CN104324186A - 治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法 - Google Patents

治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法 Download PDF

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CN104324186A
CN104324186A CN201410618570.7A CN201410618570A CN104324186A CN 104324186 A CN104324186 A CN 104324186A CN 201410618570 A CN201410618570 A CN 201410618570A CN 104324186 A CN104324186 A CN 104324186A
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Abstract

本发明涉及中医药技术领域内一种治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法,其中药方剂由鹿胎粉、鹿茸、龟板、菟丝子、破故纸、牛膝、淫羊藿、紫河车、杜仲、生地、熟地、女贞子、枸杞子、覆盆子、人参、当归、小茴香、龙骨、牡蛎、川穹、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附、山栀、白芍、柴胡29味中药组成,上述诸药配比相合,共具填精固肾,补益气血,平调阴阳,通脉敛汗,平肝安神之功,具有明显的调经散寒,改善性功能,抗衰老,提高机体抵抗力,益气补血,养容护肤,改善睡眠,减少出汗等改善更年期综合症的作用。

Description

治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法
技术领域
本发明涉及药医技术领域,特别涉及一种治疗更年期综合症的中药方剂及其该中成药制成胶囊和膏剂的制备方法。
背景技术
更年期综合症是指女性绝经前后的一段时间期内出现月经紊乱、烘热汗出、五心烦热、头晕耳鸣、心悸失眠、烦躁易怒、腰腿酸楚、记忆力下降甚或浮肿便溏、情志异常等与绝经有关的症状。本病属于医学中 “绝经前后诸证”的范畴。本病的发生是妇女在绝经前后,肾气逐渐衰竭,冲任亏虚,精血不足,天癸渐绝,使阴阳失去平衡,脏腑气血功能失调而出现的一系列脏腑功能紊乱的证候。现代医学证明:女性更年期内分泌变化是以卵巢功能衰退,雌性素分泌减少所导致的丘脑—垂体—性腺轴的改变为中心环节。科研发现,女性全身有400多种雌激素受体,分布在几乎女性全身所有的组织和器官,接受雌激素的控制和支配,当雌性素减少时,这些组织器官就会发生退行性变或代谢上的变化,导致更年期妇女在精神、心理、神经、内分泌失调等方面的症状。
发明内容
本发明的目的是提供一种有效治疗更年期综合症的中药方剂,以逐步改善更年期症状,提高免疫力和抗疲劳能力。
本发明的目的是这样实现的,一种治疗更年期综合症的中药方剂,包括以下重量配比的中药成份:鹿胎粉140份,鹿茸10—15份,龟板5—10份,共为君药;菟丝子5—10份,破故纸5—10份,牛膝5—10,淫羊藿 5—10份,紫河车18—25份,共为臣药;杜仲5—10份,生地5—10份、熟地5—10份,女贞子14—18份,枸杞子5—10,覆盆子10-15份,人参5—10份,当归 10-15,小茴香5—10份,龙骨25-30份、牡蛎25-30份,川穹5—10份,桂枝5—8份,桃仁5—10份,地骨皮14—18份,黄芪10—15份,银柴胡18—25份,香附5—10份,山栀5—10份,白芍5—10份,柴胡5—10份,共为佐使药。
