CN108703933A - A kind of antibacterial skin moistening liquid soap and preparation method thereof - Google Patents
A kind of antibacterial skin moistening liquid soap and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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Abstract
The present invention relates to a kind of antibacterial skin moistening liquid soaps and preparation method thereof.Specifically, having effects that antibacterial, moisturizing hand cleanser the present invention relates to a kind of, and its preparation method and application.The antibacterial skin moistening liquid soap of the present invention, including following component by weight percentage：1~5% neopelex, 4~8% glycerine, 1~5% dodecyldimethylammonium hydroxide inner salt, 1~8% cocoanut fatty acid diethanolamide, 3~8% dodecyldimethylamine oxide, 0.03~0.1% American-cockroach-extract, 0.1~0.5% dandelion extract, 0.1~0.5% Honegsukle flower P.E, 0.1~0.5% extractive of perilla, surplus are distilled water.The antibacterial skin moistening liquid soap of the present invention, is prepared by natural animal and plant, is free of chemical addition agent, nonirritant to human skin, is suitble to be used for a long time.
Description
Technical field
The present invention relates to a kind of hand cleanser, and in particular to and it is a kind of to have effects that antibacterial, moisturizing hand cleanser, belong to washing and uses
Product technical field.
Background technology
It is mainly season that medicine and life, which are sterilized using cationic surfactant (cationic surfactants), at present
Ammonium salt class has good surface-active in acid medium, inhibits bacterial metabolism to play antibacterial action when low concentration.Its poison
Property and irritation is high, corrosiveness is strong, it is general to gemma effect, and incompatibility is more, is its disadvantage.Hand cleanser is as a kind of
The skin care detergent based on hand is cleaned, it is for a person to use instead of perfumed soap in daily life, it is more convenient, hygienic, therefore research and develop
A natural, harmless and environment friendly and pollution-free bacteriostatic hand sanitizer is particularly important.
American cockroach (Periplaneta americana Linnaeus) is Insecta Blattidae insect, is commonly called as " roach
Dung beetle ".It is used as medicine first recorded in《Sheng Nong's herbal classic》, the treatment of Bai Nationality In Yunnan Popular Utilization American cockroach disease, especially malignant sore, wound
Reparation, anti-inflammatory etc. have long history.Inventor's early-stage study finds that the active constituent extracted from American cockroach can be effective
It removes diphenyl bitter taste diazanyl free radical (DPPH) and hydroxyl radical free radical (OH), effect shows different degrees of dose-effect
Dependence, it was confirmed that American-cockroach-extract has effects that oxidation resistant.Numerous studies discovery, dandelion (Taraxacum
Mongolicum Hand.-Mazz.) there is broad-spectrum antibacterial action, have to gram-positive bacteria, Gram-negative bacteria, fungi
It imitates and does not generate drug resistance, also cause human urogenital to infect mycoplasma solution that is common and there have been pathogenic effects with anti-
The effect of urea urea substance；Chlorogenic acid, isochlorogenic acid, ferulic acid, wood in honeysuckle (Lonicerae Japonica Thunb.)
Rhinoceros grass element is equal to have the function of stronger antibacterial and antiviral, can significantly inhibit the life of bacillus subtilis and salmonella
Long, fungistatic effect is relatively applied alone significantly when combining dandelion；Fan in purple perilla (Perilla frutescens (L.) Britt.) changes
Fragrant acid can effectively remove the effect of ultra-oxygen anion free radical and hydroxy radical, and extractive of perilla can significantly inhibit hyaluronidase
Activity, the capillary permeability caused by antagonism histamine increases.Through retrieval, in the market currently without American cockroach, Pu Gong
English, honeysuckle, purple perilla co-formulated articles for washing patented product.
Invention content
The purpose of the present invention is to provide a kind of antibacterial skin moistening liquid soaps, are prepared, are free of by natural animal and plant
Chemical addition agent, it is nonirritant to human skin, be it is a be used for a long time wash shield product.
The present invention is achieved by the following technical solutions：
A kind of antibacterial skin moistening liquid soap, including following component by weight percentage：1~5% dodecyl benzene sulfonic acid
Sodium, 4~8% glycerine, 1~5% dodecyldimethylammonium hydroxide inner salt, 1~8% coco-nut oil fatty acid diethanol acyl
Amine, 3~8% dodecyldimethylamine oxide, 0.03~0.1% American-cockroach-extract, the extraction of 0.1~0.5% dandelion
Object, 0.1~0.5% Honegsukle flower P.E, 0.1~0.5% extractive of perilla, surplus are distilled water.
