CN108309899A - A kind of hand wash for children and preparation method thereof - Google Patents
A kind of hand wash for children and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of hand wash for children and preparation method thereof.Specifically, the present invention relates to one kind having disinfection, sterilization, non-stimulated, non-corrosive hand cleanser, and its preparation method and application.The hand wash for children of the present invention is made of surfactant 2.0~8.0%, soap base 0.5~2.5%, glycerine 5~20%, plants essential oil 0.02~0.1%, bear oil 0.1~1.0%, vitamin 0.05~0.2%, Chinese medical extract 0.5~3.0%, distilled water；Wherein, Chinese medical extract refers to being obtained by one or more medicinal material extracts in aloe, ginger, honeysuckle, dandelion.The hand wash for children of the present invention is added to plants essential oil, bear oil, aloe extract and plays the role of anti-oxidant, moisturizing; stimulation and allergy of the chemicals to skin can be resisted need not apply skin care item again after washing one's hands using this hand cleanser; skin cracks can be effectively prevent, to protect skin.
Description
Technical field
The present invention relates to a kind of hand wash for children, and in particular to one kind having disinfection, sterilizes, is non-stimulated, non-corrosive
Hand cleanser belongs to articles for washing technical field.
Background technology
With the rapid development of human industryization, environmental pollution is also increasingly heavier.Hand contacts in human body with the external world
At most, various microbiological contaminations are most susceptible to.Children are weaker to the cognition for keeping hand hygiene, they like using hand
It goes to touch interested article, while can also be eaten with finger food, such way often causes children fever, flu, abdomen
Bitterly, the symptoms such as pharyngitis can also cause the propagation of pathogenic microorganism in children's room.Presently commercially available hand wash for children is mainly wide spectrum
Bacteriostatic hand sanitizer is usually added to 2,4,4- tri- chloro- 2- hydroxyls phenylates, xylene chloride phenol and triclosan etc. in hand cleanser and kills
Microbial inoculum, such components have irritation, corrosivity, and stability is poor, the antibacterial duration is short.Child skin is delicate, generally washes
Phosphorus, aluminium, alkali, sodium alkyl benzene sulfonate in hand liquid etc. injure child skin at branch, since modern society is to the vast of hand cleanser
Demand, developing a natural, mild, non-stimulated, non-corrosive and environment friendly and pollution-free hand wash for children is particularly important.
Invention content
In view of posed problems above, the purpose of the present invention is to provide a kind of green, pollution-free, non-stimulated children to wash
Hand liquid.
The present invention is achieved by the following technical solutions：
A kind of hand wash for children, including following component by weight percentage：Surfactant 2.0~8.0%, soap base
0.5~2.5%, glycerine 5~20%, plants essential oil 0.02~0.1%, bear oil 0.1~1.0%, vitamin 0.05~
0.2%, Chinese medical extract 0.5~3.0%, surplus are distilled water；Wherein, Chinese medical extract refers to by aloe, ginger, gold and silver
Flower, one or more extractions in dandelion and obtain.
The aloe, ginger, honeysuckle, dandelion preparation method be to shred raw material, be added distilled water heating extraction,
Filter residue is abandoned in filtering, obtains aloe, ginger, honeysuckle, dandelion extract.
Preferably, the extraction temperature is 50~80 DEG C, and extraction time is 1~3 hour, and extracting times are 1~3 time.
Preferably, the Chinese medical extract is formed by following parts by weight Traditional Chinese medicine decocting：20~30 parts of aloe, Ginger P.E
0~10 part, 0~20 part of honeysuckle, 8~15 parts of dandelion.
Preferably, the hand wash for children, it is characterised in that the surfactant is Tea Saponin, dimethyl
It is one or more in base amine oxide, dodecyldimethylammonium hydroxide inner salt, cocoanut fatty acid diethanolamide.
Preferably, the hand wash for children, it is characterised in that the plants essential oil be Lavender, Rosa Damascana,
Peppermint essential oil, lemon it is one or more.
Preferably, the hand wash for children, it is characterised in that the vitamin is vitamin B1, vitamin B2, dimension life
Plain C, vitamin E it is one or more.
