CN108135241A - 在阴离子阳离子聚合物和果聚糖中稳定的可溶性钙 - Google Patents
在阴离子阳离子聚合物和果聚糖中稳定的可溶性钙 Download PDFInfo
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- CN108135241A CN108135241A CN201680059322.0A CN201680059322A CN108135241A CN 108135241 A CN108135241 A CN 108135241A CN 201680059322 A CN201680059322 A CN 201680059322A CN 108135241 A CN108135241 A CN 108135241A
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- calcium
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- levulan
- parts
- solubility
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000011575 calcium Substances 0.000 title claims abstract description 63
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title claims description 41
- 229940118199 levulan Drugs 0.000 title claims description 41
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- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 29
- 229940029339 inulin Drugs 0.000 claims description 29
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 27
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Abstract
本发明提供促进大分子基质中钙离子溶剂化的方法。在过程中每个阶段的关系、浓度、物理化学条件和制备方法允许获得基于钙盐和聚合物的稳定的可溶性产品。本发明不会导致所用盐的晶体沉积,并且超过了商业钙制剂,因此它们对于其在食品、药物和/或化妆品工业中的应用具有很大的实用性。
Description
技术领域
本发明涉及一种用于稳定不溶物质的新方法,例如磷酸三钙和碳酸钙以便吸收。特别是在阳离子和阴离子聚合物中的不溶性钙盐的组合物形成可溶性络合物,当胶体比例为等摩尔时。
背景技术
近年来,对使用具有功能特性的大分子混合物的创新技术的研究、开发和应用进行了疯狂搜索,能够稳定和提供生物活性原理。主要地,因为单分子体系的物理化学性质不足以用作递送药物、脂质、生物活性分子、和矿物质的载体。在所有的施用途径中,口服途径一直是使用最多的(90%的施用),因为它提供了低成本的制剂系统,不会对消费者造成痛苦,并且允许向消费者提供活性成分而不论年龄。然而,这些系统在消化道旅程中克服了与生物活性原理的消化和吸收相关的重要挑战,具有作为主要障碍的物理、酶或免疫障碍。
