CN108350034B - 抗微生物的多黏菌素衍生的化合物 - Google Patents

抗微生物的多黏菌素衍生的化合物 Download PDF

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Publication number
CN108350034B
CN108350034B CN201680065339.7A CN201680065339A CN108350034B CN 108350034 B CN108350034 B CN 108350034B CN 201680065339 A CN201680065339 A CN 201680065339A CN 108350034 B CN108350034 B CN 108350034B
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carboxy
trifluoromethyl
bromo
chloro
heteroaryl
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CN201680065339.7A
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Chinese (zh)
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CN108350034A (zh
Inventor
K·D·罗伯特斯
J·李
T·维尔克乌
R·L·内什
P·E·汤姆森
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Monash University
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Monash University
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Priority claimed from AU2015903961A external-priority patent/AU2015903961A0/en
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Publication of CN108350034A publication Critical patent/CN108350034A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680065339.7A 2015-09-29 2016-09-29 抗微生物的多黏菌素衍生的化合物 Active CN108350034B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903961 2015-09-29
AU2015903961A AU2015903961A0 (en) 2015-09-29 Antimicrobial compounds
PCT/AU2016/050915 WO2017054047A1 (en) 2015-09-29 2016-09-29 Antimicrobial polymyxin derivative compounds

Publications (2)

Publication Number Publication Date
CN108350034A CN108350034A (zh) 2018-07-31
CN108350034B true CN108350034B (zh) 2022-03-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680065339.7A Active CN108350034B (zh) 2015-09-29 2016-09-29 抗微生物的多黏菌素衍生的化合物

Country Status (7)

Country Link
US (1) US11225505B2 (enExample)
EP (1) EP3356387B1 (enExample)
JP (2) JP7367950B2 (enExample)
CN (1) CN108350034B (enExample)
AU (1) AU2016331658B2 (enExample)
CA (1) CA3000032A1 (enExample)
WO (1) WO2017054047A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2944550C (en) 2014-04-01 2021-05-25 Monash University Polymyxin derivatives as antimicrobial compounds
WO2016083531A1 (en) 2014-11-26 2016-06-02 New Pharma Licence Holdings Limited Compounds
US11225505B2 (en) * 2015-09-29 2022-01-18 Monash University Antimicrobial polymyxin derivative compounds
KR102170659B1 (ko) * 2015-11-25 2020-10-27 오사카 유니버시티 레지스트패턴 형성방법 및 레지스트재료
AU2018359018B2 (en) 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
KR20210054500A (ko) 2018-06-25 2021-05-13 스페로 테라퓨틱스, 인코퍼레이티드 화합물
CN109402008B (zh) * 2018-11-15 2021-09-14 中国农业科学院饲料研究所 一株具有吲哚降解能力的不动杆菌tat1-6a及其应用
JP7045520B2 (ja) 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
CN111072757B (zh) * 2020-01-02 2021-10-15 上海上药第一生化药业有限公司 多黏菌素b组分或其盐及其制备方法和应用
WO2025236916A1 (en) * 2024-05-16 2025-11-20 Brii Biosciences, Inc. Compositions and methods for treating infections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010336A (zh) * 2004-07-01 2007-08-01 生物资源药物股份有限公司 肽类抗生素和制备它们的方法
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物
WO2015135976A1 (en) * 2014-03-11 2015-09-17 New Pharma Licence Holdings Limited Polymyxin derivatives and their use in combination therapy together with different antibiotics

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045156A1 (en) 2004-10-29 2006-05-04 Monash University Therapy for multi-drug resistant microorganisms
KR100750658B1 (ko) 2005-12-09 2007-08-20 한국생명공학연구원 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군
US8329645B2 (en) 2008-02-08 2012-12-11 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
US8343912B2 (en) * 2008-12-23 2013-01-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
MX360905B (es) * 2013-01-11 2018-11-21 Xellia Pharmaceuticals Aps Polimixinas, composiciones, metodos de preparacion y metodos de uso.
EP2999711B1 (en) 2013-05-22 2022-06-29 Spero Therapeutics, Inc. Polymyxin derivatives and their use in combination therapy together with different antibiotics
CA2944550C (en) * 2014-04-01 2021-05-25 Monash University Polymyxin derivatives as antimicrobial compounds
US11225505B2 (en) * 2015-09-29 2022-01-18 Monash University Antimicrobial polymyxin derivative compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010336A (zh) * 2004-07-01 2007-08-01 生物资源药物股份有限公司 肽类抗生素和制备它们的方法
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物
WO2015135976A1 (en) * 2014-03-11 2015-09-17 New Pharma Licence Holdings Limited Polymyxin derivatives and their use in combination therapy together with different antibiotics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections;Thomas V. Magee;《Medicinal Chemistry》;20130627;第56卷(第12期);第5079-5093页 *

Also Published As

Publication number Publication date
CA3000032A1 (en) 2017-04-06
JP2018531241A (ja) 2018-10-25
AU2016331658B2 (en) 2021-04-01
WO2017054047A1 (en) 2017-04-06
JP7367950B2 (ja) 2023-10-24
EP3356387A4 (en) 2019-03-13
AU2016331658A1 (en) 2018-04-19
US20180282374A1 (en) 2018-10-04
EP3356387A1 (en) 2018-08-08
EP3356387B1 (en) 2024-06-26
JP2022009368A (ja) 2022-01-14
US11225505B2 (en) 2022-01-18
CN108350034A (zh) 2018-07-31
NZ741027A (en) 2024-05-31

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