JPH09168585A - Blood bag system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a blood preparation not containing a leucocyte. SOLUTION: This blood bag system consists of a single bag 3 for collection of blood sample and a single bag 6 for separation of a blood component connected to the upstream side of a leucocyte removing filter 8, and a single bag 11 for preserving an erythrocytic liquid and a single bag 13 for separation of a blood component connected to the downstream side of the leucocyte removing filter 8. After separating the blood as a plasma component and an erythrocytic component by centrifugal separation, the leucocyte is removed from the erythrocytic component.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a so-called in-line blood bag system in which a leukocyte removal filter is connected to a communication tube of the blood bag system.

[0002]

2. Description of the Related Art A blood bag set is composed of a blood collecting needle, a blood collecting bag filled with an anticoagulant, and an empty bag for separating blood components, and each bag is aseptically connected by a tube.

In addition, a bag containing a preservative solution dedicated to component blood, which is capable of stably storing blood for a long period of time, is often incorporated in a blood bag set. The blood bag is a container made of a flexible plastic material suitable for storing blood components, and is used for aseptic preparation of blood products for transfusion. BACKGROUND ART Component transfusion therapy is widely used in which blood products for transfusion are processed into three components, a plasma product, a platelet product, and an erythrocyte product, and only the components required by the patient are transfused.

The blood product is obtained by collecting the blood of a healthy person by a volunteer in a blood collection bag and separating it into three components by using a centrifugal separator. Since the specific gravity of blood is slightly different for each component, it is separated into each component layer by the load of centrifugal force, and plasma, platelets, leukocytes, and red blood cells are concentrated in this order from the upper layer of the blood collection bag. After centrifugation, plasma and platelets are transferred from the blood transfer tube above the blood collection bag to the blood component separation bag, and red blood cells are left in the blood collection bag for storage. At this time, leukocytes in the intermediate layer are mixed with each component, which causes side effects due to blood transfusion. Therefore, it is desired to remove leukocytes.

Known methods for removing leukocytes in blood include the washed red blood cell method, the thawed red blood cell method, and the white blood cell removal filter method. Among them, the filter method that obtains a high leukocyte removal rate by a simple operation is widely used.

Therefore, a blood bag system incorporating a leukocyte removal filter has been proposed in US Pat. No. 4,596,657. This is a method of centrifuging a blood collection bag by a plasma collection method containing concentrated platelets (PRP method), priming a leukocyte depletion filter with a red blood cell preservation solution, and then filtering concentrated leukocytes. Since the blood component separation bag is not arranged, leukocyte-removed red blood cells must be stored in the red blood cell preservation solution bag. The red blood cell preservative solution bag has been approved as a drug storage container for storing the red blood cell preservative solution, and a procedure for obtaining a new drug approval as a drug storage container is required to use it for another purpose. Further, the red blood cell preservation solution bag is usually in a form suitable for storing about 100 cc, and if the red blood cells after leukocyte removal are stored in a volume of 200 to 300 cc, the red blood cell preservation solution bag will be stored in an expanded state for a long period of time, which is suitable. Not.

[0007]

DISCLOSURE OF THE INVENTION The present invention is a method for separating blood components for removing leukocytes in blood, which prevents air from being mixed in a bag for separating blood components and which uses a leukocyte removal filter. The objective is to obtain a blood product from whole blood in good yield.

[0008]

According to the present invention, one blood collection bag and one blood component separation bag are provided upstream of a leukocyte removal filter, and one red blood cell preservation solution bag and one blood component separation bag are provided downstream of a leukocyte removal filter. A blood bag system is characterized in that, using a blood bag set connected to one another, it is centrifuged to separate it into a plasma component and a red blood cell component, and then white blood cells are removed from this red blood cell component.

Further, the erythrocyte preservation solution is flown to the leukocyte removal filter and then to the blood collection bag to exhaust the air in the leukocyte removal filter to the blood collection bag, and then the separated red blood cell component in the blood collection bag is fed to the leukocyte removal filter. The gist of the above-mentioned blood bag system is characterized in that the red blood cells from which the white blood cells have been removed are stored in a blood component separation bag.

According to the present invention, the erythrocyte preservation solution in the erythrocyte preservation solution bag is flowed from the blood transfer tube to the leukocyte removal filter, and the air in the leukocyte removal filter is exhausted to the blood collection bag through the blood transfer tube. Then, the red blood cell component is transferred.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the drawings. FIG. 1 is an example of the blood bag system of the present invention.

Blood collected from the blood collecting needle 1 is stored in a blood collecting bag 3 containing an anticoagulant via a blood collecting tube 2 and temporarily stored. The blood collection bag 3 is centrifuged to be fractionated into a plasma component and an erythrocyte component.
It is stored in the blood component separation bag 6 via 5.

The red blood cell preservation solution in the red blood cell preservation solution bag 11 is removed from the blood transfer tubes 10 and 9 by the leukocyte removal filter 8.
And the air in the leukocyte removal filter 8 is exhausted to the blood collection bag 3 through the blood transfer tubes 7 and 4. When the blood components rich in red blood cells in the blood collection bag 3 are passed through the white blood cell removal filter 8, the red blood cells from which the white blood cells have been removed are stored in the blood component separation bag 13 via the blood transfer tubes 9 and 12.

In the present invention, a clamp and a bent rod are arranged and used in the middle of the blood transfer tube.

[0015]

According to the present invention, since red blood cells from which white blood cells have been removed are stored not in the red blood cell preservation solution bag but in the blood component separation bag, there is no need to newly obtain a manufacturing approval for the red blood cell preservation solution bag. The red blood cell preservation solution is passed from the leukocyte removal filter to the blood collection bag, the air in the leukocyte removal filter is exhausted to the blood collection bag, and then the blood in the blood collection bag is passed through the leukocyte removal filter. It has the effect of reducing the amount of air used.

[Brief description of the drawings]

FIG. 1 is a system diagram of a blood bag system of the present invention.

[Explanation of symbols]

 1 Blood Collection Needle 2 Blood Collection Tube 3 Blood Collection Bag 4 Blood Transfer Tube 5 Blood Transfer Tube 6 Blood Component Separation Bag 7 Blood Transfer Tube 8 Leukocyte Removal Filter 9 Blood Transfer Tube 10 Blood Transfer Tube 11 Blood Preservation Solution Bag 12 Blood Transfer Tube 13 Blood Ingredient separation bag

Claims (2)

[Claims] 1. A blood bag set in which one blood collection bag and one blood component separation bag are connected to the upstream side of the leukocyte removal filter, and one red blood cell preservation solution bag and one blood component separation bag are connected to the downstream side of the leukocyte removal filter. A blood bag system, characterized in that it is used for centrifugation and separated into a plasma component and a red blood cell component, and then white blood cells are removed from the red blood cell component. 2. The red blood cell preservation solution is passed through a leukocyte removal filter and then into a blood collection bag to exhaust the air in the leukocyte removal filter to the blood collection bag, and then the separated red blood cell component in the blood collection bag is loaded into the white blood cell removal filter. The blood bag system according to claim 1, wherein the red blood cells from which the white blood cells are removed by passing are stored in a blood component separation bag.