CN108186943A - 一种有益消化道健康的铁皮石斛组合物及其制备方法 - Google Patents
一种有益消化道健康的铁皮石斛组合物及其制备方法 Download PDFInfo
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- CN108186943A CN108186943A CN201810255463.0A CN201810255463A CN108186943A CN 108186943 A CN108186943 A CN 108186943A CN 201810255463 A CN201810255463 A CN 201810255463A CN 108186943 A CN108186943 A CN 108186943A
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Abstract
本发明提供了一种有益消化道健康的铁皮石斛组合物及其制备方法，包含铁皮石斛叶1～100份、广东虫草子实体0.5～30份、连翘叶0.3～50份、麦芽0.1～60份、银耳多糖0.01～20份、发酵大豆粉0.01～50份。其经提取、干燥、粉碎、混合及成型等制成，具有改善口腔溃疡、慢性咽炎及防治幽门螺旋杆菌阳性并消化道溃疡的作用。
Description
技术领域
本发明涉及医药、功能食品领域，具体涉及一种有益消化道健康的铁皮石斛组合物及其制备方法。
背景技术
消化道是一条起自口腔延续为咽、食管、胃、小肠、大肠、终于肛门的很长的肌性管道，包括口腔、咽、食道、胃、小肠(十二指肠、空肠、回肠)和大肠(盲肠、结肠、直肠)等部。消化系统的基本功能是食物的消化和吸收，供机体所需的物质和能量，食物中的营养物质除维生素、水和无机盐可以被直接吸收利用外，蛋白质、脂肪和糖类等物质均不能被机体直接吸收利用，需在消化管内被分解为结构简单的小分子物质，才能被吸收利用。食物在消化管内被分解成结构简单、可被吸收的小分子物质的过程就称为消化。这种小分子物质透过消化管粘膜上皮细胞进入血液和淋巴液的过程就是吸收。对于未被吸收的残渣部分，消化道(Alimentary Canal)则通过大肠以粪便形式排出体外。
消化道疾病很多，但往往由于症状不明显，容易被人忽视。具有代表性的疾病或病症有咽炎、胃炎、胃溃疡、十二指肠溃疡、恶心、呕吐、肠炎等。由于消化道直接关联食物的消化和吸收，机体能量和其它营养物质的提供，因此该类疾病或病症对生活质量影响重大。目前对于消化道疾病的治疗主要有抗生素、质子泵抑制剂、粘膜保护剂等。但是该类药物存在复发性、副作用，不能长期服用等缺点。本发明目的在于提供一种将铁皮石斛叶等多种天然原料进行合理组方加工，能充分有效地发挥和利用原料所含成分的功效，集快速缓解不适症状和长期保健功能于一体的铁皮石斛组合物及其制备方法。
发明内容
本发明第一目的在于提供一种有益消化道健康的铁皮石斛组合物，第二目的在于提供一种有益消化道健康的铁皮石斛组合物的加工制备方法。
为实现上述目的，本发明提供的一种有益消化道健康的铁皮石斛组合物，其包铁皮石斛叶、广东虫草子实体、连翘叶、麦芽、银耳多糖、发酵大豆粉。
其中，按重量份数计，所述有益消化道健康的铁皮石斛组合物包含铁皮石斛叶1～100份、广东虫草子实体0.5～30份、连翘叶0.3～50份、麦芽0.1～60份、银耳多糖0.01～20份、发酵大豆粉0.01～50份。
本发明所述的有益消化道健康的铁皮石斛组合物，可加入可接受的辅料或食品添加剂，制成片剂、固体饮料。
本发明还提供一种本发明所述有益消化道健康的铁皮石斛组合物的制备方法，所述制备方法包括如下步骤：
(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入12～50倍量的水煎煮提取3次，每次提取1～3小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入10～20倍量的40～85％乙醇煎煮提取2次，每次提取1～3小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置1～8小时，250目筛滤过，滤液于40～85℃减压浓缩至密度1.06～1.38g/ml，50～89℃减压干燥，控制水份＜3.0％，粉碎过100～300目筛，备用；
(4)将麦芽于40～60℃烘干，控制水份＜3.0％，过400～1000目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及适宜辅料或食品添加剂，制成片剂、固体饮料。