本发明的中药方剂,鹿胎粉:益气补血,调经散寒,填精益肾,美容养颜,解诸毒,返少阳;鹿茸:补督脉,益肾阳,生精髓,强筋骨;龟板:滋阴潜阳,益肾健骨,三者共为君药,全面调节性腺轴三大组成部分,滋养修复受损卵巢,恢复雌、孕激素正常分泌,使女性内分泌始终保持在平衡状态。长期服用延缓性腺轴衰老周期,推迟绝经期,提高性功能。臣药中,菟丝子:补肾固精,养肝明目;破故纸:补肾助阳;牛膝:活血祛瘀,通经,补肝肾,强筋骨;淫羊藿: 补肾助阳,祛风湿;紫河车:益气,补精血;上述臣药对内分泌有一定的调节作用,可增强下丘脑—垂体—性腺轴的功能。佐使药中,杜仲:补肝肾,强筋骨,安胎;地黄:生能滋阴凉血,熟能滋阴养血;女贞子:补肾滋阴,养肝明目;枸杞子:补肾益精,养肝明目;覆盆子:补肾,固涩;西洋参:补肺降火,益胃生津;当归:活血止痛,补血调经;小茴香:理气止痛,调中和胃;龙骨、牡蛎:重镇安神,平降肝阳,收敛固涩,牡蛎还具有软坚散结、制酸的功效;川穹:活血行气,祛风止痛;桂枝具温经通脉,通阳化气,发汗解表的功效;桃仁:活血祛瘀,润肠;地骨皮:清热凉血,退虚热;黄芪:补气升阳,固表止汗,利水消肿;银柴胡:凉血,退虚热;香附:疏肝理气调经止痛;山栀:清热泻火,凉血解毒;白芍:养血敛阴,柔肝止痛,平肝阳。柴胡:疏肝解郁,升举阳气,解表退热。其中,人参、黄芪、熟地、当归、白芍、桂枝具有益气养血,柔肝功用;柴胡、小茴香、香附疏肝理气;山栀、地骨皮、银柴胡、生地共同具有养阴清热除烦的作用;龙骨、牡蛎、覆盆子安神敛汗,而且龙牡、龟板还有补钙的作用;桃仁、川芎、川牛膝活血;熟地 、女贞子、枸杞子、白芍养阴;杜仲补肝肾,引药入肾,共为佐使。上述君臣佐使诸药相合,共具填精固肾,补益气血,平调阴阳,通脉敛汗,平肝安神之功,还具有明显的调经散寒,改善性功能,抗衰老,提高机体抵抗力,益气补血,养容护肤,改善睡眠,减少出汗等治疗更年期综合症的作用。
作为本发明的中药方剂的一种优选方案,所述的治疗更年期综合症的中药方剂,包括以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子5份,破故纸10份,牛膝 10,淫羊藿10份,紫河车18份,杜仲5 份,生地5 份、熟地5 份,女贞子14 份,枸杞子5 ,覆盆子10 份,人参5 份,当归 10 ,小茴香5 份,龙骨25份、牡蛎25份,川穹5 份,桂枝5 份,桃仁5 份,地骨皮14 份,黄芪10 份,银柴胡1 8份,香附5 份,山栀5份,白芍5 份,柴胡5份 。
作为本发明的中药方剂的一种优选方案,所述的治疗更年期综合症的中药方剂,其特征在于,由以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子8份,破故纸8份,牛膝8,淫羊藿8份,紫河车20份,杜仲8份,生地8份、熟地8份,女贞子16份,枸杞子8,覆盆子12 份,人参8份,当归12,小茴香8份,龙骨28份、牡蛎28份,川穹8份,桂枝8份,桃仁8份,地骨皮16份,黄芪12份,银柴胡20 份,香附5 份,山栀8份,白芍8份,柴胡8份 。
作为本发明的中药方剂的一种优选方案,所述的治疗更年期综合症的中药方剂,由以下重量配比的中药成份:鹿胎粉140份,鹿茸15份,龟板5份,菟丝子10份,破故纸10份,牛膝5,淫羊藿 5份,紫河车25份,杜仲10份,生地0份、熟地10份,女贞子18份,枸杞子 10,覆盆子 15份,人参 10份,当归 15,小茴香 10份,龙骨30份、牡蛎各30份,川穹 10份,桂枝 8份,桃仁 10份,地骨皮 18份,黄芪 15份,银柴胡 25份,香附 10份,山栀 10份,白芍 10份,柴胡 10份。
本发明的另一个目的是提供一种将上述治疗更年期综合症的中药方剂制成中成药胶囊的制备方法,包括如下过程,按重量配比分拣称量各药物组份。将龙骨、牡蛎于110℃—120℃烤箱烘烤1—1.5h,鹿茸 、紫河车、鹿胎粉、淫羊藿60°烤箱烘烤20—30min,其余中药成份90℃—100℃烤箱烘烤40—50 min;然后将各药物用粉碎机粉碎,过100目筛,混合搅拌均匀,称取每0.3克为一份装入零号胶囊中。
