CN108096120A - A kind of skin-protection type sterilizing hand cleanser and preparation method thereof - Google Patents
A kind of skin-protection type sterilizing hand cleanser and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of skin-protection type sterilizing hand cleanser and preparation method thereof, are related to hand cleanser technical field, and the raw material of hand cleanser includes：15 ~ 25 parts of thyme extract, 15 ~ 25 parts of Flos Nelumbinis extract, 6 ~ 10 parts of Cocoamidopropyl betaine, 4 ~ 6 parts of glycerine, 4 ~ 6 parts of moisturizing elite, 1 ~ 2 part of absolute ethyl alcohol, 0.8 ~ 1 part of chlorogenic acid, 0.3 ~ 0.7 part of trimethylglycine, 0.2 ~ 0.3 part of citric acid, 0.1 ~ 0.2 part of sodium citrate and excess water；Preparation method is included Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing.Antibacterial bacteriostatic of the present invention, performance is mild, and formula is safe and free of toxic and side effects, will not injure skin, also has certain preserving moisture and protecting skin effect to skin.
Description
Technical field
The present invention relates to hand cleanser technical fields, and in particular to a kind of skin-protection type sterilizing hand cleanser and its preparation side
Method.
Background technology
Existing hand cleanser is generally all sterilized using chemical substance, is antibacterial, using these hand cleanser except that can cause
It has dry skin outside coarse, long-time service can also damage human skin.
The content of the invention
The object of the present invention is to provide a kind of skin-protection type sterilizing hand cleanser and preparation method thereof, antibacterial bacteriostatic, performances
Mildly, formula is safe and free of toxic and side effects, will not injure skin, also has certain preserving moisture and protecting skin effect to skin.
The present invention provides following technical solutions：A kind of skin-protection type sterilizing hand cleanser includes the original of following part meter
Material：
15 ~ 25 parts of thyme extract；
15 ~ 25 parts of Flos Nelumbinis extract；
6 ~ 10 parts of Cocoamidopropyl betaine；
4 ~ 6 parts of glycerine；
4 ~ 6 parts of moisturizing elite；
1 ~ 2 part of absolute ethyl alcohol；
0.8 ~ 1 part of chlorogenic acid；
0.3 ~ 0.7 part of trimethylglycine；
0.2 ~ 0.3 part of citric acid；
0.1 ~ 0.2 part of sodium citrate；
Surplus is water.
Wherein, the preparation method of the thyme extract is：
（1）, collect thymic petal, petal is crushed, 60~70% ethanol solutions reflux for being put into 15 ~ 18 times of parts by weight carries
It takes 1~3 time, 1~3h, extracting solution is filtered and is merged every time, and recycling design is added in 40~50 DEG C of water and dissolved, slightly carried
Liquid；
（2）, to crude extract add in rare earth-iron-boron mixing, stir evenly, obtain mixed liquor；
（3）, mixed liquor is put into macroporous resin column, be first washed to colourless, then washed with volumetric concentration for 35~45% ethyl alcohol
It is de-, ethyl alcohol is recycled, it is dry, obtain thyme extract.
Wherein, the preparation method of the Flos Nelumbinis extract is：Lotus flower is cleaned, dry, is crushed, lotus flower powder is obtained, adopts
Lotus flower 2 ~ 5h of powder is impregnated under the conditions of 50 ~ 52 DEG C with 1,3-BDO and deionized water, filtering precipitation is extracted with alcohol reflux
2 ~ 3h is extracted 3 ~ 4 times, refrigerates 10 ~ 15h, filtering, filtrate is through being concentrated under reduced pressure into no ethyl alcohol to get the Flos Nelumbinis extract.
Wherein, the preparation method of the chlorogenic acid is：Honeysuckle is weighed, cleans, dry, crush, obtain Honeysuckle Flower,
Honeysuckle Flower is put into the deionized water of 7 ~ 8 times of volumes, extraction is stirred under the conditions of 65 ~ 75 DEG C, extraction is once filtered afterwards
Filtrate is collected, filter residue extracts again with 6~10 times of deionized waters again, and each extraction time is 1~2h, after merging filtrate again
Filtering using macroreticular resin absorbing method purifies and separates filtrate, obtains refined solution, spray-dried processing is to get the chlorogenic acid.
