CN107595904A - A kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill - Google Patents
A kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill Download PDFInfo
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- CN107595904A CN107595904A CN201710980825.8A CN201710980825A CN107595904A CN 107595904 A CN107595904 A CN 107595904A CN 201710980825 A CN201710980825 A CN 201710980825A CN 107595904 A CN107595904 A CN 107595904A
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- macroreticular resin
- enteric
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Abstract
The invention discloses a kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill, mainly extracts Chinese medicine Herba Andrographitis and concentrates, then macroreticular resin is handled.Obtained Herba Andrographitis extraction concentrate is well mixed and dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain Andrographis Paniculata enteric-coated micro-pill.Andrographis Paniculata enteric-coated micro-pill prepared by the present invention, can avoid the cold and cool injury to stomach Qi of Herba Andrographitis, while add concentration of its active ingredient in enteron aisle.This law prepares enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, in especially belonging to
Medicine enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, have influence on appetite of patient etc..Especially in the property of medicine bitter cold such as Herba Andrographitis
Medicine, long term usage injure one's stomach gas, influence spleen and stomach function, the healthy tendency of people is come to harm.In addition, the hydrochloric acid in gastric juice also usually can be to medicine
The active ingredient of thing plays a part of destruction, the effect of so as to have influence on medicine.Enteron aisle is the main portions of drug absorption.Enteron aisle
During infection, it is especially desirable to there is sufficient concentrations of medicine or middle the effective elements of the medicine to act on focus part, both improve curative effect, subtract
Lack the generation of side effect, also reduce the dosage of medicine.Therefore, herbal nature bitter cold and to upper digestive tract medicine excitatory
Thing, it is especially suitable for being prepared into enteric coated preparations.When particularly the lower digestive tract such as treatment diarrhoea infects, enteric coated preparations can play preferably
Curative effect.
The content of the invention
" a kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill " of the invention, it is characterised in that first press macroreticular resin
Handled according to laxative remedy：Macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, it is small in 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24
When, change a water within every 2 ~ 4 hours, the macroreticular resin to drain away the water added to 60% ~ 80% edible alcohol of 5 ~ 10 times of weight,
In soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put into rotary evaporation in vacuo and done
In dry device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, crosses 60 ~ 80 mesh sieves and go carefully
Powder, the macroreticular resin particle after being handled.Meanwhile pour into Herba Andrographitis medicine materical crude slice in the water of 5 ~ 10 times of amounts, decoct extraction twice,
Decoct 1 ~ 1.5 hour every time, filtering, merging filtrate, it is 1.05 ~ 1.10 that 55 ~ 80 DEG C, which are concentrated under reduced pressure into relative density, by this punching
1 ~ 3 part of lotus concentrate, it is well mixed with 7 ~ 9 parts of macroreticular resin after processing, is dried under reduced pressure 8 ~ 24 hours, obtains then at 50 ~ 80 DEG C
To the drug containing macroreticular resin ball heart.It is drug containing macroreticular resin that the drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
The acrylic resin II of ball heart weight 3% ~ 10%, continues to be drying to obtain finished product.
Herba Andrographitis have clearing heat and detoxicating, anti-inflammatory, analgesic and it is antitumor the effect of.Product Andrographis Paniculata enteric of the present invention
Micropill, by Herba Andrographitis extraction concentrate absorption on macroreticular resin after treatment, the pastille micropill ball heart is prepared into, then wrap up
Upper enteric coating so that the smell of Herba Andrographitis is blanked, and the Compliance of patient is greatly improved, and volatile ingredient is more
Stable, the concentration of active ingredient substantially increases in enteron aisle, and curative effect is lifted.
Embodiment
Embodiment 1
Macroreticular resin is added in the deionized water of 5 times of weight, in 50 DEG C of heat-insulation soakings 12 hours, change within every 2 hours a water, will
The macroreticular resin to drain away the water adds 60% edible alcohol of 5 times of weight, and in soaking at room temperature 2 times, immersion 2 hours every time will be through
Macroreticular resin after alcohol-pickled processing is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber
It is dried under reduced pressure in 55 DEG C 6 hours, crosses 60 mesh sieves and remove fine powder, the macroreticular resin particle after being handled.Meanwhile by Herba Andrographitis medicine materical crude slice
Pour into 8 times amount water in, decoct extraction twice, every time decoct 1 hour, filtering, merging filtrate, 55 DEG C be concentrated under reduced pressure into it is relatively close
Spend the concentrate for 1.05.By 1 part of this Herba Andrographitis concentrate, it is well mixed with 9 parts of macroreticular resin after processing, subtracts then at 60 DEG C
Press dry dry 8 hours, obtain the drug containing macroreticular resin ball heart.The drug containing macroreticular resin ball heart is wrapped into clothing layer weight with fluidized bed coating
For the acrylic resin II of drug containing macroreticular resin ball heart weight 3%, continue to be drying to obtain finished product.
