CN108042636A - A kind of preparation process of phellodendron extract enteric-coated micro-pill - Google Patents
A kind of preparation process of phellodendron extract enteric-coated micro-pill Download PDFInfo
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- CN108042636A CN108042636A CN201710980834.7A CN201710980834A CN108042636A CN 108042636 A CN108042636 A CN 108042636A CN 201710980834 A CN201710980834 A CN 201710980834A CN 108042636 A CN108042636 A CN 108042636A
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- Prior art keywords
- pill
- macroreticular resin
- coated micro
- enteric
- filtrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation processes of phellodendron extract enteric-coated micro-pill, mainly extract Chinese Medicine Cortex Phellodendri and concentrate, then macroreticular resin is handled.Cortex Phellodendri obtained extraction concentrate is uniformly mixed and is dried with macroreticular resin, obtains the ball heart of enteric-coated micro-pill.This ball heart is subjected to fluidized bed coating, then row drying with acrylic resin, you can obtain phellodendron extract enteric-coated micro-pill.Phellodendron extract enteric-coated micro-pill prepared by the present invention, can be to avoid injury of the bitter cold to stomach Qi of Cortex Phellodendri, while adds concentration of its active ingredient in enteron aisle.This law prepares enteric-coated micro-pill concise in technology, has very big economic value.
Description
Technical field
" a kind of preparation process of phellodendron extract enteric-coated micro-pill " of the invention belongs to field of traditional Chinese, especially belongs to Chinese medicine
Enteric coated pellets formulation field.
Background technology
Traditional oral preparation of Chinese traditional medicinal, such as pill, powder, granule, tablet, capsule and liquid preparation, exist mostly
Disintegration in the stomach or dissolving, it is irritant to gastric mucosa, influence appetite of patient etc..Especially the pharmacological properties such as Cortex Phellodendri it is cold and cool in
Medicine, long term usage injure one's stomach gas, influence spleen and stomach function, the healthy tendency of people is made to come to harm.In addition, the hydrochloric acid in gastric juice also usually can be to medicine
The active ingredient of object plays the role of destruction, the effect of so as to influence drug.Enteron aisle is the main portions of drug absorption.Enteron aisle
During infection, it is especially desirable to there is sufficient concentrations of drug or middle the effective elements of the medicine to act on lesion part, both improve curative effect, subtract
Lack the generation of side effect, also reduce the dosage of drug.Therefore, herbal nature is cold and cool and to upper digestive tract medicine excitatory
Object is very suitable for being prepared into enteric coated preparations.Diarrhea is particularly treated when lower digestive tracts infect, enteric coated preparations can play preferably
Curative effect.
The content of the invention
" a kind of preparation process of phellodendron extract enteric-coated micro-pill " of the invention, it is characterised in that：Cortex Phellodendri medicine materical crude slice is poured into 5 ~
In the boiling water of 10 times of weight, boiling 5 ~ 15 minutes is kept, is kept the temperature filter with 200 ~ 300 mesh screens while hot, gained filtrate 1 is spare.
The water that the obtained dregs of a decoction add 5 ~ 10 times of weight decocts twice, and boiling 30 ~ 60 minutes is kept after boiling every time, is filtered while hot,
Respectively obtain filtrate 2 and filtrate 3.Merging filtrate 1, filtrate 2 and filtrate 3, by this, 60 ~ 75 DEG C of filtrate is concentrated under reduced pressure into relatively three times
Density is 1.05 ~ 1.10 concentrate.On the other hand, macroreticular resin is added in the deionized water of 5 ~ 10 times of weight, in 50 ~ 60
When DEG C heat-insulation soaking 12 ~ 24 is small, constantly stir, it is every 2 ~ 4 it is small when change a water.It is big by what is drained away the water after last time changes water
Hole resin is added in 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in soaking at room temperature 2 ~ 3 times, impregnate every time 2 ~ 4 it is small when.