在诸如钙的大量矿物质的特殊情况下,吸收的主要问题是物理性的。钙的主要来源之一是磷酸三钙。FDA(食品和药物管理局)批准磷酸三钙作为添加剂,并出现在正式的E-341(iii)添加剂清单中。2013年,欧洲议会和理事会的欧洲委员会第1333/2008号规则附件III通过引入磷酸三钙(E341(iii))作为用于新生儿、孩子和年轻人的食品添加剂和营养食品中的抗结合剂来进行修改。这在牛奶中很自然地发现。尽管分散性和溶解性很低,但它用作强化谷物和面食的矿物质补充剂。也作为抗粘结剂、酸度调节剂、钙的来源在预防和治疗钙缺乏症(预防骨质疏松症)。它是人体系统基本生物反应的一部分(与肠道胆汁盐沉淀、血脂和胆固醇水平降低有关的益处)。目前,剂量递送是以高度不溶解的悬浮液形式,限制了它们的生物有效性。溶解性和可用性问题的解决方案并不容易;没有可行的替代方法来有效地输送钙离子。尽管如此,固体口服剂量的市场估计近年来有所增加,主要是在老年人群中。据估计,2011年市场价值为5.760亿美元,到2018年预计为8.691亿美元。在该预测中,9.6%属于矿物质市场。这对稳定离子钙的方法学的使用创造了重要的期望。
已经使用胶体技术实现了可溶性钙复合物的离子化和稳定化。有了这个概念,我们可以看到许多产品可以改进并带到消费者手中,确保宏量营养素和其他类似性质的生物活性化合物的快速吸收。本发明的可溶性钙复合物已经在实验室级使用高度可溶的天然纤维如壳聚糖、甜荚豆胶、果聚糖和菊粉来配制。在储存期间它的稳定性已经在室温下的酸性条件下进行测试。本发明基于产生和促进生产可溶性钙复合物的新方法学的发展。
在专利文件WO2007069072A2中,它描述了基于用有机或无机酸和金属阳离子如钙、镁、锌、铁、铜、锰、钠、钾、镍或钴获得的矿物盐的食品添加剂。矿物盐利用氨基酸和/或铵盐稳定,在阳离子键和配位共价键之间稳定。然而,为了使氨基酸和金属阳离子,例如钙,发挥其各自的生物学功能,一旦它们在食品补充剂中消耗,就需要化合物解离。因此,在该系统中,需要高能量消耗来处理含水介质中的游离离子;例如释放钙所需的能量大于20KJ/mol。
在专利CN1391444B中,描述了产品的强化,例如水、果汁、饮料和其它液体食品产品,添加钙和镁的盐与乳酸和柠檬酸亚稳态,并且任选地用碳水化合物来稳定。所公开的发明在文件中提及的饮料领域中具有应用。
美国专利9,023,398B描述了一种用于改善溶解性差的物质如磷酸三钙用于制药、化妆品、食品和农业工业的方法。但是,用于改善溶解性的方法包括通过机械方法将粒径减小到100μm或更小。粒径的减小意味着表面积的增加和与亲水溶液接触的增加;随后使用柠檬酸、柠檬酸盐、磷酸或硫酸软骨素来物理涂层以提高溶解度。但是,作为膳食补充剂递送钙的过程没有具体说明。
美国专利7,994,155B2描述了用于矿物吸收的促进剂产品。促进剂产品基于由四个葡萄糖残基组成的非还原性四糖,经由α-1,3和α-1,6,环{>6)-α-D-吡喃葡萄糖基-(1→3)-α-D-吡喃葡萄糖基-(1→6)-α-D-吡喃葡萄糖基-(1→3)-α-吡喃葡萄糖基(1→))循环结合和/或由其衍生的糖。但是推荐的产品是以不同的量添加的,其中每天0.01g/kg体重,或者优选每天0.5g/kg体重,或者更优选每天1.0g/kg体重或在干燥的基础上更多,及以食品、饮料、前药或药物中施用,因此是通用的四糖,其可以以推荐的浓度用于各种制剂而不是特异性的。
因此,主要技术目的是发展复杂的分子间体系,用作能够稳定和递送具有多种应用的生物活性化合物的载体。特别地,因为单分子组分的性质不足以克服不同工艺条件或稳定性的影响。
基本上,因为所有那些具有滋补目的的产品都不能实现多种营养分子的溶剂化过程。这是一个必须克服的挑战,因为90%的施用方式都是口服。
因此,本发明的主要目的是使不溶性钙盐稳定在水溶液中,并将它们作为食物补充剂或在食品、药物或化妆品中施用。
发明详述
根据本发明,提供了一种稳定的可溶性钙复合物,包含以每克样品0.05mg至15mg的量存在的钙源;阳离子聚合物,其与钙源的质量比为0.25至12.5;阴离子水解胶体;和可溶性纤维源。根据本发明还提供了制备稳定的可溶性钙复合物的方法。
