CN104906326B - A kind of gastrin magnesium granules and preparation method thereof - Google Patents
A kind of gastrin magnesium granules and preparation method thereof Download PDFInfo
- Publication number
- CN104906326B CN104906326B CN201510315118.8A CN201510315118A CN104906326B CN 104906326 B CN104906326 B CN 104906326B CN 201510315118 A CN201510315118 A CN 201510315118A CN 104906326 B CN104906326 B CN 104906326B
- Authority
- CN
- China
- Prior art keywords
- grass
- leaved sweetflag
- gastrin
- weight portion
- volatile oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to pharmaceutical technology field, specifically, relate to a kind of gastrin magnesium granules and preparation method thereof. Described gastrin magnesium granules is the granule that adds pharmaceutic adjuvant to be prepared from by after main ingredient bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, Frangula, fennel, aloe and grass-leaved sweetflag combination, wherein, the volatile oil that grass-leaved sweetflag is extracted carries out inclusion by starch Sodium Octenyl Succinate and obtains inclusion compound, then with other combination of components. The volatile oil in the present invention, grass-leaved sweetflag being extracted carries out inclusion by starch Sodium Octenyl Succinate, thereby makes the volatile ingredient of grass-leaved sweetflag in gastrin magnesium granules not volatile, and its volatile oil utilization rate is higher, is better than the beta-schardinger dextrin-method of prior art; And the curative effect that adopts the gastrin magnesium granules that makes of the method is better than the gastrin magnesium granules that the grass-leaved sweetflag cyclodextrin inclusion compound of prior art makes.
Description
Technical field
The invention belongs to pharmaceutical technology field, specifically, relate to a kind of gastrin magnesium granules and preparation method thereof.
Background technology
Stomach trouble is the common frdquently encountered disease of serious harm human health, generally refers to gastritis and gastric and duodenal ulcer disease,Its symptom initial or slight outbreak be epigastric discomfort, glutted, heartburn, retch, feel sick etc. Many reasons can cause stomachDisease, as diet, environment, heredity, medicine, bacterium and chemicals damage, smoking etc. can become the cause of disease of stomach trouble, consequentlyCause gastroxia and mucosal lesion to increase the weight of. The medicine of therefore treating stomach trouble can be divided into two classes, a class for neutralization orWeaken the medicine of hydrochloric acid in gastric juice and press down sour medicine H2Receptor antagonist; One class is the medicine that increases stomach lining defence capability.
Application number is that the patent documentation of CN03157561.7 and CN200510132701.1 discloses a kind of stomach trouble for the treatment ofPharmaceutical composition, component is bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, Frangula, fennel powder, aloePowder is or/and grass-leaved sweetflag is called Weibimei medicical composition for treating stomach disease. The bismuth aluminate wherein containing can form on stomach and DMLayer protecting film, thus mucosa regeneration and the normal healing that accelerates ulcer promoted; Sodium acid carbonate and heavy magnesium carbonate are as antiacidMedicine can neutralize part hydrochloric acid in gastric juice, thereby prevents hydrochloric acid in gastric juice and the erosion damage of pepsin to stomach lining; Radix Glycyrrhizae extractum powder contains celery sugarThe active ingredients such as liquiritin, have antiulcer action, can dissolve gastrointestinal smooth muscle spasmus; Fennel contains a certain amount of volatilizationOil, has eliminating cold to stop pain, regulating qi-flowing for harmonizing stomach effect, has the stomach and intestine of adjusting function, antiulcer, the effect of promotion choleresis; Not bright mouseLee's skin has the therapeutic action that promotes tissue repair; Grass-leaved sweetflag contains the volatile oil such as asarone, has dampness elimination appetizing, promoting the circulation of qi de-swelling workWith, can promote digestive juice secretion, prevent stomach and intestine abnormal fermentation, and can alleviate intestinal tube smooth muscle spasm; The aloe that aloe containsPolysaccharide has good anti-gastric injury effect, anti-ulcer effect.
Stomach bismuth magnesium is the Chinese and Western medicine mixture for the treatment of stomach trouble, and Western medicine takes stopgap measures, and Chinese medicine effects a permanent cure. Granule is the head of its treatment stomach troubleSelect formulation. But find in clinical practice, the aloe containing in prescription, has off-odor, taste is extremely bitter; In grass-leaved sweetflag, containVolatile oil has special peculiar smell, makes the gastrin magnesium granules finally obtaining in the time that patient takes, and mouthfeel is very bad, patient'sCompliance is very poor, and volatile oil is one of middle the effective elements of the medicine, but its poorly water-soluble, and character is unstable, in preparation easilyVolatilization oxidation, causes curative effect of medication to decline, thereby has greatly affected the curative effect of medicine.
