CN107669794A - A kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill - Google Patents
A kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill Download PDFInfo
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- CN107669794A CN107669794A CN201710980829.6A CN201710980829A CN107669794A CN 107669794 A CN107669794 A CN 107669794A CN 201710980829 A CN201710980829 A CN 201710980829A CN 107669794 A CN107669794 A CN 107669794A
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- China
- Prior art keywords
- macroreticular resin
- enteric
- pill
- coated micro
- hours
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill, mainly extracts Chinese medicine Schisandra chinensis and concentrates, then macroreticular resin is handled.Obtained fruit of Chinese magnoliavine extraction concentrate is well mixed and dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain Schisandra chinens P.E enteric-coated micro-pill.Schisandra chinens P.E enteric-coated micro-pill prepared by the present invention, can avoid the cold and cool injury to stomach Qi of the fruit of Chinese magnoliavine, while add concentration of its active ingredient in enteron aisle.Fruit of Chinese magnoliavine enteric-coated micro-pill concise in technology prepared by this law, has great practical value and economic value.
Description
Technical field
" a kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, in especially belonging to
Medicine enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, have influence on appetite of patient etc..Especially in the property of medicine bitter cold such as fruit of Chinese magnoliavine
Medicine, long term usage injure one's stomach gas, influence spleen and stomach function, the healthy tendency of people is come to harm.In addition, the hydrochloric acid in gastric juice also usually can be to medicine
The active ingredient of thing plays a part of destruction, the effect of so as to have influence on medicine.Enteron aisle is the main portions of drug absorption.Enteron aisle
During infection, it is especially desirable to there is sufficient concentrations of medicine or middle the effective elements of the medicine to act on focus part, both improve curative effect, subtract
Lack the generation of side effect, also reduce the dosage of medicine.Therefore, herbal nature bitter cold and to upper digestive tract medicine excitatory
Thing, it is especially suitable for being prepared into enteric coated preparations.When particularly the lower digestive tract such as treatment diarrhoea infects, enteric coated preparations can play preferably
Curative effect.
The content of the invention
Of the invention " a kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill ", it is characterised in that first by macroreticular resin according to
Laxative remedy is handled：Macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 hours,
Change a water within every 2 ~ 4 hours, the macroreticular resin to drain away the water is added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in
Soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put into rotary evaporation in vacuo and dried
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, crosses 60 ~ 80 mesh sieves and go carefully
Powder, the macroreticular resin particle after being handled.Meanwhile pour into fruit of Chinese magnoliavine medicine materical crude slice in the water of 5 ~ 10 times of amounts, decoct extraction twice,
Decoct 1 ~ 1.5 hour every time, filtering, merging filtrate, it is that 1.05 ~ 1.10 fruit ofs Chinese magnoliavine are dense that 55 ~ 80 DEG C, which are concentrated under reduced pressure into relative density,
Contracting liquid.By 1 ~ 3 part of this fruit of Chinese magnoliavine concentrate, it is well mixed with 7 ~ 9 parts of macroreticular resin after processing, it is dry then at 50 ~ 80 DEG C of decompressions
Dry 8 ~ 24 hours, obtain the drug containing macroreticular resin ball heart.The drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
For the acrylic resin II of drug containing macroreticular resin ball heart weight 3% ~ 10%, continue to be drying to obtain finished product.
The fruit of Chinese magnoliavine have astringe the lung, nourshing kidney, the effect of promoting the production of body fluid, receiving sweat, be puckery smart.Clinically it is usually used in treating cough due to deficiency of the lung, mouth
It is dry to make thirsty, spontaneous sweating, protracted dysentery and diarrhea etc..Product Schisandra chinens P.E enteric-coated micro-pill of the present invention, concentrate is extracted by the fruit of Chinese magnoliavine
Absorption is prepared into the pastille micropill ball heart, then superscribe enteric coating so that the fruit of Chinese magnoliavine has on macroreticular resin after treatment
Machine acid composition is more stable, and the stimulation to gastric mucosa reduces, and the concentration of active ingredient substantially increases in enteron aisle, and curative effect is carried
Rise.
