CN104825869B - 一种治疗焦虑症的药物 - Google Patents

一种治疗焦虑症的药物 Download PDF

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CN104825869B
CN104825869B CN201510211646.9A CN201510211646A CN104825869B CN 104825869 B CN104825869 B CN 104825869B CN 201510211646 A CN201510211646 A CN 201510211646A CN 104825869 B CN104825869 B CN 104825869B
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郑素娟
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Zheng Sujuan
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

本发明涉及一种治疗焦虑症的药物，它是由下述重量配比的物质制成：水蓑衣50份、华卫矛45份、石莽草45份、地锦槭40份、百日草40份、甘蓝35份、羊角草30份、红线麻30份、鸡蛋花30份、秀丽野海棠30份、佛手柑30份、鸡娃草20份、构皮麻20份、倒挂草20份和狼尾草10份。本发明所述的治疗焦虑症的药物的全部成分都是天然材料，安全性较好，适于在临床上大规模推广。

Description

一种治疗焦虑症的药物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗焦虑症的药物。
背景技术
焦虑症又称焦虑性神经症，它是以持续性紧张担心、恐惧或发作性惊恐为特征的情绪障碍，伴有植物神经系统症状和运动不安等行为特征。焦虑症患者表现出的焦虑或恐惧往往无实质内容或与现实处境不符。西医目前对本病的治疗主要使用药物干预，但现有药物存在依赖性、起效缓慢、不良反应等诸多问题。中医认为本病属于情志病范畴，过分的担忧、紧张甚至恐惧是本病最突出的表现。
发明内容
本发明的目的是提供一种治疗焦虑症的药物。
为了实现本发明的目的，本发明提供一种治疗焦虑症的药物，它是由下述重量配比的物质制成：水蓑衣50份、华卫矛45份、石莽草45份、地锦槭40份、百日草40份、甘蓝35份、羊角草30份、红线麻30份、鸡蛋花30份、秀丽野海棠30份、佛手柑30份、鸡娃草20份、构皮麻20份、倒挂草20份和狼尾草10份。
优选地，所述药物可以制成片剂、胶囊剂、散剂或汤剂。
本发明还提供组合物在制备治疗焦虑症的药物中的用途，所述药物是由下述重量配比的物质制成：水蓑衣50份、华卫矛45份、石莽草45份、地锦槭40份、百日草40份、甘蓝35份、羊角草30份、红线麻30份、鸡蛋花30份、秀丽野海棠30份、佛手柑30份、鸡娃草20份、构皮麻20份、倒挂草20份和狼尾草10份。
在本发明的组合物中，水蓑衣、华卫矛为君药，石莽草、地锦槭、百日草、甘蓝、羊角草为臣药，红线麻、鸡蛋花、秀丽野海棠、佛手柑、鸡娃草、构皮麻、倒挂草为佐药，狼尾草为使药。
本发明所述的治疗焦虑症的药物的全部成分都是天然材料，安全性较好，适于在临床上大规模推广。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例
称取水蓑衣50克、华卫矛45克、石莽草45克、地锦槭40克、百日草40克、甘蓝35克、羊角草30克、红线麻30克、鸡蛋花30克、秀丽野海棠30克、佛手柑30克、鸡娃草20克、构皮麻20克、倒挂草20克和狼尾草10克，加入水6000毫升，在密闭容器中在90℃下加热5小时，冷却至室温，过滤，滤液即为汤剂。
实验例
诊断标准
临床上有焦虑症症状的表现，符合《中国精神障碍分类与诊断标准》(中华医学会精神科分会.中国精神障碍分类与诊断标准.3版.济南:山东科学技术出版社，2001:105)焦虑症诊断标准，Hamilton焦虑量表(HAMA)14项总分≥14分(张明圆.精神科量表评定手册.长沙:湖南科学技术出版社.1993:34-137.121-126.198-202)。
排除标准
(1)排除严重的躯体和神经系统疾病(如甲状腺机能亢进、冠心病、高血压病、脑血管意外等)；(2)酒精和药物依赖者；(3)正在服用抗焦虑剂及精神药物者；(4)孕妇及哺乳期妇女。
选取符合上述标准的患者共200例，其中男130例，女70例，年龄为26-48岁，平均年龄33岁，平均病程半年。
使用实施例中制备汤剂来进行治疗，每日3次，每次口服100毫升，连续治疗6周。
评分标准
采用HAMA量表进行评定，在治疗前和治疗第1、2、4、6周末各评定1次。6周末按HAMA减分率评定疗效。量表由5名精神科医师评定，量表一致性测验的平均相关系数为0.83。
疗效标准
按照中华医学会神经精神科学会拟定的4级标准。治愈：在治疗第6周末，HAMA减分率>75％；显著进步：HAMA减分率50％～75％；进步：HAMA减分率25％～49％；无效：HAMA减分率<25％。
结果
经过治疗，发现全部患者在治疗第6周末，HAMA减分率>75％，因此全部符合治愈的疗效标准。
不良反应和毒副作用监测
通过检测患者的血压、脉搏、是否出现恶心、呕吐、眩晕的临床症状来判断不良反应。设定人体正常收缩压在90-140mmHg之间，舒张压在60-90mmHg之间，人体正常脉搏为60-100次/分钟，在治疗期间测量患者的血压、脉搏，发现所记录的血压和脉搏全部都在正常范围内，没有超出正常区间的现象发生，并且没有出现恶心、呕吐、眩晕的临床症状。这说明本发明的药物组合物没有明显的不良反应，进而证明该药物对于人体没有明显的毒副作用。

Claims (1)

1.一种治疗焦虑症的汤剂，其特征在于，它是由下述方法制成：称取水蓑衣50克、华卫矛45克、石莽草45克、地锦槭40克、百日草40克、甘蓝35克、羊角草30克、红线麻30克、鸡蛋花30克、秀丽野海棠30克、佛手柑30克、鸡娃草20克、构皮麻20克、倒挂草20克和狼尾草10克，加入水6000毫升，在密闭容器中在90℃下加热5小时，冷却至室温，过滤，滤液即得。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173712A (zh) * 2014-09-02 2014-12-03 王玉丽 一种术后安神益气的中药组合物及其制备方法
CN104324186A (zh) * 2014-11-06 2015-02-04 殷鸿 治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173712A (zh) * 2014-09-02 2014-12-03 王玉丽 一种术后安神益气的中药组合物及其制备方法
CN104324186A (zh) * 2014-11-06 2015-02-04 殷鸿 治疗更年期综合症的中药方剂及其胶囊和膏剂的制备方法

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