For overcoming above-mentioned defect, CN200610086980.7 discloses a kind of gastrin magnesium granules and preparation method thereof. It isEssential Oil of Acorus tatarinowii in granule is carried out to inclusion with beta-schardinger dextrin-, and pharmaceutic adjuvant adopts honey element and flavoring orange essence, andMake, through what preferably obtain, to remove the specific peculiar smell of volatile oil, and to strengthen the stability of volatile oil, make granule taste moreWell, patient's compliance is better.
But the space structure of beta-schardinger dextrin-is fixed, thereby the fuel load of its inclusion complex is lower, generally at 10-16%; And because beta-schardinger dextrin-solubility in normal-temperature water is lower. Thereby, in the time of inclusion, generally all to remain on higher temperaturesUnder degree (60 DEG C of left and right), make it dissolve, the preparation method of grass-leaved sweetflag inclusion compound as disclosed in CN200610086980.7 is: by stoneCalamus volatile oil dilutes with appropriate ethanol, obtains volatile oil dilution; The beta-schardinger dextrin-of 14 times of amounts of volatile oil is joined to equal-volume70-80 DEG C of hot water in, in mortar, grind evenly; Grinding ring dextrin solution limit, limit splashes into volatile oil dilution gradually, and grindsGrind 1 hour, obtain liquid grass-leaved sweetflag inclusion compound; 40-50 DEG C dry, pulverize, and crosses 100 mesh sieves, obtains grass-leaved sweetflag inclusion compound. ThisSample, volatile oil easily volatilizees, and inclusion complex surface oil is also higher; Thereby the utilization rate of volatile oil is declined.
In view of this, special proposition the present invention.
Summary of the invention
The object of the present invention is to provide a kind of gastrin magnesium granules, in this gastrin magnesium granules, volatile ingredient is not volatile,Volatile oil utilization rate is high.
For realizing object of the present invention, the present invention adopts following technical scheme:
A kind of gastrin magnesium granules, by main ingredient bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, buckthornThe granule that adds pharmaceutic adjuvant to be prepared from after skin, fennel, aloe and grass-leaved sweetflag combination, is characterized in that, grass-leaved sweetflag is carriedThe volatile oil of getting carries out inclusion by starch Sodium Octenyl Succinate and obtains inclusion compound, then with other combination of components.
The irritant smell of volatile oil that in gastrin magnesium granules, grass-leaved sweetflag contains, poorly water-soluble, volatile in preparation, propertyMatter is unstable, thereby causes curative effect of medication to decline. Prior art adopts beta-schardinger dextrin-to comprise mostly. But, beta-schardinger dextrin-Space structure fix, thereby the fuel load of its inclusion complex is lower, generally at 10-16%; And because beta-schardinger dextrin-existsIn normal-temperature water, solubility is lower. Thereby, in the time of inclusion, generally all to remain under higher temperature (60 DEG C of left and right) it is dissolved,The preparation method of grass-leaved sweetflag inclusion compound as disclosed in CN200610086980.7 is: Essential Oil of Acorus tatarinowii is rare with appropriate ethanolRelease, obtain volatile oil dilution; The beta-schardinger dextrin-of 14 times of amounts of volatile oil is joined in isopyknic 70-80 DEG C hot water, at mortarMiddle grinding is even; Grinding ring dextrin solution limit, limit splashes into volatile oil dilution gradually, and grinds 1 hour, obtains liquid grass-leaved sweetflagInclusion compound; 40-50 DEG C dry, pulverize, and crosses 100 mesh sieves, obtains grass-leaved sweetflag inclusion compound. Like this, volatile oil easily volatilizees, inclusion complexSurface oil is also higher; Thereby the utilization rate of volatile oil is declined.
The present invention is carrying out after a large amount of tests, adopts starch Sodium Octenyl Succinate to carry out inclusion to grass-leaved sweetflag, andFind to adopt starch Sodium Octenyl Succinate legal system for grass-leaved sweetflag inclusion compound, its volatile oil utilization rate is higher, is better than pleasantly surprisedlyThe beta-schardinger dextrin-method of prior art; And adopt the standby grass-leaved sweetflag inclusion compound system of starch Sodium Octenyl Succinate legal system of the present inventionGastrin magnesium granules, its curative effect is better than the gastrin magnesium granules that the grass-leaved sweetflag cyclodextrin inclusion compound of prior art makes.
The volume ratio of the volatile oil that further, the consumption of described starch Sodium Octenyl Succinate and grass-leaved sweetflag extract is10～15g：1ml。
Specifically, described inclusion compound is adopted with the following method and is prepared:
Get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature, obtain slurries; Under agitation, to instituteThe volatile oil that adds grass-leaved sweetflag to extract in the slurries that obtain, makes colostrum; Colostrum is carried out to homogeneous processing and obtain volatile oil emulsion; AgainBy the inclusion compound described in dry the obtaining of volatile oil emulsion spraying of gained.
In said method, described homogeneous is homogeneous twice, first class pressure 25～35MPa, secondary pressure 8～12MPa.