Embodiment
Embodiment 1
Macroreticular resin is added in the deionized water of 5 times of weight, in 50 DEG C of heat-insulation soakings 12 hours, change within every 2 hours a water, will
The macroreticular resin to drain away the water adds 60% edible alcohol of 5 times of weight, and in soaking at room temperature 2 times, immersion 2 hours every time will be through
Macroreticular resin after alcohol-pickled processing is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber
It is dried under reduced pressure in 55 DEG C 6 hours, crosses 60 mesh sieves and remove fine powder, the macroreticular resin particle after being handled.Meanwhile the fruit of Chinese magnoliavine is poured into
In the water of 8 times of amounts, extraction being decocted twice, being decocted 1 hour every time, filtering, merging filtrate, 55 DEG C are concentrated under reduced pressure into relative density and are
1.05 concentrate.By 1 part of this fruit of Chinese magnoliavine concentrate, it is well mixed with 9 parts of macroreticular resin after processing, it is dry then at 60 DEG C of decompressions
Dry 8 hours, obtain the drug containing macroreticular resin ball heart.By the drug containing macroreticular resin ball heart with fluidized bed coating wrap clothing layer weight be containing
The acrylic resin II of medicine macroreticular resin ball heart weight 3%, continues to be drying to obtain finished product.
Embodiment 2
Macroreticular resin is handled according to laxative remedy first：Macroreticular resin is added in the deionized water of 10 times of weight, in 60 DEG C
Heat-insulation soaking 24 hours, change a water within every 4 hours, the macroreticular resin to drain away the water is added to 80% edible wine of 10 times of weight
Essence, in soaking at room temperature 3 times, immersion 4 hours, put rotary evaporation in vacuo by the macroreticular resin after alcohol-pickled processing and dry every time
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 8 hours in 60 DEG C, crosses 80 mesh sieves and remove fine powder, obtain everywhere
Macroreticular resin particle after reason.Meanwhile pour into the fruit of Chinese magnoliavine in the water of 10 times of amounts, decoct extraction twice, it is small to decoct 1.5 every time
When, filtering, merging filtrate, 80 DEG C are concentrated under reduced pressure into the concentrate that relative density is 1.10.By 3 parts of this fruit of Chinese magnoliavine concentrate, with
7 parts of macroreticular resin after processing is well mixed, is dried under reduced pressure then at 80 DEG C 24 hours, obtains the drug containing macroreticular resin ball heart.It will contain
The medicine macroreticular resin ball heart wraps the acrylic resin that clothing layer weight is drug containing macroreticular resin ball heart weight 5% with fluidized bed coating
II, continue to be drying to obtain finished product.
Claims (3)
- A kind of 1. preparation technology of Schisandra chinens P.E enteric-coated micro-pill, it is characterised in that：Fruit of Chinese magnoliavine medicine materical crude slice is poured into 5 ~ 10 times of weights Extraction is decocted in the water of amount twice, 1 ~ 1.5 hour every time, is filtered while hot, merges filtrate twice, being concentrated under reduced pressure into relative density is 1.05 ~ 1.10 concentrate, 1 ~ 3 part of this fruit of Chinese magnoliavine concentrate is well mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C are dried under reduced pressure 8 ~ 24 hours, obtain the drug containing macroreticular resin ball heart.
- A kind of 2. preparation technology of Schisandra chinens P.E enteric-coated micro-pill according to claim 1, it is characterised in that：Described The processing mode of macroreticular resin after processing is added macroreticular resin in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of guarantors Temperature immersion 12 ~ 24 hours, change a water within every 2 ~ 4 hours, by the macroreticular resin to drain away the water add 5 ~ 10 times of weight 60% ~ 80% edible alcohol, in soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put very In empty rotary evaporation drier after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, mistake 60 ~ 80 mesh sieves remove fine powder, the macroreticular resin particle after being handled.
- A kind of 3. preparation technology of Schisandra chinens P.E enteric-coated micro-pill according to claim 1, it is characterised in that：By right It is required that the drug containing macroreticular resin ball heart in 1 with fluidized bed coating wrap clothing layer weight be drug containing macroreticular resin ball heart weight 3% ~ 10% acrylic resin II, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980829.6A CN107669794A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980829.6A CN107669794A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill |
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| Publication Number | Publication Date |
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| CN107669794A true CN107669794A (en) | 2018-02-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710980829.6A Pending CN107669794A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Schisandra chinens P.E enteric-coated micro-pill |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
-
2017
- 2017-10-20 CN CN201710980829.6A patent/CN107669794A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
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Application publication date: 20180209 |
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