Macroreticular resin after alcohol immersion treatment is put into recovered alcohol in rotary evaporation in vacuo drier, then the big of alcohol will have been recycled
Hole resin be transferred in vacuum drying chamber in 50 ~ 80 DEG C be dried under reduced pressure 4 ~ 8 it is small when, cross 40 ~ 80 mesh sieves, remove fine powder, obtain through place
Macroreticular resin particle after reason.Using this macroreticular resin as the ball heart of enteric-coated micro-pill, by foregoing Cortex Phellodendri extraction concentrate by weight
1 ~ 3 part is taken, is sufficiently mixed uniformly by weight 7 ~ 9 parts with the macroreticular resin after aforementioned processing, 50 ~ 60 DEG C are dried under reduced pressure 8 ~ 24
Hour, obtain drug containing macroreticular resin.Using this drug containing macroreticular resin as the ball heart of enteric-coated micro-pill, wrapped and contained with fluidized bed coating
The acrylic resin II of medicine macroreticular resin ball heart weight 3% ~ 10%, is drying to obtain finished product.
Cortex Phellodendri plays the role of spectrum antibacterial, anti-inflammatory etc..Its pharmacological property very bitter cold, it is oral to have injury to spleen and stomach function,
The compliance of medication is bad.Classical TCM medicine document is recorded, and Cortex Phellodendri can descend clearly the heat of coke.Enteric-coated micro-pill is prepared into, makes it
Only be just disintegrated, discharge under the pH environment of enteron aisle, solve its bitter cold injure one's stomach gas the drawbacks of, reduce its bitter taste to oral mucosa
Sense of discomfort, meanwhile, also improve the concentration that its active ingredient is acted on and absorbed at enteron aisle position, add the heat of its clear lower coke
Function.
Specific embodiment
Facility example 1
Cortex Phellodendri medicine materical crude slice is poured into the boiling water of 8 times of weight, keep boiling 10 minutes, kept the temperature filter with 200 mesh screens while hot, gained
Filtrate is spare.The water that the dregs of a decoction add 5 times of weight decocts twice, and boiling 60 minutes is kept after boiling every time, is filtered while hot.Merge
Filtrate three times is concentrated under reduced pressure into the concentrate that relative density is 1.05.On the other hand, macroreticular resin is added in into 8 times of weight
Deionized water in, when 50 DEG C of heat-insulation soakings 12 are small, constantly stir, it is every 2 it is small when change a water.The macropore tree that will be drained away the water
Fat adds 60% edible alcohol of 5 times of weight, in soaking at room temperature 2 times, impregnate every time 2 it is small when.It will be after alcohol immersion treatment
Macroreticular resin put in rotary evaporation in vacuo drier after recovered alcohol, be then transferred in vacuum drying chamber and be dried under reduced pressure in 50 DEG C
6 it is small when, cross 60 mesh sieves and remove fine powder, the macroreticular resin particle that obtains that treated.Foregoing Cortex Phellodendri is extracted into 2 parts of concentrate, with place
8 parts of macroreticular resin particle after reason is sufficiently mixed uniformly, 55 DEG C be dried under reduced pressure 12 it is small when, obtain the drug containing macroreticular resin ball heart.It will
This drug containing macroreticular resin ball heart wraps the acrylic resin II of the heart of ball containing medicated resin weight 3% ~ 10% with fluidized bed coating, dry
It gets product.
Facility example 2
Cortex Phellodendri medicine materical crude slice is poured into the boiling water of 10 times of weight, keep boiling 30 minutes, kept the temperature filter with 300 mesh screens while hot, institute
It is spare to obtain filtrate.The water that the dregs of a decoction add 8 times of weight decocts twice, and boiling 30 minutes is kept after boiling every time, is filtered while hot.It closes
And filtrate three times, it is concentrated under reduced pressure into the concentrate that relative density is 1.10.On the other hand, macroreticular resin is added in into 10 times of weights
In the deionized water of amount, when 60 DEG C of heat-insulation soakings 24 are small, constantly stir, it is every 4 it is small when change a water.The macropore that will be drained away the water
Resin adds 80% edible alcohol of 8 times of weight, in soaking at room temperature 3 times, impregnate every time 4 it is small when.It will be through alcohol immersion treatment
Macroreticular resin afterwards is put in rotary evaporation in vacuo drier after recovered alcohol, is then transferred in vacuum drying chamber dry in 60 DEG C of decompressions
It is dry 8 it is small when, cross 80 mesh sieves and remove fine powder, the macroreticular resin particle that obtains that treated.Foregoing Cortex Phellodendri is extracted into 3 parts of concentrate, with
Treated, and 7 parts of macroreticular resin particle is sufficiently mixed uniformly, 55 DEG C be dried under reduced pressure 24 it is small when, obtain the drug containing macroreticular resin ball heart.