Wherein, the moisturizing elite includes the raw material of following part meter：0.5 ~ 0.7 part of Butyrospermum parkii fruit fat, passion fruit extraction
0.5 ~ 0.7 part of object, 0.2 ~ 0.3 part of menthone glycerol ketals, 0.1 ~ 0.2 part of tea polyphenols, Abies sibirica extract 0.04 ~
0.01 ~ 0.05 part of 0.07 part, 0.04 ~ 0.07 part of Radix Aucklandiae extract and resveratrol.
Wherein, the preparation method of the egg berry extract is：Passion fruit pulp is squeezed the juice, quality hundred is made in filtering plus water
Point than the egg fruit juice for 30 ~ 40%, according to for 100：1 ratio mixes egg fruit juice and papain, digests 3 ~ 4h
Enzymolysis liquid is obtained, egg juice solution, spray-dried obtained egg berry extract is obtained by filtration in enzymolysis liquid.
Wherein, the preparation method of the Abies sibirica extract is：The blade of Abies sibirica is cleaned, is cut
It is broken, aqueous citric acid solution is then added in, extracting through microwave heating is used 3 times after impregnating 3, filtering, filtrate is through being dried under reduced pressure to get institute
State Abies sibirica extract；The mass concentration of aqueous citric acid solution be 2 ~ 3g/ L, the blade of the Abies sibirica and
The weight ratio of aqueous citric acid solution is 1：10.
The present invention provides a kind of preparation method of skin-protection type sterilizing hand cleanser, includes the following steps：
（1）, by Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing, be heated to 58 ~ 62 DEG C, add
Glycerine stirs, and cooling obtains mixed liquor；
（2）, liquid temperature degree to be mixed is when being down to 20 ~ 28 DEG C, add thyme extract, Flos Nelumbinis extract, absolute ethyl alcohol and profit
Skin elite, stirs evenly, and temperature is risen to 50 DEG C, 1 ~ 2h is stirred with the speed conditions of 400 ~ 500r/min, then again by temperature
20 ~ 28 DEG C are down to, citric acid-sodium citrate buffer solution is configured to citric acid and sodium citrate, by the pH value of mixed liquor to tune
To 6.8 ~ 7.6, the skin-protection type sterilizing hand cleanser is obtained.
Wherein, the pH value of the citric acid-sodium citrate buffer solution is 6~7.6.
Beneficial effects of the present invention：Antibacterial bacteriostatic, performance is mild, and formula is safe and free of toxic and side effects, will not injure skin,
Also there is certain preserving moisture and protecting skin effect to skin, it is specific as follows：
（1）, the present invention add chlorogenic acid in the feed, chlorogenic acid is Honegsukle flower P.E, is the main antibacterial, disease-resistant of honeysuckle
Malicious effectively one of pharmaceutical component, is soluble in ethyl alcohol and acetone, and chlorogenic acid has wide antibacterial action；Chlorogenic acid is that one kind has
The phenolic antioxidant of effect, it contains a certain amount of R-OH bases, the hydroperoxyl radical with antioxidation can be formed, to eliminate hydroxyl
The activity of the free radicals such as base free radical and superoxide anion so as to which protective tissue is from the damage of oxidation, can protect skin
Skin tissue；
（2）, the present invention add trimethylglycine in the feed, play the role of foaming thickening；
（3）, the present invention moisturizing elite form protective film in hand, preserving moisture and protecting skin is non-stimulated to skin also with fungicidal effectiveness
Property, it has no toxic side effect；
（4）, the present invention add moisturizing elite in the feed, compared to the drying generated after hand cleanser use in the prior art, dry
The symptoms such as itch, moisturizing elite has protection skin, prevents the effect of skin water loss and nourishes rough skin, wherein adding butter
Fruit tree fruit fat is a kind of super moisturiser and emollient, obtains and the process of processing does not use any chemical substance.Only
Simply butter fruit is smashed, and boils extraction fat in water, when applied to the skin, can melt and readily penetrate through rapidly
Skin, in addition, Butyrospermum parkii fruit fat includes a large amount of vitamin As（Rosemary Extract）And vitamin E（Age resister）；
（5）, the present invention Radix Aucklandiae extract and Abies sibirica extract are added in moisturizing elite, antibacterial can be promoted to disappear
Inflammation can inhibit streptococcic growth, also have certain inhibitory action to Escherichia coli and corynebacterium diphtheriae；
（6）, the present invention add thyme extract and Flos Nelumbinis extract in the feed, smell is pure and fresh, to be light fragrant and sweet, contains
Multiple biological activities ingredient, effective anti-inflammatory sterilization improve skin, while product main component of the present invention is natural products, is had
Have Small side effects, safety, it is environmentally friendly the advantages that, have positive facilitation to health；
（7）, the present invention pH value between 6.8 ~ 7.6, non-stimulated to skin, the foam of generation is few and tiny, will not form down
Water channel blocks.
