CN113209221A - 一种中药补肾胶囊及其制备方法 - Google Patents

一种中药补肾胶囊及其制备方法 Download PDF

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CN113209221A
CN113209221A CN202110608177.XA CN202110608177A CN113209221A CN 113209221 A CN113209221 A CN 113209221A CN 202110608177 A CN202110608177 A CN 202110608177A CN 113209221 A CN113209221 A CN 113209221A
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金青奎
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Abstract

本申请提供了一种中药补肾胶囊及其制备方法，制备中药补肾胶囊的原料包括鹿茸55～65份，沉香26～35份，肉苁蓉28～33份，天冬27～32份，麦冬25～34份，人参25～34份，熟地黄28～33份，巴戟天28～35份，山药110～128份，茯苓26～33份，五味子28～34份，当归27～33份，山茱萸29～34份，杜仲25～34份，半夏27～35份，小茴香29～33份，栀子26～34份，石菖蒲28～33份，龟甲25～32份，菟丝子57～65份；取相应重量份数的研磨、筛分、装入胶囊，即可得到所述的一种中药补肾胶囊。本申请以平衡人体阴阳为原则，以肾阴肾阳双补为目的，实现标本兼治，并且具有药量低、起效快、治愈率高、无毒副作用、停药不复发的特点；本申请将传统中药制成粉剂，不用熬煎，服用方便。

