CN108144142A - A kind of centrifugal type blood composition separate cup and separation method - Google Patents
A kind of centrifugal type blood composition separate cup and separation method Download PDFInfo
- Publication number
- CN108144142A CN108144142A CN201810046701.7A CN201810046701A CN108144142A CN 108144142 A CN108144142 A CN 108144142A CN 201810046701 A CN201810046701 A CN 201810046701A CN 108144142 A CN108144142 A CN 108144142A
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- blood
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- cup
- red blood
- blood cell
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- 210000004369 blood Anatomy 0.000 title claims abstract description 87
- 239000008280 blood Substances 0.000 title claims abstract description 87
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 238000000926 separation method Methods 0.000 title claims abstract description 23
- 238000010227 cup method (microbiological evaluation) Methods 0.000 title abstract description 5
- 210000002381 plasma Anatomy 0.000 claims abstract description 97
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 55
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002002 slurry Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 230000003139 buffering effect Effects 0.000 claims 1
- 239000000470 constituent Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention provides a kind of centrifugal type blood composition separate cup and separation method, separate cup includes cup body, stator, detach core, it is hollow structure inside the cup body, the stator is arranged on above cup body, the stator is hollow structure, one red blood cell exit is set on stator, plasma outlet port and blood entry port, the stator interior is equipped with blood drainage conduit, red blood cell drainage catheter is provided with outside the blood drainage conduit, blood plasma drainage catheter, the separation core is arranged on cup body inner upper for T-shaped structure, a cavity is formed between cup body, the separation core top is equipped with two chambers, outside is red blood cell cushion chamber, inside is blood plasma cushion chamber.Red blood cell is transferred out of cup body by the present invention by red blood cell drainage catheter, more blood is made to enter separate cup cup body to be detached, to be rapidly achieved acquisition blood plasma desired value, blood donor can not only be shortened and contribute the time of blood plasma process, and also improve blood constituent disintegrate-quality.
Description
Technical field
The present invention relates to a kind of medical instrument, more particularly, to a kind of centrifugal type blood composition separate cup and separation method.
Background technology
In medical applications, the treatment technology of plasma exchange and blood product or drug using blood plasma as raw material are commonly used,
Blood plasma is the important component in blood of human body.The acquisition technique of blood plasma has membrane filtration technique and centrifugal isolation technics.From
Core type isolation technics plasma composition in order to obtain needs using sampled plasma equipment, then matches disposable heparin tube
Road, collecting bag and separate cup, blood of human body is extracted out, is injected into separate cup, is generated according to ingredient proportion difference each in blood
Centrifugal force principle of different sizes, each ingredient forms different layerings in separate cup in blood, innermost for blood plasma point
Layer, outermost to be layered for red blood cell, current acquisition plasma composition method is at present：One drainage of design is led on the inside of separate cup
Plasma composition is delivered to blood plasma collecting bag by pipe, and red blood cell component is rested in separate cup, with the increase of plasma collection amount, is divided
Also increasing from red blood cell volume in cup, when plasma composition is all acquired to blood plasma collecting bag, i.e., red blood cell component is filled
Separate cup at this point, stopping collecting blood plasma, the red blood cell component in separate cup is all fed back in blood donor's body, that is, is completed
The plasma collection of one cycle.It according to the plasma collection target capacity of setting, repeats the above process again, until plasma collection amount
Reach desired value.
In order to ensure that blood donor is safe, the single extracorporal circulatory system botal blood volume during acquisition blood plasma is limited to be no more than
600ml, single cycle（Single）Sampled plasma maximum is no more than 300g, and it is too low to be otherwise likely to result in blood donor's blood volume,
Cause and suffer a shock or cause death when serious.
Existing centrifugal blood formula separator plasma composition collection method still has deficiency：
1. for plasma content junior in blood donor's blood, since separate cup capacity is limited, single acquisition plasma volume often reaches
Less than 300g, need multiple cycles that can just be collected into target collection amount, loop number is more, then acquiring blood and also blood transfusion liquid needs
The time wanted can increase；
2. it for plasma content the higher person in blood donor's blood, and since separate cup capacity is big, and needs Centrifuge Cup full of
It can start to acquire blood plasma, cause temporal waste；
3. in the latter end for collecting blood plasma, it is not completely segregated into the blood in Centrifuge Cup, blood plasma and red blood cell separating effect
It is poor, cause its disintegrate-quality relatively low；
4. for plasma content junior in blood donor's blood, when single acquisition plasma volume is to limiting value, red blood cell is easily mixed into
Blood plasma collecting bag causes the pollution of plasma composition.
