CN108295166A - 一种骨折用外敷药膏配方及制备方法和应用 - Google Patents

一种骨折用外敷药膏配方及制备方法和应用 Download PDF

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CN108295166A
CN108295166A CN201810433050.7A CN201810433050A CN108295166A CN 108295166 A CN108295166 A CN 108295166A CN 201810433050 A CN201810433050 A CN 201810433050A CN 108295166 A CN108295166 A CN 108295166A
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葛畅
葛祺
王莉
葛定丽
葛新军
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Abstract

本发明涉及一种骨折用外敷药膏配方及其制备方法和应用，包括主要组分和辅助组分，所述的主要组分包括粗药浸膏和细药粉，所述的辅助组分包括基质及透皮剂，其中，基质：粗药浸膏：细药粉的重量比例为100:10‑30:5‑15，透皮剂的加入量为基质质量的1‑5％。与现有技术相比，本发明解决了中药的高温破坏问题，保证了药物的本效。采用粗药浸膏及细药粉复合的制备方法，加大了药膏的载药量，促进了药物吸收，降低了对皮肤的刺激，提高了疗效。该药膏适用于各种稳定性骨折、骨折不愈合或延期愈合以及急慢性软组织损伤，对骨折后止痛、消肿及刺激骨痂生长亦有较好效果。