The present invention also provides a kind of preparation methods of hand wash for children, include the following steps：
(1) distilled water is heated to 50~80 DEG C, sequentially adds surfactant, soap base, glycerine, constant temperature at the uniform velocity stirs
So that it is mixed well, then make its slow cooling to 40~60 DEG C, plants essential oil, bear oil is added, continuation constant temperature, which at the uniform velocity stirs, to be made
It is mixed well；
(2) distilled water is heated to 40~70 DEG C, vitamin, Chinese medical extract is added to the container successively and constant temperature stirs
Uniformly, it is then slowly added to the mixture obtained in step (1), is then stirred 2~5 hours, mixing speed is maintained at 20~
60r/min, after mixing, bottling, you can obtain hand wash for children.
The beneficial effect of the present invention compared with the prior art includes：
(1) plants essential oil, the Chinese medical extract contained in hand wash for children of the invention has sterilization, antiviral, expelling parasite
Effect, can be used for skin degerming, mould, fungi and virus infection, plants essential oil and Chinese medical extract can effectively be inhibited to assist
With using more notable to the lethal effect of pathogenic microorganism.
(2) hand wash for children of the invention be added to plants essential oil, bear oil, aloe extract play it is anti-oxidant, moisturizing
Effect, can resist stimulation and allergy of the chemicals to skin need not apply skin care item again after washing one's hands using this hand cleanser, can
Skin cracks are effectively prevent, to protect skin.
(3) raw material resources in the animal and plant source in the present invention are abundant, and preparation process is simple, is easy to extensive life
Production, and preparation process is pollution-free.
Specific implementation mode
Invention is further described in detail With reference to embodiment.It should be emphasized that：Following the description is only
It is merely exemplary, the range being not intended to be limiting of the invention and its application.If without specified otherwise, the percentage in this explanation
It refer to weight percent.
Embodiment 1
1.1 prepare hand wash for children by formula as below：Surfactant 5.0% (3 parts of Tea Saponin, dodecyl dimethyl
2 parts of amine oxide), soap base 1.0%, glycerine 12%, plants essential oil 0.08% (3 parts of Rosa Damascana, 5 parts of Lavender), bear
Oil 0.6%, vitamin 0.14% (2 parts of vitamin B2,5 parts of vitamin C), Chinese medical extract 2.0% (3 parts of aloe extract,
5 parts of Ginger P.E, 3 parts of Honegsukle flower P.E), surplus is distilled water.
1.2 respectively shred enough aloes, ginger, traditional Chinese medicine honeysuckle, and addition distilled water is heated to 50 DEG C and extracts 2 times,
Filter residue is abandoned in each 2h, filtering；Take 0.15 kilogram of aloe extract, 0.25 kilogram of Ginger P.E, Honegsukle flower P.E 0.15 public
Jin, mixing is to get Chinese medical extract；
The preparation of 1.3 hand wash for children：
(1) 10 liters of distilled water is heated to 60 DEG C, sequentially adds 1.0 kilograms of surfactant, soap base 0.2 in 1.1
Kilogram, 2.4 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and then makes its slow cooling to 40 DEG C, adds 1.1
In 16 grams of plants essential oil, 120 grams of bear oil, continue constant temperature and at the uniform velocity stir and so that it is mixed well, is spare；
(2) 6.0 liters of distilled water is heated to 40 DEG C, will be prepared into 28 grams of the vitamin and 1.2 in 1.1 successively
To Chinese medical extract (0.4 kilogram) be added to the container and constant temperature stirs evenly, be then slowly added to obtain in step (1) mixed
Object is closed, continues to stir 2h, mixing speed is maintained at 50r/min, and after mixing, bottling (200ml/ bottles) is to get 100 bottles of children
Hand cleanser.
Embodiment 2
1.1 prepare hand wash for children by formula as below：Surfactant 4.0% (2 parts of dodecyldimethylammonium hydroxide inner salt,
2 parts of cocoanut fatty acid diethanolamide), soap base 0.8%, glycerine 8%, plants essential oil 0.06% (2 parts of Rosa Damascana, lemon
4 parts of lemon essential oil), bear oil 0.5%, vitamin 0.16% (2 parts of vitamin B1,2 parts of vitamin B2,4 parts of vitamin C), Chinese medicine
Extract 2.0% (5 parts of aloe extract, 2 parts of Ginger P.E, 3 parts of dandelion extract), surplus is distilled water.