在本发明中涉及的稳定的可溶性钙复合物意指在以液体形式和/或固体形式的食品添加剂的制备中以消耗的应用,其单独或结合,与固体食物、半固体、液体、凝胶或饮料。还包括采用本过程中使用的任何处理方法的原材料和中间产品。本发明中所称的术语可溶性钙是指由磷酸三钙或氯化钙或碳酸钙或正磷酸钙或氧化钙组成的复合物;壳聚糖或动物或植物来源的蛋白质;瓜尔豆胶;果聚糖和/或菊粉。它可以用作有效提供钙和可溶性纤维的液体或固体产品。单独或与上述组合施用。在本发明中,术语“可溶性矿物质”称为所需的矿物质,例如钙、磷、铁、镁、钾、铜、硒和碘。主要是以固体和液体形式在营养补充剂配方中作出贡献所必需的二价和单价矿物元素。矿物元素可以包含在本发现的复合物中。除壳聚糖和/或其衍生物外,它还含有海藻酸及其盐;钠、钾和丙二醇海藻酸、豆胶、阿尔加罗沃胶、黄原胶,用作活体中矿物质吸收的载体。多糖中含有的天然矿物质或与其一起加工的产品含量。钙盐的实例:磷酸三钙、碳酸钙、氯化钙和氧化钙。
钙利用率取决于许多因素,包括年龄、人口类型、性别和健康状况。除了这些因素之外,从化学观点来看,溶解度和吸收率取决于所用源的结构、电离能力和介质中可得到的氢离子的浓度。这两个因素都会改变钙吸收的效率。提高矿物质吸收的一种方式,例如钙,是在本发明中提到的在大分子体系中以离子化复合物的形式提供。
附图简述
图1显示了壳聚糖(--Q)、阿拉伯胶分子量(--GA)和磷酸三钙(--CP)的红外电磁波谱。用壳聚糖、阿拉伯树胶、果聚糖和/或菊粉形成可溶性钙的分子。
图2显示如实施例1中所述的1.5份磷酸三钙、1份壳聚糖、20份阿拉伯胶、和10份果聚糖和/或5份果聚糖与5份菊粉的可溶性复合物的红外电磁波谱。
图3显示如实施例2中所述的2.5份磷酸三钙、1份壳聚糖、20份阿拉伯胶、和10个果聚糖或5份果聚糖与5份菊粉的可溶性复合物的平均红外电磁波谱。
图4显示了如实施例3中所述的5.0份磷酸三钙、1份壳聚糖;、20份阿拉伯胶、10份果聚糖或5份果聚糖与5份菊粉的可溶性复合物的红外电磁波谱。
图5显示1.5份磷酸三钙、1份壳聚糖;、20份阿拉伯胶、和10份果聚糖、果聚糖5份和菊粉5份,如实施例1中所述,或果聚糖7.5份和菊糖2.5份的溶于水的可溶性复合物的电子显微照片(2500X)。
图6显示2.5份磷酸三钙-壳聚糖、20份阿拉伯胶、和10份果聚糖、5份果聚糖和5份菊糖,如实施例2所述,溶于水中的可溶性复合物的电子显微照片(2500X)。
图7显示了5.0份磷酸三钙-壳聚糖、20份阿拉伯胶、和10份果聚糖、或5份果聚糖和5份菊糖,实施例2中所述,溶于水的可溶性复合物的电子显微照片(2500X)。
图8显示了本发明的目的的用于制备可溶性钙的主要步骤。
实施本发明的最佳方法
以下是对本发明的一些方面的更详细的描述,以便更好地理解本发明;但并不是以任何方式限制。
根据本发明的用于制备稳定的可溶性钙复合物的方法包括以下步骤:
1、制备0.19g至5g的磷酸三钙溶液,特别地是0.5至3g,但优选为1ml的磷酸中1g。向溶液中加入8mL水。
2、制备0.01g至4g之间的壳聚糖溶液,优选将0.4g壳聚糖分散在20mL 1%乙酸中。
3、将步骤1获得的溶液与步骤2的溶液混合。温度保持在1℃至70℃之间,优选30℃。保持磷酸三钙和壳聚糖之间的质量比例在0.25和12.5之间,优选2.5。
4、维持获得的溶液在1.0和6.5的pH之间,优选在3.5的pH下。将溶液静置1至24小时,优选12小时。控制温度在-5℃至40℃之间,优选在4℃。
5、分散在阴离子食品级水解胶体溶液中,例如:阿拉伯胶、瓜尔豆胶、海藻酸钠或海藻酸钾、海藻酸丙二醇酯、豆胶、黄原胶、刺槐豆胶、酪蛋白或果胶。海藻酸盐和阿拉伯胶从0.01g到50g。优选20克阿拉伯胶或海藻酸盐或上述关系的两种聚合物的混合物或反之亦然,之前描述的0.25克至12克磷酸钙-壳聚糖复合物。
6、加入10g果聚糖和/或10g菊糖,优选5g果聚糖和5g菊糖,或更优选7.5g果聚糖和2.5g菊糖或2.5g果聚糖和7.5g菊糖。将得到的溶液调节成液体形式供应。溶液中的总固体浓度在每100mL溶液中30g至35g的范围内。为了减小体积,溶液在喷雾干燥器中干燥。
另外,为了更详细地提供本发明的其他方面,提供了以下非限制性实施例。
实施例1