Preferably, described first class pressure is 30MPa, and secondary pressure is 10MPa.
Described pharmaceutic adjuvant is sucrose.
The consumption of described sucrose is 1～3 times of main ingredient weight.
Described main ingredient forms by following proportioning:
Bismuth aluminate 100-250 weight portion, heavy magnesium carbonate 300-500 weight portion, sodium acid carbonate 150-250 weight portion, sweetGrass extract powder 150-300 weight portion, Frangula 5-30 weight portion, fennel powder 5-30 weight portion, aloe powder 10-30 weightPart, grass-leaved sweetflag 5-50 weight portion.
Preferably, described main ingredient forms by following proportioning:
Bismuth aluminate 180-220 weight portion, heavy magnesium carbonate 350-450 weight portion, sodium acid carbonate 200-250 weight portion, sweetGrass extract powder 200-300 weight portion, Frangula 10-20 weight portion, fennel powder 10-20 weight portion, aloe powder 20-30 weightPart, grass-leaved sweetflag 10-30 weight portion.
More preferably, described main ingredient forms by following proportioning:
Bismuth aluminate 200 weight portions, heavy magnesium carbonate 400 weight portions, sodium acid carbonate 250 weight portions, Radix Glycyrrhizae extractum powder 250 weightsAmount part, Frangula 15 weight portions, fennel powder 15 weight portions, aloe powder 30 weight portions, grass-leaved sweetflag 12.5 weight portions.
Bismuth aluminate of the present invention, heavy magnesium carbonate, these several components of sodium acid carbonate all can adopt and meet at present countryThe commercially available prod of the drug standards, or according to the method on pharmacy of Chinese materia medica, raw material disposal is pulverized to products obtained therefrom.
Radix Glycyrrhizae extractum powder of the present invention can be that the extract of licorice root that meets the national drug standards adopts pharmacy of Chinese materia medicaOn method process to pulverize and obtain. As a kind of preferred version, Radix Glycyrrhizae extractum powder of the present invention preferably adopts as belowMethod obtains:
Clean the Radix Glycyrrhizae of recipe quantity medicinal material is put in extractor, soaked 1 hour, heating decocts three times, each 2 hours, adds waterAmount is respectively 7 times, 5 times, 5 times of medicinal material amount, and in leaching process, control jacket steam pressure and must not exceed 0.3Mpa, temperature 95～100 DEG C of micro-boiling, filter, and filtrate leaves standstill 8～12 hours, gets supernatant concentration, and control steam pressure 0.09Mpa is following, an effect temperatureSpend 95 DEG C of following, two effect temperature below 65 DEG C, below vacuum 0.09Mpa, be condensed into relative density 1.10～1.15 (60～65DEG C) medicinal extract; Medicinal extract is dry with spray drier, control 200～220 DEG C of EATs, 90～100 DEG C of leaving air temps,Charging flow velocity 0.5～1L/ minute, to obtain final product.
Buckthorn micromicro of the present invention adopts the commercially available prod that meets at present the national drug standards, or according to Chinese medicineMethod in pharmacy is pulverized raw material disposal to obtain. As a kind of preferred version, Frangula of the present invention isAdopt the Frangula extract powder obtaining with the following method:
Clean the davurian buckthorn bark of recipe quantity medicinal material is put in extractor, soaked 1 hour, heating decocts three times, each 1.5 littleTime, amount of water is respectively 7 times, 5 times, 5 times of medicinal material amount, and in leaching process, control jacket steam pressure and must not exceed 0.3Mpa,95～100 DEG C of micro-boiling of temperature, filter, merging filtrate, and filtrate is concentrated with double-effect evaporation inspissator, controls steam pressure 0.09MpaBelow, 65 DEG C of following, two effect temperature of 95 DEG C of temperature of effect are following, below vacuum 0.09Mpa, be condensed into relative density 1.10～After the medicinal extract of 1.15 (60～65 DEG C), medicinal extract is continued concentratedly, control that steam pressure 0.09Mpa is following, temperature 70 C is following, trueBelow reciprocal of duty cycle 0.08Mpa, turn next procedure after being concentrated into relative density 1.26～1.35 (60～70 DEG C); Davurian buckthorn bark is soakedCream is put in vacuum drier dry, control that steam pressure 0.2Mpa is following, 75 DEG C of temperature are following, below vacuum 0.09Mpa, dryAfter dry, davurian buckthorn bark medicinal extract 100 mesh sieves are pulverized, after pulverizing, obtained Frangula extract powder.
Fennel powder of the present invention is fennel seeds, can adopt the method on pharmacy of Chinese materia medica to process pulverizing gained; AsA kind of preferred version, preferably adopt with the following method and obtain:
Fennel seeds medicinal material after washing is put in vacuum drier and is dried, and control steam pressure 0.2Mpa is following, temperature 50 CBelow, below vacuum 0.09Mpa, with pulverizing mill pulverize, stand-by after the assay was approved.
