CN114452226A - Preparation method of traditional Chinese medicine compound thyme washing-free disinfection gel - Google Patents
Preparation method of traditional Chinese medicine compound thyme washing-free disinfection gel Download PDFInfo
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- 241000246358 Thymus Species 0.000 title claims abstract description 69
- 235000007303 Thymus vulgaris Nutrition 0.000 title claims abstract description 69
- 239000001585 thymus vulgaris Substances 0.000 title claims abstract description 69
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 48
- 239000003814 drug Substances 0.000 title claims abstract description 30
- 150000001875 compounds Chemical class 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000243 solution Substances 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 238000002156 mixing Methods 0.000 claims abstract description 30
- 238000006243 chemical reaction Methods 0.000 claims abstract description 27
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 22
- 244000252337 Epipremnum pinnatum Species 0.000 claims abstract description 20
- 229940069521 aloe extract Drugs 0.000 claims abstract description 20
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002131 composite material Substances 0.000 claims abstract description 18
- 239000000661 sodium alginate Substances 0.000 claims abstract description 18
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 18
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 18
- 229920001661 Chitosan Polymers 0.000 claims abstract description 17
- 239000007864 aqueous solution Substances 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 238000001914 filtration Methods 0.000 claims description 22
- 241001116389 Aloe Species 0.000 claims description 16
- 235000011399 aloe vera Nutrition 0.000 claims description 16
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 11
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 11
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 11
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 238000002386 leaching Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 28
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 8
- 238000000227 grinding Methods 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 5
- 230000000249 desinfective effect Effects 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention provides a preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel, which comprises the following steps: s1, dissolving the emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and mixing uniformly to obtain a solution A; s2, uniformly mixing the solution A with 0.1-0.3% sodium alginate aqueous solution, adjusting the pH value to 3-5, then adding 0.1-0.3% chitosan aqueous solution, carrying out ultrasonic reaction at 20-30 ℃, then adding aloe extract, carrying out ultrasonic reaction at 20-30 ℃, after the reaction is finished, adjusting the pH value to 6-7, and standing at 0-5 ℃ for 12-24 hours to obtain the traditional Chinese medicine composite thyme hand-washing-free disinfection gel. Through the mutual matching of the thyme extract, the scindapsus aureus extract and the aloe extract, the hand skin can be well moisturized while the sterilization and disinfection effects are good, and the skin anaphylactic reaction is avoided.
Description
Technical Field
The invention relates to the technical field of preparation of disinfection gel, in particular to a preparation method of traditional Chinese medicine composite thyme hand-washing-free disinfection gel.
Background
Hand disinfection products on the market are various, and comprise water-based disinfectant, disinfection gel and the like. At present, the hand can be disinfected by the common hand-washing-free disinfection gel through a rubbing surgical hand washing method, so that the waste of water resources is saved, the hand disinfection time can be saved, and the common hand-washing-free disinfection gel has a good disinfection effect.
However, most of the conventional no-wash hand disinfection gels adopt irritant chemical components, which not only easily cause skin allergic irritation reaction, but also easily cause hand skin damage, such as skin chapping and peeling. Therefore, there is a need to provide a safer plant-derived hand-washing disinfecting gel, which has a good disinfecting effect while protecting the hand skin.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide a preparation method of a traditional Chinese medicine compound thyme hand-washing-free disinfection gel.
In order to achieve the above object, the technical solution of the present invention is as follows.
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, dissolving an emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s2, uniformly mixing the solution A with 0.1-0.3% sodium alginate aqueous solution, adjusting the pH value to 3-5, then adding 0.1-0.3% chitosan aqueous solution, carrying out ultrasonic reaction at 20-30 ℃, then adding aloe extract, carrying out ultrasonic reaction at 20-30 ℃, after the reaction is finished, adjusting the pH value to 6-7, and standing at 0-5 ℃ for 12-24 hours to obtain the traditional Chinese medicine composite thyme hand-washing-free disinfection gel.
Further, in S1, the emulsifier is any one or a mixture of several of Span80, Tween80, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, and methyl cellulose.
