CN108057074A - 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物 - Google Patents

含枸杞、菊花和茶氨酸的缓解视疲劳的组合物 Download PDF

Info

Publication number
CN108057074A
CN108057074A CN201810142351.4A CN201810142351A CN108057074A CN 108057074 A CN108057074 A CN 108057074A CN 201810142351 A CN201810142351 A CN 201810142351A CN 108057074 A CN108057074 A CN 108057074A
Authority
CN
China
Prior art keywords
composition
chrysanthemum
matrimony vine
parts
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810142351.4A
Other languages
English (en)
Inventor
魏巍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chengdu Map Biotechnology Co Ltd
Original Assignee
Chengdu Map Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Map Biotechnology Co Ltd filed Critical Chengdu Map Biotechnology Co Ltd
Priority to CN201810142351.4A priority Critical patent/CN108057074A/zh
Publication of CN108057074A publication Critical patent/CN108057074A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/24—Organic nitrogen compounds
    • A21D2/245—Amino acids, nucleic acids
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/36—Vegetable material
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明涉及含枸杞、菊花和茶氨酸的缓解视疲劳的组合物，属于医药健康领域。本发明提供了缓解视疲劳的组合物，其活性成分包括枸杞、菊花和茶氨酸。人群试用结果表明，本发明组合物不仅针对视疲劳眼睛局部症状，更能够明显改善不同程度视疲劳引起的精神神经症状，如注意力不集中、记忆力下降等，缓解视疲劳效果显著，具有广阔的市场前景。

