CN108042605A - A kind of preparation process of Radix Gentianae extract enteric-coated micro-pill - Google Patents
A kind of preparation process of Radix Gentianae extract enteric-coated micro-pill Download PDFInfo
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- CN108042605A CN108042605A CN201710980846.XA CN201710980846A CN108042605A CN 108042605 A CN108042605 A CN 108042605A CN 201710980846 A CN201710980846 A CN 201710980846A CN 108042605 A CN108042605 A CN 108042605A
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- Prior art keywords
- pill
- coated micro
- macroreticular resin
- filtrate
- enteric
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Medical Informatics (AREA)
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation processes of Radix Gentianae extract enteric-coated micro-pill, mainly extract Chinese medicine felwort and concentrate, then macroreticular resin is handled.Felwort obtained extraction concentrate is uniformly mixed and is dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain Radix Gentianae extract enteric-coated micro-pill.Radix Gentianae extract enteric-coated micro-pill prepared by the present invention, can be to avoid injury of the bitter cold to stomach Qi of felwort, while adds concentration of its active ingredient in enteron aisle.This law prepares felwort enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation process of Radix Gentianae extract enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, in especially belonging to
Medicine enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, influence appetite of patient etc..Especially the pharmacological properties such as felwort it is cold and cool in
Medicine, long term usage injure one's stomach gas, influence spleen and stomach function, the healthy tendency of people is made to come to harm.In addition, the hydrochloric acid in gastric juice also usually can be to medicine
The active ingredient of object plays the role of destruction, the effect of so as to influence drug.Enteron aisle is the main portions of drug absorption.Enteron aisle
During infection, it is especially desirable to there is sufficient concentrations of drug or middle the effective elements of the medicine to act on lesion part, both improve curative effect, subtract
Lack the generation of side effect, also reduce the dosage of drug.Therefore, herbal nature is cold and cool and to upper digestive tract medicine excitatory
Object is very suitable for being prepared into enteric coated preparations.
The content of the invention
" a kind of preparation process of Radix Gentianae extract enteric-coated micro-pill " of the invention, it is characterised in that：Felwort medicine materical crude slice is fallen
In the boiling water for entering 5 ~ 10 times of weight, boiling 5 ~ 15 minutes is kept, is kept the temperature filter with 200 ~ 300 mesh screens while hot, gained filtrate 1 is standby
With.The water that the obtained dregs of a decoction add 5 ~ 10 times of weight decocts twice, boiling 30 ~ 60 minutes is kept after boiling every time, while hot mistake
Filter, respectively obtains filtrate 2 and filtrate 3.Merging filtrate 1, filtrate 2 and filtrate 3, by this, 60 ~ 75 DEG C of filtrate is concentrated under reduced pressure into three times
Relative density is 1.05 ~ 1.10 concentrate.On the other hand, macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, in
When 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 are small, constantly stir, it is every 2 ~ 4 it is small when change a water.After last time changes water, it will drain away the water
Macroreticular resin add in 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in soaking at room temperature 2 ~ 3 times, it is small to impregnate 2 ~ 4 every time
When.Macroreticular resin after alcohol immersion treatment is put into recovered alcohol in rotary evaporation in vacuo drier, then alcohol will have been recycled
Macroreticular resin be transferred in vacuum drying chamber in 50 ~ 80 DEG C be dried under reduced pressure 4 ~ 8 it is small when, cross 40 ~ 80 mesh sieves, remove fine powder, obtain
Macroreticular resin particle after processing.Using this macroreticular resin as the ball heart of enteric-coated micro-pill, foregoing felwort extraction concentrate is pressed
Weight ratio takes 1 ~ 3 part, is sufficiently mixed uniformly by weight 7 ~ 9 parts with the macroreticular resin after aforementioned processing, 50 ~ 60 DEG C of decompressions are dry
It is dry 8 ~ 24 it is small when, obtain drug containing macroreticular resin.Using this drug containing macroreticular resin as the ball heart of enteric-coated micro-pill, fluidized bed coating is used
The acrylic resin II of drug containing macroreticular resin ball heart weight 3% ~ 10% is wrapped, is drying to obtain finished product.
Felwort has heat-clearing and damp-drying drug, the effect of purging the liver of pathogenic fire is calmed the frightened.Its pharmacological property very bitter cold, it is oral to have injury to spleen and stomach function,
The compliance of medication is bad.Enteric-coated micro-pill is prepared into, it is made only just to be disintegrated, discharge under the pH environment of enteron aisle, is solved
Its bitter cold injure one's stomach gas the drawbacks of, reduce sense of discomfort of its bitter taste to oral mucosa, meanwhile, also improve its active ingredient in intestines
The concentration that road position acts on and absorbs, enhances its curative effect.
