CN108026527B - 确定的多偶联寡核苷酸 - Google Patents

确定的多偶联寡核苷酸 Download PDF

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CN108026527B
CN108026527B CN201680048179.5A CN201680048179A CN108026527B CN 108026527 B CN108026527 B CN 108026527B CN 201680048179 A CN201680048179 A CN 201680048179A CN 108026527 B CN108026527 B CN 108026527B
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isolated compound
cleavable
oligonucleotides
stranded
sirna
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CN108026527A (zh
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P.哈德维格
H-P.沃恩洛彻
J.M.布朗
J.E.达尔曼
K.K.H.纽曼
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MPEG LA LLC
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CN201680048179.5A 2015-06-15 2016-06-15 确定的多偶联寡核苷酸 Active CN108026527B (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562175718P 2015-06-15 2015-06-15
US201562175714P 2015-06-15 2015-06-15
US201562175709P 2015-06-15 2015-06-15
US62/175,718 2015-06-15
US62/175,714 2015-06-15
US62/175,709 2015-06-15
US201562203243P 2015-08-10 2015-08-10
US62/203,243 2015-08-10
US201562216318P 2015-09-09 2015-09-09
US201562216317P 2015-09-09 2015-09-09
US201562216314P 2015-09-09 2015-09-09
US62/216,317 2015-09-09
US62/216,314 2015-09-09
US62/216,318 2015-09-09
PCT/US2016/037685 WO2016205410A2 (en) 2015-06-15 2016-06-15 Defined multi-conjugate oligonucleotides

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CN108026527B true CN108026527B (zh) 2022-05-10

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EP (2) EP4541374A2 (enExample)
JP (1) JP7033452B2 (enExample)
KR (2) KR20250016526A (enExample)
CN (1) CN108026527B (enExample)
AU (3) AU2016280709B2 (enExample)
CA (1) CA2988603A1 (enExample)
HK (1) HK1252970A1 (enExample)
IL (2) IL316159A (enExample)
MX (2) MX2017016088A (enExample)
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JP2022523226A (ja) * 2019-03-04 2022-04-21 エムペグ エルエイ リミテッド ライアビリティ カンパニー 増強された生理活性を有する多量体オリゴヌクレオチド
WO2020210207A2 (en) * 2019-04-11 2020-10-15 Northeastern University Oligonucleotide-polymer miktoarm conjugates and methods of use
CA3144467A1 (en) * 2019-07-30 2021-02-04 Jonathan Miles Brown Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity
CN114502730A (zh) 2019-08-09 2022-05-13 马萨诸塞大学 经化学修饰的靶向snp的寡核苷酸
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
CN111041025B (zh) 2019-12-17 2021-06-18 深圳市瑞吉生物科技有限公司 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法
CN112111524B (zh) * 2020-01-10 2024-02-27 深圳瑞吉生物科技有限公司 mRNA-GalNAc靶向分子的制备方法及其体内递送系统和应用
WO2021222635A2 (en) * 2020-04-30 2021-11-04 Mpeg La, L.L.C. Multimeric oligonucleotides with divided strands
CA3178559A1 (en) * 2020-05-19 2021-11-25 Jonathan Miles Brown Orthogonally linked multimeric oligonucleotides
CN111744019B (zh) 2020-07-01 2023-08-04 深圳瑞吉生物科技有限公司 基于甘露糖的mRNA靶向递送系统及其应用
JP2024506042A (ja) * 2021-02-08 2024-02-08 ラクティゲン セラピューティクス 多価オリゴヌクレオチド薬剤およびその使用方法
EP4359539A4 (en) 2021-06-23 2025-05-14 University Of Massachusetts ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS OPTIMIZED FOR THE TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
CN115010794A (zh) * 2022-06-30 2022-09-06 武汉瑞佶生物科技有限公司 蛋白质介导的mRNA靶向分子及其制备方法和应用
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