Aloe powder of the present invention can adopt the commercially available prod that meets at present the national drug standards, or according to Chinese drugs agentiaMethod on is pulverized raw material disposal to obtain. As a kind of preferred version, the present invention preferably adopts with the following method and obtains:
Get aloe medicinal material and put sterilizing in Chinese patent drug sterilizing cabinet, 115 DEG C of temperature, moist heat sterilization 5 minutes, proceeds to vacuum drierIn dry, control that steam pressure 0.2Mpa is following, 75 DEG C of temperature are following, below vacuum 0.09Mpa, dried medicinal material is usedPulverizer is pulverized at the bottom of 100 mesh sieves are installed, stand-by after the assay was approved after pulverizing.
Grass-leaved sweetflag of the present invention is the dry rhizome of acorus gramineus araceae plant, and its volatile oil can adopt water extractionMethod extraction obtains, and specifically, can adopt with the following method and extract and obtain:
Clean the grass-leaved sweetflag of recipe quantity medicinal material is put in extractor, added the water of 4 times of amounts of about medicinal material, soak water 36 hoursSteam distillation method is extracted volatile oil, keeps liquid level boiling, controls below steam pressure 0.3Mpa, collects Essential Oil of Acorus tatarinowii, closeClose, please test, in 2～10 DEG C of refrigerations, for subsequent use after the assay was approved.
The preparation method who the present invention also aims to the gastrin magnesium granules that provides described, described preparation method is:
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, to the volatile oil that adds in the slurries of gained grass-leaved sweetflag to extract, make colostrum; Colostrum is carried out to homogeneous placeReason obtains volatile oil emulsion; Again by the grass-leaved sweetflag inclusion compound described in dry the obtaining of volatile oil emulsion spraying of gained;
Sucrose is pulverized, sieved for subsequent use;
By bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, davurian buckthorn bark, fennel powder, aloe powder, for subsequent useCane sugar powder and grass-leaved sweetflag inclusion compound mix, obtain the material after premix;
Material after premix is made to softwood for 20-30 minute with 75% ethanol mixing, 18 eye mesh screen granulations, control turnsSpeed is 9-12 rev/min, drier under EAT 70-80 DEG C, the temperature 60-70 of fluidising chamber DEG C condition, whole grain, and packing, to obtain final product.
In the present invention, first the volatile oil of grass-leaved sweetflag is adopted starch Sodium Octenyl Succinate to make after grass-leaved sweetflag inclusion compound againMix and make gastrin magnesium granules with other raw material and sucrose, its Essential Oil of Acorus tatarinowii utilization rate is higher, is better than prior artBeta-schardinger dextrin-method, and the curative effect of the gastrin magnesium granules that makes of the method is better than prior art.
Compared with prior art, tool of the present invention has the following advantages:
(1) adopt starch Sodium Octenyl Succinate legal system of the present invention for grass-leaved sweetflag inclusion compound, its volatile oil utilization rate ratioHigher, be better than the beta-schardinger dextrin-method of prior art;
(2) the stomach bismuth magnesium that adopts the standby grass-leaved sweetflag inclusion compound of starch Sodium Octenyl Succinate legal system of the present invention to makeGrain, its curative effect is better than the gastrin magnesium granules that the grass-leaved sweetflag cyclodextrin inclusion compound of prior art makes.
Detailed description of the invention
Be below the specific embodiment of the present invention, described embodiment is in order to further describe the present invention, instead ofRestriction the present invention.
Embodiment 1
Prescription:
The preparation of Essential Oil of Acorus tatarinowii: clean the grass-leaved sweetflag of recipe quantity medicinal material is put in extractor, added about medicinal material 4 times of amountsWater, soaks 36 hours, uses extraction by steam distillation volatile oil, keeps liquid level boiling, controls below steam pressure 0.3Mpa, receivesCollection Essential Oil of Acorus tatarinowii, airtight, please test, in 2～10 DEG C of refrigerations, for subsequent use after the assay was approved;
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, in the slurries of gained, add Essential Oil of Acorus tatarinowii for subsequent use, wherein starch Sodium Octenyl SuccinateThe volume ratio of the volatile oil that consumption and grass-leaved sweetflag extract is 10g:1ml, makes colostrum; Colostrum is carried out to homogeneous processing to be volatilizedFat liquor, wherein first class pressure is 25MPa, secondary pressure is 8MPa; Again by dry the volatile oil emulsion spraying of the gained institute that obtainsThe grass-leaved sweetflag inclusion compound of stating.
In writing out a prescription, sucrose is pulverized, and crosses 100 mesh sieves, for subsequent use;
By bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, davurian buckthorn bark, fennel powder, reed after weighingLuxuriant growth powder, cane sugar powder and grass-leaved sweetflag inclusion compound for subsequent use mix 20 minutes, obtain the material after premix.
