B CN 108350504B CN 201680048957 A CN201680048957 A CN 201680048957A CN 108350504 B CN108350504 B CN 108350504B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1511152.9A GB201511152D0 (en) | 2015-06-24 | 2015-06-24 | Method of diagnosing bladder cancer |
| GB1511152.9 | 2015-06-24 | ||
| PCT/GB2016/051903 WO2016207656A1 (en) | 2015-06-24 | 2016-06-24 | Methods of diagnosing bladder cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108350504A CN108350504A (zh) | 2018-07-31 |
| CN108350504B true CN108350504B (zh) | 2023-09-29 |
Family
ID=53784470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680048957.0A Active CN108350504B (zh) | 2015-06-24 | 2016-06-24 | 膀胱癌的诊断方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11473148B2 (enExample) |
| EP (1) | EP3314016B1 (enExample) |
| JP (2) | JP7002334B2 (enExample) |
| CN (1) | CN108350504B (enExample) |
| AU (1) | AU2016283063B2 (enExample) |
| GB (1) | GB201511152D0 (enExample) |
| MA (1) | MA42238A (enExample) |
| WO (1) | WO2016207656A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018213550A1 (en) * | 2017-05-18 | 2018-11-22 | Genomic Health, Inc. | Dna methylation and mutational analysis methods for bladder cancer surveillance |
| US11851711B2 (en) | 2017-09-29 | 2023-12-26 | Arizona Board Of Regents On Behalf Of The University Of Arizona | DNA methylation biomarkers for cancer diagnosing |
| CN111655869B (zh) | 2017-11-30 | 2024-06-28 | 梅约医学教育与研究基金会 | 检测乳腺癌 |
| WO2019195268A2 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| CN108588219B (zh) * | 2018-04-19 | 2021-10-26 | 安徽达健医学科技有限公司 | 一种用于早期膀胱癌检测的试剂盒及其使用方法 |
| WO2020013693A1 (en) * | 2018-07-11 | 2020-01-16 | Stichting Vumc | Urine dna methylation markers for bladder cancer |
| AU2019351130B2 (en) | 2018-09-27 | 2025-10-23 | GRAIL, Inc | Methylation markers and targeted methylation probe panel |
| EP4656739A2 (en) * | 2018-11-16 | 2025-12-03 | Oslo Universitetssykehus HF | Methods and compositions for characterizing bladder cancer |
| CN111206093A (zh) * | 2018-11-21 | 2020-05-29 | 立森印迹诊断技术（无锡）有限公司 | 一种用于检测浸润性膀胱癌的标志物及其应用 |
| AU2020212057A1 (en) * | 2019-01-25 | 2021-08-26 | GRAIL, Inc | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| EP4485464A3 (en) * | 2019-02-05 | 2025-02-19 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| CN109971860B (zh) * | 2019-04-30 | 2022-10-11 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物stamp-ep8及其应用 |
| BR112021022084A2 (pt) * | 2019-05-03 | 2022-02-08 | Univ Cornell | Marcadores para identificar e quantificar a mutação da sequência de ácido nucleico, expressão, variante de splice, translocação, número de cópias ou alterações de metilação |
| US11396679B2 (en) | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| WO2020251851A2 (en) * | 2019-06-14 | 2020-12-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Dna methylation biomarkers for cancer diagnosing and treatment |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| US11851714B2 (en) | 2019-12-26 | 2023-12-26 | Anchordx Medical Co., Ltd. | Combinations, detection methods and kits of DNA methylation biomarker |
| EP4083232A4 (en) * | 2019-12-26 | 2024-03-20 | Anchordx Medical Co., Ltd. | COMBINATION OF DNA METHYLATION BIOMARKERS, AND ITS DETECTION METHOD AND ASSOCIATED KIT |
| CN110872631B (zh) * | 2019-12-26 | 2021-08-10 | 广州市基准医疗有限责任公司 | Dna甲基化生物标志物组合、检测方法和试剂盒 |
| CN117248024A (zh) * | 2019-12-31 | 2023-12-19 | 上海奕谱生物科技有限公司 | 新型的诊断肿瘤的标志物及其应用 |
| KR102637032B1 (ko) * | 2020-01-28 | 2024-02-15 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도 |
| CN111635938B (zh) * | 2020-04-30 | 2022-07-29 | 广州康立明生物科技股份有限公司 | 一种肿瘤检测试剂及试剂盒 |
| US12467096B2 (en) | 2020-05-15 | 2025-11-11 | Universal Diagnostics, S.A. | Methods and systems for identifying methylation biomarkers |
| CN111560436A (zh) * | 2020-05-28 | 2020-08-21 | 郑成云 | 一种tert突变检测试剂盒及在肿瘤无创诊断中的应用 |