Preferably, the antibacterial skin moistening liquid soap, is made of following weight percent：2~3% dodecyl benzene sulfonic acid
Sodium, 4~8% glycerine, 3~4% dodecyldimethylammonium hydroxide inner salt, 3~4% coco-nut oil fatty acid diethanol acyl
Amine, 3~5% dodecyldimethylamine oxide, 0.03~0.1% American-cockroach-extract, the extraction of 0.1~0.5% dandelion
Object, 0.1~0.5% Honegsukle flower P.E, 0.1~0.5% extractive of perilla, surplus are distilled water.
Preferably, the antibacterial skin moistening liquid soap, is made of following weight percent：3% neopelex,
4~8% glycerine, 3% dodecyldimethylammonium hydroxide inner salt, 3% cocoanut fatty acid diethanolamide, 3~5%0
Dialkyl dimethyl amine oxide, 0.03~0.1% American-cockroach-extract, 0.1~0.5% dandelion extract, 0.1~
0.5% Honegsukle flower P.E, 0.1~0.5% extractive of perilla, surplus are distilled water.
Preferably, the American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla are according to 1 ︰
The weight ratio of 8 ︰, 6 ︰ 4 is formulated.
Preferably, the preparation method of the American-cockroach-extract is that protozoon is placed in petroleum ether to impregnate for 24 hours, discards stone
After oily ether, polypide is ground into 20~40 mesh by 30~40 DEG C of solvents volatilized in protozoon, and 85% medicinal alcohol heating leaching is added
It carries, filter residue is abandoned in filtering, obtains American-cockroach-extract.
Preferably, the dandelion, honeysuckle, extractive of perilla preparation method be that raw material is ground into 40~80 mesh,
It is subsequently placed in petroleum ether and impregnates for 24 hours, after discarding petroleum ether, 30~40 DEG C of solvents volatilized in medicinal powder are added 70% in medicinal powder
Medicinal alcohol heating extraction, filtering abandon filter residue, obtain dandelion, honeysuckle, extractive of perilla.
The extraction temperature is 50~80 DEG C, and extraction time is 1~5h, and extracting times are 1~4 time.
The present invention also provides a kind of preparation methods of antibacterial skin moistening liquid soap, include the following steps：
(1) distilled water is heated to 50 DEG C, sequentially add neopelex, dodecyldimethylammonium hydroxide inner salt,
Cocoanut fatty acid diethanolamide, dodecyldimethylamine oxide, glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well,
Then make its slow cooling to 40 DEG C, American-cockroach-extract is added, continuation constant temperature, which at the uniform velocity stirs, makes it mix well；
(2) distilled water is heated to 40 DEG C, dandelion extract, Honegsukle flower P.E, extractive of perilla is added successively
In container and constant temperature stirs evenly, and is then slowly added to the mixture obtained in step (1), then stirs 2~3h, mixing speed
It is maintained at 30~60r/min, after mixing, bottling, you can obtain antibacterial skin moistening liquid soap.
The beneficial effect of the present invention compared with the prior art includes：
(1) dandelion extract, the Honegsukle flower P.E contained in antibacterial skin moistening liquid soap of the invention has sterilization, resists
Virus, the effect of expelling parasite, can be used for skin degerming, can effectively inhibit mould, fungi and virus infection, when the two collaboration uses
It is more notable to the lethal effect of pathogenic microorganism.
(2) it is added to the plant extract with high-efficiency antioxidant ability in antibacterial skin moistening liquid soap preparation method of the invention
Object and American-cockroach-extract, wherein extractive of perilla also have effects that antianaphylactic, American-cockroach-extract has good rush
The effect of skin repair, therefore, hand cleanser disclosed by the invention, are effective against stimulation and allergy of the chemicals to skin, when making
After being washed one's hands with this hand cleanser, skin care item need not be applied again, you can skin cracks are effectively prevent, to protect skin.