1.2 respectively shred enough aloes, ginger, dandelion raw material, and addition distilled water is heated to 70 DEG C and extracts 2 times,
Filter residue is abandoned in each 3h, filtering, takes 0.25 kilogram of aloe extract, 0.1 kilogram of Ginger P.E, dandelion extract 0.15 public
Jin, mixing is to get Chinese medical extract；
The preparation of 1.3 hand wash for children：
(1) 10 liters of distilled water is heated to 70 DEG C, sequentially adds 0.8 kilogram of surfactant, soap base 0.16 in 1.1
Kilogram, 1.6 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and then makes its slow cooling to 50 DEG C, adds 1.1
In 12 grams of plants essential oil, 100 grams of bear oil, continue constant temperature and at the uniform velocity stir and so that it is mixed well, is spare；
(2) 7.0 liters of distilled water is heated to 50 DEG C, will be prepared into 32 grams of the vitamin and 1.2 in 1.1 successively
To Chinese medical extract (0.4 kilogram) be added to the container and constant temperature stirs evenly, be then slowly added to obtain in step (1) mixed
Object is closed, continues to stir 3h, mixing speed is maintained at 30r/min, and after mixing, bottling (200ml/ bottles) is to get 100 bottles of children
Hand cleanser.
Embodiment 3
1.1 preparing hand wash for children by formula as below：Surfactant 4.0% (2 parts of Tea Saponin, dodecyl dimethyl
2 parts of amine oxide, 2 parts of cocoanut fatty acid diethanolamide), soap base 1.0%, glycerine 10%, plants essential oil 0.08% (smoke clothing
3 parts of careless essential oil, 5 parts of lemon), bear oil 0.8%, vitamin 0.10% (2 parts of vitamin B1,3 parts of vitamin C, vitamin
5 parts of E), Chinese medical extract 2.0% (2 parts of aloe extract, 4 parts of Honegsukle flower P.E, 3 parts of dandelion extract), surplus is
Distilled water.
1.2 respectively shred enough aloes, honeysuckle, dandelion raw material, and distilled water is added and is heated to 60 DEG C of extractions 3
Secondary, filter residue is abandoned in each 1h, filtering, takes 0.1 kilogram of aloe extract, 0.2 kilogram of Ginger P.E, Honegsukle flower P.E 0.15 public
Jin, mixing is to get Chinese medical extract；
The preparation of 1.3 hand wash for children：
(1) 10 liters of distilled water is heated to 70 DEG C, sequentially adds 0.8 kilogram of surfactant, soap base 0.2 in 1.1
Kilogram, 2.0 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and then makes its slow cooling to 60 DEG C, adds 1.1
In 16 grams of plants essential oil, 160 grams of bear oil, continue constant temperature and at the uniform velocity stir and so that it is mixed well, is spare；
(2) 6.5 liters of distilled water is heated to 60 DEG C, will be prepared into 20 grams of the vitamin and 1.2 in 1.1 successively
To Chinese medical extract (0.4 kilogram) be added to the container and constant temperature stirs evenly, be then slowly added to obtain in step (1) mixed
Object is closed, continues to stir 4h, mixing speed is maintained at 20r/min, and after mixing, bottling (200ml/ bottles) is to get 100 bottles of children
Hand cleanser.
Test example 1
Anti-oxidant (scavenging ability of DPPH free radical) verification experimental verification
1.1 plants essential oil, bear oil, vitamin, the Chinese medical extracts that the various embodiments described above are prepared are implemented as corresponding
Formula in example is mixed, and AX-A (embodiment 1), AX-B (embodiment 2), AX-C (embodiment 3) sample, precision weighing are obtained
It is respectively placed in volumetric flask after sample and is settled to 50mL with absolute ethyl alcohol, shaken up, be then diluted to each sample to be tested in proportion
The testing sample solution of final concentration of 200,100,50,25,12.5,6.25 μ g/mL；
1.2 precisions weigh positive control vitamin C (Vit C) 50mg and are placed in volumetric flask and are settled to absolute ethyl alcohol
50mL shakes up, and then waits for test sample by what Vit C were diluted to final concentration of 62.50,31.25,15.63,7.81 μ g/mL in proportion
Product solution；
1.3 precisions weigh the DPPH powder of 4.4mg, and with absolute ethyl alcohol dissolving and constant volume is in 50mL volumetric flasks, shakes up,
Up to the DPPH ethanol solutions of 0.2mmol/L, used after room temperature avoid light place 30min.