三份磷酸三钙与10份磷酸混合。所得混合物与89份水混合。磷酸三钙借助混合器混合5分钟。将100份本实施例与80份实施例3中制备的溶液混合。加入足够量的强碱以将所得溶液的pH调节至3.5。制备的溶液在溶液中含有666.7mg钙。图1和图2所示的电磁波谱显示相对于所使用的阳离子聚合物的比例为1.5的钙稳定的证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例2
三份碳酸钙与12份磷酸混合。所得混合物与87份水混合。借助混合器将碳酸钙混合5分钟。将100份本实施例与80份实施例3制备的溶液混合。加入足够量的强碱以将所得溶液的pH调节至3.5。制备的溶液在溶液中含有666.7mg钙。图1和图2所示的电磁波谱显示相对于所使用的阳离子聚合物的比例为1.5的钙稳定的证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例3
3份壳聚糖在1份乙酸和99份水的98份溶液中混合。借助混合器将实施例1的溶液混合5分钟。根据实施例1:将16.5份得到的溶液与13份由该实施例获得的分散体混合。加入足够量的强碱将pH调节至3.5。所得溶液在溶液中含有671mg钙。图1和图2所示的电磁波谱显示相对于所使用的阳离子聚合物比例为1.5的钙稳定的证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例4
基于实施例1将33份与13份实施例3的溶液混合。借助混合器将实施例1的溶液混合15分钟。加入足够量的强碱将pH调节至3.5。溶液可以通过加热到60℃进行整合。将获得的溶液调节至25℃以下。所得溶液在溶液中含有860.8mg钙。图1和图3所示的电磁波谱显示与所用阳离子聚合物的比例为2.5的钙稳定性证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例5
根据实施例2将33份得到的溶液与13份实施例3中获得的溶液混合。将实施例2的溶液借助混合器混合15分钟。添加足够的强碱来调节pH值至3.5。溶液可以通过加热到60℃进行混合。将获得的溶液调节至25℃以下。所得溶液在溶液中含有860.8mg钙。图1和图3中显示的电磁波谱显示与所用阳离子聚合物的比值为2.5的钙稳定性证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例6
将66份实施例1中获得的溶液加入13份由实施例3获得的溶液中。将溶液加热至50℃。实施例一的溶液,借助混合器混合15分钟。用强碱将分散体的pH调节至3.5单位。将获得的溶液调节至25℃以下。所得溶液在溶液中含有1000mg的钙。图1和图4所示的电磁波谱显示了与所用阳离子聚合物的比例为5.0的钙稳定证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
实施例7
将66份实施例2中获得的溶液与13份实施例3获得的溶液混合。将溶液加热至50℃。借助混合器将实施例2的溶液整合15分钟。加入足够量的强碱将pH调节至3.5。将溶液调节至20℃。所得溶液在溶液中含有1000mg的钙。图1和图4所示的电磁波谱显示了与所用阳离子聚合物的比例为5.0的钙稳定证据。图2包含壳聚糖、阿拉伯胶、果聚糖和菊粉。
以下引用的实施例8至15解释了钙组合物和用于含有可溶性钙的基质的不同比例。
实施例8
a)将5份果聚糖与50份水混合。所得溶液在每100mL溶液中含有10%总表观固体。
b)将2.5份菊粉和2.5份果聚糖与50份水混合。该溶液在每100m溶液中含有10%总表观固体。
c)将1.25份菊粉和3.75份果聚糖与50份水混合。该溶液在每100m溶液中含有10%总表观固体。
d)将3.75份菊粉和1.25份果聚糖与50份水混合。该溶液在每100m溶液中含有10%总表观固体。
e)将5份菊粉与50份水混合。所得溶液在每100mL溶液中含有10%总表观固体。
实施例9