Further, in S1, the emulsifier is Span80, Tween80 and hydroxyethyl cellulose in a mass ratio of 1-2: 8: 0.1 to 0.5.
Further, in S1, the mass ratio of the emulsifier to the thyme extract to the scindapsus aureus extract is 1: 1-3: 1 to 3.
Further, in S1, the preparation process of the thyme extract is as follows:
after smashing thyme, adding an ethanol solution with the mass being 8-10 times of that of the thyme, leaching for 12-24 hours under the stirring condition, filtering, and concentrating to obtain a thyme extract.
Further, in S1, the scindapsus aureus extract is prepared as follows:
crushing the scindapsus aureus, adding an ethanol solution with the mass of 4-8 times of that of the scindapsus aureus, performing reflux extraction, filtering, and concentrating to obtain the scindapsus aureus extract.
Further, in S2, the mass ratio of sodium alginate to chitosan is 1: 1.
further, in S2, the aloe extract is prepared as follows:
peeling aloe, soaking in water for 5-15 min, adding water into the cleaned aloe, crushing, and filtering to obtain an aloe extract; wherein the mass ratio of the cleaned aloe to the water is 1: 0.2 to 0.5.
The invention has the beneficial effects that:
1. according to the invention, the thyme extract, the scindapsus aureus extract and the aloe extract are matched with each other, so that the hand skin moisturizing cream has good sterilization and disinfection effects, and can also have a good moisturizing effect on hand skin, and avoids skin allergic reaction.
2. The invention has good stabilizing effect by matching the emulsifier with the aloe extract.
3. According to the invention, the sodium alginate is matched with the chitosan to form an oil-in-water microsphere gel system, and the hydroxyethyl cellulose has a stabilizing effect on the microsphere shell structure.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 10 times of that of the ground thyme, leaching for 24 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, crushing the whole green bonnie plant, adding 95% ethanol solution with the mass being 4 times that of the green bonnie plant for reflux extraction, filtering, concentrating to be dry, and dissolving with water to obtain the green bonnie extract.
S3, peeling the aloe, soaking in water for 10min, and taking the cleaned aloe according to the mass ratio of 1: 0.3 adding water, pulverizing with pulverizer, and filtering to obtain Aloe extract.
S4, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 1.5: 8: 0.5, mixing to obtain a composite emulsifier; dissolving the composite emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s5, uniformly mixing the solution A with 0.1 wt% of sodium alginate aqueous solution, adjusting the pH to 4 by using acetic acid, then adding 0.1 wt% of chitosan aqueous solution, carrying out ultrasonic reaction at 30 ℃ for 30min, then adding an aloe extract, carrying out ultrasonic reaction at 20 ℃ for 30min, after the reaction is finished, adjusting the pH to 6.0, and standing at 4 ℃ for 24h to obtain the traditional Chinese medicine compound thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
example 2
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 8 times that of the ground thyme, leaching for 24 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, crushing the whole green bonnie plant, adding a 95% ethanol solution with the mass 5 times that of the green bonnie plant for reflux extraction, filtering, concentrating to be dry, and dissolving with water to obtain the green bonnie extract.
S3, peeling the aloe, soaking in water for 15min, and taking the cleaned aloe according to the mass ratio of 1: 0.5 adding water, pulverizing with pulverizer, and filtering to obtain Aloe extract.
S4, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 1: 8: 0.5, mixing to obtain a composite emulsifier; dissolving the composite emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s5, uniformly mixing the solution A with 0.2 wt% of sodium alginate aqueous solution, adjusting the pH to 5 by using acetic acid, then adding 0.2 wt% of chitosan aqueous solution, carrying out ultrasonic reaction at 20 ℃ for 30min, then adding an aloe extract, carrying out ultrasonic reaction at 20 ℃ for 30min, after the reaction is finished, adjusting the pH to 6.5, and standing at 5 ℃ for 24h to obtain the traditional Chinese medicine compound thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
example 3
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 10 times of that of the ground thyme, leaching for 12 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, crushing the whole green bonnie plant, adding 95% ethanol solution with the mass being 8 times that of the green bonnie plant for reflux extraction, filtering, concentrating to be dry, and dissolving with water to obtain the green bonnie extract.