1.4 accurate 3.0mL absolute ethyl alcohols of drawing are mixed with 3.0mL DPPH solution, are shaken up, are protected from light in 37 DEG C of constant temperature quiet
After setting 30min, reference is made with absolute ethyl alcohol, absorbance value A0 is measured at 517nm, each sample replication 3 times is averaged
Value；
1.5 accurate AX-A, AX-B, AX-C for drawing 3.0mL various concentrations of difference and other testing sample solutions, add respectively
The DPPH solution of 3.0mL, measures respective absorbance value Ai, and each sample replication 3 times is averaged；
1.6 accurate AX-A, AX-B, AX-C for drawing 3.0mL various concentrations and other testing sample solutions again, respectively plus
3.0mL absolute ethyl alcohols measure respective absorbance value Aj, each sample replication 3 times, and according to formula P (%)=1- (Ai-
Aj)/A0 × 100% calculates the clearance rate P of DPPH；It is effective that its half is calculated according to the clearance rate of the corresponding DPPH of each concentration
Concentration EC50。
2. result
AX-A, AX-B, AX-C are in preferable dose-effect relationship to the removing of DPPH, and its medium effective concentration and Vit C
Compared to close to (table 1), prompt AX-A, AX-B, AX-C of the present invention that there is significant DPPH free radical scavenging activities, Ke Yijin
One step is developed into antioxidant.
1 AX-A, AX-B, AX-C extract of table and Vit C remove the EC of DPPH free radicals50
Test example 2
Antibacterial tests are verified
1.1 plants essential oil, bear oil, vitamin, the Chinese medical extracts that the various embodiments described above are prepared are implemented as corresponding
Formula in example is mixed, and AX-A (embodiment 1), AX-B (embodiment 2), AX-C (embodiment 3) sample, precision weighing are obtained
It is respectively placed in volumetric flask after sample and is settled to 50mL with sterile saline, shaken up, then pressed each sample to be tested diluter than arranging
It is interpreted into the testing sample solution of final concentration of 100,50,25,12.5,6.25,3.125,1.5625mg/mL；
1.2 precision weighs penicillin respectively, streptomysin is configured to 100 with sterile saline, 50,25,12.5,6.25,
The testing sample solution (positive control) of 3.125 μ g/mL, clotrimazole is configured to 2 with sterile saline, 1,0.5,0.25,
0.125, the testing sample solution (positive control) of 0.0625mg/mL；
1.3 aseptically, and tablet is made with sterilized culture medium, first one layer about 5mL culture medium.Wait for it
After cooled and solidified, Oxford cup is placed on tablet, each tablet is equidistantly placed 3 Oxfords through high pressure steam sterilization and drying
Cup, then about 10mL culture medium.After its solidification, Oxford cup is gripped out with aseptic nipper.Respectively by prepared golden yellow
The bacteria suspension of staphylococcus (25923), Escherichia coli (25922), candida albicans bacterium (10231), takes 0.1mL to set with liquid-transfering gun
It is uniform with sterile painting rod coating on tablet.It takes 100 μ L liquids in hole with liquid-transfering gun, while setting blank control (in equal volume
Physiological saline).The filter paper of sterilized processing is placed on culture dish, is covered with culture ware lid.
The tablet of 1.4 staphylococcus aureuses (25923) and Escherichia coli (25922) inoculation is placed in 37 DEG C of incubator cultures
For 24 hours, the tablet of candida albicans bacterium (10231) inoculation is placed in 37 DEG C of incubator culture 48h, takes out observation, records AX-A, AX-
B, minimum inhibitory concentration (MIC) value of AX-C, each sample replication 3 times are averaged.
2. result
The minimum inhibitory concentration of AX-A, AX-B, AX-C extract is below greatly 10mg/mL (table 2), prompts it to golden yellow
Staphylococcus, Escherichia coli, candida albicans bacterium have it is preferable inhibit accretion, prompt the present invention AX-A, AX-B,
AX-C has significant bacteriostasis, can be developed further into as bacteriostatic agent.