This drug containing macroreticular resin ball heart with fluidized bed coating is wrapped to the acrylic resin II of the heart of ball containing medicated resin weight 3% ~ 10%, is done
It is dry to get product.
Claims (3)
1. a kind of preparation process of phellodendron extract enteric-coated micro-pill, it is characterised in that：Cortex Phellodendri medicine materical crude slice is poured into 5 ~ 10 times of weight
In boiling water, boiling 5 ~ 15 minutes is kept, is kept the temperature filter with 200 ~ 300 mesh screens while hot, gained filtrate 1 is spare；The dregs of a decoction add 5
The water of ~ 10 times of weight decocts twice, and boiling 30 ~ 60 minutes is kept after boiling every time, is filtered while hot, respectively obtains filtrate 2 and filter
Liquid 3；Merging filtrate 1, filtrate 2 and filtrate 3, by this, filtrate decompression is concentrated into the concentrate that relative density is 1.05 ~ 1.10 three times.
2. a kind of preparation process of phellodendron extract enteric-coated micro-pill according to claim 1, it is characterised in that：By macropore tree
Fat add in 5 ~ 10 times of weight deionized water in, when 50 ~ 60 DEG C of heat-insulation soakings 12 ~ 24 are small, it is every 2 ~ 4 it is small when change a water, will
The macroreticular resin to drain away the water adds 60% ~ 80% edible alcohol of 5 ~ 10 times of weight, in soaking at room temperature 2 ~ 3 times, soaks every time
When bubble 2 ~ 4 is small, the macroreticular resin after alcohol immersion treatment is put in rotary evaporation in vacuo drier after recovered alcohol, is retransferred
Into vacuum drying chamber in 50 ~ 60 DEG C be dried under reduced pressure 4 ~ 8 it is small when, cross 60 ~ 80 mesh sieves and remove fine powder, the macroreticular resin that obtains that treated
Particle.
3. a kind of preparation process of phellodendron extract enteric-coated micro-pill according to claim 1, it is characterised in that：It will by right
The Cortex Phellodendri in 1 is asked to extract 1 ~ 3 part of concentrate, is sufficiently mixed uniformly with 7 ~ 9 parts of macroreticular resin in claim 2 after processing,
50 ~ 60 DEG C be dried under reduced pressure 8 ~ 24 it is small when, the drug containing macroreticular resin ball heart is obtained, by this drug containing macroreticular resin ball heart fluidized bed coating
Method wraps the acrylic resin II of drug containing macroreticular resin ball heart weight 3% ~ 10%, is drying to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980834.7A CN108042636A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of phellodendron extract enteric-coated micro-pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710980834.7A CN108042636A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of phellodendron extract enteric-coated micro-pill |
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| Publication Number | Publication Date |
|---|---|
| CN108042636A true CN108042636A (en) | 2018-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710980834.7A Pending CN108042636A (en) | 2017-10-20 | 2017-10-20 | A kind of preparation process of phellodendron extract enteric-coated micro-pill |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
-
2017
- 2017-10-20 CN CN201710980834.7A patent/CN108042636A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813899A (en) * | 2005-12-02 | 2006-08-09 | 王衡新 | Anti cancer Chinese medicine for mulation and its preparing method |
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102133256A (en) * | 2010-03-09 | 2011-07-27 | 成都中医药大学 | Rhodiola crenulata extract and preparation method thereof |
| CN107158063A (en) * | 2017-05-11 | 2017-09-15 | 临沂大学 | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof |
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Application publication date: 20180518 |