The time that above deficiency causes blood donor to contribute blood plasma process is too long, be easy to cause blood donor and does not accommodate occupancy and offers
Blood person's time, the enthusiasm for contributing blood plasma to blood donor has an adverse effect, so as to influence whole sampled plasma amount.
Invention content
The purpose of the present invention is to provide a kind of centrifugal type blood composition separate cup and separation method, to solve the prior art
In caused the above-mentioned defects, it not only shortens the time that blood donor contributes blood plasma process, but also to blood constituent point
It increases from quality, has extremely important effect and benefit to the medical institutions of blood donor and plasma collection.
The technical scheme is that：A kind of centrifugal type blood composition separate cup, including cup body, stator, separation core, institute
It states and is arranged on above cup body for hollow structure, the stator inside cup body, the stator is hollow structure, and setting one is red on stator
Cell outlet, plasma outlet port and blood entry port, the stator interior are equipped with blood drainage conduit, the blood drainage conduit
Outside is provided with red blood cell drainage catheter, blood plasma drainage catheter, and the separation core is arranged on for T-shaped structure on cup body inside
Side, forms a cavity between cup body, and the separation core top is equipped with two chambers, and outside is red blood cell cushion chamber, inside
For blood plasma cushion chamber.
Further, the hollow-cavity capacity formed between the separation core and cup body is 200ml to scheme.
Scheme further, forms a cavity, with plasma outlet port between the blood drainage conduit and blood plasma drainage catheter
Connection.
Scheme further, forms a cavity, with red blood cell between the blood plasma liquid stream conduit and red blood cell drainage catheter
Outlet.
A kind of centrifugal type blood composition separate cup separation method includes：
（1）Single sampled plasma amount is set as 200g, carries out sampled plasma, tracks sampled plasma amount；
（2）When single sampled plasma amount is less than 200g, red blood cell is transferred to from separate cup by red blood cell drainage catheter
In red blood cell bag, shifted when acquiring blood until blood reaches capacity in separate cup, stopping transfer red blood cell continues to acquire blood
Slurry is until collection capacity reaches 200g；
（3）When single sampled plasma amount reaches 200g, terminate acquisition blood；
（4）The defeated feedback blood person of red blood cell in separate cup or red blood cell bag is internal, and single sampled plasma terminates；
（5）It repeats the above process, until plasma collection amount reaches desired value.
The beneficial effects of the invention are as follows：
After 1. Centrifuge Cup capacity is decreased to 200ml, for plasma content the higher person in blood donor's blood, due to separate cup capacity
It is small, so more current Centrifuge Cup starts to acquire blood plasma time advance, and the blood needed for more current Centrifuge Cup acquisition same amount blood plasma
Amount is reduced, so as to reduce the time needed for conveying blood；
2. single cycle（Single）Sampled plasma maximum be limited to be no more than 200g after, for plasma content in blood donor's blood compared with
Low person, single cycle（Single）Sampled plasma amount more easily reachs 200g；
3. after increasing by one group of red blood cell drainage catheter and red blood cell exit in Centrifuge Cup, for plasma content in blood donor's blood compared with
Red blood cell in Centrifuge Cup can be transferred out of Centrifuge Cup by low person, single acquisition plasma volume when 200g is not achieved, more so as to make
Blood enters separate cup and is detached, and increases sampled plasma amount, and reduction is adopted slurry recurring number and adopted the slurry time.
Description of the drawings
Fig. 1 is cross-sectional view of the present invention.
Fig. 2 is structure top view of the present invention.
Wherein：1st, cup body, 2, red blood cell exit, 3, plasma outlet port, 4, blood entry port, 5, red blood cell drainage catheter, 6, blood
Starch drainage catheter, 7, red blood cell cushion chamber, 8, blood plasma cushion chamber, 9, blood drainage conduit, 10, separation core, 11, stator.
Specific embodiment
Clearly complete description is done to the present invention below in conjunction with the accompanying drawings, so that those skilled in the art is not needing to make
Under conditions of creative work, it can fully implement the present invention.