本发明还提供一种将上述治疗更年期综合症的中药方剂制成中成药膏剂的制备方法,包括如下过程:
A)按重量配比分拣称量各药物组份,将紫河车、鹿茸研磨成100目以上粉体后与鹿胎粉混合均匀制成粉体一备用;
B)龙骨、牡蛎、龟板加8-10倍重量的水,在0.15—0.18 MPa压力下,煮沸后保压浓煎30-40分钟,提取汁液一;杜仲、生地、熟地、 女贞子、枸杞子、复盆子、破故纸、当归 、小茴香、淫羊藿、 川穹、牛膝 、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附 、山栀、白芍、 柴胡、菟丝子、人参加8-10倍重量的水,置广口铜锅,大火烧开,文火煎30钟,提取汁液二后,再加6-8倍重量的水,大火烧开,文火煎30钟,提取汁液三。
(C)将步骤B所得汁液一、汁液二和汁液三混合文火浓缩形成浓稀粥样混合物,加入步骤A)所得的粉体一,混合均匀,再加干中药总重量5%—15%的蜂蜜调匀,最后装瓶密封保存。
本发明的中成药胶囊和中成药膏剂制备方法,通过各自合适的煎,烘工艺很好的保持了各成分药物中的有效成分,治疗妇女更年期综合症疗效显著,现成可用,携带和存放方便,安全,无副作用。
具体实施方式
 实施例1
一种治疗更年期综合症的中药方剂,包括以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子5份,破故纸10份,牛膝 10,淫羊藿10份,紫河车18份,杜仲5 份,生地5 份、熟地,女贞子14 份,枸杞子5 ,覆盆子10 份,人参5 份,当归 10 ,小茴香5 份,龙骨25份、牡蛎25份,川穹5 份,桂枝5 份,桃仁5 份,地骨皮14 份,黄芪10 份,银柴胡1 8份,香附5 份,山栀5份,白芍5 份,柴胡5份 。
将上述中药方剂制成中成药胶囊的制备方法包括如下过程,按重量配比分拣称量各药物组份,将龙骨、牡蛎于110℃烤箱烘烤1.5h,鹿茸 、紫河车、鹿胎粉、淫羊藿60°烤箱烘烤20min,其余中药成份90℃烤箱烘烤50 min;然后将各药物用粉碎机粉碎,过100目筛,混合搅拌均匀,称取每0.3克为一份分装入零号胶囊中。
将上述中药方剂制成中成药膏剂的制备方法包括如下过程:A)按重量配比分拣称量各药物组份,将紫河车、鹿茸研磨成100目以上粉体后与鹿胎粉混合均匀制成粉体一备用;B)龙骨、牡蛎、龟板加10倍重量的水,在0.15 MPa压力下,煮沸后保压浓煎40分钟,提取汁液一;杜仲、生地、熟地、 女贞子、枸杞子、复盆子、破故纸、当归 、小茴香、淫羊藿、 川穹、牛膝 、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附 、山栀、白芍、 柴胡、菟丝子、人参加8倍重量的水,置广口铜锅,大火烧开,文火煎30钟,提取汁液二后,再加6倍重量的水,大火烧开,文火煎30钟,提取汁液三。C)将步骤B所得汁液一、汁液二和汁液三混合文火浓缩形成浓稀粥样混合物,加入步骤A)所得的粉体一,混合均匀,再加干中药总重量5%的蜂蜜调匀,最后装瓶密封保存。
实施例2
     与实施例1不同之处在于,本发明的治疗更年期综合症的中药方剂,由以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子8份,破故纸8份,牛膝8,淫羊藿8份,紫河车20份,杜仲8份,生地8份、熟地8份,女贞子16份,枸杞子8,覆盆子12 份,人参8份,当归12,小茴香8份,龙骨28份、牡蛎28份,川穹8份,桂枝8份,桃仁8份,地骨皮16份,黄芪12份,银柴胡20 份,香附5 份,山栀8份,白芍8份,柴胡8份 。