Specific embodiment
With reference to specific embodiment, the present invention is further explained.These embodiments are merely to illustrate the present invention and do not have to
In limiting the scope of the invention.
Embodiment 1
A kind of skin-protection type sterilizing hand cleanser includes the raw material of following part meter：
15 parts of thyme extract；
15 parts of Flos Nelumbinis extract；
6 parts of Cocoamidopropyl betaine；
4 parts of glycerine；
4 parts of moisturizing elite；
1 part of absolute ethyl alcohol；
0.8 part of chlorogenic acid；
0.3 part of trimethylglycine；
0.2 part of citric acid；
0.1 part of sodium citrate；
Surplus is water.
Wherein, the preparation method of the thyme extract is：
（1）, collect thymic petal, petal is crushed, is put into the 60% ethanol solution refluxing extraction 1 time of 15 times of parts by weight,
Each 1h, extracting solution is filtered and is merged, and recycling design adds in 40 DEG C of water and dissolves, obtains crude extract；
（2）, to crude extract add in rare earth-iron-boron mixing, stir evenly, obtain mixed liquor；
（3）, mixed liquor is put into macroporous resin column, be first washed to it is colourless, then with volumetric concentration be 35% ethanol elution, return
Ethyl alcohol is received, it is dry, obtain thyme extract.
Wherein,
The preparation method of the Flos Nelumbinis extract is：Lotus flower is cleaned, dry, is crushed, obtains lotus flower powder, using 1,3- fourths two
Alcohol and deionized water impregnate lotus flower powder 2h under the conditions of 50 DEG C, and filtering precipitation is extracted 2h with alcohol reflux, extracted 3 times, refrigeration
10h, filtering, filtrate is through being concentrated under reduced pressure into no ethyl alcohol to get the Flos Nelumbinis extract.
Wherein,
The preparation method of the chlorogenic acid is：Honeysuckle is weighed, cleans, dry, crush, Honeysuckle Flower is obtained, by honeysuckle
Powder is put into the deionized water of 7 ~ times volume, and extraction is stirred under the conditions of 65 DEG C, and filtrate, filter residue is once collected by filtration in extraction afterwards
It is extracted again with 6 times of deionized waters again, each extraction time is 1h, filters after merging filtrate, is inhaled using macroreticular resin again
Attached method purifies and separates filtrate obtains refined solution, and spray-dried processing is to get the chlorogenic acid.
Wherein,
The moisturizing elite includes the raw material of following part meter：0.5 part of Butyrospermum parkii fruit fat, 0.5 part of egg berry extract, menthones
0.2 part of glycerol ketals, 0.1 part of tea polyphenols, 0.04 part of Abies sibirica extract, 0.04 part of Radix Aucklandiae extract and resveratrol
0.01 part.
Wherein,
The preparation method of the egg berry extract is：Passion fruit pulp is squeezed the juice, filtering plus water are made mass percent and are
30% egg fruit juice, according to for 100：1 ratio mixes egg fruit juice and papain, and enzymolysis 3h obtains enzymolysis liquid,
Egg juice solution, spray-dried obtained egg berry extract is obtained by filtration in enzymolysis liquid.