Specific embodiment
Embodiment 1
Felwort medicine materical crude slice is poured into the boiling water of 8 times of weight, keep boiling 10 minutes, kept the temperature filter with 200 mesh screens while hot, institute
It is spare to obtain filtrate.The water that the dregs of a decoction add 5 times of weight decocts twice, and boiling 60 minutes is kept after boiling every time, is filtered while hot.It closes
And filtrate three times, it is concentrated under reduced pressure into the concentrate that relative density is 1.05.On the other hand, macroreticular resin is added in into 8 times of weights
In the deionized water of amount, when 50 DEG C of heat-insulation soakings 12 are small, constantly stir, it is every 2 it is small when change a water.The macropore that will be drained away the water
Resin adds 60% edible alcohol of 5 times of weight, in soaking at room temperature 2 times, impregnate every time 2 it is small when.It will be through alcohol immersion treatment
Macroreticular resin afterwards is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber dry in 50 DEG C of decompressions
It is dry 6 it is small when, cross 60 mesh sieves and remove fine powder, the macroreticular resin particle that obtains that treated.Foregoing felwort is extracted into 2 parts of concentrate,
8 parts of macroreticular resin particle is sufficiently mixed uniformly with treated, 55 DEG C be dried under reduced pressure 12 it is small when, obtain drug containing macroreticular resin ball
The heart.This drug containing macroreticular resin ball heart is wrapped to the acrylic resin of the heart of ball containing medicated resin weight 3% ~ 10% with fluidized bed coating
II is drying to obtain finished product.
Embodiment 2
Felwort medicine materical crude slice is poured into the boiling water of 10 times of weight, keeps boiling 30 minutes, kept the temperature filter with 300 mesh screens while hot,
Gained filtrate is spare.The water that the dregs of a decoction add 8 times of weight decocts twice, and boiling 30 minutes is kept after boiling every time, is filtered while hot.
Merge filtrate three times, be concentrated under reduced pressure into the concentrate that relative density is 1.10.On the other hand, macroreticular resin is added in 10 times
In the deionized water of weight, when 60 DEG C of heat-insulation soakings 24 are small, constantly stir, it is every 4 it is small when change a water.It is big by what is drained away the water
Hole resin adds 80% edible alcohol of 8 times of weight, in soaking at room temperature 3 times, impregnate every time 4 it is small when.At will be through alcohol immersion
Macroreticular resin after reason is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber in 60 DEG C of decompressions
It is dry 8 it is small when, cross 80 mesh sieves and remove fine powder, the macroreticular resin particle that obtains that treated.Foregoing felwort is extracted into concentrate 3
Part, 7 parts of macroreticular resin particle is sufficiently mixed uniformly with treated, 55 DEG C be dried under reduced pressure 24 it is small when, obtain drug containing macroreticular resin
The ball heart.This drug containing macroreticular resin ball heart is wrapped to the acrylic resin of the heart of ball containing medicated resin weight 3% ~ 10% with fluidized bed coating
II is drying to obtain finished product.
Claims (3)
1. a kind of preparation process of Radix Gentianae extract enteric-coated micro-pill, it is characterised in that：Felwort medicine materical crude slice is poured into 5 ~ 10 times of weights
In the boiling water of amount, boiling 5 ~ 15 minutes is kept, is kept the temperature filter with 200 ~ 300 mesh screens while hot, gained filtrate 1 is spare；The dregs of a decoction are again
The water for adding in 5 ~ 10 times of weight decocts twice, and boiling 30 ~ 60 minutes is kept after boiling every time, filters while hot, respectively obtains filtrate 2
With filtrate 3；Merging filtrate 1, filtrate 2 and filtrate 3, by this three times filtrate decompression be concentrated into relative density be 1.05 ~ 1.10 it is dense
Contracting liquid.
2. a kind of preparation process of Radix Gentianae extract enteric-coated micro-pill according to claim 1, it is characterised in that：By macropore
Resin add in 5 ~ 10 times of weight deionized water in, when 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 are small, it is every 2 ~ 4 it is small when change a water,
The macroreticular resin to drain away the water is added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in soaking at room temperature 2 ~ 3 times, every time
When immersion 2 ~ 4 is small, the macroreticular resin after alcohol immersion treatment is put in rotary evaporation in vacuo drier after recovered alcohol, then is turned
Move on in vacuum drying chamber in 50 ~ 60 DEG C be dried under reduced pressure 4 ~ 8 it is small when, cross 60 ~ 80 mesh sieves and remove fine powder, the macropore tree that obtains that treated
Fat particle.
3. a kind of preparation process of Radix Gentianae extract enteric-coated micro-pill according to claim 1, it is characterised in that：By right
It is required that felwort 1 ~ 3 part of the concentrate of extraction in 1, is sufficiently mixed with 7 ~ 9 parts of macroreticular resin in claim 2 after processing
It is even, 50 ~ 60 DEG C be dried under reduced pressure 8 ~ 24 it is small when, the drug containing macroreticular resin ball heart is obtained, by this drug containing macroreticular resin ball heart fluid bed
Coating method wraps the acrylic resin II of drug containing macroreticular resin ball heart weight 3% ~ 10%, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980846.XA CN108042605A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of Radix Gentianae extract enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980846.XA CN108042605A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of Radix Gentianae extract enteric-coated micro-pill |
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| CN108042605A true CN108042605A (en) | 2018-05-18 |
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| CN201710980846.XA Pending CN108042605A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of Radix Gentianae extract enteric-coated micro-pill |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
-
2017
- 2017-10-20 CN CN201710980846.XA patent/CN108042605A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
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Application publication date: 20180518 |
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