(3) animal extracts in the present invention and plant extract source are rich and easy to get, and preparation process is simple, is easy to advise greatly
Mould produces, and preparation process is pollution-free.
Specific implementation mode
Invention is further described in detail With reference to embodiment.It should be emphasized that：Following the description is only
It is merely exemplary, the range being not intended to be limiting of the invention and its application.If without specified otherwise, the percentage in this explanation
It refer to weight percent.
Embodiment 1
1.1 prepare antibacterial skin moistening liquid soap by following weight percent：3% neopelex, the 12 of 3%
Alkyl dimethyl betaine, 3% cocoanut fatty acid diethanolamide, 3% dodecyldimethylamine oxide, 4% third
Triol, 0.05% American-cockroach-extract, 0.4% dandelion extract, 0.3% Honegsukle flower P.E, the extraction of 0.2% purple perilla
Object, surplus are distilled water；The American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla are according to 1 ︰
8 ︰, 6 ︰ 4 are formulated；
Enough American cockroaches, dandelion, honeysuckle, purple perilla raw material crushed 20 mesh sieve by 1.2 respectively, then be added
70% medicinal alcohol is heated to 50 DEG C and extracts 2 times, each 2h, and filter residue is abandoned in filtering, obtains American-cockroach-extract, dandelion carries
Take object, Honegsukle flower P.E, extractive of perilla；
The preparation of 1.3 antibacterial skin moistening liquid soaps：
(1) by distilled water 10 liters be heated to 50 DEG C, sequentially add 0.6 kilogram of neopelex, dodecyl two
0.6 kilogram of methyl betaine, 0.6 kilogram of cocoanut fatty acid diethanolamide, 0.6 kilogram of dodecyldimethylamine oxide,
0.8 kilogram of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and then makes its slow cooling to 40 DEG C；
(2) by distilled water 7 liters be heated to 40 DEG C, 10 grams of American-cockroach-extract, the Pu Gong that will be prepared in 1.2 successively
80 grams of English extract, 60 grams of Honegsukle flower P.E, 40 grams of extractive of perilla is added to the container and constant temperature stirs evenly, then slowly
The mixture obtained in step (1) is added, then stirs 2h, mixing speed is maintained at 60r/min, after mixing, bottling
(200ml/ bottles) are to get 100 bottles of antibacterial skin moistening liquid soaps.
Embodiment 2
1.1 prepare antibacterial skin moistening liquid soap by following weight percent：2% neopelex, the 12 of 4%
Alkyl dimethyl betaine, 4% cocoanut fatty acid diethanolamide, 5% dodecyldimethylamine oxide, 6% third
Triol, 0.1% American-cockroach-extract, 0.4% dandelion extract, 0.3% Honegsukle flower P.E, 0.2% extractive of perilla,
Surplus is distilled water, and the American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla are according to 1 ︰, 4 ︰
3 ︰ 2 are formulated；
Enough American cockroaches, dandelion, honeysuckle, purple perilla raw material crushed 20 mesh sieve by 1.2, then be soaked in respectively
In petroleum ether for 24 hours, after discarding petroleum ether, the petroleum ether in medicinal powder is volatilized, the medicinal alcohol of addition 60% is heated into medicinal powder
70 DEG C extract 3 times, each 1h, and filter residue is abandoned in filtering, obtains American-cockroach-extract, dandelion extract, Honegsukle flower P.E, purple
Soviet Union's extract；
The preparation of 1.3 antibacterial skin moistening liquid soaps：
(1) by distilled water 10 liters be heated to 50 DEG C, sequentially add 0.4 kilogram of neopelex, dodecyl two
0.8 kilogram of methyl betaine, 0.8 kilogram of cocoanut fatty acid diethanolamide, 1.0 kilograms of dodecyldimethylamine oxide,
1.2 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and then makes its slow cooling to 40 DEG C, is added in 1.2 and is prepared into
20 grams of the American-cockroach-extract arrived, continuation constant temperature, which at the uniform velocity stirs, makes it mix well；
(2) by distilled water 6 liters be heated to 40 DEG C, successively by 80 grams of dandelion extract being prepared in 1.2, honeysuckle
60 grams of extract, 40 grams of extractive of perilla is added to the container and constant temperature stirs evenly, and is then slowly added to obtain in step (1)
Then mixture stirs 3h, mixing speed is maintained at 45r/min, and after mixing, bottling (200ml/ bottles) presses down to get 100 bottles
Bacterium skin moistening liquid soap.