Description

一种中药补肾胶囊及其制备方法
技术领域
本申请涉及中药技术领域，尤其涉及到一种中药补肾胶囊及其制备方法。
背景技术
目前，人们的生活压力较大，工作繁忙，运动量少，体质越来越差，男子腰膝酸软乏力、肾虚肾亏成为常见的疾病之一。西医方面，用于补肾的西药很多，但副作用较大，不便于长期服用。而目前市场上中药补肾药物疗效还不稳定，停药容易复发；如果使用不当，可能致肾脏及其它脏器受损。因此，针对肾虚肾亏症状，寻找一种用药方便安全的壮阳补肾中药是很有必要的。
发明内容
针对现有技术的不足，本申请的目的就在于提供一种用药安全、无毒副作用、停药不复发的中药补肾胶囊及其制备方法。
本申请采用的技术方案如下：
一种中药补肾胶囊，制备中药补肾胶囊的原料包括：鹿茸55～65份，沉香26～35份，肉苁蓉28～33份，天冬27～32份，麦冬25～34份，人参25～34份，熟地黄28～33份，巴戟天28～35份，山药110～128份，茯苓26～33份，五味子28～34份，当归27～33份，山茱萸29～34份，杜仲25～34份，半夏27～35份，小茴香29～33份，栀子26～34份，石菖蒲28～33份，龟甲25～32份，菟丝子57～65份。
进一步地，一种中药补肾胶囊，制备中药补肾胶囊的原料包括：鹿茸60份，沉香30份，肉苁蓉30份，天冬30份，麦冬30份，人参30份，熟地黄30份，巴戟天30份，山药120份，茯苓30份，五味子30份，当归30份，山茱萸30份，杜仲30份，半夏30份，小茴香30份，栀子30份，石菖蒲30份，龟甲30份，菟丝子60份。
进一步地，一种中药补肾胶囊，制备中药补肾胶囊的原料包括：鹿茸60份，沉香32份，肉苁蓉30份，天冬29份，麦冬27份，人参28份，熟地黄30份，巴戟天33份，山药116份，茯苓29份，五味子31份，当归30份，山茱萸30份，杜仲26份，半夏32份，小茴香31份，栀子30份，石菖蒲33份，龟甲30份，菟丝子63份。
进一步地，一种中药补肾胶囊的制备方法，包括以下步骤：
(1)山药预处理：将鲜山药洗净去皮，切成厚度为8-12mm的块状，放入烘干机，温度75-85℃，烘至干燥，期间随时翻动，得到干品山药；
(2)当归预处理：将当归药材切成厚度为4～5mm的片状，干燥后加黄酒闷润1～1.5h，置于锅内炒制12～20min，得到酒当归；
(3)栀子预处理：挑选栀子，清洗烘干后倒入锅内加热炒制15～20min，得到炒栀子；
(4)称取鹿茸、沉香、肉苁蓉、天冬、麦冬、人参、熟地黄、巴戟天、干品山药、茯苓、五味子、酒当归、山茱萸、杜仲、半夏、小茴香、炒栀子、石菖蒲、龟甲、菟丝子，放入中药超微粉碎机中研磨20min；
(5)将研磨后的粗粉末用800目筛网筛分，得到细粉末；
(6)将筛分后的细粉末分装入胶囊内，每颗胶囊装入药粉0.6g。
进一步地，所述中药补肾胶囊的服用方法为饭前或饭后服用，一天三次，一次五粒，温开水送服。
本申请的有益效果在于：
(1)申请人依据中医理论的研究和临床试验的反复验证，提供了一种用于用药安全、无毒副作用的中药组合物，选择鹿茸、沉香、肉苁蓉、天冬、麦冬、人参、熟地黄、巴戟天、山药、茯苓、五味子、当归、山茱萸、杜仲、半夏、小茴香、栀子、石菖蒲、龟甲和菟丝子为原料，通过合理的配比设计，使得药物之间形成协同的功效，进而能够有效的治疗肾虚肾亏，并且疗效显著，有效率达到90％以上。
(2)本申请以平衡人体阴阳为原则，以肾阴肾阳双补为目的，实现标本兼治，并且具有药量低、起效快、治愈率高、无毒副作用、停药不复发的特点。
(3)本申请将传统中药制成粉剂，不用熬煎，服用方便；由于对原料中的中药进行粉碎处理，使得中药的有效成分不流失，因此提高了对肾虚肾亏患者的治疗效果。
具体实施方式
下面将结合本申请实施例，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。基于本申请中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
实施例1
一种中药补肾胶囊，由下列重量份配比的原料制成：鹿茸60份，沉香30份，肉苁蓉30份，天冬30份，麦冬30份，人参30份，熟地黄30份，巴戟天30份，山药120份，茯苓30份，五味子30份，当归30份，山茱萸30份，杜仲30份，半夏30份，小茴香30份，炒栀子30份，石菖蒲30份，龟甲30份，菟丝子60份。其制备方法包括以下步骤：
(1)山药预处理：将鲜山药洗净去皮，切成厚度为8-12mm的块状，放入烘干机，温度75-85℃，烘至干燥，期间随时翻动，得到干品山药；
(2)当归预处理：将当归药材切成厚度为4～5mm的片状，干燥后加黄酒闷润1～1.5h，置于锅内炒制12～20min，得到酒当归；
(3)栀子预处理：挑选栀子，清洗烘干后倒入锅内加热炒制15～20min，得到炒栀子；
(4)称取鹿茸60g、沉香30g、肉苁蓉30g、天冬30g、麦冬30g、人参30g、熟地黄30g、巴戟天30g、干品山药120g、茯苓30g、五味子30g、酒当归30g、山茱萸30g、杜仲30g、半夏30g、小茴香30g、炒栀子30g、石菖蒲30g、龟甲30g、菟丝子60g，放入中药超微粉碎机中研磨20min；
(5)将研磨后的粗粉末用800目筛网筛分，得到细粉末；
(6)将筛分后的细粉末分装入胶囊内，每颗胶囊装入药粉0.6g。
实施例2
一种中药补肾胶囊，由下列重量份配比的原料制成：鹿茸60份，沉香32份，肉苁蓉30份，天冬29份，麦冬27份，人参28份，熟地黄30份，巴戟天33份，山药116份，茯苓29份，五味子31份，当归30份，山茱萸30份，杜仲26份，半夏32份，小茴香31份，栀子30份，石菖蒲33份，龟甲30份，菟丝子63份。其制备方法包括以下步骤：
(1)山药预处理：将鲜山药洗净去皮，切成厚度为8-12mm的块状，放入烘干机，温度75-85℃，烘至干燥，期间随时翻动，得到干品山药；
(2)当归预处理：将当归药材切成厚度为4～5mm的片状，干燥后加黄酒闷润1～1.5h，置于锅内炒制12～20min，得到酒当归；
(3)栀子预处理：挑选栀子，清洗烘干后倒入锅内加热炒制15～20min，得到炒栀子；
(4)称取鹿茸60g、沉香32g、肉苁蓉30g、天冬29g、麦冬27g、人参28g、熟地黄30g、巴戟天33g、干品山药116g、茯苓29g、五味子31g、酒当归30g、山茱萸30g、杜仲26g、半夏32g、小茴香31g、炒栀子30g、石菖蒲33g、龟甲30g、菟丝子63g，放入中药超微粉碎机中研磨20min；
(5)将研磨后的粗粉末用800目筛网筛分，得到细粉末；
(6)将筛分后的细粉末分装入胶囊内，每颗胶囊装入药粉0.6g。
以下通过实施例来进一步阐述本申请所述中药组合物的有益效果，这些实施例包括本申请药物的动物毒性试验报告和临床疗效观察资料。
应用例1本申请药物组合物的动物毒性试验
选取SPF级昆明小鼠90只，体重20±2g，雌雄各半，随机分为如下五组：空白组(18只)，不服用药物；实施例1组(18只)，正常量试验组；实施例1组(18只)，超剂量试验组；实施例2组(18只)，正常量试验组；实施例2组(18只)，超剂量试验组。
人体每天服用药物9g，每人按60kg体重计算，相当于0.15g/日/kg。正常量试验组用药量为0.15g/日/kg；超剂量试验组用药量0.3g/日/kg。用药方式为灌胃法给药，各组每天灌胃1次，连续30天，每天观察给药反应。
实验结果表明，五组大鼠活动、饮食正常，药物无不良毒副作用。
应用例2本申请药物组合物的临床疗效观察
经多年临床试验研究表明，本申请实施例制备的一种中药补肾胶囊应用于临床观察病例276例，选用本申请实施例1～实施例2提供的中药补肾胶囊，给患者服用，每次服用5粒，每天服用3次，7天为一个疗程，连续服用4个疗程。
通过以下指标作为诊断标准：①腰脊酸痛；②腰酸膝软或足跟痛；③尿不尽或尿失禁；④性功能衰退。
疗效判定标准：①治愈：症状完全消失、停药后3个月无反复；②显效：症状明显得到缓解；③有效：症状有所减轻，但偶尔会加重；④无效：症状无缓解或有加重。
经以上临床实验表明，本申请的药物组合物疗效显著。
临床治愈229例，占83％；显效19例，占7％；有效11例，占4％；无效17例，占6％。总有效率94％。
由上述临床实验结果可知，本申请方案制备的药物对治疗肾虚肾亏患者具有显著的治疗效果，并且痊愈率达到80％以上；总有效率达94％。由于对原料中的中药进行粉碎处理，使得中药的有效成分不流失，因此提高了对肾虚肾亏患者的治疗效果。
典型病例：
1、卢某，男，56岁，患有肾虚病症1年有余，后因出现头晕、腰膝酸软、气短乏力而就诊，通过服用本申请药物7天后，症状得到缓解，连续服用21天，所有症状均消失，痊愈，随访至今无复发。
2、和某，男，27岁，半年以来，头晕无力、失眠多梦、水肿、尿频，曾多次治疗，但效果不佳；服用本申请药物3天，症状得到缓解，服用25天后，所有症状均消失，达到治愈，经过半年的观察，未出现复发的情况。
以上所述仅为本申请的较佳实施例而已，并不用以限制本申请，凡依本申请范围所做的均等变化与修饰，皆应属本申请的涵盖范围。此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (5)