Material after premix is made to softwood for 20-30 minute with 75% ethanol mixing, 18 eye mesh screen granulations, control turnsSpeed is 9-12 rev/min, drier under EAT 70-80 DEG C, the temperature 60-70 of fluidising chamber DEG C condition, whole grain, and packing, to obtain final product.
Embodiment 2
Prescription:
The preparation of Essential Oil of Acorus tatarinowii: with embodiment 1.
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, in the slurries of gained, add Essential Oil of Acorus tatarinowii for subsequent use, wherein starch Sodium Octenyl SuccinateThe volume ratio of the volatile oil that consumption and grass-leaved sweetflag extract is 15g:1ml, makes colostrum; Colostrum is carried out to twice homogeneous processing to be obtainedVolatile oil emulsion, wherein first class pressure is 35MPa, secondary pressure is 12MPa; Again the volatile oil emulsion spraying of gained is driedTo described grass-leaved sweetflag inclusion compound.
In writing out a prescription, sucrose is pulverized, and crosses 100 mesh sieves, for subsequent use;
By bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, davurian buckthorn bark, fennel powder, reed after weighingLuxuriant growth powder, cane sugar powder and grass-leaved sweetflag inclusion compound for subsequent use mix 20 minutes, obtain the material after premix.
Material after premix is mixed and within 20 minutes, makes softwood with 75% ethanol, and 18 eye mesh screen granulations, control rotating speedBe 9 revs/min, drier under 70 DEG C of EATs, fluidising chamber's temperature 60 C condition, whole grain, packing.
Embodiment 3
Prescription:
The preparation of Essential Oil of Acorus tatarinowii: with embodiment 1.
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, in the slurries of gained, add Essential Oil of Acorus tatarinowii for subsequent use, wherein starch Sodium Octenyl SuccinateThe volume ratio of the volatile oil that consumption and grass-leaved sweetflag extract is 12g:1ml, makes colostrum; Colostrum is carried out to homogeneous processing to be volatilizedFat liquor, wherein first class pressure is 30MPa, secondary pressure is 10MPa; Again by dry the volatile oil emulsion spraying of the gained institute that obtainsThe grass-leaved sweetflag inclusion compound of stating.
In writing out a prescription, sucrose is pulverized, and crosses 100 mesh sieves, for subsequent use;
By bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, davurian buckthorn bark, fennel powder, reed after weighingLuxuriant growth powder, cane sugar powder and grass-leaved sweetflag inclusion compound for subsequent use mix 20 minutes, obtain the material after premix.
Material after premix is mixed and within 30 minutes, makes softwood with 75% ethanol, and 18 eye mesh screen granulations, control rotating speedBe 12 revs/min, drier under 80 DEG C of EATs, fluidising chamber's temperature 70 C condition, whole grain, packing.
Embodiment 4
Prescription:
The preparation of Essential Oil of Acorus tatarinowii: with embodiment 1.
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, in the slurries of gained, add Essential Oil of Acorus tatarinowii for subsequent use, wherein starch Sodium Octenyl SuccinateThe volume ratio of the volatile oil that consumption and grass-leaved sweetflag extract is 13g:1ml, makes colostrum; Colostrum is carried out to homogeneous processing to be volatilizedFat liquor, wherein first class pressure is 28MPa, secondary pressure is 9MPa; Again by dry the volatile oil emulsion spraying of the gained institute that obtainsThe grass-leaved sweetflag inclusion compound of stating.
Other preparation method is with embodiment 1.
Embodiment 5
Prescription:
The preparation of Essential Oil of Acorus tatarinowii: with embodiment 1.
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature,Slurries; Under agitation, in the slurries of gained, add Essential Oil of Acorus tatarinowii for subsequent use, wherein starch Sodium Octenyl SuccinateThe volume ratio of the volatile oil that consumption and grass-leaved sweetflag extract is 14g:1ml, makes colostrum; Colostrum is carried out to homogeneous processing to be volatilizedFat liquor, wherein first class pressure is 32MPa, secondary pressure is 11MPa; Again by dry the volatile oil emulsion spraying of the gained institute that obtainsThe grass-leaved sweetflag inclusion compound of stating.
The other the same as in Example 1.
Comparative example 1
This comparative example has compared its volatile oil utilization rate of different grass-leaved sweetflag inclusion compounds.
Beta-schardinger dextrin-method: the ethanol dilution of 20ml for 7ml Essential Oil of Acorus tatarinowii, obtains volatile oil dilution; 100g β-ring is stuck with pasteFinishing enters in 100ml70-80 DEG C of hot water, grinds evenly in mortar; It is rare that grinding ring dextrin solution limit, limit splashes into volatile oil graduallyRelease liquid, and grind 1 hour, obtain liquid grass-leaved sweetflag inclusion compound; 45-50 DEG C dry, pulverize, and crosses 100 mesh sieves, obtains grass-leaved sweetflag ringCyclodextrin inclusion compound.
