CN110177784A - 一种含芳环化合物、其制备方法、药物组合物及应用 - Google Patents

一种含芳环化合物、其制备方法、药物组合物及应用 Download PDF

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CN110177784A
CN110177784A CN201880007037.3A CN201880007037A CN110177784A CN 110177784 A CN110177784 A CN 110177784A CN 201880007037 A CN201880007037 A CN 201880007037A CN 110177784 A CN110177784 A CN 110177784A
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base
hetero atom
methyl
yuan
variety
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胡永韩
蔡冬梅
朱久香
董平
李曼华
林凯文
董加强
王铁林
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Luoxin Biotechnology Shanghai Co ltd
Shandong Luoxin Pharmaceutical Group Co Ltd
Shandong Luoxin Pharmaceutical Co Ltd
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Luoxin Biotechnology Shanghai Co ltd
Shandong Luoxin Pharmaceutical Group Co Ltd
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

本发明公开了一种含芳环化合物、其制备方法、药物组合物及应用。本发明提供了一种如式1所示的含芳环的化合物、其药学上可接受的盐、其立体异构体、其互变异构体或其溶剂化物，该化合物可有效地结合BET家族BRD4、BRD3、BRD2和BRDT的溴结构域，以调控下游基因c‑myc和其相关靶基因的转录，进而调节下游的信号通路，发挥特定作用，包括治疗疾病如炎性疾病、癌症和AIDS；其中部分化合物具有很高的活性，并且具有较好的细胞活性和代谢稳定性，因此可以成为治疗肿瘤的有效药物。

Description

PCT国内申请，说明书已公开。

Claims (27)

  1. PCT国内申请，权利要求书已公开。
CN201880007037.3A 2017-01-16 2018-01-16 一种含芳环化合物、其制备方法、药物组合物及应用 Pending CN110177784A (zh)

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CN201710033493.2A CN108314680A (zh) 2017-01-16 2017-01-16 一种含芳环化合物、其制备方法、药物组合物及应用
CN2017100334932 2017-01-16
PCT/CN2018/072872 WO2018130227A1 (zh) 2017-01-16 2018-01-16 一种含芳环化合物、其制备方法、药物组合物及应用

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KR102622152B1 (ko) * 2019-10-31 2024-01-08 홀로스메딕 주식회사 신규한 화합물 및 이를 포함하는 암 예방 또는 치료용 약학 조성물
CN115667254A (zh) * 2020-05-21 2023-01-31 贝达药业股份有限公司 作为溴结构域蛋白质抑制剂的化合物和组合物

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Application publication date: 20190827