Description

含枸杞、菊花和茶氨酸的缓解视疲劳的组合物
技术领域
本发明涉及含枸杞、菊花和茶氨酸的缓解视疲劳的组合物，属于医药健康领域。
背景技术
视疲劳又称眼疲劳，是以患者眼的自觉症状为基础，眼或全身器质性因素与精神(心理)因素相互交织的综合征，并非独立的眼病，因而常常被称为眼疲劳综合征(参见：1、李凤鸣.中华眼科学[M].北京：人民卫生出版社，2006，7～8；2、渠鸿颖等.视疲劳病因及其治疗的研究进展[J].中国中医眼科杂志，2003，14(1)：59～61)。轻度视疲劳会在用眼后出现眼部酸、胀等眼部症状，休息后很快恢复；中度视疲劳会有明显的眼部症状，影响学习和工作；重度视疲劳除有明显的眼部症状和视作业不能持久外，还有记忆力减退、失眠等全身不适症状，干扰患者的视觉和生活质量，严重影响学习、工作和生活(参见：马越.花青素饮料缓解视疲劳作用的人体试验观察.中国食品学报[J].2015，8(15)：8)。
大量的临床实践证明，屈光不正是视疲劳的主要原因之一，如远视、散光、近视患者，在未予矫正屈光不正时，看远或看近时动用较大的调节使睫状肌持续紧张造成患者的调节性视疲劳。另外，长时间近距离工作、工作或阅读环境照明不足等因素都可以导致人眼调节紧张，产生视疲劳。患者的精神状态和全身情况也与视疲劳的发生密切相关，精神压力大、体质衰弱的患者易产生视疲劳。
随着手机、平板电脑广泛进入人们的生活，人群全体用眼时间不断延长，近距离用眼强度增大，各年龄阶层视疲劳的发生率急速增多。能够改善视疲劳，并缓解由视疲劳带来的注意力、记忆力下降等问题的产品越来越受到消费者青睐。
目前，市面上改善视疲劳的产品通常仅针对蓝光损伤本身，对眼睛局部症状的改善效果不明显，而且并不能解决不同程度视疲劳引起的其他症状，如注意力不集中，记忆力下降等。因此，提供一种对视疲劳眼睛局部症状及精神神经症状缓解效果明显的产品，成为了一个亟待解决的问题。
发明内容
本发明的目的在于提供缓解视疲劳的组合物。
本发明提供了缓解视疲劳的组合物，活性成分包括枸杞、菊花和茶氨酸。
进一步地，所述活性成分的重量配比为：枸杞500～12000份、菊花500～6000份、茶氨酸20～1000份。
进一步地，所述活性成分的重量配比为：枸杞6000～12000份、菊花3000～6000份、茶氨酸100～400份。
优选地，所述活性成分的重量配比为：枸杞6000～12000份、菊花3000～6000份、茶氨酸200～400份。
进一步地，所述枸杞为宁夏枸杞、中华枸杞、黑果枸杞、新疆枸杞、截萼枸杞、柱筒枸杞、云南枸杞、黄果枸杞、红枝枸杞、北方枸杞中一种或两种以上。
进一步地，所述菊花为杭菊、亳菊、贡菊、滁菊中一种或两种以上。
进一步地，活性成分还包括DHA、覆盆子、薄荷、叶黄素、叶黄素酯、(3R，3'R)-二羟基-β-胡萝卜素中一种或两种以上的混合物。
进一步地，活性成分还包括DHA10-1000份。
进一步地，活性成分还包括叶黄素和/或叶黄素酯0.6～25份。
进一步地，活性成分还包括(3R，3'R)-二羟基-β-胡萝卜素0.2～10份。
进一步地，活性成分还包括覆盆子500～1000份。
进一步地，活性成分还包括薄荷1000～3000份。
进一步地，所述的组合物是各重量配比的活性成分，加入可接受的辅料或者辅助性成分制备而成的食品、保健品或药品。
进一步地，所述食品、保健品或药品为口服形式。
进一步地，所述食品或保健品为糖果、饮料、饼干、面包、果冻或膳食补充剂。
本发明提供了所述组合物的制备方法，包括如下步骤：取各重量配比的活性成分，加入食品、保健品或药品中可接受的辅料或者辅助性成分，即得。
本发明提供了所述组合物在制备缓解视疲劳的食品、保健品或药品中的用途。
进一步地，所述食品、保健品或药品具有缓解视疲劳所致眼睛局部症状和/或精神神经症状的功效。
进一步地，所述眼睛局部症状为眼酸痛、眼胀、畏光、视物模糊、眼干涩、异物感或流泪。
进一步地，所述精神神经症状为注意力下降、记忆力减退、焦虑或失眠。
本发明提供了缓解视疲劳的组合物。人群试用结果表明，本发明组合物不仅针对视疲劳眼睛局部症状，更能够明显改善不同程度视疲劳引起的精神神经症状，如注意力不集中、记忆力下降等，缓解视疲劳效果显著，具有广阔的市场前景。
具体实施方式
本发明具体实施方式中使用的原料、设备均为已知产品，通过购买市售产品获得。
本发明提供了缓解视疲劳的组合物，其活性成分包括枸杞、菊花和茶氨酸。
本发明通过将枸杞、菊花和茶氨酸组合使用，不仅能够有效改善由视疲劳带来的严重影响工作与生活的全身不适症状，包括可以减轻或缓解注意力及记忆力下降问题，试用者普遍反映使用后情绪焦虑缓解明显，由眼疲劳引发的睡眠问题也明显缓解，而且，人群试用试验表明，本发明组合物改善视疲劳眼睛局部症状的效果较枸杞和菊花更加明显，比如，眼酸痛、眼胀、畏光、视物模糊、眼干涩、异物感、流泪等症状都能够得到一定程度的改善，对视疲劳的治疗效果十分显著。
实施例1本发明糖果制备
原料按重量份数计：叶黄素酯6份；(3R，3'R)-二羟基-β-胡萝卜素2份；枸杞10000份；菊花3000份；覆盆子500份；薄荷1000份；茶氨酸300份；低聚果糖150份。
制备方法：
1、按重量配比将枸杞、菊花、覆盆子、薄荷加入10倍的清水中煮沸15-30分钟，过滤，固体物质再加入同样量的水重复上述过程2次，收齐三次的滤液浓缩、干燥、粉碎后与(3R，3'R)-二羟基-β-胡萝卜素、茶氨酸、叶黄素酯、低聚果糖混合均匀后加入糖浆搅拌均匀。
2、注模冷却成型后可按需制成凝胶软糖、压片糖、巧克力糖、硬糖、酥质糖、彩虹糖、充气糖果、胶基糖等类型。
实施例2本发明饮料的制备
原料按重量份数计：叶黄素酯12份；(3R，3'R)-二羟基-β-胡萝卜素4份；枸杞10000份；菊花6000份；覆盆子500份；薄荷2000份，茶氨酸200份。
制备方法：
1、按重量配比将枸杞、菊花、覆盆子、薄荷加入10倍的清水中煮沸15-30分钟，过滤，固体物质再加入同样量的水重复上述过程2次，收齐三次的滤液浓缩、干燥、粉碎。
2、按重量百分比将1的粉碎物和(3R,3'R)-二羟基-β-胡萝卜素、茶氨酸、叶黄素酯混合均匀后加入糖浆搅拌均匀。
3、按需制成各种饮料。
以下通过试验例证明本发明的有益效果。
试验例1本发明组合物缓解视疲劳及其相关症状的试用观察
本实验根据《视疲劳诊疗专家共识(2014年)》及国食药监保化[2012]107号《缓解视疲劳功能评价方法》制订视疲劳评定量表。征集试食者240人，男性116人，女性124人。分别于试食前后进行眼部症状及眼底检查，血、尿常规检查，肝、肾功能检查，症状询问、用眼情况调查，SAS评分，明视持久度和视力检查，远视力检查。眼睛局部症状：眼酸痛、眼胀、畏光、视物模糊、眼干涩、异物感、流泪7种症状中有任3种改善，且其他症状无恶化即判定眼睛局部症状改善，全身不适(包括注意力下降、记忆力减退、失眠)进行单项统计。计算两组症状改善例数和两组症状改善有效率。症状改善有效率(％)计算方法为症状改善例数/试食例数×100。将两组症状改善有效率进行统计学检验。
表1视疲劳评定量表
将受试者随机分为8组，每组30例，1组给予活性成分为枸杞6000mg菊花3000mg的糖果，2组给予活性成分为枸杞6000mg菊花3000mg茶氨酸400mg的糖果，3组给予活性成分为枸杞500mg菊花6000mg茶氨酸20mg的糖果，4组给予活性成分为枸杞12000mg菊花6000mg茶氨酸400mg的糖果，5组给予活性成分为枸杞6000mg菊花6000mg茶氨酸100mg的糖果，6组给予活性成分为枸杞12000mg菊花3000mg茶氨酸400mg的糖果，7组给予活性成分为枸杞6000mg菊花6000mg茶氨酸200mg的糖果，8组给予活性成分为枸杞12000mg菊花500mg茶氨酸1000mg的糖。各组糖果均按照实施例1方法制备，采用宁夏枸杞和杭菊。8组均连续服用60天(以上均为每日服用量)。分别于1天、60天统计眼睛局部症状改善的有效率，以及影响工作生活的视疲劳精神神经症状主要包括注意力下降、焦虑、失眠的变化，服用前后对比结果见下表：
表2缓解视疲劳症状有效率统计表
试验组1仅添加了枸杞和菊花，试用结果表明其具有缓解视疲劳眼睛局部症状的效果，服用60天后有效率达到30％，但起效较慢，短时间内没有明显效果。
试验组2～8在杞菊的基础上添加了茶氨酸，结果明显加速了对眼睛局部症状的缓解效果，服用1天后显效更加明显，而且长期服用后对眼睛局部症状的缓解效果较试验组1更佳。此外，加入茶氨酸的试验组还能明显改善注意力和记忆力情况。
本发明组合物能够全面改善视疲劳症状，且起效较市面上其它产品快，易于消费者坚持使用最终达到缓解视疲劳的目的。