S3, peeling the aloe, soaking in water for 5min, and taking the cleaned aloe according to the mass ratio of 1: 0.2 adding water, pulverizing with pulverizer, and filtering to obtain Aloe extract.
S4, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 2: 8: 0.1, mixing to obtain a composite emulsifier; dissolving the composite emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s5, uniformly mixing the solution A with 0.3 wt% of sodium alginate aqueous solution, adjusting the pH to 5 by using acetic acid, then adding 0.3 wt% of chitosan aqueous solution, carrying out ultrasonic reaction at 30 ℃ for 30min, then adding an aloe extract, carrying out ultrasonic reaction at 30 ℃ for 30min, after the reaction is finished, adjusting the pH to 7.0, and standing at 2 ℃ for 12h to obtain the traditional Chinese medicine compound thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
comparative example 1
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 10 times of that of the ground thyme, leaching for 24 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, peeling the aloe, soaking in water for 10min, and taking the cleaned aloe according to the mass ratio of 1: 0.3 adding water, pulverizing with pulverizer, and filtering to obtain Aloe extract.
S3, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 1.5: 8: 0.5, mixing to obtain a composite emulsifier; dissolving a composite emulsifier in water, adding a thyme extract, and uniformly mixing to obtain a solution A;
s4, uniformly mixing the solution A with 0.1 wt% of sodium alginate aqueous solution, adjusting the pH to 4 by using acetic acid, then adding 0.1 wt% of chitosan aqueous solution, carrying out ultrasonic reaction at 30 ℃ for 30min, then adding an aloe extract, carrying out ultrasonic reaction at 20 ℃ for 30min, after the reaction is finished, adjusting the pH to 6.0, and standing at 4 ℃ for 24h to obtain the traditional Chinese medicine compound thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
comparative example 2
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 10 times of that of the ground thyme, leaching for 24 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, crushing the whole green bonnie plant, adding 95% ethanol solution with the mass being 4 times that of the green bonnie plant for reflux extraction, filtering, concentrating to be dry, and dissolving with water to obtain the green bonnie extract.
S3, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 1.5: 8: 0.5, mixing to obtain a composite emulsifier; dissolving the composite emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s4, uniformly mixing the solution A with 0.1 wt% of sodium alginate aqueous solution, adjusting the pH to 4 by using acetic acid, then adding 0.1 wt% of chitosan aqueous solution, carrying out ultrasonic reaction at 30 ℃ for 30min, after the reaction is finished, adjusting the pH to 6.0, and standing at 4 ℃ for 24h to obtain the traditional Chinese medicine compound thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
comparative example 3
A preparation method of traditional Chinese medicine compound thyme hand-washing-free disinfection gel comprises the following steps:
s1, grinding thyme, adding 90% ethanol solution with the mass being 10 times of that of the ground thyme, leaching for 24 hours under the condition of stirring, filtering, and concentrating to 1/2 of the original volume to obtain the thyme extract.
S2, crushing the whole green bonnie plant, adding 95% ethanol solution with the mass being 4 times that of the green bonnie plant for reflux extraction, filtering, concentrating to be dry, and dissolving with water to obtain the green bonnie extract.
S3, peeling the aloe, soaking in water for 10min, and taking the cleaned aloe according to the mass ratio of 1: 0.3 adding water, pulverizing with pulverizer, and filtering to obtain Aloe extract.