将本实施例的中药方剂制成中成药胶囊的方法为:按重量配比分拣称量各药物组份,将龙骨、牡蛎于120℃烤箱烘烤1h,鹿茸 、紫河车、鹿胎粉、淫羊藿60°烤箱烘烤30min,其余中药成份100℃烤箱烘烤40min;然后将各药物用粉碎机粉碎,过100目筛,混合搅拌均匀,称取每0.3克为一份装入零号胶囊中。
将本实施例的中药方剂制成中成药膏剂的方法为:A)按重量配比分拣称量各药物组份,将紫河车、鹿茸研磨成100目以上粉体后与鹿胎粉混合均匀制成粉体一备用;B)龙骨、牡蛎、龟板加9倍重量的水,在0.18 MPa压力下,煮沸后保压浓煎30分钟,提取汁液一;杜仲、生地、熟地、 女贞子、枸杞子、复盆子、破故纸、当归 、小茴香、淫羊藿、 川穹、牛膝 、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附 、山栀、白芍、 柴胡、菟丝子、人参加9倍重量的水,置广口铜锅,大火烧开,文火煎30钟,提取汁液二后,再加7倍重量的水,大火烧开,文火煎30钟,提取汁液三。C)将步骤B所得汁液一、汁液二和汁液三混合文火浓缩形成浓稀粥样混合物,加入步骤A)所得的粉体一,混合均匀,再加干中药总重量10%的蜂蜜调匀,最后装瓶密封保存。
实施例3
与实施例1不同之处在于,本发明的治疗更年期综合症的中药方剂,由以下重量配比的中药成份:鹿胎粉140份,鹿茸15份,龟板5份,菟丝子10份,破故纸10份,牛膝5,淫羊藿 5份,紫河车25份,杜仲10份,生、熟地各10份,女贞子18份,枸杞子 10,覆盆子 15份,人参 10份,当归 15,小茴香 10份,龙骨、牡蛎各 30份,川穹 10份,桂枝 8份,桃仁 10份,地骨皮 18份,黄芪 15份,银柴胡 25份,香附 10份,山栀 10份,白芍 10份,柴胡 10份。
将本实施例的中药方剂制成中成药胶囊的方法为:按重量配比分拣称量各药物组份,将龙骨、牡蛎于120℃烤箱烘烤1.2h,鹿茸 、紫河车、鹿胎粉、淫羊藿60°烤箱烘烤25min,其余中药成份95℃烤箱烘烤45min;然后将各药物用粉碎机粉碎,过100目筛,混合搅拌均匀,称取每0.3克为一份装入零号胶囊中。
 将本实施例的中药方剂制成中成药膏剂的方法为:A)按重量配比分拣称量各药物组份,将紫河车、鹿茸研磨成100目以上粉体后与鹿胎粉混合均匀制成粉体一备用;B)龙骨、牡蛎、龟板加8倍重量的水,在0.16 MPa压力下,煮沸后保压浓煎35分钟,提取汁液一;杜仲、生地、熟地、 女贞子、枸杞子、复盆子、破故纸、当归 、小茴香、淫羊藿、 川穹、牛膝 、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附 、山栀、白芍、 柴胡、菟丝子、人参加10倍重量的水,置广口铜锅,大火烧开,文火煎30钟,提取汁液二后,再加8倍重量的水,大火烧开,文火煎30钟,提取汁液三。C)将步骤B所得汁液一、汁液二和汁液三混合文火浓缩形成浓稀粥样混合物,加入步骤A)所得的粉体一,混合均匀,再加干中药总重量15%的蜂蜜调匀,最后装瓶密封保存。
治疗效果实例
采用本发明的中药合剂制成的中药成胶囊或膏剂在2012年2至2014年8月期间,对120例45—55岁的患者进行用药观察。其中,有60例服用实施例2中成药胶囊治疗,服用剂量为每日2,每次2粒;还有另外60例服用实施例2中成药膏剂,服用剂量为每日2次,每次10ml。连续服用30天为一个疗程。其中92位患者服用一个疗程后,更年期症状有明显好转,23位患者症状减轻,治疗有效,其余5位效果没有明显改善,总体上,一个疗程的治疗有效率达95.8%,继续服用一个疗程,有90位患者痊愈,25位患者明显好转,并且上述患者停药一年后基本没有复发,其余5位比较重的患者症状也有一定程度的减轻。上述患者服药两个疗程后,痊愈率达75%,治疗有效率达95.8%。

Claims (6)