Description

一种骨折用外敷药膏配方及制备方法和应用
技术领域
本发明涉及外用药物领域，特别是一种止痛的外敷药膏，具体涉及骨折用外敷药膏配方及制备方法。
背景技术
药膏作为一种外用中药，原理为利用中药归经原则配成复方药，通过各药的协同作用发挥疗效，主要应用于活血化瘀、消除肿痛、治疗疮疖等。药膏紧贴于肌肤，复方中的群药可在引药带领下直达病灶，具有较好的疗效，被广泛应用于接骨、颈肩腰腿痛及关节炎等疾病。然而，目前用于接骨的药膏仍有一定的局陷：(1)大多采用了高温提取方法，对热敏性药物损伤较大，降低了药效；(2)药膏载药量相对较小，药效有待进一步提高；(3)药物吸收速度偏慢；(4)对皮肤具有一定的刺激性。
发明内容
本发明的目的就是为了克服上述现有技术存在的缺陷而提供一种药效高、吸收快、对皮肤无刺激的骨折用外敷药膏配方及制备方法和应用。
本发明的目的可以通过以下技术方案来实现：一种骨折用外敷药膏配方，其特征在于，包括主要组分和辅助组分，所述的主要组分包括粗药浸膏和细药粉，所述的辅助组分包括基质及透皮剂，其中，基质：粗药浸膏：细药粉的重量比例为100:10-30:5-15，透皮剂的加入量为基质质量的1-5％。
进一步地，所述的粗药浸膏是以植物藤、根、茎之类的中药作为粗药，经浸提、熬制及浓缩制成粗药浸膏。
进一步地，所述的粗药的基本配方包括以下重量份的组分：生大黄20-40份，生枝子10-30份，生南星10-30份，骨碎补20-40份，续断20-40份，当归40-60份，赤芍20-40份，川芎20-40份，杜仲20-40份，桑寄生20-40份，威灵仙20-40份，红花40-60份。
进一步地，所述的粗药浸膏通过以下方法制得：将粗药和5-10倍质量的清水置于容器中，浸泡30-60h后将内容物转移至铁锅内加热，沸腾后继续小火熬制半小时停火，将药汁倒入准备好的缸内储存，向铁锅内加入适量清水对粗药残余进行重复煎熬，对药物进行重复提取，每次所得药汁均倒入同一个缸内，所得药汁自然放置3天后倒入铁锅浓缩成浸膏备用。
进一步地，所述的细药粉的基本配方包括以下重量份的组分：鹿茸20-40份，炮山甲20-40份，自然铜40-60份，地鳖虫10-30份，血竭5-15份，三七20-40份，乳香20-40份，没药20-40份，生马钱子10-30份，将上述各组分粉碎成100-200目的细粉混合即为细药。
进一步地，所述的基质是由植物油与黄丹混合熬制而成，为药膏中的常用材料，用于混合粗药和细药；所述的透皮剂也为药膏中常用材料，主要成分为月桂氮酮。
上述骨折用外敷药膏配方的制备方法，其特征在于，该方法包括以下步骤：利用蒸汽将基质融化后，先后加入粗药浸膏、透皮剂及细药粉并搅拌均匀，最后摊涂成药膏。
上述骨折用外敷药膏配方的应用，其特征在于，用于各种稳定性骨折、骨折不愈合或延期愈合、急慢性软组织受伤，对骨折后止痛、消肿、刺激骨痂生长有较好效果。
与现有技术相比，本发明具有以下有益效果：本发明解决了中药的高温破坏问题，保证了药物的本效。采用粗药浸膏及细药粉复合的制备方法，加大了药膏的载药量，促进了药物吸收，降低了对皮肤的刺激，提高了疗效。该药膏适用于各种稳定性骨折、骨折不愈合或延期愈合以及急慢性软组织损伤，对骨折后止痛、消肿及刺激骨痂生长亦有较好效果。
具体实施方式
下面对本发明的实施例作详细说明，本实施例在以本发明技术方案为前提下进行实施，给出了详细的实施方式和具体的操作过程，但本发明的保护范围不限于下述的实施例。
实施例1
粗药配方：生大黄30g，生枝子20g，生南星20g，骨碎补30g，续断30g，当归50g，赤芍30g，川芎30g，杜仲30g，桑寄生30g，威灵仙30g，红花50g。
粗药浸膏制备：称取380g粗药2850g清水置于容器中，浸泡45h后将内容物转移至铁锅内加热，沸腾后继续小火熬制半小时停火，将药汁倒入准备好的缸内储存，向铁锅内加入适量清水对粗药残余进行重复煎熬(总计3次)，对药物进行重复提取，每次所得药汁均倒入同一个缸内。所得药汁自然放置3天后倒入铁锅浓缩成浸膏备用。
细药配方：鹿茸30g，炮山甲30g，自然铜50g，地鳖虫20g，血竭10g，三七30g，乳香30g，没药30g，生马钱子20g。
细药粉制备：称取250g细药，用药碾将称取的细药碾碎并过筛，取100-200目粒度的细药粉备用。
基质：由植物油与黄丹混合熬制而成。
透皮剂：主要组分为月桂氮酮。
药膏制备方法：称取200g基质，用蒸汽加热至融化后加入40g粗药浸膏搅拌均匀，再加入6g透皮剂搅拌均匀，最后加入20g细药粉搅拌均匀，滩涂成药膏。
本实施例药膏对骨折愈合具有较好疗效。
实施例2
粗药配方：生大黄20g，生枝子10g，生南星10g，骨碎补20g，续断20g，当归40g，赤芍20g，川芎20g，杜仲20g，桑寄生20g，威灵仙20g，红花40g。
粗药浸膏制备：称取500g粗药2500g清水置于容器中，浸泡30h后将内容物转移至铁锅内加热，沸腾后继续小火熬制半小时停火，将药汁倒入准备好的缸内储存，向铁锅内加入适量清水对粗药残余进行重复煎熬(总计3次)，对药物进行重复提取，每次所得药汁均倒入同一个缸内。所得药汁自然放置3天后倒入铁锅浓缩成浸膏备用。
细药配方：鹿茸20g，炮山甲20g，自然铜40g，地鳖虫10g，血竭5g，三七20g，乳香20g，没药20g，生马钱子10g。
细药粉制备：称取600g细药，用药碾将称取的细药碾碎并过筛，取100-200目粒度的细药粉备用。
基质：由植物油与黄丹混合熬制而成，为本领域的常用材料。
透皮剂：由月桂氮酮、肉桂油对苯甲酸中的一种或多种混合而成，为本领域的常用材料。
药膏制备方法：称取100g基质，用蒸汽加热至融化后加入10g粗药浸膏搅拌均匀，再加入1g透皮剂搅拌均匀，最后加入5g细药粉搅拌均匀，滩涂成药膏。
本实施例药膏对各种稳定性骨折、骨折不愈合或延期愈合、急慢性软组织受伤等病症的治疗，对骨折后止痛、消肿、刺激骨痂生长亦有较好效果。
实施例3
粗药配方：生大黄40g，生枝子30g，生南星30g，骨碎补40g，续断40g，当归60g，赤芍40g，川芎40g，杜仲40g，桑寄生40g，威灵仙40g，红花60g。
粗药浸膏制备：称取500g粗药5000g清水置于容器中，浸泡60h后将内容物转移至铁锅内加热，沸腾后继续小火熬制半小时停火，将药汁倒入准备好的缸内储存，向铁锅内加入适量清水对粗药残余进行重复煎熬(总计3次)，对药物进行重复提取，每次所得药汁均倒入同一个缸内。所得药汁自然放置3天后倒入铁锅浓缩成浸膏备用。
细药配方：鹿茸40g，炮山甲40g，自然铜60g，地鳖虫30g，血竭15g，三七40g，乳香40g，没药40g，生马钱子30g。
细药粉制备：称取600g细药，用药碾将称取的细药碾碎并过筛，取100-200目粒度的细药粉备用。
基质：由植物油与黄丹混合熬制而成，为本领域的常用材料。
透皮剂：由月桂氮酮、肉桂油对苯甲酸中的一种或多种混合而成，为本领域的常用材料。
药膏制备方法：称取100g基质，用蒸汽加热至融化后加入30g粗药浸膏搅拌均匀，再加入5g透皮剂搅拌均匀，最后加入15g细药粉搅拌均匀，滩涂成药膏。
本实施例药膏对各种稳定性骨折、骨折不愈合或延期愈合、急慢性软组织受伤等病症的治疗，对骨折后止痛、消肿、刺激骨痂生长亦有较好效果。
本发明不局限于上述说明及实施例。通过上述说明及实施例，相关人员完全可以在不偏离本发明所述思想基础上进行变更及修改，此类变更及修改均应属于本发明权利要求范围。