将20份阿拉伯胶分散在85份水中。调节分散体适用于任何实施例,本发明的产品。例如,将29.5份实施例1中得到的分散体与100份本实施例混合。加入50份实施例8的c)中获得的溶液。获得流体溶液。该溶液可以以通常的方式干燥以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体剂型施用。
实施例10
基于实施例1将29.5份与23.6份实施例3混合。加入100份实施例9的溶液。最后加入50份实施例8的a)或e)部分的溶液。该溶液含有3.4%磷酸三钙、2.6%阳离子聚合物、75.2%阴离子聚合物和18.8%果聚糖或菊粉。百分比以干物质为基础。在图2的电磁波谱和图5的电子显微照片(2,500X)中观察到钙稳定的证据,其中,钙稳定在壳聚糖、阿拉伯胶、果聚糖或菊粉的基质中,如实施例8的(a)或(e)中所述。
实施例11
基于实施例2的将29.5份与23.6份实施例3混合。加入100份来自实施例9的溶液。最后加入50份来自实施例8(b)的溶液。该溶液含有3.3%磷酸三钙、1.32%钙离子、2.7%阳离子聚合物、75.2%的阴离子聚合物和9.4%的果聚糖和9.4%的菊粉。百分比以干物质为基础。图2所示的电磁波谱和图5所示的电子显微照片(2500X),显示相对于所用阳离子聚合物以1.5的比例的钙稳定的证据。获得流体溶液。溶液可以以常规方式干燥,例如在喷雾干燥器中干燥,以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体形式施用。
实施例12
将46份基于实施例4的与100份实施例9混合。加入50份实施例8的d)。获得流体溶液。该溶液可以以通常的方式干燥以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体形式施用。本发明产品组合物的组成为3.75%磷酸三钙、1.5%可溶钙、1.4%阳离子聚合物、75.8%阴离子聚合物、14.2%菊粉和4.7%果聚糖。图3所示的电磁波谱和图6所示的电子显微照片(2500X),显示相对于所用阳离子聚合物的比例为2.5的可溶性钙证据。
实施例13
基于实施例5将46份与100份实施例9混合。加入50份实施例9的c)。获得流体溶液。该溶液可以以通常的方式干燥以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体形式施用。本发明产品组合物的组成为3.75%磷酸三钙、1.5%可溶钙、1.4%阳离子聚合物、75.8%阴离子聚合物、4.7%菊糖和14.2%果聚糖。图3中所示的电磁波谱和图6所示的电子显微照片(2500X)显示相对于所用阳离子聚合物以2.5的比例的钙稳定的证据。
实施例14
将79份基于实施例6与100份实施例9混合。加入50份实施例8的d)。获得流体溶液。该溶液可以以通常的方式干燥以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体形式施用。本发明产品组合物的组成为3.75%磷酸三钙、1.5%可溶钙、1.4%阳离子聚合物、75.8%阴离子聚合物、14.2%菊粉和4.7%果聚糖。图4所示的电磁波谱和图7所示的电子显微照片(2500X)显示了与所用阳离子聚合物的比例为5.0的钙稳定的证据。
实施例15
将79份基于实施例7与100份实施例9混合。加入50份实施例8的e)部分。获得流体溶液。该溶液可以以通常的方式干燥以产生细粉末。该产品含有钙和可溶性纤维。该产品可以以液体或固体形式施用。本发明产品组合物的组成为3.75%磷酸三钙、1.5%可溶钙、1.4%阳离子聚合物、75.8%阴离子聚合物、18.9%菊粉。图4所示的电磁波谱和图7所示的电子显微照片(2500X)显示了与所用阳离子聚合物的比例为5.0的钙稳定的证据。
Claims (13)
1.稳定的可溶性钙复合物,其特征在于,它包含:
a)以每克样品中0.05mg至15mg的量存在的钙源;
b)与钙源的质量比为0.25至12.5的阳离子聚合物;
c)阴离子水解胶体;和
d)可溶性纤维源。
