CN107595917A - A kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill - Google Patents
A kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill Download PDFInfo
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- CN107595917A CN107595917A CN201710980815.4A CN201710980815A CN107595917A CN 107595917 A CN107595917 A CN 107595917A CN 201710980815 A CN201710980815 A CN 201710980815A CN 107595917 A CN107595917 A CN 107595917A
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- macroreticular resin
- pill
- coated micro
- radix aucklandiae
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Abstract
The invention discloses a kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill, mainly extracts the Chinese medicine banksia rose and concentrates, then macroreticular resin is handled.Obtained banksia rose extraction concentrate is well mixed and dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain Radix Aucklandiae extract enteric-coated micro-pill.Radix Aucklandiae extract enteric-coated micro-pill prepared by the present invention, the loss of the volatile ingredient of the banksia rose can be avoided, add concentration of its active ingredient in enteron aisle, simultaneously, moreover it is possible to covered its bad smell, improve the Compliance of patient.This law prepares Radix Aucklandiae extract enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, especially belongs to Chinese medicine
Enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, have influence on appetite of patient etc..Some medicines due to containing bad odor,
So that the Compliance of patient declines.In addition, the hydrochloric acid in gastric juice also usually can play destruction to the active ingredient of medicine
Effect, the effect of so as to have influence on medicine.Enteron aisle is the main portions of drug absorption.During enteric infection, it is especially desirable to have enough
The medicine of concentration or middle the effective elements of the medicine act on focus part, both improve curative effect, reduce the generation of side effect, also drop
The low dosage of medicine.The property of medicine is cold and cool, or irritant to upper digestive tract, or has the Chinese medicine of bad smell and volatile component,
It is suitable for being prepared into enteric coated preparations.The banksia rose with special smell, many patients due to being difficult to receive.Meanwhile banksia rose smell
Volatilization, also results in the reduction of active ingredient, so as to cause the decline of curative effect.Therefore, banksia rose enteric-coated micro-pill will be by clinic
Doctor and the favor of patient.
The content of the invention
Of the invention " a kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill ", it is characterised in that first by macroreticular resin according to
Laxative remedy is handled：Macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 hours,
Change a water within every 2 ~ 4 hours, the macroreticular resin to drain away the water is added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in
Soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put into rotary evaporation in vacuo and dried
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, crosses 60 ~ 80 mesh sieves and go carefully
Powder, the macroreticular resin particle after being handled.Meanwhile pour into banksia rose medicine materical crude slice in the water of 5 ~ 10 times of amounts, decoct extraction twice, often
Secondary to decoct 1 ~ 1.5 hour, filtering, merging filtrate, it is 1.05 ~ 1.10 that 55 ~ 80 DEG C, which are concentrated under reduced pressure into relative density, and this banksia rose is dense
1 ~ 3 part of contracting liquid, it is well mixed with 7 ~ 9 parts of macroreticular resin after processing, is dried under reduced pressure 8 ~ 24 hours, is contained then at 50 ~ 80 DEG C
The medicine macroreticular resin ball heart.It is the drug containing macroreticular resin ball heart that the drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
The acrylic resin II of weight 3% ~ 10%, continues to be drying to obtain finished product.
The banksia rose has the effect of promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.Product Radix Aucklandiae extract enteric-coated micro-pill of the present invention, the banksia rose is carried
Concentrate absorption is taken to be prepared into the pastille micropill ball heart, then superscribe enteric coating so that wood on macroreticular resin after treatment
Fragrant smell is blanked, and the Compliance of patient is greatly improved, and volatile ingredient is more stable, active ingredient it is dense
Degree substantially increases in enteron aisle, and curative effect will be lifted.