Embodiment 3
1.1 prepare antibacterial skin moistening liquid soap by following weight percent：3% neopelex, the 12 of 3%
Alkyl dimethyl betaine, 4% cocoanut fatty acid diethanolamide, 4% dodecyldimethylamine oxide, 6% third
Triol, 0.1% American-cockroach-extract, 0.5% dandelion extract, 0.5% Honegsukle flower P.E, 0.1% extractive of perilla,
Surplus is distilled water, and the American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla are according to 1 ︰, 5 ︰
5 ︰ 1 are formulated；
1.2 are soaked in enough American cockroach full worms in petroleum ether for 24 hours, after discarding petroleum ether, volatilize American cockroach worm
Petroleum ether in body beats powder and crosses 20 mesh sieve, and the medicinal alcohol that 85% is added into medicinal powder is heated to 80 DEG C of extractions 2 times, each 4h,
Filter residue is abandoned in filtering, obtains American-cockroach-extract；Dandelion, honeysuckle, purple perilla raw material be crushed into 40 mesh sieve respectively, then divided
It is not soaked in petroleum ether for 24 hours, after discarding petroleum ether, volatilizes the petroleum ether in medicinal powder, 50% medicinal second is added into medicinal powder
Alcohol is heated to 70 DEG C and extracts 3 times, each 2h, and filter residue is abandoned in filtering, obtains American-cockroach-extract, dandelion extract, honeysuckle
Extract, extractive of perilla；
The preparation of 1.3 antibacterial skin moistening liquid soaps：
(1) by distilled water 10 liters be heated to 40 DEG C, sequentially add 0.6 kilogram of neopelex, dodecyl two
0.6 kilogram of methyl betaine, 0.8 kilogram of cocoanut fatty acid diethanolamide, 0.8 kilogram of dodecyldimethylamine oxide,
1.2 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and 20 grams of American-cockroach-extract being prepared in 1.2 is added,
Continuation constant temperature, which at the uniform velocity stirs, makes it mix well；
(2) by distilled water 6 liters be heated to 40 DEG C, 100 grams of dandelion extract, the gold and silver that will be prepared in 1.2 successively
100 grams of flower extract, 20 grams of extractive of perilla is added to the container and constant temperature stirs evenly, and is then slowly added to obtain in step (1)
Then the mixture arrived stirs 3h, mixing speed is maintained at 30r/min, and after mixing, bottling (200ml/ bottles) is to get 100
The antibacterial skin moistening liquid soap of bottle.
Embodiment 4
A kind of bacteriostatic hand sanitizer is made of following weight percent：2% neopelex, 3% dodecane
Base dimethyl betaine, 4% cocoanut fatty acid diethanolamide, 3% dodecyldimethylamine oxide, 8% the third three
It is alcohol, 0.1% American-cockroach-extract, 0.3% dandelion extract, 0.5% Honegsukle flower P.E, 0.2% extractive of perilla, remaining
Amount is distilled water, and the American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla are according to 1 ︰, 3 ︰, 5 ︰ 2
It is formulated；
1.2 are soaked in enough American cockroach full worms in petroleum ether for 24 hours, after discarding petroleum ether, volatilize American cockroach worm
Petroleum ether in body beats powder and crosses 20 mesh sieve, and the medicinal alcohol that 70% is added into medicinal powder is heated to 60 DEG C of extractions 3 times, each 3h,
Filter residue is abandoned in filtering, obtains American-cockroach-extract；Dandelion, honeysuckle, purple perilla raw material be crushed into 40 mesh sieve respectively, then divided
It is not soaked in petroleum ether for 24 hours, after discarding petroleum ether, volatilizes the petroleum ether in medicinal powder, 60% medicinal second is added into medicinal powder
Alcohol is heated to 50 DEG C and extracts 3 times, each 2h, and filter residue is abandoned in filtering, obtains American-cockroach-extract, dandelion extract, honeysuckle
Extract, extractive of perilla；
The preparation of 1.3 antibacterial skin moistening liquid soaps：
(1) by distilled water 10 liters be heated to 40 DEG C, sequentially add 0.4 kilogram of neopelex, dodecyl two
0.6 kilogram of methyl betaine, 0.8 kilogram of cocoanut fatty acid diethanolamide, 0.6 kilogram of dodecyldimethylamine oxide,
1.6 kilograms of glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, and 20 grams of American-cockroach-extract being prepared in 1.2 is added,
Continuation constant temperature, which at the uniform velocity stirs, makes it mix well；
(2) by distilled water 6 liters be heated to 40 DEG C, successively by 60 grams of dandelion extract being prepared in 1.2, honeysuckle
100 grams of extract, 40 grams of extractive of perilla is added to the container and constant temperature stirs evenly, and is then slowly added to obtain in step (1)
Mixture, then stir 2h, mixing speed is maintained at 30r/min, after mixing, bottling (200ml/ bottles) to get 100 bottles
Antibacterial skin moistening liquid soap.