| WO2022002424A1 (en) * | 2020-06-30 | 2022-01-06 | Universal Diagnostics, S.L. | Systems and methods for detection of multiple cancer types |
| EP4350347A4 (en) | 2021-06-03 | 2024-12-25 | NSK Ltd. | GREASE DETERIORATION DETECTION METHOD AND LUBRICANT DETERIORATION DETECTION METHOD |
| CN113652490B (zh) * | 2021-09-27 | 2022-07-22 | 广州凯普医药科技有限公司 | 一种用于膀胱癌早期筛查和/或预后监测的引物探针组合及试剂盒 |
| CN114107513B (zh) * | 2022-01-27 | 2022-05-03 | 北京优乐复生科技有限责任公司 | 一种用于膀胱尿路上皮癌诊断的检测方法和试剂盒 |
| CN116042820B (zh) * | 2022-09-07 | 2023-09-29 | 浙江大学 | 一组结肠癌dna甲基化分子标志物及其在制备用于结肠癌早期诊断试剂盒中的应用 |
| WO2024176212A1 (en) * | 2023-02-21 | 2024-08-29 | Nucleix Ltd. | Assessment of hematuria and other urinary tract symptoms |
| CN116987787B (zh) * | 2023-06-09 | 2024-07-30 | 北京泛生子基因科技有限公司 | 检测膀胱癌是否复发的装置和计算机可读存储介质 |
| CN116555432B (zh) * | 2023-07-05 | 2023-09-05 | 广州凯普医药科技有限公司 | 一种膀胱癌快速检测试剂盒 |
| CN118006781B (zh) * | 2024-02-27 | 2025-01-07 | 广州中鑫基因医学科技有限公司 | 用于检测尿路上皮癌的标志物、引物组、高敏感性和高特异性的试剂盒及检测方法 |
| CN118222710A (zh) * | 2024-03-25 | 2024-06-21 | 江苏阔然生物医药科技有限公司 | 检测dmrta2、runx3和twist1基因的甲基化水平的试剂在制备膀胱癌诊断产品中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010123354A2 (en) * | 2009-04-20 | 2010-10-28 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120184447A1 (en) | 2009-06-26 | 2012-07-19 | Reinhold Wasserkort | Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders |
| US9249467B2 (en) | 2011-09-16 | 2016-02-02 | Steven Goodison | Bladder cancer detection composition, kit and associated methods |
| US9096905B2 (en) | 2012-02-23 | 2015-08-04 | Medical Diagnostic Laboratories, Llc | Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans |
-
2015
- 2015-06-24 GB GBGB1511152.9A patent/GB201511152D0/en not_active Ceased
-
2016
- 2016-06-24 US US15/738,539 patent/US11473148B2/en active Active
- 2016-06-24 EP EP16732729.5A patent/EP3314016B1/en active Active
- 2016-06-24 JP JP2017567208A patent/JP7002334B2/ja active Active
- 2016-06-24 WO PCT/GB2016/051903 patent/WO2016207656A1/en not_active Ceased
- 2016-06-24 CN CN201680048957.0A patent/CN108350504B/zh active Active
- 2016-06-24 AU AU2016283063A patent/AU2016283063B2/en active Active
- 2016-06-24 MA MA042238A patent/MA42238A/fr unknown
-
2021
- 2021-10-15 JP JP2021169917A patent/JP2022025090A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010123354A2 (en) * | 2009-04-20 | 2010-10-28 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
Non-Patent Citations (5)
| Title |
|---|
| Comprehensive genome methylation analysis in bladder cancer:identification and validation of novel methylated genes and application of these as urinary tumor markers;Thomsa Reinert等;《Clinical Cancer Research》;20110725;第17卷(第17期);第5582-5592 * |
| Diagnostic markers of urothelial cancer based on DNA methylation analysis;Yoshitomo Chihara;《BMC CANCER》;20130604;第13卷(第1期);Article number:275(2013) * |
| Methylation Markers for Urine - Based Detection of Bladder Cancer: The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer;Thomas Reinert等;《Advances in Urology》;20120618;第2012卷;第8页第2段 * |
| Thomas Reinert等.Methylation Markers for Urine - Based Detection of Bladder Cancer: The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer.《Advances in Urology》.2012,第2012卷Article ID503271. * |
| Using high-density DNA methylation arrays to profile copy number alterations;Andrew Feber等;《Genome Biology》;20140203;第15卷(第2期);R30 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11473148B2 (en) | 2022-10-18 |
| WO2016207656A1 (en) | 2016-12-29 |
| GB201511152D0 (en) | 2015-08-05 |
| MA42238A (fr) | 2018-05-02 |
| AU2016283063B2 (en) | 2022-01-20 |
| JP2022025090A (ja) | 2022-02-09 |
| EP3314016B1 (en) | 2024-05-29 |
| EP3314016A1 (en) | 2018-05-02 |
| JP2018520672A (ja) | 2018-08-02 |
| US20180305765A1 (en) | 2018-10-25 |
| CN108350504A (zh) | 2018-07-31 |
| AU2016283063A1 (en) | 2018-02-08 |
| JP7002334B2 (ja) | 2022-02-04 |
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