The present invention specific embodiment be：As shown in Figure 1, 2, a kind of centrifugal type blood composition separate cup, including cup body
1st, stator 11, separation core 10,1 inside of cup body are hollow structure, and the stator 11 is arranged on 1 top of cup body, described fixed
Son 11 is hollow structure, sets a red blood cell exit 2, plasma outlet port 3 and blood entry port 4 on stator 11, in the stator 11
Portion is equipped with blood drainage conduit 9, and red blood cell drainage catheter 5, blood plasma drainage catheter are provided with outside the blood drainage conduit 9
6, a cavity is formed between the blood drainage conduit 9 and blood plasma drainage catheter 6, is connected with plasma outlet port 3, the blood plasma liquid stream
A cavity is formed between conduit 6 and red blood cell drainage catheter 5, is connected with red blood cell exit 2, the separation core 10 is T shape knots
Structure is arranged on 1 inner upper of cup body, forms a cavity between cup body 1, hollow-cavity capacity 200ml, in the separation core 10
Portion is equipped with two chambers, and outside is red blood cell cushion chamber 7, and inside is blood plasma cushion chamber 8.
Based on above-mentioned, a kind of separation method of centrifugal type blood composition separate cup is to the plasma composition in blood and red thin
The separation of born of the same parents' ingredient,, will be red thin in Centrifuge Cup if single cycle sampled plasma amount cannot reach 200g during blood plasma is acquired
Born of the same parents are delivered to red blood cell transfering bag by red blood cell drainage catheter 5 from red blood cell exit 2, at this point, blood continues to enter centrifugation
Red blood cell in Centrifuge Cup cup body 1, is only transferred out by cup cup body 1.So plasma composition is increasingly in Centrifuge Cup cup body 1
It is more, when plasma composition reaches certain capacity, stop transfer red blood cell, blood plasma is acquired again, until single cycle plasma volume reaches
During 200g, stop acquisition blood plasma, start the red blood cell in Centrifuge Cup and in red blood cell transfering bag being fed back to blood donor's body together
Interior, single cycle terminates.It repeats the above process, until plasma collection amount reaches desired value.It can not only shorten blood donor's donated blood
The time of slurry process, and also improve blood constituent disintegrate-quality.It is that one group is increased on the basis of existing separate cup
Red blood cell drainage catheter 5 and red blood cell exit 2 during sampled plasma, when red blood cell is full of cup body 1, are drawn by red blood cell
Red blood cell is transferred out of cup body 1 by conductance pipe 5, and more blood is made to enter separate cup cup body 1 and are detached, to be rapidly achieved acquisition
Blood plasma desired value saves the time of acquisition blood plasma, simultaneously as the separate cup internal structure of the present invention and acquisition blood plasma mode
Optimization, makes it also increase blood plasma disintegrate-quality.
Presently preferred embodiments of the present invention is described above, it should be pointed out that the invention is not limited in above-mentioned
Particular implementation, wherein the equipment and structure be not described in detail to the greatest extent are construed as giving reality with the common mode in this field
It applies；Any those skilled in the art, without departing from the scope of the technical proposal of the invention, technology according to the present invention
Essence any simple modifications, equivalents, and modifications made to the above embodiment still fall within technical solution of the present invention protection
In the range of.
Claims (5)
1. a kind of centrifugal type blood composition separate cup, which is characterized in that including cup body, stator, separation core, inside the cup body
For hollow structure, the stator is arranged on above cup body, and the stator is hollow structure, set on stator a red blood cell exit,
Plasma outlet port and blood entry port, the stator interior are equipped with blood drainage conduit, are set outside the blood drainage conduit
There are red blood cell drainage catheter, blood plasma drainage catheter, the separation core is arranged on cup body inner upper for T-shaped structure, with cup body
Between form a cavity, the separation core top is equipped with two chambers, and outside is red blood cell cushion chamber, and inside is blood plasma buffering
Chamber.
2. a kind of centrifugal type blood composition separate cup according to claim 1, which is characterized in that the separation core and cup
The hollow-cavity capacity formed between body is 200ml.
A kind of 3. centrifugal type blood composition separate cup according to claim 2, which is characterized in that the blood drainage conduit
A cavity is formed between blood plasma drainage catheter, is connected with plasma outlet port.
A kind of 4. centrifugal type blood composition separate cup according to claim 3, which is characterized in that the blood plasma liquid stream conduit
A cavity is formed between red blood cell drainage catheter, is connected with red blood cell exit.