Wherein, the preparation method of the Abies sibirica extract is：The blade of Abies sibirica is cleaned, is cut
It is broken, aqueous citric acid solution is then added in, extracting through microwave heating is used 3 times after impregnating 3, filtering, filtrate is through being dried under reduced pressure to get institute
State Abies sibirica extract；The mass concentration of aqueous citric acid solution be 2g/ L, the blade and lemon of the Abies sibirica
The weight ratio of lemon aqueous acid is 1：10.
A kind of preparation method of skin-protection type sterilizing hand cleanser in the present embodiment is provided, is included the following steps：
（1）, by Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing, be heated to 58 DEG C, add sweet
Oil stirs, and cooling obtains mixed liquor；
（2）, liquid temperature degree to be mixed is when being down to 20 DEG C, add thyme extract, Flos Nelumbinis extract, absolute ethyl alcohol and moisturizing essence
China stirs evenly, and temperature is risen to 50 DEG C, stirs 1h with the speed conditions of 400r/min, then cools the temperature to 20 DEG C again, uses
Citric acid and sodium citrate are configured to citric acid-sodium citrate buffer solution, by the pH value of mixed liquor to being adjusted to 6.8, obtain described
Skin-protection type sterilizing hand cleanser.
Wherein, the pH value of the citric acid-sodium citrate buffer solution is 6.
Embodiment 2
A kind of skin-protection type sterilizing hand cleanser includes the raw material of following part meter：
25 parts of thyme extract；
25 parts of Flos Nelumbinis extract；
10 parts of Cocoamidopropyl betaine；
6 parts of glycerine；
6 parts of moisturizing elite；
2 parts of absolute ethyl alcohol；
1 part of chlorogenic acid；
0.7 part of trimethylglycine；
0.3 part of citric acid；
0.2 part of sodium citrate；
Surplus is water.
Wherein, the preparation method of the thyme extract is：
（1）, collect thymic petal, petal is crushed, is put into the 70% ethanol solution refluxing extraction 3 times of 18 times of parts by weight,
Each 3h, extracting solution is filtered and is merged, and recycling design adds in 50 DEG C of water and dissolves, obtains crude extract；
（2）, to crude extract add in rare earth-iron-boron mixing, stir evenly, obtain mixed liquor；
（3）, mixed liquor is put into macroporous resin column, be first washed to it is colourless, then with volumetric concentration be 45% ethanol elution, return
Ethyl alcohol is received, it is dry, obtain thyme extract.
Wherein,
The preparation method of the Flos Nelumbinis extract is：Lotus flower is cleaned, dry, is crushed, obtains lotus flower powder, using 1,3- fourths two
Alcohol and deionized water impregnate lotus flower powder 5h under the conditions of 52 DEG C, and filtering precipitation is extracted 3h with alcohol reflux, extracted 4 times, refrigeration
15h, filtering, filtrate is through being concentrated under reduced pressure into no ethyl alcohol to get the Flos Nelumbinis extract.
The preparation method of the chlorogenic acid is：Honeysuckle is weighed, cleans, dry, crush, Honeysuckle Flower is obtained, by gold
Honeysuckle flower powder is put into the deionized water of 8 times of volumes, and extraction is stirred under the conditions of 75 DEG C, and filtrate is once collected by filtration in extraction afterwards,
Filter residue is extracted again with 10 times of deionized waters again, and each extraction time is 2h, is filtered again after merging filtrate, uses macropore tree
Fat purification via adsorption-based process separating filtrate obtains refined solution, and spray-dried processing is to get the chlorogenic acid.
Wherein,
The moisturizing elite includes the raw material of following part meter：0.7 part of Butyrospermum parkii fruit fat, 0.7 part of egg berry extract, menthones
0.3 part of glycerol ketals, 0.2 part of tea polyphenols, 0.07 part of Abies sibirica extract, 0.07 part of Radix Aucklandiae extract and resveratrol
0.05 part.
Wherein,
The preparation method of the egg berry extract is：Passion fruit pulp is squeezed the juice, filtering plus water are made mass percent and are
40% egg fruit juice, according to for 100：1 ratio mixes egg fruit juice and papain, and enzymolysis 4h obtains enzymolysis liquid,
Egg juice solution, spray-dried obtained egg berry extract is obtained by filtration in enzymolysis liquid.