Embodiment
Embodiment 1
Macroreticular resin is added in the deionized water of 5 times of weight, in 50 DEG C of heat-insulation soakings 12 hours, change within every 2 hours a water, will
The macroreticular resin to drain away the water adds 60% edible alcohol of 5 times of weight, and in soaking at room temperature 2 times, immersion 2 hours every time will be through
Macroreticular resin after alcohol-pickled processing is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber
It is dried under reduced pressure in 55 DEG C 6 hours, crosses 60 mesh sieves and remove fine powder, the macroreticular resin particle after being handled.Meanwhile banksia rose medicine materical crude slice is fallen
In the water for entering 8 times of amounts, extraction being decocted twice, being decocted 1 hour every time, filtering, merging filtrate, 55 DEG C are concentrated under reduced pressure into relative density
For 1.05, by 1 part of this banksia rose concentrate, it is well mixed, is dried under reduced pressure then at 60 DEG C 8 hours with 9 parts of macroreticular resin after processing,
Obtain the drug containing macroreticular resin ball heart.It is drug containing macropore tree that the drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
The acrylic resin II of fat ball heart weight 3%, continues to be drying to obtain finished product.
Embodiment 2
Macroreticular resin is added in the deionized water of 10 times of weight, in 60 DEG C of heat-insulation soakings 24 hours, changes a water within every 4 hours,
The macroreticular resin to drain away the water is added to 80% edible alcohol of 10 times of weight, in soaking at room temperature 3 times, immersion 4 hours every time,
Macroreticular resin after alcohol-pickled processing is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred to vacuum drying
It is dried under reduced pressure 8 hours in 60 DEG C in case, crosses 80 mesh sieves and remove fine powder, the macroreticular resin particle after being handled.Meanwhile the banksia rose is drunk
Piece is poured into the water of 10 times of amounts, decocts extraction twice, is decocted 1.5 hours every time, and filtering, merging filtrate, 80 DEG C are concentrated under reduced pressure into
Relative density is 1.10, and 3 parts of this banksia rose concentrate is well mixed with 7 parts of macroreticular resin after processing, dry then at 80 DEG C of decompressions
Dry 24 hours, obtain the drug containing macroreticular resin ball heart.The drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating is
The acrylic resin II of drug containing macroreticular resin ball heart weight 5%, continues to be drying to obtain finished product.
Claims (3)
- A kind of 1. preparation technology of Radix Aucklandiae extract enteric-coated micro-pill, it is characterised in that：Banksia rose medicine materical crude slice is poured into the water of 5 ~ 10 times of amounts In, decoct extraction twice, decoct 1 ~ 1.5 hour every time, filtering, merging filtrate, 55 ~ 80 DEG C are concentrated under reduced pressure into relative density and are 1.05 ~ 1.10,1 ~ 3 part of this banksia rose concentrate is well mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C of decompressions Dry 8 ~ 24 hours, obtain the drug containing macroreticular resin ball heart.
- A kind of 2. preparation technology of Radix Aucklandiae extract enteric-coated micro-pill according to claim 1, it is characterised in that：Described place The processing mode of macroreticular resin after reason is added macroreticular resin in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of insulations Immersion 12 ~ 24 hours, change a water within every 2 ~ 4 hours, by the macroreticular resin to drain away the water add 5 ~ 10 times of weight 60% ~ 80% edible alcohol, in soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put very In empty rotary evaporation drier after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, mistake 60 ~ 80 mesh sieves remove fine powder, the macroreticular resin particle after being handled.
- A kind of 3. preparation technology of Radix Aucklandiae extract enteric-coated micro-pill according to claim 1, it is characterised in that：Will by right Seek the drug containing macroreticular resin ball heart in 1, with fluidized bed coating, wrap clothing layer weight for drug containing macroreticular resin ball heart weight 3% ~ 10% acrylic resin II, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980815.4A CN107595917A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980815.4A CN107595917A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107595917A true CN107595917A (en) | 2018-01-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710980815.4A Pending CN107595917A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Radix Aucklandiae extract enteric-coated micro-pill |
Country Status (1)
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
-
2017
- 2017-10-20 CN CN201710980815.4A patent/CN107595917A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
Non-Patent Citations (5)
| Title |
|---|
| 常增荣等: "中药提取物中的大孔吸附树脂残留物限量检查研究", 《中国中药杂志》 * |
| 张东方等: "《中药现代分离技术》", 31 May 2006, 辽宁大学出版社 * |
| 梁生旺: "《中药制剂分析》", 30 April 2013, 中国中医药出版社 * |
| 谢秀琼: "《现代中药制剂新技术》", 30 April 2004, 化学工业出版社 * |
| 陈平: "《制药工艺学》", 31 March 2008, 湖北科学技术出版社 * |
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Application publication date: 20180119 |