1.一种治疗更年期综合症的中药方剂,其特征在于,包括以下重量配比的中药成份:鹿胎粉140份,鹿茸10—15份,龟板5—10份,共为君药;菟丝子5—10份,破故纸5—10份,牛膝5—10,淫羊藿 5—10份,紫河车18—25份,共为臣药;杜仲5—10份,生地5—10份、熟地5—10份,女贞子14—18份,枸杞子5—10,覆盆子10-15份,人参5—10份,当归 10-15,小茴香5—10份,龙骨25-30份、牡蛎25-30份,川穹5—10份,桂枝5—8份,桃仁5—10份,地骨皮14—18份,黄芪10—15份,银柴胡18—25份,香附5—10份,山栀5—10份,白芍5—10份,柴胡5—10份,共为佐使药。
2.根据权利要求1所述的治疗更年期综合症的中药方剂,其特征在于,包括以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子5份,破故纸10份,牛膝 10,淫羊藿10份,紫河车18份,杜仲5 份,熟地5 份、生地5 份,女贞子14 份,枸杞子5 ,覆盆子10 份,人参5 份,当归 10 ,小茴香5 份,龙骨25份、牡蛎25份,川穹5 份,桂枝5 份,桃仁5 份,地骨皮14 份,黄芪10 份,银柴胡1 8份,香附5 份,山栀5份,白芍5 份,柴胡5份 。
3.根据权利要求1所述的治疗更年期综合症的中药方剂,其特征在于,由以下重量配比的中药成份:鹿胎粉140份,鹿茸10份,龟板10份,菟丝子8份,破故纸8份,牛膝8,淫羊藿8份,紫河车20份,杜仲8份,熟地8份、生地8份,女贞子16份,枸杞子8,覆盆子12 份,人参8份,当归12,小茴香8份,龙骨28份、牡蛎28份,川穹8份,桂枝8份,桃仁8份,地骨皮16份,黄芪12份,银柴胡20 份,香附5 份,山栀8份,白芍8份,柴胡8份 。
4.根据权利要求1所述的治疗更年期综合症的中药方剂,其特征在于,由以下重量配比的中药成份:鹿胎粉140份,鹿茸15份,龟板5份,菟丝子10份,破故纸10份,牛膝5,淫羊藿 5份,紫河车25份,杜仲10份,生地10份、熟地10份,女贞子18份,枸杞子 10,覆盆子 15份,人参 10份,当归 15,小茴香 10份,龙骨30份、牡蛎30份,川穹 10份,桂枝 8份,桃仁 10份,地骨皮 18份,黄芪 15份,银柴胡 25份,香附 10份,山栀 10份,白芍 10份,柴胡 10份。
5.一种权利要求1—4任一项所述的治疗更年期综合症的中药胶囊的制备方法,其特征在于,包括如下过程,按重量配比分拣称量各药物组份,将龙骨、牡蛎于110℃—120℃烤箱烘烤1—1.5h,鹿茸 、紫河车、鹿胎粉、淫羊藿60°烤箱烘烤20—30min,其余中药成份90℃—100℃烤箱烘烤40—50 min;然后将各药物用粉碎机粉碎,过100目筛,混合搅拌均匀,称取每0.3克为一份装入零号胶囊。
6.一种权利要求1—4任一项所述的治疗更年期综合症的中药膏剂的制备方法,其特征在于,包括如下过程,
A)按重量配比分拣称量各药物组份,将紫河车、鹿茸研磨成100目以上粉体后与鹿胎粉混合均匀制成粉体一备用;
B)龙骨、牡蛎、龟板加8-10倍重量的水,在0.15—0.18 MPa压力下,煮沸后保压浓煎30-40分钟,提取汁液一;杜仲、生地、熟地、 女贞子、枸杞子、复盆子、破故纸、当归 、小茴香、淫羊藿、 川穹、牛膝 、桂枝、桃仁、地骨皮、黄芪、银柴胡、香附 、山栀、白芍、 柴胡、菟丝子、人参加8-10倍重量的水,置广口铜锅,大火烧开,文火煎30钟,提取汁液二后,再加6-8倍重量的水,大火烧开,文火煎30钟,提取汁液三;
(C)将步骤B所得汁液一、汁液二和汁液三混合文火浓缩形成浓稀粥样混合物,加入步骤A)所得的粉体一,混合均匀,再加干中药总重量5%—15%的蜂蜜调匀,最后装瓶密封保存。
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