5. a kind of separation method of centrifugal type blood composition separate cup according to claim 4, which is characterized in that including：
（1）Single sampled plasma amount is set as 200g, carries out sampled plasma, tracks sampled plasma amount；
（2）When single sampled plasma amount is less than 200g, red blood cell is transferred to from separate cup by red blood cell drainage catheter
In red blood cell bag, shifted when acquiring blood until blood reaches capacity in separate cup, stopping transfer red blood cell continues to acquire blood
Slurry is until collection capacity reaches 200g；
（3）When single sampled plasma amount reaches 200g, terminate acquisition blood；
（4）The defeated feedback blood person of red blood cell in separate cup or red blood cell bag is internal, and single sampled plasma terminates；
（5）It repeats the above process, until plasma collection amount reaches desired value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810046701.7A CN108144142A (en) | 2018-01-18 | 2018-01-18 | A kind of centrifugal type blood composition separate cup and separation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810046701.7A CN108144142A (en) | 2018-01-18 | 2018-01-18 | A kind of centrifugal type blood composition separate cup and separation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108144142A true CN108144142A (en) | 2018-06-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810046701.7A Pending CN108144142A (en) | 2018-01-18 | 2018-01-18 | A kind of centrifugal type blood composition separate cup and separation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109107776A (en) * | 2018-07-31 | 2019-01-01 | 广州穗阳生物学研究有限公司 | A kind of centrifuge separation cup and continuous separation method |
| CN109177202A (en) * | 2018-08-21 | 2019-01-11 | 北京南格尔生物科技有限公司 | A kind of automatic package system of blood plasma separate cup and method |
| CN110448751A (en) * | 2019-07-26 | 2019-11-15 | 北京中科盛康科技有限公司 | A kind of Autoblood recovery device |
| WO2022252910A1 (en) * | 2021-05-31 | 2022-12-08 | 衷博瑞佳生物技术(上海)有限公司 | Piston-type biological liquid separation bottle having inner core and separation method thereof |
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| CN202777224U (en) * | 2012-09-23 | 2013-03-13 | 四川南格尔生物医学股份有限公司 | Small capacity plasma-separating cup |
| CN202892981U (en) * | 2012-09-28 | 2013-04-24 | 四川南格尔生物医学股份有限公司 | High-capacity plasma separation cup |
| CN104870098A (en) * | 2012-11-05 | 2015-08-26 | 美国血液技术公司 | Continuous flow separation chamber |
| CN106925438A (en) * | 2017-03-29 | 2017-07-07 | 艾沃生物科技（苏州）有限公司 | A kind of low capacity blood plasma separate cup based on ultra-sonic welding techniques |
| CN208003172U (en) * | 2018-01-18 | 2018-10-26 | 董亚东 | A kind of centrifugal type blood composition separate cup |
-
2018
- 2018-01-18 CN CN201810046701.7A patent/CN108144142A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202777224U (en) * | 2012-09-23 | 2013-03-13 | 四川南格尔生物医学股份有限公司 | Small capacity plasma-separating cup |
| CN202892981U (en) * | 2012-09-28 | 2013-04-24 | 四川南格尔生物医学股份有限公司 | High-capacity plasma separation cup |
| CN104870098A (en) * | 2012-11-05 | 2015-08-26 | 美国血液技术公司 | Continuous flow separation chamber |
| CN106925438A (en) * | 2017-03-29 | 2017-07-07 | 艾沃生物科技（苏州）有限公司 | A kind of low capacity blood plasma separate cup based on ultra-sonic welding techniques |
| CN208003172U (en) * | 2018-01-18 | 2018-10-26 | 董亚东 | A kind of centrifugal type blood composition separate cup |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109107776A (en) * | 2018-07-31 | 2019-01-01 | 广州穗阳生物学研究有限公司 | A kind of centrifuge separation cup and continuous separation method |
| CN109177202A (en) * | 2018-08-21 | 2019-01-11 | 北京南格尔生物科技有限公司 | A kind of automatic package system of blood plasma separate cup and method |
| CN109177202B (en) * | 2018-08-21 | 2020-10-27 | 北京南格尔生物科技有限公司 | Automatic assembling system and method for plasma separating cup |
| CN110448751A (en) * | 2019-07-26 | 2019-11-15 | 北京中科盛康科技有限公司 | A kind of Autoblood recovery device |
| CN110448751B (en) * | 2019-07-26 | 2023-08-29 | 北京中科盛康科技有限公司 | Autologous blood recovery device |
| WO2022252910A1 (en) * | 2021-05-31 | 2022-12-08 | 衷博瑞佳生物技术(上海)有限公司 | Piston-type biological liquid separation bottle having inner core and separation method thereof |
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