Test example 1
Anti-oxidant (removing OH free radicals ability) verification experimental verification
1.1 the various embodiments described above are prepared American-cockroach-extract, dandelion extract, Honegsukle flower P.E,
Extractive of perilla is mixed by the formula in corresponding embodiment, obtains AX-I (embodiment 1), AX-II (embodiment 2), AX-
III (embodiment 3), AX-IV (embodiment 4) sample are respectively placed in after precision weighing sample in volumetric flask and use absolute ethyl alcohol constant volume
It to 50mL, shakes up, each sample to be tested is then diluted to final concentration of 200,100,50,25,12.5,6.25 μ g/mL in proportion
Testing sample solution；
1.2 precisions weigh positive control vitamin C (Vit C) 50mg and are placed in volumetric flask and are settled to absolute ethyl alcohol
50mL shakes up, and then waits for test sample by what Vit C were diluted to final concentration of 62.50,31.25,15.63,7.81 μ g/mL in proportion
Product solution；
1.3 sequentially add the FeSO of 2.0mmol/L in 25mL volumetric flasks4Solution 3.0mL and H l.0mmol/L2O2
The salicylic acid solution 3.0mL of 6.0mmol/L is added after mixing by solution 3.0mL, and absolute ethyl alcohol constant volume shakes up, and takes above-mentioned mixing molten
Liquid 5.0mL and absolute ethyl alcohol 1.0mL makees reference with absolute ethyl alcohol, extinction is measured at 510nm in 37 DEG C of water bath with thermostatic control 15min
Angle value A0, each sample replication 3 times is averaged；
1.4 take AX-I, AX-II, AX-III, AX-IV of various concentration and other testing sample solution 1.0mL, add respectively
Enter above-mentioned mixed solution 5.0mL, mixing surveys absorbance value A, each sample weight in 37 DEG C of water bath with thermostatic control 15min at 510nm
Repetition measurement is 3 times fixed, and according to formula I (%)=(A0-A)/A0× 100% calculates the clearance rate I of OH；It is corresponding according to each concentration
OH free radical scavenging activities calculate its medium effective concentration EC50。
2. result
AX-I, AX-II, AX-III, AX-IV, which have stronger removing, to be shown to the clearance rate measurement of OH free radicals
The weight of the ability of OH free radicals, wherein American-cockroach-extract, dandelion extract, Honegsukle flower P.E, extractive of perilla
Than for 1 ︰, 86 ︰ 4 of ︰ when, (sample AX-I) oxidation resistance is best (table 1).
1 AX-I, AX-II, AX-III, AX-IV and Vit C of table removes the EC of OH free radicals50
Test example 2
Antibacterial tests are verified
1.1 are mixed the extract that the various embodiments described above are prepared by above-mentioned compatibility, obtain AX-I (embodiments
1), AX-II (embodiment 2), AX-III (embodiment 3), AX-IV (embodiment 4) sample are respectively placed in appearance after precision weighing sample
It is settled to 50mL with sterile saline in measuring bottle, is shaken up, each sample to be tested is then diluted to final concentration of 100 in proportion,
50, the testing sample solution of 25,12.5,6.25,3.125,1.5625mg/mL；
1.2 precision weighs penicillin respectively, streptomysin is configured to 100 with sterile saline, 50,25,12.5,6.25,
The testing sample solution (positive control) of 3.125 μ g/mL, clotrimazole is configured to 2 with sterile saline, 1,0.5,0.25,
0.125, the testing sample solution (positive control) of 0.0625mg/mL；
1.3 aseptically, and tablet is made with sterilized culture medium, first very thin one layer, about 5mL cultures
Base.After its cooled and solidified, Oxford cup is placed on tablet, each tablet is equidistantly placed 3 and high pressure steam sterilization and has dried
Dry Oxford cup, then about 10mL culture medium.After its solidification, Oxford cup is gripped out with aseptic nipper.It will prepare respectively
Staphylococcus aureus (25923), Escherichia coli (25922), candida albicans bacterium (10231) bacteria suspension, use liquid-transfering gun
0.1mL is taken to be placed on tablet, it is uniform with sterile painting rod coating.It takes 100 μ L liquids in hole with liquid-transfering gun, while setting blank control
(with isometric physiological saline).The filter paper of sterilized processing is placed on culture dish, is covered with culture ware lid.