S4, mixing Span80, Tween80 and hydroxyethyl cellulose according to the mass ratio of 1.5: 8: 0.5, mixing to obtain a composite emulsifier; dissolving the composite emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s5, uniformly mixing the solution A with 0.1 wt% of sodium alginate aqueous solution, adjusting the pH value to 4 by using acetic acid, carrying out ultrasonic reaction at 30 ℃ for 30min, adding an aloe extract, carrying out ultrasonic reaction at 20 ℃ for 30min, after the reaction is finished, adjusting the pH value to 6.0, and standing at 4 ℃ for 24h to obtain the traditional Chinese medicine composite thyme hand-washing-free disinfection gel; wherein the mass ratio of sodium alginate to chitosan is 1: 1.
the effect of the traditional Chinese medicine compound thyme hand-free disinfection gel in the embodiments 1-3 of the invention is basically the same, so that the following sterilization test comparison is carried out only by using the hand-free disinfection gel obtained in the embodiment 1 and the comparative examples 1-3.
The no-clean hand disinfection gel obtained in example 1 and comparative examples 1 to 3 was subjected to a bacterial sterilization test, wherein the sterilization effect was the sterilization rate after 25 seconds of sterilization, and the results are shown in table 1.
TABLE 1 Sterilization test results
| Example 1 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Staphylococcus aureus | 99.6％ | 87.1％ | 90.4％ | 90.1％ |
| Escherichia coli | 96.7％ | 34.2％ | 80.2％ | 86.2％ |
| Bacillus subtilis | 96.5％ | 50.4％ | 78.9％ | 85.4％ |
From the above results, it can be seen that the no-wash hand sanitizer gel of the present invention has a very good bactericidal effect.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A preparation method of a traditional Chinese medicine compound thyme hand-washing-free disinfection gel is characterized by comprising the following steps:
s1, dissolving an emulsifier in water, adding the thyme extract and the scindapsus aureus extract, and uniformly mixing to obtain a solution A;
s2, uniformly mixing the solution A with 0.1-0.3% sodium alginate aqueous solution, adjusting the pH value to 3-5, then adding 0.1-0.3% chitosan aqueous solution, carrying out ultrasonic reaction at 20-30 ℃, then adding aloe extract, carrying out ultrasonic reaction at 20-30 ℃, after the reaction is finished, adjusting the pH value to 6-7, and standing at 0-5 ℃ for 12-24 hours to obtain the traditional Chinese medicine composite thyme hand-washing-free disinfection gel.
2. The method for preparing the traditional Chinese medicine composite thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S1, the emulsifier is any one or a mixture of several of Span80, Tween80, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose and methyl cellulose.
3. The preparation method of the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 2, wherein in S1, the emulsifier is Span80, Tween80 and hydroxyethyl cellulose in a mass ratio of 1-2: 8: 0.1 to 0.5.
4. The preparation method of the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S1, the mass ratio of the emulsifier to the thyme extract to the scindapsus aureus is 1: 1-3: 1 to 3.
5. The method for preparing the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S1, the preparation process of thyme extract is as follows:
after smashing thyme, adding an ethanol solution with the mass being 8-10 times of that of the thyme, leaching for 12-24 hours under the stirring condition, filtering, and concentrating to obtain a thyme extract.
6. The method for preparing the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S1, the preparation process of the scindapsus aureus extract is as follows:
crushing the scindapsus aureus, adding an ethanol solution with the mass of 4-8 times of that of the scindapsus aureus, performing reflux extraction, filtering, and concentrating to obtain the scindapsus aureus extract.
7. The preparation method of the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S2, the mass ratio of sodium alginate to chitosan is 1: 1.
8. the method for preparing the traditional Chinese medicine compound thyme hand-washing-free disinfection gel as claimed in claim 1, wherein in S2, the preparation process of the aloe extract is as follows:
peeling aloe, soaking in water for 5-15 min, adding water into the cleaned aloe, crushing, and filtering to obtain an aloe extract; wherein the mass ratio of the cleaned aloe to the water is 1: 0.2 to 0.5.
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| CN107412585A (en) * | 2017-04-28 | 2017-12-01 | 吉林大学 | A kind of disposable hand-wrist bones gel of environmental type and preparation method thereof |
| CN108096120A (en) * | 2018-02-07 | 2018-06-01 | 合肥华盖生物科技有限公司 | A kind of skin-protection type sterilizing hand cleanser and preparation method thereof |
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