Starch Sodium Octenyl Succinate method: get 100g starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled toRoom temperature, obtains slurries; Under agitation, to 7ml Essential Oil of Acorus tatarinowii in the slurries of gained, make colostrum; Colostrum is carried out to homogeneous placeReason obtains volatile oil emulsion, and wherein first class pressure is 25MPa, and secondary pressure is 8MPa; Again by the volatile oil emulsion spraying of gainedGrass-leaved sweetflag starch Sodium Octenyl Succinate inclusion compound described in dry obtaining.
The mensuration of Essential Oil of Acorus tatarinowii utilization rate in inclusion compound: with reference to " Chinese pharmacopoeia " (2010 editions annex XD) volatilizationOil determination method is measured, and by dry gained inclusion compound precise weighing, utilizes volatile oil extractor to extract 5h, while no longer increasing to oil massStop heating. Sufficient standing reading, calculates volatile oil utilization rate in inclusion compound, and formula is as follows:
Inclusion compound recovery rate (Q1)=inclusion compound actual weight × (beta-schardinger dextrin-+throwing oil mass)-1×100％
(note: in the time being starch Sodium Octenyl Succinate method, the beta-schardinger dextrin-in formula is starch Sodium Octenyl Succinate)
Actual oil content in Essential Oil of Acorus tatarinowii utilization rate (Q2)=inclusion compound × (throwing oil mass) in inclusion compound-1×100％
The result of two kinds of grass-leaved sweetflag inclusion compounds, in table 1:
The comparison of table 1, two kinds of grass-leaved sweetflag inclusion compound results
| Inclusion compound | Q1(％) | Q2(％) |
| Starch Sodium Octenyl Succinate method | 96.81 | 73.52 |
| Beta-schardinger dextrin-method | 90.65 | 45.38 |
Note: every numerical value is the average of three groups of parallel laboratory tests.
Can find out from above-mentioned experimental result, the present invention adopts starch Sodium Octenyl Succinate to prepare grass-leaved sweetflag inclusion compound,Its volatile oil utilization rate is higher, is better than the beta-schardinger dextrin-method of prior art.
Comparative example 2
This comparative example has compared the clinical efficacy of the gastrin magnesium granules that different grass-leaved sweetflag inclusion compounds make.
1, data and method
Case selection: 1. enter group standard: in July, 2013-2014 accept for medical treatment year June after gastroscope, be diagnosed as chronic gastritis and14CPositive definite patient's 80 examples that exist the existing disease of Hp to infect of urea breath test, wherein inpatient 50 examples, out-patient's 30 examples; Man54 examples, female's 26 examples; Treatment group man 24 examples, female's 16 examples, age 25-50 year, average (36.9 ± 3.2) year; Control group man 30 examples, female10 examples, age 25-49 year, average (35.7 ± 4.1) year. All patients are wanting in sex, age, stomach lining inflammation situation etc.Different equal not statistically significant (P > 0.05), there is comparativity. 2. exclusion standard: treat and took antibiotic, bismuth agent, H for first 2 weeks2Receptor antagonist and PPI person; Gestation or women breast-feeding their children; With serious disease as serious hepatopathy, heart disease, kidney trouble, perniciousTumour and alcoholic, peptic ulcer and mental illness can not partners.
Grouping and medication: 80 selected routine patients are divided into treatment group and control group at random. Treatment group is each serving EssoAzoles 20mg, CLA 500mg, Amoxicillin 1000mg, 2 times/day draw in U.S.A; The gastrin magnesium granules that the embodiment of the present invention 1 makes3.0g, 3 times/day, 14 days courses for the treatment of; Control group is each serving esomeprazole 20mg, CLA 500mg, Amoxicillin 1000mg,2 times/day; The gastrin magnesium granules 3.0g that in CN200610086980.7, the method for detailed description of the invention makes, 3 times/day, the course for the treatment of 14My god.
Evaluation index: stop said medicine 30 days after treatment finishes, do after 31 days14C urea breath test check Hp, negative patientBe judged as Hp and eradicate, positive in treating unsuccessfully (representing that Hp does not eradicate). Record simultaneously and analyze the bad reaction of appearance.
Statistical procedures: adopt SPSS11.0 statistical software to analyze, each group categories data acquisition x2Inspection, P≤0.05 isDifference has statistical significance.
2, result
After two groups of treatments, Hp eradicates effect comparison, in table 2.
After table 2, two groups of treatments, Hp eradicates effect comparison (example)
| Group | Number of cases | Hp (feminine gender) | Hp (positive) | Eradication rate |
| Treatment group | 40 | 38 | 2 | 95.0％ |
| Control group | 40 | 35 | 5 | 87.5％ |
Can find out from above-mentioned result of the test, eradicate chronic gastritis containing the quadruple chemotherapy of gastrin magnesium granules of the present invention and mergeThe total effective rate that Hp infects is 95.0%, higher than the total effective rate (87.5%) of control group.