本发明有益消化道健康的铁皮石斛组合物口感良好，无异味，服用方式容易被众多消费者接受，有助于其推广使用。本发明具有以下有益效果：本发明有益消化道健康的铁皮石斛组合物有改善口腔溃疡、慢性咽炎及防治幽门螺旋杆菌阳性并消化道溃疡的作用。
具体实施方式
下面通过具体实施方式进一步说明本发明，下述实施例、试验例中所用的原料、试剂材料等，如无特殊说明，均购买市售产品，其中发酵大豆粉来自加拿大Lallemand’sCommitents，商品名为Gastro-AD。以下实施例仅用于说明本发明，其中所述的实验方法，如无特殊定义，均为常规方法。
实施例1
原料：铁皮石斛叶100份、广东虫草子实体30份、连翘叶50份、麦芽60份、银耳多糖20份、发酵大豆粉0.01份。
制备方法：(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入50倍量的水煎煮提取3次，每次提取3小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入20倍量的85％乙醇煎煮提取2次，每次提取3小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置8小时，250目筛滤过，滤液于85℃减压浓缩至密度1.38g/ml，89℃减压干燥，控制水份＜3.0％，粉碎过300目筛，备用；
(4)将麦芽于60℃烘干，控制水份＜3.0％，过1000目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及甜菊糖苷0.10份、木糖醇50份、结晶果糖10份，制成固体饮料。
实施例2
原料：铁皮石斛叶1份、广东虫草子实体0.5份、连翘叶0.3份、麦芽0.1份、银耳多糖0.01份、发酵大豆粉50份。
制备方法：(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入12倍量的水煎煮提取3次，每次提取1小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入10倍量的40％乙醇煎煮提取2次，每次提取1小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置1小时，250目筛滤过，滤液于40℃减压浓缩至密度1.06g/ml，50℃减压干燥，控制水份＜3.0％，粉碎过100目筛，备用；
(4)将麦芽于40℃烘干，控制水份＜3.0％，过400目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及交联聚维酮0.05份、羧甲基淀粉钠0.05份、微晶纤维素10份、硬脂酸镁0.01份，制成片剂。
实施例3
原料：铁皮石斛叶50份、广东虫草子实体16份、连翘叶24份、麦芽30份、银耳多糖10份、发酵大豆粉25份。
制备方法：(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入30倍量的水煎煮提取3次，每次提取2小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入15倍量的63％乙醇煎煮提取2次，每次提取2小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置4小时，250目筛滤过，滤液于60℃减压浓缩至密度1.22g/ml，69℃减压干燥，控制水份＜3.0％，粉碎过200目筛，备用；
(4)将麦芽于50℃烘干，控制水份＜3.0％，过700目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及罗汉果苷0.050份，赤藓糖醇80份、低聚异麦芽糖醇10份、阿洛酮糖5份，制成固体饮料。
实施例4
原料：铁皮石斛叶1.5份、广东虫草子实体0.5份、连翘叶0.5份、麦芽0.3份、银耳多糖0.1份、发酵大豆粉1份。
制备方法：(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入25倍量的水煎煮提取3次，每次提取1.5小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入12倍量的65％乙醇煎煮提取2次，每次提取1小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置4小时，250目筛滤过，滤液于70℃减压浓缩至密度1.12g/ml，65℃减压干燥，控制水份＜3.0％，粉碎过100目筛，备用；