Claims (14)

1.缓解视疲劳的组合物，其特征是：活性成分包括枸杞、菊花和茶氨酸。
2.如权利要求1所述的组合物，其特征是：所述活性成分的重量配比为：枸杞500～12000份、菊花500～6000份、茶氨酸20～1000份。
3.如权利要求2所述的组合物，其特征是：所述活性成分的重量配比为：枸杞6000～12000份、菊花3000～6000份、茶氨酸100～400份；优选地，所述活性成分的重量配比为：枸杞6000～12000份、菊花3000～6000份、茶氨酸200～400份。
4.如权利要求1～3任意一项所述的组合物，其特征是：所述枸杞为宁夏枸杞、中华枸杞、黑果枸杞、新疆枸杞、截萼枸杞、柱筒枸杞、云南枸杞、黄果枸杞、红枝枸杞、北方枸杞中一种或两种以上。
5.如权利要求1～3任意一项所述的组合物，其特征是：所述菊花为杭菊、亳菊、贡菊、滁菊中一种或两种以上。
6.如权利要求1～5任意一项所述的组合物，其特征是：活性成分还包括DHA、覆盆子、薄荷、叶黄素、叶黄素酯、(3R，3'R)-二羟基-β-胡萝卜素中一种或两种以上的混合物。
7.如权利要求1～6任意一项所述的组合物，其特征是：是各重量配比的活性成分，加入可接受的辅料或者辅助性成分制备而成的食品、保健品或药品。
8.如权利要求7所述的组合物，其特征是：所述食品、保健品或药品为口服形式。
9.如权利要求8所述的组合物，其特征是：所述食品或保健品为糖果、饮料、饼干、面包、果冻或膳食补充剂。
10.权利要求1～9任意一项所述组合物的制备方法，其特征是：包括如下步骤：取各重量配比的活性成分，加入食品、保健品或药品中可接受的辅料或者辅助性成分，即得。
11.权利要求1～9任意一项所述组合物在制备缓解视疲劳的食品、保健品或药品中的用途。
12.如权利要求11所述的用途，其特征是：所述食品、保健品或药品具有缓解视疲劳所致眼睛局部症状和/或精神神经症状的功效。
13.如权利要求12所述的用途，其特征是：所述眼睛局部症状为眼酸痛、眼胀、畏光、视物模糊、眼干涩、异物感或流泪。
14.如权利要求12所述的用途，其特征是：所述精神神经症状为注意力下降、记忆力减退、焦虑或失眠。
CN201810142351.4A 2018-02-11 2018-02-11 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物 Pending CN108057074A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810142351.4A CN108057074A (zh) 2018-02-11 2018-02-11 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810142351.4A CN108057074A (zh) 2018-02-11 2018-02-11 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物