The prepared gastrin magnesium granules of other embodiment of the present invention is also carried out to above-mentioned test, the result phase of its acquisitionSeemingly.
Claims (9)
1. a gastrin magnesium granules is by main ingredient bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, buckthornThe granule that skin, fennel, aloe and grass-leaved sweetflag add pharmaceutic adjuvant to be prepared from, is characterized in that, what grass-leaved sweetflag was extracted wavesHair oil carries out inclusion by starch Sodium Octenyl Succinate and obtains inclusion compound, then with other combination of components, described octenyl amberThe volume ratio of the volatile oil that the consumption of acid-starch sodium and grass-leaved sweetflag extract is 10～15g:1ml; Described main ingredient is by following proportioningComposition:
Bismuth aluminate 100-250 weight portion, heavy magnesium carbonate 300-500 weight portion, sodium acid carbonate 150-250 weight portion, Radix Glycyrrhizae are soakedCream powder 150-300 weight portion, Frangula 5-30 weight portion, fennel powder 5-30 weight portion, aloe powder 10-30 weight portion, stoneCalamus 5-50 weight portion.
2. gastrin magnesium granules according to claim 1, is characterized in that, described inclusion compound is adopted with the following method and is prepared intoArrive:
Get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature, obtain slurries; Under agitation, to gainedThe volatile oil that adds grass-leaved sweetflag to extract in slurries, makes colostrum; Colostrum is carried out to homogeneous processing and obtain volatile oil emulsion; Again by instituteInclusion compound described in dry the obtaining of volatile oil emulsion spraying obtaining.
3. gastrin magnesium granules according to claim 2, is characterized in that, described homogeneous is homogeneous twice, first class pressure25～35MPa, secondary pressure 8～12MPa.
4. gastrin magnesium granules according to claim 3, is characterized in that, described first class pressure is 30MPa, secondary pressureFor 10MPa.
5. according to the gastrin magnesium granules described in claim 3 or 4, it is characterized in that, described pharmaceutic adjuvant is sucrose.
6. gastrin magnesium granules according to claim 5, is characterized in that, the consumption of described sucrose is 1 of main ingredient weight～3 times.
7. gastrin magnesium granules according to claim 6, is characterized in that, described main ingredient forms by following proportioning:
Bismuth aluminate 180-220 weight portion, heavy magnesium carbonate 350-450 weight portion, sodium acid carbonate 200-250 weight portion, Radix Glycyrrhizae are soakedCream powder 200-300 weight portion, Frangula 10-20 weight portion, fennel powder 10-20 weight portion, aloe powder 20-30 weight portion,Grass-leaved sweetflag 10-30 weight portion.
8. gastrin magnesium granules according to claim 7, is characterized in that, described main ingredient forms by following proportioning:
Bismuth aluminate 200 weight portions, heavy magnesium carbonate 400 weight portions, sodium acid carbonate 250 weight portions, Radix Glycyrrhizae extractum powder 250 weightPart, Frangula 15 weight portions, fennel powder 15 weight portions, aloe powder 30 weight portions, grass-leaved sweetflag 12.5 weight portions.
9. a preparation method for the gastrin magnesium granules described in claim 1-8 any one, is characterized in that, described preparationMethod is:
The preparation of grass-leaved sweetflag inclusion compound: get starch Sodium Octenyl Succinate, add boiling water, be stirred to dissolve, be chilled to room temperature, obtain slurryLiquid; Under agitation, to the volatile oil that adds in the slurries of gained grass-leaved sweetflag to extract, make colostrum; Colostrum is carried out to homogeneous processingObtain volatile oil emulsion; Again by the grass-leaved sweetflag inclusion compound described in dry the obtaining of volatile oil emulsion spraying of gained;
Sucrose is pulverized, sieved for subsequent use;
By bismuth aluminate, heavy magnesium carbonate, sodium acid carbonate, Radix Glycyrrhizae extractum powder, davurian buckthorn bark, fennel powder, aloe powder, sugarcane for subsequent useIcing Sugar and grass-leaved sweetflag inclusion compound mix, and obtain the material after premix;
Material after premix is made to softwood for 20-30 minute with 75% ethanol mixing, 18 eye mesh screen granulations, control rotating speed is9-12 rev/min, drier under EAT 70-80 DEG C, the temperature 60-70 of fluidising chamber DEG C condition, whole grain, packing, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510315118.8A CN104906326B (en) | 2015-06-10 | 2015-06-10 | A kind of gastrin magnesium granules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510315118.8A CN104906326B (en) | 2015-06-10 | 2015-06-10 | A kind of gastrin magnesium granules and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104906326A CN104906326A (en) | 2015-09-16 |
| CN104906326B true CN104906326B (en) | 2016-05-11 |
Family