The preparation method of the Abies sibirica extract is：The blade of Abies sibirica is cleaned, is shredded, then
Aqueous citric acid solution is added in, extracting through microwave heating is used 3 times after impregnating 3, filtering, filtrate is through being dried under reduced pressure to get described western primary
Leah fir extract；The mass concentration of aqueous citric acid solution be 3g/ L, the blade and citric acid water of the Abies sibirica
The weight ratio of solution is 1：10.
A kind of preparation method of skin-protection type sterilizing hand cleanser in the present embodiment is provided, is included the following steps：
（1）, by Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing, be heated to 62 DEG C, add sweet
Oil stirs, and cooling obtains mixed liquor；
（2）, liquid temperature degree to be mixed is when being down to 28 DEG C, add thyme extract, Flos Nelumbinis extract, absolute ethyl alcohol and moisturizing essence
China stirs evenly, and temperature is risen to 50 DEG C, stirs 2h with the speed conditions of 500r/min, then cools the temperature to 28 DEG C again, uses
Citric acid and sodium citrate are configured to citric acid-sodium citrate buffer solution, by the pH value of mixed liquor to being adjusted to 7.6, obtain described
Skin-protection type sterilizing hand cleanser.
Wherein, the pH value of the citric acid-sodium citrate buffer solution is 7.6.
Embodiment 3
A kind of skin-protection type sterilizing hand cleanser includes the raw material of following part meter：
20 parts of thyme extract；
20 parts of Flos Nelumbinis extract；
8 parts of Cocoamidopropyl betaine；
5 parts of glycerine；
5 parts of moisturizing elite；
1.5 parts of absolute ethyl alcohol；
0.9 part of chlorogenic acid；
0.5 part of trimethylglycine；
0.25 part of citric acid；
0.15 part of sodium citrate；
Surplus is water.
Wherein,
The preparation method of the thyme extract is：
（1）, collect thymic petal, petal is crushed, is put into the 65% ethanol solution refluxing extraction 2 times of 6 times of parts by weight, often
Secondary 2h, extracting solution is filtered and is merged, and recycling design adds in 45 DEG C of water and dissolves, obtains crude extract；
（2）, to crude extract add in rare earth-iron-boron mixing, stir evenly, obtain mixed liquor；
（3）, mixed liquor is put into macroporous resin column, be first washed to it is colourless, then with volumetric concentration be 40% ethanol elution, return
Ethyl alcohol is received, it is dry, obtain thyme extract.
Wherein,
The preparation method of the Flos Nelumbinis extract is：Lotus flower is cleaned, dry, is crushed, obtains lotus flower powder, using 1,3- fourths two
Alcohol and deionized water impregnate lotus flower powder 4h under the conditions of 51 DEG C, and filtering precipitation is extracted 2.5h with alcohol reflux, extracted 3 times, cold
12h is hidden, filtering, filtrate is through being concentrated under reduced pressure into no ethyl alcohol to get the Flos Nelumbinis extract.
The preparation method of the chlorogenic acid is：Honeysuckle is weighed, cleans, dry, crush, Honeysuckle Flower is obtained, by gold
Honeysuckle flower powder is put into the deionized water of 7 times of volumes, and extraction is stirred under the conditions of 70 DEG C, and filtrate is once collected by filtration in extraction afterwards,
Filter residue is extracted again with 8 times of deionized waters again, and each extraction time is 1.5h, is filtered again after merging filtrate, uses macropore
Resin adsorption method purifies and separates filtrate obtains refined solution, and spray-dried processing is to get the chlorogenic acid.
Wherein,
The moisturizing elite includes the raw material of following part meter：0.6 part of Butyrospermum parkii fruit fat, 0.6 part of egg berry extract, menthones
0.25 part of glycerol ketals, 0.15 part of tea polyphenols, 0.05 part of Abies sibirica extract, 0.05 part of Radix Aucklandiae extract and white black false hellebore
0.03 part of alcohol.
The preparation method of the egg berry extract is：Passion fruit pulp is squeezed the juice, mass percent is made in filtering plus water
For 35% egg fruit juice, according to for 100：1 ratio mixes egg fruit juice and papain, and enzymolysis 3.5h is digested
Egg juice solution, spray-dried obtained egg berry extract is obtained by filtration in enzymolysis liquid by liquid.