The minimum inhibitory concentration of 2 AX-A, AX-B, AX-C extract of table
Liquid and preparation method thereof simplicity disclosed by the invention of washing one's hands, main composition plants essential oil therein, bear oil, vitamin, in
The preparation method of medicament extract etc. is at low cost, easy to operate, efficient, is suitable for large-scale production, has a good application prospect.
The above content is the further descriptions that the embodiment for combining specific/optimization is the present invention, cannot
Assert that the specific implementation of the present invention is confined to these explanations.It is understood that those skilled in the art,
Without departing from the inventive concept of the premise, some replacements or modification can also be made to the embodiment that these have been described, and
These are substituted or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (7)
1. a kind of hand wash for children, including following component by weight percentage：Surfactant 2.0~8.0%, soap base 0.5
~2.5%, glycerine 5~20%, plants essential oil 0.02~0.1%, bear oil 0.1~1.0%, vitamin 0.05~0.2%, in
Medicament extract 0.5~3.0%, surplus are distilled water；Wherein, Chinese medical extract refers to by aloe, ginger, honeysuckle, dandelion
In one or more medicinal material extracts and obtain.
2. hand wash for children according to claim 1, it is characterised in that the Chinese medical extract refers to by aloe, ginger, gold and silver
One or more medicinal raw materials in flower, dandelion shred, and distilled water heating extraction is added, and filtering abandons filter residue to get accordingly carrying
Take object；Wherein, extraction temperature is 50~80 DEG C, and extraction time is 1~3 hour, and extracting times are 1~3 time.
3. hand wash for children according to claim 1, it is characterised in that the Chinese medical extract is by following parts by weight Traditional Chinese medicine decocting
It forms：20~30 parts of aloe, 0~10 part of Ginger P.E, 0~20 part of honeysuckle, 8~15 parts of dandelion.
4. hand wash for children according to claim 1, it is characterised in that the surfactant refers to Tea Saponin, dodecyl two
It is one or more in methyl oxidation amine, dodecyldimethylammonium hydroxide inner salt, cocoanut fatty acid diethanolamide.
5. hand wash for children according to claim 1, it is characterised in that the plants essential oil refers to Lavender, rhodamine toner
It is one or more in oil, Peppermint essential oil, lemon.
6. hand wash for children according to claim 1, it is characterised in that the vitamin is vitamin B1, vitamin B2, dimension life
Plain C, vitamin E it is one or more.
7. the preparation method of any hand wash for children of claim 1~6, includes the following steps：
(1) distilled water is heated to 50~80 DEG C, sequentially adds surfactant, soap base, glycerine, constant temperature, which at the uniform velocity stirs, makes it
It mixes well, then makes its slow cooling to 40~60 DEG C, add plants essential oil, bear oil, continuation constant temperature, which at the uniform velocity stirs, makes it
It mixes well；
(2) distilled water is heated to 40~70 DEG C, vitamin, Chinese medical extract is added to the container successively and constant temperature stirs
It is even, it is then slowly added to the mixture obtained in step (1), continues stirring 2~5 hours, mixing speed is maintained at 20~60r/
Min, after mixing, bottling to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810448680.1A CN108309899A (en) | 2018-05-12 | 2018-05-12 | A kind of hand wash for children and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810448680.1A CN108309899A (en) | 2018-05-12 | 2018-05-12 | A kind of hand wash for children and preparation method thereof |
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| Publication Number | Publication Date |
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| CN108309899A true CN108309899A (en) | 2018-07-24 |
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ID=62896605
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803418A (en) * | 2020-07-31 | 2020-10-23 | 广州荃智美肤生物科技研究院有限公司 | Antiviral composition and application thereof in daily necessities for children |
-
2018
- 2018-05-12 CN CN201810448680.1A patent/CN108309899A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803418A (en) * | 2020-07-31 | 2020-10-23 | 广州荃智美肤生物科技研究院有限公司 | Antiviral composition and application thereof in daily necessities for children |
| CN111803418B (en) * | 2020-07-31 | 2023-08-04 | 广州荃智美肤生物科技研究院有限公司 | Antiviral composition and application thereof in children daily necessities |
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