ID=54076042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510315118.8A Active CN104906326B (en) | 2015-06-10 | 2015-06-10 | A kind of gastrin magnesium granules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104906326B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854500A (en) * | 2017-12-28 | 2018-03-30 | 广东伊茗药业有限公司 | A kind of pharmaceutical preparation for treating stomach trouble |
| CN115531448B (en) * | 2022-11-24 | 2023-03-10 | 弘美制药（中国）有限公司 | Francisella fern bark extract powder, preparation thereof and application thereof in stomach bismuth magnesium granules |
| CN116392515B (en) * | 2023-05-29 | 2023-08-15 | 弘美制药（中国）有限公司 | Fennel powder inclusion compound and preparation method thereof and stomach-harmonizing bismuth magnesium granule compound preparation |
| CN116350699B (en) * | 2023-06-01 | 2023-08-15 | 弘美制药（中国）有限公司 | Preparation method of rhizoma acori graminei volatile oil and stomach bismuth magnesium granule compound preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579473A (en) * | 2003-09-24 | 2005-02-16 | 太平洋医药（通化）有限公司 | Medicine composition for treating stomach disease, its preparation method and use |
| CN1824131A (en) * | 2005-12-20 | 2006-08-30 | 诺氏制药（吉林）有限公司 | Weibimei medicical composition for treating stomach disease and its preparation method |
| CN1895520A (en) * | 2006-06-22 | 2007-01-17 | 诺氏制药（吉林）有限公司 | Gastrin magnesium granules and preparation thereof |
-
2015
- 2015-06-10 CN CN201510315118.8A patent/CN104906326B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579473A (en) * | 2003-09-24 | 2005-02-16 | 太平洋医药（通化）有限公司 | Medicine composition for treating stomach disease, its preparation method and use |
| CN1824131A (en) * | 2005-12-20 | 2006-08-30 | 诺氏制药（吉林）有限公司 | Weibimei medicical composition for treating stomach disease and its preparation method |
| CN1895520A (en) * | 2006-06-22 | 2007-01-17 | 诺氏制药（吉林）有限公司 | Gastrin magnesium granules and preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| 低粘度辛烯基琥珀酸淀粉钠作微胶囊壁材包埋柠檬油(英文);黄强等;《天然产物研究与开发》;20070228(第19期);138-142，第139页右栏第3段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104906326A (en) | 2015-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104906326B (en) | A kind of gastrin magnesium granules and preparation method thereof | |
| US11931394B2 (en) | Herbal supplements and methods of use thereof | |
| CN105166544A (en) | Pig mixed feed and preparation method thereof | |
| CN101297889A (en) | Chinese medicine preparation for treating foot-and-mouth disease and preparation method thereof | |
| CN104739960B (en) | Stomach antibacterial combination, the stomach antibacterials containing said composition and preparation | |
| CN107875210A (en) | A kind of Chinese medicine composition, its preparation method and application for preventing and treating Colon and rectum adenoma | |
| CN1286501C (en) | Medicine composition for treating stomach disease, its preparation method and use | |
| CN104758451A (en) | Traditional Chinese medicine composite for treating gout | |
| CN104825700A (en) | Traditional Chinese medicine composition for resisting bacteria and diminishing inflammation | |
| CN101390965A (en) | Veterinary traditional Chinese herb medicine for treating livestock and poultry bacterial and viral infectious diseases and preparation method thereof | |
| CN1686424A (en) | Medicinal composition containing scutellaria and bupleurum and its preparation method | |
| CN104013696B (en) | A kind of plant drug composition of preventing and treating metabolism syndrome and its application | |
| CN103861007B (en) | A kind of Chinese herbal compound preparation for the treatment of chicken diarrhea | |
| CN105770054A (en) | Pharmaceutical composition for preventing and treating chicken coccocidiosis, additive and feed | |
| CN104547125A (en) | Gastrointestinal drug and application thereof | |
| CN110404006A (en) | A kind of pharmaceutical composition for treating chicken necrotizing enterocolitis | |
| CN103893512B (en) | A kind of Chinese medicine composition for treating urarthritis | |
| CN104491338B (en) | A kind of medicine-food dual-purpose composition to relax bowel and preparation method thereof | |
| CN104606627B (en) | A kind of pharmaceutical composition for treating grice diarrhoea and preparation method thereof | |
| CN103599288A (en) | Traditional Chinese medicine oral liquid for treating chicken infectious laryngotracheitis and preparation method thereof | |
| CN105748589A (en) | Chinese and western medicine compound veterinary drug for treating diarrhea as well as preparation method and application of Chinese and western medicine compound veterinary drug | |
| CN109731044B (en) | Traditional Chinese medicine compound granule for treating intestinal infection of poultry and preparation method thereof | |
| CN102302575A (en) | Oral medicament for treating white scour of piglets and preparation method thereof | |
| CN1304018C (en) | Cough-stopping throat-clearing medicament made from chrysanthemum flower | |
| CN101926955B (en) | Medicament for treating stomach illness |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |