CN107753534A - A kind of preparation technology of angelica extract enteric-coated micro-pill - Google Patents
A kind of preparation technology of angelica extract enteric-coated micro-pill Download PDFInfo
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- CN107753534A CN107753534A CN201710980831.3A CN201710980831A CN107753534A CN 107753534 A CN107753534 A CN 107753534A CN 201710980831 A CN201710980831 A CN 201710980831A CN 107753534 A CN107753534 A CN 107753534A
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- China
- Prior art keywords
- macroreticular resin
- pill
- coated micro
- angelica extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation technology of angelica extract enteric-coated micro-pill, mainly extracts Chinese traditional medicine angelica and concentrates, then macroreticular resin is handled.Obtained Radix Angelicae Sinensis extraction concentrate is well mixed and dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain angelica extract enteric-coated micro-pill.Angelica extract enteric-coated micro-pill prepared by the present invention, the loss of the volatile ingredient of Radix Angelicae Sinensis can be avoided, add concentration of its active ingredient in enteron aisle, simultaneously, moreover it is possible to covered its bad smell, improve the Compliance of patient.This law prepares angelica extract enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation technology of angelica extract enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, especially belongs to Chinese medicine
Enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, have influence on appetite of patient etc..Some medicines due to containing bad odor,
So that the Compliance of patient declines.In addition, the hydrochloric acid in gastric juice also usually can play destruction to the active ingredient of medicine
Effect, the effect of so as to have influence on medicine.Enteron aisle is the main portions of drug absorption.During enteric infection, it is especially desirable to have enough
The medicine of concentration or middle the effective elements of the medicine act on focus part, both improve curative effect, reduce the generation of side effect, also drop
The low dosage of medicine.Therefore, the property of medicine is cold and cool, or irritant to upper digestive tract, or has bad smell and volatile medicine,
It is especially suitable for being prepared into enteric coated preparations.Radix Angelicae Sinensis with special smell, many patients due to being difficult to receive.Meanwhile Radix Angelicae Sinensis gas
The volatilization of taste, the reduction of active ingredient is also resulted in, so as to cause the decline of curative effect.Therefore, Radix Angelicae Sinensis enteric coated pellets formulation will
Favored by clinician and patient.
The content of the invention
Of the invention " a kind of preparation technology of angelica extract enteric-coated micro-pill ", it is characterised in that first by macroreticular resin according to
Laxative remedy is handled：Macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 hours,
Change a water within every 2 ~ 4 hours, the macroreticular resin to drain away the water is added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in
Soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put into rotary evaporation in vacuo and dried
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, crosses 60 ~ 80 mesh sieves and go carefully
Powder, the macroreticular resin particle after being handled.Meanwhile pour into angelica sinensis in the water of 5 ~ 10 times of amounts, decoct extraction twice, often
Secondary to decoct 1 ~ 1.5 hour, filtering, merging filtrate, it is 1.05 ~ 1.10 that 55 ~ 80 DEG C, which are concentrated under reduced pressure into relative density, and this Radix Angelicae Sinensis is dense
1 ~ 3 part of contracting liquid, it is well mixed with 7 ~ 9 parts of macroreticular resin after processing, is dried under reduced pressure 8 ~ 24 hours, is contained then at 50 ~ 80 DEG C
The medicine macroreticular resin ball heart.It is the drug containing macroreticular resin ball heart that the drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
The acrylic resin II of weight 3% ~ 10%, continues to be drying to obtain finished product.
Radix Angelicae Sinensis cures mainly all cards of the deficiency of blood, can be clinically used for irregular menstruation, Amenorrhea, dysmenorrhoea, and abdominal mass knot gathers, uterine bleeding, asthenia cold abdominalgia,
Impotence numbness, numbness, intestines are dry and shit is difficult, weight, ulcer sores, injury from falling down after dysentery characterized by blood in the stool.Product angelica extract enteric of the present invention is micro-
Ball, by the macroreticular resin of Radix Angelicae Sinensis extraction concentrate absorption after treatment, the pastille micropill ball heart is prepared into, then superscribe enteric
Clothing so that the smell of Radix Angelicae Sinensis is blanked, and the Compliance of patient is greatly improved, and volatile ingredient is more stable, has
The concentration of effect composition substantially increases in enteron aisle, and curative effect will be lifted.
Embodiment
Facility example 1
Macroreticular resin is added in the deionized water of 5 times of weight, in 50 DEG C of heat-insulation soakings 12 hours, change within every 2 hours a water, will
The macroreticular resin to drain away the water adds 60% edible alcohol of 5 times of weight, and in soaking at room temperature 2 times, immersion 2 hours every time will be through
Macroreticular resin after alcohol-pickled processing is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber
It is dried under reduced pressure in 55 DEG C 6 hours, crosses 60 mesh sieves and remove fine powder, the macroreticular resin particle after being handled.Meanwhile angelica sinensis is fallen
In the water for entering 8 times of amounts, extraction being decocted twice, being decocted 1 hour every time, filtering, merging filtrate, 55 DEG C are concentrated under reduced pressure into relative density
For 1.05, by 1 part of this Radix Angelicae Sinensis concentrate, it is well mixed, is dried under reduced pressure then at 60 DEG C 8 hours with 9 parts of macroreticular resin after processing,
Obtain the drug containing macroreticular resin ball heart.It is drug containing macropore tree that the drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
The acrylic resin II of fat ball heart weight 3%, continues to be drying to obtain finished product.
Facility example 2
Macroreticular resin is handled according to laxative remedy first：Macroreticular resin is added in the deionized water of 10 times of weight, in 60 DEG C
Heat-insulation soaking 24 hours, change a water within every 4 hours, the macroreticular resin to drain away the water is added to 80% edible wine of 10 times of weight
Essence, in soaking at room temperature 3 times, immersion 4 hours, put rotary evaporation in vacuo by the macroreticular resin after alcohol-pickled processing and dry every time
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 8 hours in 60 DEG C, crosses 80 mesh sieves and remove fine powder, obtain everywhere
Macroreticular resin particle after reason.Meanwhile pour into angelica sinensis in the water of 10 times of amounts, decoct extraction twice, it is small to decoct 1.5 every time
When, filtering, merging filtrate, 80 DEG C are concentrated under reduced pressure into relative density as 1.10, and big after processing by 3 parts of this Radix Angelicae Sinensis concentrate
7 parts of hole resin is well mixed, is dried under reduced pressure then at 80 DEG C 24 hours, obtains the drug containing macroreticular resin ball heart.By drug containing macroreticular resin
The ball heart wraps the acrylic resin II that clothing layer weight is drug containing macroreticular resin ball heart weight 5% with fluidized bed coating, continues drying
Get product.
Claims (3)
- A kind of 1. preparation technology of angelica extract enteric-coated micro-pill, it is characterised in that：Angelica sinensis is poured into the water of 5 ~ 10 times of amounts In, decoct extraction twice, decoct 1 ~ 1.5 hour every time, filtering, merging filtrate, 55 ~ 80 DEG C are concentrated under reduced pressure into relative density and are 1.05 ~ 1.10,1 ~ 3 part of this Radix Angelicae Sinensis concentrate is well mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C of decompressions Dry 8 ~ 24 hours, obtain the drug containing macroreticular resin ball heart.
- A kind of 2. preparation technology of angelica extract enteric-coated micro-pill according to claim 1, it is characterised in that：Described place The processing mode of macroreticular resin after reason is added macroreticular resin in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of insulations Immersion 12 ~ 24 hours, change a water within every 2 ~ 4 hours, by the macroreticular resin to drain away the water add 5 ~ 10 times of weight 60% ~ 80% edible alcohol, in soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put very In empty rotary evaporation drier after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, mistake 60 ~ 80 mesh sieves remove fine powder, the macroreticular resin particle after being handled.
- A kind of 3. preparation technology of angelica extract enteric-coated micro-pill according to claim 1, it is characterised in that：Will by right It is drug containing macroreticular resin ball heart weight 3% ~ 10% to ask the drug containing macroreticular resin ball heart in 1 to wrap clothing layer weight with fluidized bed coating Acrylic resin II, be drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980831.3A CN107753534A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of angelica extract enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980831.3A CN107753534A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of angelica extract enteric-coated micro-pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753534A true CN107753534A (en) | 2018-03-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710980831.3A Pending CN107753534A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of angelica extract enteric-coated micro-pill |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
-
2017
- 2017-10-20 CN CN201710980831.3A patent/CN107753534A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
Non-Patent Citations (5)
| Title |
|---|
| 常增荣等: "中药提取物中的大孔吸附树脂残留物限量检查研究", 《中国中药杂志》 * |
| 张东方等: "《中药现代分离技术》", 31 May 2006, 辽宁大学出版社 * |
| 梁生旺: "《中药制剂分析》", 30 April 2013, 中国中医药出版社 * |
| 谢秀琼: "《现代中药制剂新技术》", 30 April 2004, 化学工业出版社 * |
| 陈平: "《制药工艺学》", 31 March 2008, 湖北科学技术出版社 * |
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Application publication date: 20180306 |
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