The tablet of 1.4 staphylococcus aureuses (25923) and Escherichia coli (25922) inoculation is placed in 37 DEG C of incubator cultures
For 24 hours, the tablet of candida albicans bacterium (10231) inoculation is placed in 37 DEG C of incubator culture 48h, takes out observation, records AX-I, AX-
Minimum inhibitory concentration (MIC) value of II, AX-III, AX-IV, each sample replication 3 times are averaged.
2. result
The minimum inhibitory concentration of AX-I, AX-II, AX-III, AX-IV are below greatly 10mg/mL (table 2), prompt it to gold
Staphylococcus aureus, Escherichia coli, candida albicans bacterium have preferable inhibition accretion.The experimental result display present invention's
AX-I, AX-II, AX-III, AX-IV have certain bacteriostasis, can be developed further into as bacteriostatic agent.Its Central America is big
Lian extracts, dandelion extract, Honegsukle flower P.E, extractive of perilla weight ratio be 1 ︰, 86 ︰ 4 of ︰ when, (sample AX-I)
Fungistatic effect is best.
The minimum inhibitory concentration of table 2 AX-I, AX-II, AX-III, AX-IV
Liquid and preparation method thereof simplicity disclosed by the invention of washing one's hands；Main composition therein, big Lian extracts, dandelion extraction
Object, Honegsukle flower P.E, the preparation method of extractive of perilla are at low cost, easy to operate, efficient, are suitable for large-scale production, tool
There is good application prospect.
The above content is the further descriptions that the embodiment for combining specific/optimization is the present invention, cannot
Assert that the specific implementation of the present invention is confined to these explanations.It is understood that those skilled in the art,
Without departing from the inventive concept of the premise, some replacements or modification can also be made to the embodiment that these have been described, and
These are substituted or variant all shall be regarded as belonging to protection scope of the present invention.
Claims (7)
1. a kind of antibacterial skin moistening liquid soap, including following component by weight percentage：1~5% neopelex,
4~8% glycerine, 1~5% dodecyldimethylammonium hydroxide inner salt, 1~8% cocoanut fatty acid diethanolamide, 3
~8% dodecyldimethylamine oxide, 0.03~0.1% American-cockroach-extract, 0.1~0.5% dandelion extract,
0.1~0.5% Honegsukle flower P.E, 0.1~0.5% extractive of perilla, surplus are distilled water.
2. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that the hand cleanser is made of following weight percent：
2~3% neopelex, 4~8% glycerine, 3~4% dodecyldimethylammonium hydroxide inner salt, 3~4%
Cocoanut fatty acid diethanolamide, 3~5% dodecyldimethylamine oxide, 0.05~0.1% American-cockroach-extract,
0.3~0.5% dandelion extract, 0.3~0.5% Honegsukle flower P.E, 0.1~0.2% extractive of perilla, surplus are distillation
Water.
3. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that the hand cleanser is made of following weight percent：
3% neopelex, 4% glycerine, 3% dodecyldimethylammonium hydroxide inner salt, 3% coco-nut oil fatty acid
Diglycollic amide, 3% dodecyldimethylamine oxide, 0.05~0.1% American-cockroach-extract, 0.3~0.5% dandelion
Extract, 0.3~0.5% Honegsukle flower P.E, 0.1~0.2% extractive of perilla, surplus are distilled water.
4. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that the American-cockroach-extract, dandelion extraction
Object, Honegsukle flower P.E, extractive of perilla are prepared according to the weight ratio of 1 ︰, 8 ︰, 6 ︰ 4.
5. according to any antibacterial skin moistening liquid soap of Claims 1 to 4, it is characterised in that the preparation of the American-cockroach-extract
Method is that American cockroach protozoon is placed in petroleum ether to impregnate 24 hours, and after discarding petroleum ether, 30~40 DEG C volatilize in protozoon
Polypide is ground into 20~40 mesh by solvent, be added 85% medicinal alcohol heating extraction, filtering abandon filter residue to get.
6. according to any antibacterial skin moistening liquid soap of Claims 1 to 4, it is characterised in that the dandelion extract, honeysuckle
Extract, extractive of perilla preparation method be that dandelion, honeysuckle, purple perilla medicinal raw material are ground into 40~80 mesh respectively,
It is subsequently placed in petroleum ether and impregnates 24 hours, after discarding petroleum ether, 30~40 DEG C of solvents volatilized in medicinal powder are added in medicinal powder
70% medicinal alcohol heating extraction, filtering abandon filter residue to get corresponding extract；Wherein, extraction temperature is 50~80 DEG C, extraction
Time is 1~5 hour, and extracting times are 1~4 time.
7. the preparation method of any antibacterial skin moistening liquid soap of Claims 1 to 4, includes the following steps：
(1) distilled water is heated to 50 DEG C, sequentially adds neopelex, dodecyldimethylammonium hydroxide inner salt, coconut
Fatty acid oil diglycollic amide, dodecyldimethylamine oxide, glycerine, constant temperature, which at the uniform velocity stirs, makes it mix well, then
Make its slow cooling to 40 DEG C, American-cockroach-extract is added, continuation constant temperature, which at the uniform velocity stirs, makes it mix well；
(2) distilled water is heated to 40 DEG C, container is added in dandelion extract, Honegsukle flower P.E, extractive of perilla successively
In and constant temperature stir evenly, be then slowly added to the mixture obtained in step (1), then stir 2~3 hours, mixing speed
Be maintained at 30~60r/min, after mixing, bottling to get.
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| CN201810446265.2A CN108703933A (en) | 2018-05-12 | 2018-05-12 | A kind of antibacterial skin moistening liquid soap and preparation method thereof |
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| CN201810446265.2A CN108703933A (en) | 2018-05-12 | 2018-05-12 | A kind of antibacterial skin moistening liquid soap and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104435020A (en) * | 2013-09-22 | 2015-03-25 | 成都百草和济科技有限公司 | Composition for improving skin quality and application thereof |
| CN104490665A (en) * | 2014-12-04 | 2015-04-08 | 成都顺发消洗科技有限公司 | Preparation method of sterilizing hand sanitizer |
| CN105476948A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Essence containing periplaneta Americana and preparation method thereof |
| CN106699849A (en) * | 2015-11-11 | 2017-05-24 | 暨南大学 | Novel polypeptide and Periplaneta americana total polypeptide extract capable of promoting tissue repair, and application thereof |
| CN107929326A (en) * | 2017-12-26 | 2018-04-20 | 大理大学 | A kind of American-cockroach-extract, preparation method and its application in anti-oxidant adjusting |
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2018
- 2018-05-12 CN CN201810446265.2A patent/CN108703933A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435020A (en) * | 2013-09-22 | 2015-03-25 | 成都百草和济科技有限公司 | Composition for improving skin quality and application thereof |
| CN104490665A (en) * | 2014-12-04 | 2015-04-08 | 成都顺发消洗科技有限公司 | Preparation method of sterilizing hand sanitizer |
| CN106699849A (en) * | 2015-11-11 | 2017-05-24 | 暨南大学 | Novel polypeptide and Periplaneta americana total polypeptide extract capable of promoting tissue repair, and application thereof |
| CN105476948A (en) * | 2015-12-28 | 2016-04-13 | 昆明东特农业科技有限公司 | Essence containing periplaneta Americana and preparation method thereof |
| CN107929326A (en) * | 2017-12-26 | 2018-04-20 | 大理大学 | A kind of American-cockroach-extract, preparation method and its application in anti-oxidant adjusting |
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Application publication date: 20181026 |