CN108349972B - 用于治疗呼吸疾病的jak激酶抑制剂化合物 - Google Patents

用于治疗呼吸疾病的jak激酶抑制剂化合物 Download PDF

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Publication number
CN108349972B
CN108349972B CN201680063886.1A CN201680063886A CN108349972B CN 108349972 B CN108349972 B CN 108349972B CN 201680063886 A CN201680063886 A CN 201680063886A CN 108349972 B CN108349972 B CN 108349972B
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alkyl
compound
ethyl
formula
hydrogen
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Chinese (zh)
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CN108349972A (zh
Inventor
保罗·R·法特里
约翰·R·雅各布森
安妮-玛丽·博索莱伊
加里·E·L·勃兰特
梅丽莎·弗勒里
姜岚
卡梅伦·史密斯
史蒂文·D·E·沙利文
洛里·琼·范奥登
皮埃尔-让·科尔松
吉恩·蒂莫西·法斯
米罗斯拉夫·拉普塔
诺亚·本杰明
马尔塔·达布罗斯
文卡特·R·萨兰迪
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Theravance Biopharma R&D IP LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680063886.1A 2015-11-03 2016-11-02 用于治疗呼吸疾病的jak激酶抑制剂化合物 Expired - Fee Related CN108349972B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (2)

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CN108349972A CN108349972A (zh) 2018-07-31
CN108349972B true CN108349972B (zh) 2021-06-08

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US (6) US10100049B2 (OSRAM)
EP (1) EP3371186A1 (OSRAM)
JP (1) JP6800969B2 (OSRAM)
KR (1) KR20180073687A (OSRAM)
CN (1) CN108349972B (OSRAM)
AU (1) AU2016350816B2 (OSRAM)
BR (1) BR112018008966B1 (OSRAM)
CA (1) CA3001542C (OSRAM)
CL (1) CL2018001145A1 (OSRAM)
CO (1) CO2018005640A2 (OSRAM)
EA (1) EA034914B1 (OSRAM)
HK (1) HK1252685A1 (OSRAM)
IL (1) IL258772B (OSRAM)
MX (1) MX374605B (OSRAM)
MY (1) MY195427A (OSRAM)
NZ (1) NZ741737A (OSRAM)
PH (1) PH12018500828B1 (OSRAM)
SA (1) SA518391470B1 (OSRAM)
TW (1) TWI710560B (OSRAM)
UA (1) UA123633C2 (OSRAM)
WO (1) WO2017079205A1 (OSRAM)
ZA (1) ZA201802496B (OSRAM)

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AU2016350816B2 (en) 2015-11-03 2020-06-25 Theravance Biopharma R&D Ip, Llc JAK kinase inhibitor compounds for treatment of respiratory disease
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EA037261B1 (ru) * 2017-03-09 2021-03-01 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Ингибиторы jak, содержащие 4-членный гетероциклический амид
KR20200003121A (ko) 2017-05-01 2020-01-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물의 결정형
CA3059785A1 (en) * 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
US20200281857A1 (en) 2017-11-22 2020-09-10 Dauntless 1, Inc. Therapeutic compound formulations
EP3810094A1 (en) 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor
SI3837258T1 (sl) 2018-09-04 2024-09-30 Theravance Biopharma R&D Ip, Llc Dimetil amino azetidin amidi, ki se uporabljajo kot JAK zaviralci
CA3108848A1 (en) * 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
ES2955717T3 (es) 2018-09-04 2023-12-05 Theravance Biopharma R&D Ip Llc Amidas heterocíclicas de 5 a 7 elementos como inhibidores de JAK
EP3853229A1 (en) * 2018-10-29 2021-07-28 Theravance Biopharma R&D IP, LLC 2-azabicyclo hexane compound as jak inhibitor
JP2022509152A (ja) * 2018-11-19 2022-01-20 ニューヨーク ユニバーシティ 治療薬としてのＧｌｉ１の阻害剤開示の背景
JP7514025B2 (ja) * 2019-02-25 2024-07-10 ホーナン メディノ ファーマシューティカル テクノロジー カンパニー リミテッド Ｊａｋ阻害剤化合物及びその使用
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
MX2021010545A (es) 2019-03-05 2021-11-17 Incyte Corp Inhibidores de la vía de cinasa janus 1 (jak1) para el tratamiento de la disfunción crónica del aloinjerto pulmonar.
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021136345A1 (zh) * 2019-12-30 2021-07-08 路良 Jak抑制剂化合物及其用途
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2022178215A1 (en) 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
TW202304902A (zh) * 2021-03-26 2023-02-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之二鹽酸鹽之結晶形式
EP4359402A1 (en) * 2021-06-25 2024-05-01 Theravance Biopharma R&D IP, LLC Imidazolo indazole compounds as jak inhibitors
CN114181055A (zh) * 2021-12-21 2022-03-15 苏州楚凯药业有限公司 1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法
WO2023215478A1 (en) 2022-05-05 2023-11-09 Theravance Biopharma R&D Ip, Llc Nezulcitinib for delivery by nebulized oral inhalation

