CN108349962A - 取代的吡唑和吡咯化合物以及使用其用于抑制翻译起始和治疗与其相关的疾病和病症的方法 - Google Patents
取代的吡唑和吡咯化合物以及使用其用于抑制翻译起始和治疗与其相关的疾病和病症的方法 Download PDFInfo
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- CN108349962A CN108349962A CN201680045318.9A CN201680045318A CN108349962A CN 108349962 A CN108349962 A CN 108349962A CN 201680045318 A CN201680045318 A CN 201680045318A CN 108349962 A CN108349962 A CN 108349962A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562169376P | 2015-06-01 | 2015-06-01 | |
US62/169,376 | 2015-06-01 | ||
PCT/US2016/035288 WO2016196644A1 (en) | 2015-06-01 | 2016-06-01 | Substituted pyrazole and pyrrole compounds and methods for using them for inhibition of initiation of translation and treatment of diseases and disorders relating thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108349962A true CN108349962A (zh) | 2018-07-31 |
Family
ID=56118071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201680045318.9A Pending CN108349962A (zh) | 2015-06-01 | 2016-06-01 | 取代的吡唑和吡咯化合物以及使用其用于抑制翻译起始和治疗与其相关的疾病和病症的方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US10537558B2 (de) |
EP (1) | EP3303332A1 (de) |
JP (1) | JP6707630B2 (de) |
CN (1) | CN108349962A (de) |
BR (1) | BR112017025851A2 (de) |
CA (1) | CA3025492A1 (de) |
IL (1) | IL255898A (de) |
MX (1) | MX2017015456A (de) |
WO (1) | WO2016196644A1 (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110603254A (zh) * | 2016-11-30 | 2019-12-20 | 班塔姆制药有限责任公司 | 被取代的吡唑化合物以及使用其治疗过度增生性疾病的方法 |
CN110769823A (zh) * | 2016-11-30 | 2020-02-07 | 班塔姆制药有限责任公司 | 使用被取代的吡唑和吡咯化合物以及治疗过度增生性疾病的方法 |
CN110950848A (zh) * | 2018-09-27 | 2020-04-03 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
CN114867724A (zh) * | 2019-05-31 | 2022-08-05 | 班塔姆制药有限责任公司 | 用于制备噻唑基吡唑甲酸及其中间体的方法 |
CN115515685A (zh) * | 2020-03-03 | 2022-12-23 | 皮克医疗公司 | Eif4e抑制剂及其用途 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10537558B2 (en) | 2015-06-01 | 2020-01-21 | Bantam Pharmaceutical, Llc | Substituted pyrazole and pyrrole compounds and methods for using them for inhibition of initiation of translation and treatment of diseases and disorders relating thereto |
JP7301042B2 (ja) | 2018-03-30 | 2023-06-30 | 住友化学株式会社 | 複素環化合物及びそれを含有する有害節足動物防除組成物 |
WO2019236966A2 (en) | 2018-06-07 | 2019-12-12 | Bantam Pharmaceutical, Llc | Methods of treatment of cancer with substituted pyrrole and pyrazole compounds and diagnosis of cancers susceptible to treatment with substituted pyrrole and pyrazole compounds |
EP3846793B1 (de) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e-inhibitoren und verwendungen davon |
EP4053123A4 (de) | 2019-11-01 | 2023-10-11 | Unimatec Co., Ltd. | Fluorierte pyrimidinverbindung und verfahren zu ihrer herstellung |
Citations (7)
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---|---|---|---|---|
US6468979B1 (en) * | 1998-07-30 | 2002-10-22 | Zambon Group S.P.A. | Erythromycin derivatives with antibiotic activity |
US20030220356A1 (en) * | 2002-04-04 | 2003-11-27 | Prabha Ibrahim | ABCA-1 elevating compounds |
WO2004094395A2 (en) * | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
WO2007138110A2 (en) * | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
WO2009027393A2 (en) * | 2007-08-27 | 2009-03-05 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
EP2264017A1 (de) * | 2008-04-04 | 2010-12-22 | Takeda Pharmaceutical Company Limited | Heterocyclisches derivat und seine verwendung |
WO2014066304A1 (en) * | 2012-10-22 | 2014-05-01 | Egenix, Inc. | Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
TR200302047T4 (tr) * | 1999-12-03 | 2004-01-21 | Pfizer Products Inc. | Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri. |
WO2004089303A2 (en) | 2003-04-03 | 2004-10-21 | Merck & Co., Inc. | Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