Embodiment 2
Macroreticular resin is handled according to laxative remedy first：Macroreticular resin is added in the deionized water of 10 times of weight, in 60 DEG C
Heat-insulation soaking 24 hours, change a water within every 4 hours, the macroreticular resin to drain away the water is added to 80% edible wine of 10 times of weight
Essence, in soaking at room temperature 3 times, immersion 4 hours, put rotary evaporation in vacuo by the macroreticular resin after alcohol-pickled processing and dry every time
In device after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 8 hours in 60 DEG C, crosses 80 mesh sieves and remove fine powder, obtain everywhere
Macroreticular resin particle after reason.Meanwhile pour into Herba Andrographitis medicine materical crude slice in the water of 10 times of amounts, decoct extraction twice, decoct 1.5 every time
Hour, filtering, merging filtrate, 80 DEG C are concentrated under reduced pressure into the concentrate that relative density is 1.10.By 3 parts of this Herba Andrographitis concentrate,
It is well mixed, is dried under reduced pressure then at 80 DEG C 24 hours with 7 parts of macroreticular resin after processing, obtains the drug containing macroreticular resin ball heart.Will
The drug containing macroreticular resin ball heart wraps the acrylic acid tree that clothing layer weight is drug containing macroreticular resin ball heart weight 5% with fluidized bed coating
Fat II, continue to be drying to obtain finished product.
Claims (3)
- A kind of 1. preparation technology of Andrographis Paniculata enteric-coated micro-pill, it is characterised in that：Herba Andrographitis medicine materical crude slice is poured into 5 ~ 10 times of weights Extraction is decocted in the water of amount twice, 1 ~ 1.5 hour every time, is filtered while hot, merges filtrate twice, being concentrated under reduced pressure into relative density is 1.05 ~ 1.10 concentrate, 1 ~ 3 part of this Herba Andrographitis concentrate is well mixed with 7 ~ 9 parts of macroreticular resin after processing, then at 50 ~ 80 DEG C are dried under reduced pressure 8 ~ 24 hours, obtain the drug containing macroreticular resin ball heart.
- A kind of 2. preparation technology of Andrographis Paniculata enteric-coated micro-pill according to claim 1, it is characterised in that：Described The processing mode of macroreticular resin after processing is added macroreticular resin in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60 DEG C of guarantors Temperature immersion 12 ~ 24 hours, change a water within every 2 ~ 4 hours, by the macroreticular resin to drain away the water add 5 ~ 10 times of weight 60% ~ 80% edible alcohol, in soaking at room temperature 2 ~ 3 times, soak 2 ~ 4 hours every time, the macroreticular resin after alcohol-pickled processing is put very In empty rotary evaporation drier after recovered alcohol, it is then transferred in vacuum drying chamber and is dried under reduced pressure 4 ~ 8 hours in 50 ~ 60 DEG C, mistake 60 ~ 80 mesh sieves remove fine powder, the macroreticular resin particle after being handled.
- A kind of 3. preparation technology of Andrographis Paniculata enteric-coated micro-pill according to claim 1, it is characterised in that：By right It is required that the drug containing macroreticular resin ball heart in 1 with fluidized bed coating wrap clothing layer weight be drug containing macroreticular resin ball heart weight 3% ~ 10% acrylic resin II, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980825.8A CN107595904A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980825.8A CN107595904A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill |
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| Publication Number | Publication Date |
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| CN107595904A true CN107595904A (en) | 2018-01-19 |
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| CN201710980825.8A Pending CN107595904A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation technology of Andrographis Paniculata enteric-coated micro-pill |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
-
2017
- 2017-10-20 CN CN201710980825.8A patent/CN107595904A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180119 |