(4)将麦芽于55℃烘干，控制水份＜3.0％，过900目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及乳糖0.6份、微晶纤维素0.6份、硬脂酸镁0.01份、甜菊糖苷0.04份，制成片剂。
试验例1对幽门螺旋杆菌阳性并消化性溃疡的效果观察
1、人群及纳入标准
幽门螺旋杆菌阳性并消化性溃疡患者，年龄20岁～55岁，纳入共40人，随机分为4组，其他生理指标稳定，无重大疾病史。
2、治疗方法
本发明组：本发明实施例4样品，口服，每日3次，每次1g，服用60天。
对照组1：奥美拉唑20mg，口服，每日2次，服用60天。
对照组2：发酵大豆粉，口服，每日3次，每次1g，服用60天。
对照组3：银耳多糖，口服，每日3次，每次1g，服用60天。
3、评价标准：腹痛、腹胀、反酸、嗳气症状按严重程度计分。无症：0分；偶有症状：1分；常有症状，但不影响工作或学习：2分；严重症状，影响工作或学习：3分。60天再次进行幽门螺旋杆菌14C尿素呼吸试验。
4、治疗效果：本发明对幽门螺旋杆菌阳性并消化性溃疡有很好的防治效果，有利于幽门螺旋杆菌阳性转阴。具体结果见表1。
表1服用前后症状积分和根除效果(x±s)
试验例2对口腔溃疡的影响
1、人群及纳入标准
口腔黏膜出现单个或数个直径3～5mm的溃疡，烧热疼痛为主要症状，此起彼伏，病程长，愈后常易复发患者，年龄18岁～65岁，纳入共138人，随机分为6组，其他生理指标稳定，无重大疾病史。
2、治疗方法
本发明组：本发明实施例1-4样品，口服，每日3次，每次0.5～2g，服用90天。
对照组1：铁皮石斛粉，温水冲散后口服，每日3次，每次2g，服用90天。
对照组2：银耳多糖，温水冲散后口服，每日3次，每次0.5g，服用90天。
3、评价标准：治愈：口腔溃疡完全愈合，且1年内未复发；好转：口腔溃疡愈合，1年内即有复发，但发作次数较原来明显减少，溃疡个数明显减少，疼痛程度减轻，愈合间隙缩短3天以上；无效：口腔溃疡仍反复发生，发作时疼痛及溃疡个数及发作间隙同前无明显变化。
4、治疗效果：本发明对口腔溃疡有很好的防治效果。具体结果见表2。
表2对口腔溃疡的影响(x±s)
试验例3对慢性咽炎的影响
1、人群及纳入标准
有急性喉痹反复发作史，咽部伴有异物感，咽痒并咳患者，年龄25岁～61岁，纳入共120人，随机分为4组，其他生理指标稳定，无重大疾病史。
2、治疗方法
本发明组：本发明实施例1-4样品，口服，每日3次，每次0.5～2g，服用60天。
3、评价标准：治愈：咽部异物感、痒感、灼热干燥感等自觉症状消失，咽部黏膜充血、水肿，咽后壁淋巴滤泡等体征消失。好转：咽部异物感、痒感、灼热干燥感等自觉症状明显好转，咽部充血、水肿、咽后壁淋巴滤泡等体征明显减轻。未愈：症状和体征无明显变化。
4、治疗效果：本发明对慢性咽炎有很好的防治效果。具体结果见表3。
表3对慢性咽炎的影响(x±s)
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
Claims (4)
1.一种有益消化道健康的铁皮石斛组合物，其包含铁皮石斛叶、广东虫草子实体、连翘叶、麦芽、银耳多糖、发酵大豆粉。
2.根据权利要求1所述的有益消化道健康的铁皮石斛组合物，其特征在于，按重量份数计，所述有益消化道健康的铁皮石斛组合物包含铁皮石斛叶1～100份、广东虫草子实体0.5～30份、连翘叶0.3～50份、麦芽0.1～60份、银耳多糖0.01～20份、发酵大豆粉0.01～50份。
3.根据权利要求1至2任一所述的有益消化道健康的铁皮石斛组合物，其特征在于加入可接受的辅料或食品添加剂，制成片剂、固体饮料。
4.一种根据权利要求1至3任一所述的有益消化道健康的铁皮石斛组合物的制备方法，所述制备方法包括如下步骤：
(1)将铁皮石斛叶、广东虫草子实体、连翘叶加入12～50倍量的水煎煮提取3次，每次提取1～3小时，收集滤液，合并三次滤液，250目筛滤过，备用；
(2)将(1)中滤渣加入10～20倍量的40～85％乙醇煎煮提取2次，每次提取1～3小时，合并两次滤液，250目筛滤过，备用；
(3)将(1)、(2)中滤液合并，静置1～8小时，250目筛滤过，滤液于40～85℃减压浓缩至密度1.06～1.38g/ml，50～89℃减压干燥，控制水份＜3.0％，粉碎过100～300目筛，备用；
(4)将麦芽于40～60℃烘干，控制水份＜3.0％，过400～1000目筛，备用；
(5)将(3)、(4)中物料加入银耳多糖、发酵大豆粉及适宜辅料或食品添加剂，制成片剂、固体饮料。
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Application publication date: 20180622 |