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AU2016350816B2 (en) 2015-11-03 2020-06-25 Theravance Biopharma R&D Ip, Llc JAK kinase inhibitor compounds for treatment of respiratory disease
EA037261B1 (ru) 2017-03-09 2021-03-01 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Ингибиторы jak, содержащие 4-членный гетероциклический амид
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ES2955717T3 (es) 2018-09-04 2023-12-05 Theravance Biopharma R&D Ip Llc Amidas heterocíclicas de 5 a 7 elementos como inhibidores de JAK
SI3837258T1 (sl) 2018-09-04 2024-09-30 Theravance Biopharma R&D Ip, Llc Dimetil amino azetidin amidi, ki se uporabljajo kot JAK zaviralci
EP3853229A1 (en) 2018-10-29 2021-07-28 Theravance Biopharma R&D IP, LLC 2-azabicyclo hexane compound as jak inhibitor
TW202304902A (zh) 2021-03-26 2023-02-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之二鹽酸鹽之結晶形式

Patent Citations (3)

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WO2013014567A1 (en) * 2011-07-27 2013-01-31 Pfizer Limited Indazoles
WO2014111380A1 (en) * 2013-01-17 2014-07-24 Galapagos Nv Novel compound useful for the treatment of degenerative and inflammatory diseases

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PH12018500828A1 (en) 2018-10-29
NZ741737A (en) 2023-11-24
US11718616B2 (en) 2023-08-08
US20170121327A1 (en) 2017-05-04
ZA201802496B (en) 2025-01-29
MX374605B (es) 2025-03-06
MX2018005446A (es) 2018-08-01
MY195427A (en) 2023-01-20
SA518391470B1 (ar) 2021-03-31
KR20180073687A (ko) 2018-07-02
CA3001542A1 (en) 2017-05-11
US20210130351A1 (en) 2021-05-06
IL258772A (en) 2018-06-28
US20200087303A1 (en) 2020-03-19
UA123633C2 (uk) 2021-05-05
CL2018001145A1 (es) 2018-07-06
TW201726673A (zh) 2017-08-01
IL258772B (en) 2021-01-31
US20220306624A1 (en) 2022-09-29
EA034914B1 (ru) 2020-04-06
EA201891091A1 (ru) 2018-12-28
WO2017079205A1 (en) 2017-05-11
EP3371186A1 (en) 2018-09-12
TWI710560B (zh) 2020-11-21
HK1252685A1 (zh) 2019-05-31
CO2018005640A2 (es) 2018-05-31
JP6800969B2 (ja) 2020-12-16
US20190106420A1 (en) 2019-04-11
US10100049B2 (en) 2018-10-16
JP2018531982A (ja) 2018-11-01
US10913740B2 (en) 2021-02-09
US20180319796A1 (en) 2018-11-08
PH12018500828B1 (en) 2023-06-30
AU2016350816A1 (en) 2018-05-17
BR112018008966A2 (pt) 2018-11-27
BR112018008966B1 (pt) 2023-05-02
US11299492B2 (en) 2022-04-12
AU2016350816B2 (en) 2020-06-25
US10183942B2 (en) 2019-01-22
CA3001542C (en) 2021-02-16
CN108349972A (zh) 2018-07-31
US10526330B2 (en) 2020-01-07

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