CN107929342A - A kind of preparation process of atractylodes chinensis enteric-coated micro-pill - Google Patents
A kind of preparation process of atractylodes chinensis enteric-coated micro-pill Download PDFInfo
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- CN107929342A CN107929342A CN201710980887.9A CN201710980887A CN107929342A CN 107929342 A CN107929342 A CN 107929342A CN 201710980887 A CN201710980887 A CN 201710980887A CN 107929342 A CN107929342 A CN 107929342A
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- Prior art keywords
- macroreticular resin
- enteric
- pill
- coated micro
- small
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
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- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation process of atractylodes chinensis enteric-coated micro-pill, mainly extracts Chinese medicine rhizoma atractylodis and concentrates, then macroreticular resin is handled.Obtained rhizoma atractylodis extraction concentrate is uniformly mixed and is dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain atractylodes chinensis enteric-coated micro-pill.Atractylodes chinensis enteric-coated micro-pill prepared by the present invention, can add concentration of its active ingredient in enteron aisle, at the same time, moreover it is possible to cover its bad smell, improve the Compliance of patient to avoid the loss of the volatile ingredient of rhizoma atractylodis.This law prepares atractylodes chinensis enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation process of atractylodes chinensis enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, especially belongs to Chinese medicine
Enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, influence appetite of patient etc..Some medicines due to containing bad odor,
So that the Compliance of patient declines.In addition, the hydrochloric acid in gastric juice also usually can play destruction to the active ingredient of medicine
Effect, so that the effect of influencing medicine.Enteron aisle is the main portions of drug absorption.During enteric infection, it is especially desirable to have enough
The medicine of concentration or middle the effective elements of the medicine act on lesion part, both improve curative effect, reduce the generation of side effect, also drop
The low dosage of medicine.Pharmacological property is cold and cool, or irritant to upper digestive tract, or has the Chinese medicine of bad smell and volatile component,
It is suitable for being prepared into enteric coated preparations.Rhizoma atractylodis with special smell, many patients due to being difficult to receive.Meanwhile rhizoma atractylodis smell
Volatilization, also results in the reduction of active ingredient, so as to cause the decline of curative effect.Therefore, rhizoma atractylodis enteric-coated micro-pill will be subject to clinic
Doctor and the favor of patient.
The content of the invention
Of the invention " a kind of preparation process of atractylodes chinensis enteric-coated micro-pill ", it is characterised in that first by macroreticular resin according to
Laxative remedy is handled：Macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, when 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 are small,
It is every 2 ~ 4 it is small when change a water, the macroreticular resin to drain away the water is added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in
Soaking at room temperature 2 ~ 3 times, when immersion 2 ~ 4 is small every time, rotary evaporation in vacuo drying is put by the macroreticular resin after alcohol immersion treatment
In device after recovered alcohol, be then transferred in vacuum drying chamber in 50 ~ 60 DEG C be dried under reduced pressure 4 ~ 8 it is small when, cross 60 ~ 80 mesh sieves go carefully
Powder, the macroreticular resin particle after being handled.Meanwhile pour into rhizoma atractylodis medicine materical crude slice in the water of 5 ~ 10 times of amounts, decoct extraction twice, often
It is secondary decoct 1 ~ 1.5 it is small when, filtering, merging filtrate, 55 ~ 80 DEG C are concentrated under reduced pressure into relative density as 1.05 ~ 1.10, this rhizoma atractylodis are dense
1 ~ 3 part of contracting liquid, is uniformly mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C be dried under reduced pressure 8 ~ 24 it is small when, contained
The medicine macroreticular resin ball heart.It is the drug containing macroreticular resin ball heart that the drug containing macroreticular resin ball heart is wrapped clothing layer weight with fluidized bed coating
The acrylic resin II of weight 3% ~ 10%, continues to be drying to obtain finished product.
Rhizoma atractylodis have effects that to expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion.Product atractylodes chinensis enteric-coated micro-pill of the present invention, will
Rhizoma atractylodis extraction concentrate absorption is prepared into the medicated pellet ball heart on macroreticular resin after treatment, then superscribes enteric coating,
So that the smell of rhizoma atractylodis is blanked, the Compliance of patient is greatly improved, volatile ingredient more stablize, effectively into
The concentration divided substantially increases in enteron aisle, and curative effect will be lifted.