1.一种中药补肾胶囊，其特征在于：制备中药补肾胶囊的原料包括：鹿茸55～65份，沉香26～35份，肉苁蓉28～33份，天冬27～32份，麦冬25～34份，人参25～34份，熟地黄28～33份，巴戟天28～35份，山药110～128份，茯苓26～33份，五味子28～34份，当归27～33份，山茱萸29～34份，杜仲25～34份，半夏27～35份，小茴香29～33份，栀子26～34份，石菖蒲28～33份，龟甲25～32份，菟丝子57～65份。
2.根据权利要求1所述的一种中药补肾胶囊，其特征在于：制备中药补肾胶囊的原料包括：鹿茸60份，沉香30份，肉苁蓉30份，天冬30份，麦冬30份，人参30份，熟地黄30份，巴戟天30份，山药120份，茯苓30份，五味子30份，当归30份，山茱萸30份，杜仲30份，半夏30份，小茴香30份，栀子30份，石菖蒲30份，龟甲30份，菟丝子60份。
3.根据权利要求1所述的一种中药补肾胶囊，其特征在于：制备中药补肾胶囊的原料包括：鹿茸60份，沉香32份，肉苁蓉30份，天冬29份，麦冬27份，人参28份，熟地黄30份，巴戟天33份，山药116份，茯苓29份，五味子31份，当归30份，山茱萸30份，杜仲26份，半夏32份，小茴香31份，栀子30份，石菖蒲33份，龟甲30份，菟丝子63份。
4.根据权利要求1所述的一种中药补肾胶囊的制备方法，其特征在于：包括以下步骤：
(1)山药预处理：将鲜山药洗净去皮，切成厚度为8-12mm的块状，放入烘干机，温度75～85℃，烘至干燥，期间随时翻动，得到干品山药；
(2)当归预处理：将当归药材切成厚度为4～5mm的片状，干燥后加黄酒闷润1～1.5h，置于锅内炒制12～20min，得到酒当归；
(3)栀子预处理：挑选栀子，清洗烘干后倒入锅内加热炒制15～20min，得到炒栀子；
(4)称取鹿茸、沉香、肉苁蓉、天冬、麦冬、人参、熟地黄、巴戟天、干品山药、茯苓、五味子、酒当归、山茱萸、杜仲、半夏、小茴香、炒栀子、石菖蒲、龟甲、菟丝子，放入中药超微粉碎机中研磨20min；
(5)将研磨后的粗粉末用800目筛网筛分，得到细粉末；
(6)将筛分后的细粉末分装入胶囊内，每颗胶囊装入药粉0.6g。
5.根据权利要求1所述的一种中药补肾胶囊，其特征在于：所述中药补肾胶囊的服用方法为饭前或饭后服用，一天三次，一次五粒，温开水送服。
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CN101041007A (zh) * 2007-04-21 2007-09-26 刘长庚 一种补肾生精的中药及其制备方法
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