Publications (1)

Publication Number Publication Date
CN108057074A true CN108057074A (zh) 2018-05-22

Family

ID=62134492

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810142351.4A Pending CN108057074A (zh) 2018-02-11 2018-02-11 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物

Country Status (1)

Country Link
CN (1) CN108057074A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111012851A (zh) * 2019-10-09 2020-04-17 山东翳明生物科技有限公司 一种治疗近视眼的中药外敷热敷眼袋

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850064A (zh) * 2006-02-26 2006-10-25 郭凌云 一种减轻紧张症状的制剂
CN103125644A (zh) * 2011-11-23 2013-06-05 汤汉忠 一种菊花茶的制作方法
CN104256817A (zh) * 2014-09-19 2015-01-07 河南福森药业有限公司 一种缓解视疲劳的功能饮料及制备方法
CN104366510A (zh) * 2014-11-28 2015-02-25 北京康比特体育科技股份有限公司 茶叶茶氨酸保健食品组合物及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850064A (zh) * 2006-02-26 2006-10-25 郭凌云 一种减轻紧张症状的制剂
CN103125644A (zh) * 2011-11-23 2013-06-05 汤汉忠 一种菊花茶的制作方法
CN104256817A (zh) * 2014-09-19 2015-01-07 河南福森药业有限公司 一种缓解视疲劳的功能饮料及制备方法
CN104366510A (zh) * 2014-11-28 2015-02-25 北京康比特体育科技股份有限公司 茶叶茶氨酸保健食品组合物及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
石亚亚，等: "茶氨酸保健功能研究进展", 《氨基酸和生物资源》 *
金鑫，等: "缓解视疲劳功能食品及其功效成分研究进展", 《食品科学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111012851A (zh) * 2019-10-09 2020-04-17 山东翳明生物科技有限公司 一种治疗近视眼的中药外敷热敷眼袋

Similar Documents

Publication Publication Date Title
CN100473406C (zh) 用于眼科保健、缓解视疲劳的中药制剂
CN102763847A (zh) 一种具有缓解视疲劳的保健食品及其制备方法
CN104432036B (zh) 缓解视疲劳的保健营养组合物及其制备方法与应用
CN101595977A (zh) 有益于眼睛明视持久度的配方食品及其应用
CN108294305A (zh) 含原花青素的缓解视疲劳组合物
CN108078972A (zh) γ-氨基丁酸在制备缓解视疲劳的食品、保健品或药品中的用途
CN108159036A (zh) 含茶氨酸、磷脂酰丝氨酸和原花青素的缓解视疲劳的组合物
CN108157575A (zh) 一种缓解视疲劳的压片糖果及其制备方法与应用
CN108042652A (zh) 含枸杞、菊花和γ-氨基丁酸的缓解视疲劳的组合物
CN108261472A (zh) 含枸杞、菊花、γ-氨基丁酸和茶氨酸的缓解视疲劳的组合物
KR20090132229A (ko) 고령자용 기능성 면 및 이의 제조방법
CN112715729A (zh) 一种缓解视疲劳的蓝莓叶黄素酯压片糖果及其制备方法
CN106880058A (zh) 一种无糖糖浆及其制备方法
CN108354175A (zh) 含鱼眼、茶氨酸和γ-氨基丁酸的缓解视疲劳的组合物
CN101341972A (zh) 一种可以调控血糖的食品及其制备方法
CN108354918A (zh) 含茶氨酸、γ-氨基丁酸和原花青素的缓解视疲劳的组合物
CN100486456C (zh) 一种用于缓解视疲劳的保健食品及其制备方法
CN108324705A (zh) 含茶氨酸、γ-氨基丁酸和花青素的缓解视疲劳的组合物
CN108185427A (zh) 含鱼眼、茶氨酸和磷脂酰丝氨酸的缓解视疲劳的组合物
CN108210640A (zh) 含茶叶提取物的缓解视疲劳组合物
CN108057074A (zh) 含枸杞、菊花和茶氨酸的缓解视疲劳的组合物
CN112385770A (zh) 一种鸡蛋面及其制备方法
CN108078974A (zh) 含茶氨酸、γ-氨基丁酸和虾青素的缓解视疲劳的组合物
CN108338364A (zh) 含茶氨酸和虾青素的缓解视疲劳的组合物
CN109007573A (zh) 一种调节亚健康的五谷类养生代餐粉及其加工工艺

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180522

RJ01 Rejection of invention patent application after publication