2.根据权利要求1所述的稳定的可溶性钙复合物,其特征在于,所述钙源选自:磷酸三钙、碳酸钙、正磷酸钙、氯化钙、和氧化钙。
3.根据权利要求1-2中任一项所述的稳定的可溶性钙复合物,其特征在于,所述阳离子聚合物是:动物或植物来源的壳聚糖或蛋白质。
4.根据权利要求1至3中任一项所述的稳定的可溶性钙复合物,其特征在于,所述水解胶体选自:阿拉伯树胶、瓜尔豆胶、海藻酸钠、海藻酸钾、海藻酸丙二醇酯、豆胶、黄原胶、刺槐豆胶、酪蛋白、果胶和阿拉伯胶。
5.根据权利要求1-4中任一项所述的稳定的可溶性钙复合物,其特征在于,所述可溶性纤维源选自:果聚糖和/或菊粉。
6.根据权利要求1-5中任一项所述的稳定的可溶性钙复合物,其特征在于,所述复合物还包含其他可溶性矿物质,包括:磷、铁、镁、钾、铜、硒和碘。
7.如权利要求1-6中任一项所述的制备稳定的可溶性钙复合物的方法,其特征在于,它包括以下步骤:
a)制备含有0.05g至5g钙源、1mL磷酸和8mL水的第一溶液;
b)制备含有0.01g至4g阳离子聚合物和20mL1%冰醋酸的第二溶液;
c)通过将步骤a)和b)中获得的溶液合并来制备第三溶液,将第三溶液保持在1℃至70℃的温度之间,并且保持钙和阳离子聚合物源的质量比例在0.25和12.5之间;
d)维持c)的溶液的pH在1.0至6.5的pH之间,静置1到24小时,以及控制温度在-5℃到20℃;
e)将步骤d)的溶液分散在阴离子水解胶体中,其选自阿拉伯胶、瓜尔胶、海藻酸钠或海藻酸钾、海藻酸丙二醇酯、豆胶、黄原胶、刺槐豆胶、酪蛋白或果胶;
f)加入可溶性纤维源,选自龙舌兰果聚糖、菊粉或其混合物;
g)调节步骤f)的溶液以液体形式供应,通过在喷雾干燥器中雾化来减少溶液的体积至每100ml溶液30g至35g的总固体终浓度。
8.根据权利要求7所述的方法,其特征在于,所述钙源选自:磷酸三钙、碳酸钙、正磷酸钙、或氧化钙。
9.根据权利要求7-8中任一项所述的方法,其特征在于,所述阳离子聚合物是壳聚糖、动物或植物来源的钾。
10.根据权利要求7-9中任一项的方法,其特征在于,所述阴离子水解胶体优选选自海藻酸盐、阿拉伯胶或其混合物,其存在量为0.01g至50g,具有0.25g至12g的钙-壳聚糖复合物。
11.根据权利要求7-10中任一项所述的方法,其特征在于,所示可溶性纤维源的添加比例为:10g果聚糖、10g菊粉、5g果聚糖和5g菊粉、7.5g果聚糖和2.5g菊粉、或2.5g果聚糖和7.5g菊粉。
12.根据权利要求1-6中任一项所述的稳定的可溶性钙复合物的用途,用于制备液体或固体形式的食物补充剂以消耗,单独或与固体、半固体、液体、凝胶或饮料组合。
13.根据权利要求12所述的用途,用于制备液体或固体形式的食品,有效提供钙和可溶性纤维。
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US10709160B2 (en) | 2020-07-14 |
EP3363300A4 (en) | 2019-08-07 |
CA2985462A1 (en) | 2017-04-20 |
EP3363300A1 (en) | 2018-08-22 |
WO2017065596A1 (es) | 2017-04-20 |
JP6764933B2 (ja) | 2020-10-07 |
BR112018007160A2 (pt) | 2018-12-11 |
JP2018530339A (ja) | 2018-10-18 |
US20180116269A1 (en) | 2018-05-03 |
KR20180067542A (ko) | 2018-06-20 |
KR102431908B1 (ko) | 2022-08-11 |
HK1250565A1 (zh) | 2018-12-28 |
MX2015014522A (es) | 2017-04-14 |
CA2985462C (en) | 2021-10-19 |
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