Wherein,
The preparation method of the Abies sibirica extract is：The blade of Abies sibirica is cleaned, is shredded, is then added in
Aqueous citric acid solution uses extracting through microwave heating 3 times after impregnating 3, and filtering, filtrate is through being dried under reduced pressure to get the Siberia
Fir extract；The mass concentration of aqueous citric acid solution is 2.5g/ L, and the blade and citric acid of the Abies sibirica are water-soluble
The weight ratio of liquid is 1：10.
A kind of preparation method of skin-protection type sterilizing hand cleanser in the present embodiment is provided, is included the following steps：
（1）, by Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing, be heated to 60 DEG C, add sweet
Oil stirs, and cooling obtains mixed liquor；
（2）, liquid temperature degree to be mixed is when being down to 24 DEG C, add thyme extract, Flos Nelumbinis extract, absolute ethyl alcohol and moisturizing essence
China stirs evenly, and temperature is risen to 50 DEG C, stirs 1.5h with the speed conditions of 450r/min, then cools the temperature to 24 DEG C again,
Citric acid-sodium citrate buffer solution is configured to citric acid and sodium citrate, by the pH value of mixed liquor to being adjusted to 7, is obtained described
Skin-protection type sterilizing hand cleanser.
Wherein, the pH value of the citric acid-sodium citrate buffer solution is 6.8.
The present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, according to
So it can modify to the technical solution recorded in foregoing embodiments or which part technical characteristic is equally replaced
It changes.Within the spirit and principles of the invention, any modifications, equivalent replacements and improvements are made should be included in the present invention
Protection domain within.
Claims (10)
1. a kind of skin-protection type sterilizing hand cleanser, which is characterized in that include the raw material of following part meter：
15 ~ 25 parts of thyme extract；
15 ~ 25 parts of Flos Nelumbinis extract；
6 ~ 10 parts of Cocoamidopropyl betaine；
4 ~ 6 parts of glycerine；
4 ~ 6 parts of moisturizing elite；
1 ~ 2 part of absolute ethyl alcohol；
0.8 ~ 1 part of chlorogenic acid；
0.3 ~ 0.7 part of trimethylglycine；
0.2 ~ 0.3 part of citric acid；
0.1 ~ 0.2 part of sodium citrate；
Surplus is water.
2. skin-protection type sterilizing hand cleanser according to claim 1, which is characterized in that include the raw material of following part meter：
20 parts of thyme extract；
20 parts of Flos Nelumbinis extract；
8 parts of Cocoamidopropyl betaine；
5 parts of glycerine；
5 parts of moisturizing elite；
1.5 parts of absolute ethyl alcohol；
0.9 part of chlorogenic acid；
0.5 part of trimethylglycine；
0.25 part of citric acid；
0.15 part of sodium citrate；
Surplus is water.
3. skin-protection type sterilizing hand cleanser according to claim 1, which is characterized in that the system of the thyme extract
Preparation Method is：
（1）, collect thymic petal, petal is crushed, 60~70% ethanol solutions reflux for being put into 15 ~ 18 times of parts by weight carries
It takes 1~3 time, 1~3h, extracting solution is filtered and is merged every time, and recycling design is added in 40~50 DEG C of water and dissolved, slightly carried
Liquid；
（2）, to crude extract add in rare earth-iron-boron mixing, stir evenly, obtain mixed liquor；
（3）, mixed liquor is put into macroporous resin column, be first washed to colourless, then washed with volumetric concentration for 35~45% ethyl alcohol
It is de-, ethyl alcohol is recycled, it is dry, obtain thyme extract.
4. skin-protection type sterilizing hand cleanser according to claim 1, which is characterized in that the preparation of the Flos Nelumbinis extract
Method is：Lotus flower is cleaned, dry, is crushed, obtains lotus flower powder, using 1,3-BDO and deionized water in 50 ~ 52 DEG C of items
Lotus flower 2 ~ 5h of powder is impregnated under part, filtering precipitation is extracted 2 ~ 3h with alcohol reflux, extracted 3 ~ 4 times, refrigerate 10 ~ 15h, filters, filter
Liquid is through being concentrated under reduced pressure into no ethyl alcohol to get the Flos Nelumbinis extract.