Claims (8)

1.一种骨折用外敷药膏配方，其特征在于，包括主要组分和辅助组分，所述的主要组分包括粗药浸膏和细药粉，所述的辅助组分包括基质及透皮剂，其中，基质：粗药浸膏：细药粉的重量比例为100:10-30:5-15，透皮剂的加入量为基质质量的1-5％。
2.根据权利要求1所述的骨折用外敷药膏配方，其特征在于，所述的粗药浸膏是以植物藤、根、茎之类的中药作为粗药，经浸提、熬制及浓缩制成粗药浸膏。
3.根据权利要求2所述的骨折用外敷药膏配方，其特征在于，所述的粗药的基本配方包括以下重量份的组分：生大黄20-40份，生枝子10-30份，生南星10-30份，骨碎补20-40份，续断20-40份，当归40-60份，赤芍20-40份，川芎20-40份，杜仲20-40份，桑寄生20-40份，威灵仙20-40份，红花40-60份。
4.根据权利要求2或3所述的骨折用外敷药膏配方，其特征在于，所述的粗药浸膏通过以下方法制得：将粗药和5-10倍质量的清水置于容器中，浸泡30-60h后将内容物转移至铁锅内加热，沸腾后继续小火熬制半小时停火，将药汁倒入准备好的缸内储存，向铁锅内加入适量清水对粗药残余进行重复煎熬，对药物进行重复提取，每次所得药汁均倒入同一个缸内，所得药汁自然放置3天后倒入铁锅浓缩成浸膏备用。
5.根据权利要求1所述的骨折用外敷药膏配方，其特征在于，所述的细药粉的基本配方包括以下重量份的组分：鹿茸20-40份，炮山甲20-40份，自然铜40-60份，地鳖虫10-30份，血竭5-15份，三七20-40份，乳香20-40份，没药20-40份，生马钱子10-30份，将上述各组分粉碎成100-200目的细粉混合即为细药。
6.根据权利要求1所述的骨折用外敷药膏配方，其特征在于，所述的基质是由植物油与黄丹混合熬制而成，为药膏中的常用材料，用于混合粗药和细药；所述的透皮剂也为药膏中常用材料，主要成分为月桂氮酮。
7.一种如权利要求1所述的骨折用外敷药膏配方的制备方法，其特征在于，该方法包括以下步骤：利用蒸汽将基质融化后，先后加入粗药浸膏、透皮剂及细药粉并搅拌均匀，最后摊涂成药膏。
8.一种如权利要求1所述的骨折用外敷药膏配方的应用，其特征在于，用于各种稳定性骨折、骨折不愈合或延期愈合、急慢性软组织受伤，对骨折后止痛、消肿、刺激骨痂生长有较好效果。
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