Embodiment
Embodiment 1
By macroreticular resin add 5 times of weight deionized water in, when 50 DEG C of heat-insulation soakings 12 are small, it is every 2 it is small when change a water, will
The macroreticular resin to drain away the water adds 60% edible alcohol of 5 times of weight,, will be through when immersion 2 is small every time in soaking at room temperature 2 times
Macroreticular resin after alcohol immersion treatment is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber
In 55 DEG C be dried under reduced pressure 6 it is small when, cross 60 mesh sieves remove fine powder, the macroreticular resin particle after being handled.Meanwhile rhizoma atractylodis medicine materical crude slice is fallen
In the water for entering 8 times of amounts, extraction is decocted twice, when decoction 1 is small every time, filtering, merging filtrate, 55 DEG C are concentrated under reduced pressure into relative density
For 1.05,1 part of this rhizoma atractylodis concentrate is uniformly mixed with 9 parts of macroreticular resin after processing, then at 60 DEG C be dried under reduced pressure 8 it is small when,
Obtain the drug containing macroreticular resin ball heart.It is drug containing macropore tree that the drug containing macroreticular resin ball heart is wrapped clothing layer weight with fluidized bed coating
The acrylic resin II of fat ball heart weight 3%, continues to be drying to obtain finished product.
Embodiment 2
Macroreticular resin is handled according to laxative remedy first：Macroreticular resin is added in the deionized water of 10 times of weight, in 60 DEG C
When heat-insulation soaking 24 is small, it is every 4 it is small when change a water, the macroreticular resin to drain away the water is added to 80% edible wine of 10 times of weight
Essence, in soaking at room temperature 3 times, when immersion 4 is small every time, rotary evaporation in vacuo drying is put by the macroreticular resin after alcohol immersion treatment
In device after recovered alcohol, be then transferred in vacuum drying chamber in 60 DEG C be dried under reduced pressure 8 it is small when, cross 80 mesh sieves remove fine powder, obtain everywhere
Macroreticular resin particle after reason.Meanwhile pour into rhizoma atractylodis medicine materical crude slice in the water of 10 times of amounts, decoct extraction twice, it is small to decoct 1.5 every time
When, filtering, merging filtrate, 80 DEG C are concentrated under reduced pressure into relative density as 1.10, and big after processing by 3 parts of this rhizoma atractylodis concentrate
7 parts of hole resin is uniformly mixed, then at 80 DEG C be dried under reduced pressure 24 it is small when, obtain the drug containing macroreticular resin ball heart.By drug containing macroreticular resin
The ball heart wraps the acrylic resin II that clothing layer weight is drug containing macroreticular resin ball heart weight 5% with fluidized bed coating, continues drying
Get product.
Claims (3)
- A kind of 1. preparation process of atractylodes chinensis enteric-coated micro-pill, it is characterised in that：Rhizoma atractylodis medicine materical crude slice is poured into the water of 5 ~ 10 times of amounts In, decoct extraction twice, decoct every time 1 ~ 1.5 it is small when, filtering, merging filtrate, 55 ~ 80 DEG C are concentrated under reduced pressure into relative density and are 1.05 ~ 1.10,1 ~ 3 part of this rhizoma atractylodis concentrate is uniformly mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C of decompressions When drying 8 ~ 24 is small, the drug containing macroreticular resin ball heart is obtained.
- A kind of 2. preparation process of atractylodes chinensis enteric-coated micro-pill according to claim 1, it is characterised in that：The place The processing mode of macroreticular resin after reason is added macroreticular resin in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of insulations Immersion 12 ~ 24 it is small when, it is every 2 ~ 4 it is small when change a water, by the macroreticular resin to drain away the water add 5 ~ 10 times of weight 60% ~ 80% edible alcohol, in soaking at room temperature 2 ~ 3 times, soak every time 2 ~ 4 it is small when, the macroreticular resin after alcohol immersion treatment is put very In empty rotary evaporation drier after recovered alcohol, be then transferred in vacuum drying chamber in 50 ~ 60 DEG C be dried under reduced pressure 4 ~ 8 it is small when, mistake 60 ~ 80 mesh sieves remove fine powder, the macroreticular resin particle after being handled.
- A kind of 3. preparation process of atractylodes chinensis enteric-coated micro-pill according to claim 1, it is characterised in that：Will by right Seek the drug containing macroreticular resin ball heart in 1, with fluidized bed coating, wrap clothing layer weight for drug containing macroreticular resin ball heart weight 3% ~ 10% acrylic resin II, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980887.9A CN107929342A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of atractylodes chinensis enteric-coated micro-pill |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980887.9A CN107929342A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of atractylodes chinensis enteric-coated micro-pill |
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| Publication Number | Publication Date |
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| CN107929342A true CN107929342A (en) | 2018-04-20 |
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| CN201710980887.9A Pending CN107929342A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of atractylodes chinensis enteric-coated micro-pill |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
-
2017
- 2017-10-20 CN CN201710980887.9A patent/CN107929342A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
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Application publication date: 20180420 |