5. skin-protection type sterilizing hand cleanser according to claim 1, which is characterized in that the preparation method of the chlorogenic acid
For：Honeysuckle is weighed, cleans, dry, crush, obtain Honeysuckle Flower, Honeysuckle Flower is put into the deionization of 7 ~ 8 times of volumes
In water, extraction is stirred under the conditions of 65 ~ 75 DEG C, filtrate is once collected by filtration in extraction afterwards, and filter residue is again with 6~10 times of deionized waters
It extracts again, each extraction time is 1~2h, filters after merging filtrate, is filtered using macroreticular resin absorbing method purifies and separates again
Liquid obtains refined solution, and spray-dried processing is to get the chlorogenic acid.
6. skin-protection type sterilizing hand cleanser according to claim 1, which is characterized in that the moisturizing elite includes following
The raw material of part meter：0.5 ~ 0.7 part of Butyrospermum parkii fruit fat, 0.5 ~ 0.7 part of egg berry extract, menthone glycerol ketals 0.2 ~ 0.3
Part, 0.1 ~ 0.2 part of tea polyphenols, 0.04 ~ 0.07 part of Abies sibirica extract, 0.04 ~ 0.07 part of Radix Aucklandiae extract and white lamb's-quarters
0.01 ~ 0.05 part of reed alcohol.
7. skin-protection type sterilizing hand cleanser according to claim 6, which is characterized in that the system of the egg berry extract
Preparation Method is：Passion fruit pulp is squeezed the juice, filtering plus water be made mass percent be 30 ~ 40% egg fruit juice, according to for
100：1 ratio mixes egg fruit juice and papain, and 3 ~ 4h of enzymolysis obtains enzymolysis liquid, and enzymolysis liquid is obtained by filtration egg
Juice solution, spray-dried obtained egg berry extract.
8. skin-protection type sterilizing hand cleanser according to claim 6, which is characterized in that the Abies sibirica extraction
The preparation method of object is：The blade of Abies sibirica is cleaned, is shredded, then adds in aqueous citric acid solution, is used after impregnating 3
Extracting through microwave heating 3 times, filtering, filtrate is through being dried under reduced pressure to get the Abies sibirica extract；Aqueous citric acid solution
Mass concentration is 2 ~ 3g/ L, and the blade of the Abies sibirica and the weight ratio of aqueous citric acid solution are 1：10.
9. a kind of preparation method according to claim 1 ~ 8 any one of them skin-protection type sterilizing hand cleanser, feature exists
In including the following steps：
（1）, by Cocoamidopropyl betaine, trimethylglycine, chlorogenic acid and water mixing, be heated to 58 ~ 62 DEG C, add
Glycerine stirs, and cooling obtains mixed liquor；
（2）, liquid temperature degree to be mixed is when being down to 20 ~ 28 DEG C, add thyme extract, Flos Nelumbinis extract, absolute ethyl alcohol and profit
Skin elite, stirs evenly, and temperature is risen to 50 DEG C, 1 ~ 2h is stirred with the speed conditions of 400 ~ 500r/min, then again by temperature
20 ~ 28 DEG C are down to, citric acid-sodium citrate buffer solution is configured to citric acid and sodium citrate, by the pH value of mixed liquor to tune
To 6.8 ~ 7.6, the skin-protection type sterilizing hand cleanser is obtained.
10. the preparation method of skin-protection type sterilizing hand cleanser according to claim 9, which is characterized in that the lemon
The pH value of acid-sodium citrate buffer solution is 6~7.6.
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| CN114209635A (en) * | 2021-11-26 | 2022-03-22 | 宁波大学 | Tea polyphenol hand sanitizer and preparation method thereof |
| CN114452226A (en) * | 2022-03-19 | 2022-05-10 | 陇东学院 | Preparation method of traditional Chinese medicine compound thyme washing-free disinfection gel |
| CN118059014A (en) * | 2024-04-19 | 2024-05-24 | 广州汇芬生物科技有限公司 | Antibacterial agent for pet skin and preparation method thereof |
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Application publication date: 20180601 |