WO2008121861A2 (en) | 2007-03-28 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Pyrazole and pyrrole compounds useful in treating iron disorders |
KR101608259B1 (ko) | 2008-04-28 | 2016-04-01 | 교린 세이야꾸 가부시키 가이샤 | 시클로펜틸아크릴산아미드 유도체 |
ES2650744T3 (es) * | 2010-12-14 | 2018-01-22 | Electrophoretics Limited | Inhibidores de la caseína quinasa 1 delta (CK1delta) |
AU2015236855B2 (en) | 2014-03-27 | 2018-11-01 | Cancer Research Technology Limited | Pyridyl piperidines |
WO2016169886A1 (en) | 2015-04-24 | 2016-10-27 | Syngenta Crop Protection Ag | Pesticidally active polycyclic derivatives with sulfur substituted five-membered ring heterocyles |
US10537558B2 (en) | 2015-06-01 | 2020-01-21 | Bantam Pharmaceutical, Llc | Substituted pyrazole and pyrrole compounds and methods for using them for inhibition of initiation of translation and treatment of diseases and disorders relating thereto |
-
2016
- 2016-06-01 US US15/578,585 patent/US10537558B2/en active Active
- 2016-06-01 MX MX2017015456A patent/MX2017015456A/es unknown
- 2016-06-01 EP EP16728546.9A patent/EP3303332A1/de not_active Withdrawn
- 2016-06-01 CA CA3025492A patent/CA3025492A1/en not_active Abandoned
- 2016-06-01 WO PCT/US2016/035288 patent/WO2016196644A1/en active Application Filing
- 2016-06-01 CN CN201680045318.9A patent/CN108349962A/zh active Pending
- 2016-06-01 BR BR112017025851-0A patent/BR112017025851A2/pt not_active Application Discontinuation
- 2016-06-01 JP JP2018515175A patent/JP6707630B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-26 IL IL255898A patent/IL255898A/en unknown
-
2020
- 2020-01-21 US US16/748,429 patent/US11602526B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6468979B1 (en) * | 1998-07-30 | 2002-10-22 | Zambon Group S.P.A. | Erythromycin derivatives with antibiotic activity |
US20030220356A1 (en) * | 2002-04-04 | 2003-11-27 | Prabha Ibrahim | ABCA-1 elevating compounds |
WO2004094395A2 (en) * | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
WO2007138110A2 (en) * | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
WO2009027393A2 (en) * | 2007-08-27 | 2009-03-05 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
EP2264017A1 (de) * | 2008-04-04 | 2010-12-22 | Takeda Pharmaceutical Company Limited | Heterocyclisches derivat und seine verwendung |
WO2014066304A1 (en) * | 2012-10-22 | 2014-05-01 | Egenix, Inc. | Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e |
Non-Patent Citations (1)
Title |
---|
SAMIA M. RIDA,等: "Synthesis of Novel Benzofuran and Related Benzimidazole Derivatives for Evaluation of In Vitro Anti-HIV-1, Anticancer and Antimicrobial Activities", 《ARCH PHARM RES》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110603254A (zh) * | 2016-11-30 | 2019-12-20 | 班塔姆制药有限责任公司 | 被取代的吡唑化合物以及使用其治疗过度增生性疾病的方法 |
CN110769823A (zh) * | 2016-11-30 | 2020-02-07 | 班塔姆制药有限责任公司 | 使用被取代的吡唑和吡咯化合物以及治疗过度增生性疾病的方法 |
CN110603254B (zh) * | 2016-11-30 | 2024-04-12 | 班塔姆制药有限责任公司 | 被取代的吡唑化合物以及使用其治疗过度增生性疾病的方法 |
CN110950848A (zh) * | 2018-09-27 | 2020-04-03 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
CN114867724A (zh) * | 2019-05-31 | 2022-08-05 | 班塔姆制药有限责任公司 | 用于制备噻唑基吡唑甲酸及其中间体的方法 |
CN115515685A (zh) * | 2020-03-03 | 2022-12-23 | 皮克医疗公司 | Eif4e抑制剂及其用途 |
Also Published As
Publication number | Publication date |
---|---|
CA3025492A1 (en) | 2016-12-08 |
EP3303332A1 (de) | 2018-04-11 |
US20200261424A1 (en) | 2020-08-20 |
JP2018521119A (ja) | 2018-08-02 |
MX2017015456A (es) | 2018-11-29 |
BR112017025851A2 (pt) | 2018-10-16 |
JP6707630B2 (ja) | 2020-06-10 |
US10537558B2 (en) | 2020-01-21 |
US20180311218A1 (en) | 2018-11-01 |
IL255898A (en) | 2018-01-31 |
WO2016196644A1 (en) | 2016-12-08 |
US11602526B2 (en) | 2023-03-14 |
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Application publication date: 20180731 |
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